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The map label for this gene is chuR [H]

Identifier: 170754226

GI number: 170754226

Start: 3433001

End: 3434407

Strand: Reverse

Name: chuR [H]

Synonym: CLD_1367

Alternate gene names: 170754226

Gene position: 3434407-3433001 (Counterclockwise)

Preceding gene: 170757321

Following gene: 170755232

Centisome position: 86.77

GC content: 28.22

Gene sequence:

>1407_bases
ATGAAACAAAATGCTTTTTTTCATTTGTTCAAAACAAGAAATTGTTGCTATATATATGATGTAAATACTAATTTATTTTT
AAAGGTACCTAAAGAAACATATAGTGCTTTAGAGAACTATAATGGTGATCTAGAAGCTTTAAAAGACGATAGCGTTATCC
TAAACTTAAAAGAAAAAGGATATTTATCATCTAATAGAGCTGAAGAAATAGAACATTCATTAACTGATGCATTAGAAAGT
ATTTTAGACAATTCGCTAAATACTCTTACACTCCAAATTACACAAGAATGCAATTTAAGATGCAGTTATTGTGTATATTC
TGGTAGCTATTTGAATAGATCTCACTCACACAAGATAATGAGTATAGATACAGCAAAAAAAGGTATAGATTTTATAATAA
ATCATTCTAAAAATTCACCTACAGTTAATTTTGCATTTTATGGAGGAGAACCACTTTTAAGATTTAATTTTATAAAAGAA
TGTGTAGCTTATGCAAAGGAGAAAGGAGAAGGTAAAAAAATAACATTCAATATGACTATAAATGGTACTTTACTTACTGA
TGAAATTATAAAATTTATGAAAGATAATGAAGTTTCGTTACTCATTAGCATGGATGGACCAAAGGAGATACATGATAAGA
ATAGAGTGTTTTCAAACGGAATGGGTTCATTTGATAAAATAATGAATAATATAAATAAAATAAAAGTAAAATTTCCTGAA
TATGTTGAGAAAAATGTAGGGTTTAATATTGTTATGGACGGACAGAACGATTTTAGTTGCATAAATAACTTTTTTGCAAA
TTATGATACAGTAAAAGATTCTCGTGTAAATGCAACTGATGTAAGTACGTTAGGAGCATTAGAGGAGAAAGCAATTTCAG
AAGAATTTATCCAAGATGAGAAATACGAAAGATTTAAGATTTTATTACATAAACTTGGAAAACTAGATGAAAAATATATT
TCAAAGCTTCTATTGAGTCAATTTGAACATATAAACCATACTTTAAATGTAAAGAGAGAAGCTAACGAAAAAGTCCCTAA
AAAAATGCATCCAGGAGGTCCTTGTATTCCTGGATTAAATAGGCTATTTATGACTGTAGATGGAAAGTTTTGCCCTTGTG
AGAGAGTAAATGAAGAATCAGAAGCCATGAATATAGGTAATGTTAATACTGGCTTTGAGATAGAAAAAATCAAGAAATTA
ATCAATGTAGGAGAAATGACCAAGCAAAAGTGCAAAAATTGTTGGGCATTTAGATATTGTTATTTATGTGCTGCGTTTGC
TGATGATATGAATGAATTAAGTGGAGTCAAAAGAGCTAAGTTCTGCAATGATGTTAAAAGAAATACAGAAGAAATGTTTA
AAGTATATTGTACAATGATGGAATTTGGATATAAATTTGAAGAATAA

Upstream 100 bases:

>100_bases
GTCATGATTAAAGTTTAAAGCTTTATTATTAAAATTAAACGACATAAAGATTATCCTTTATGTCGTTTATATTAATTAAA
TTGATTTAAGGAGAAAATTT

Downstream 100 bases:

>100_bases
TAGAGTAATATATAATATGTGTAATATGGAGGCTTATTAAATGAATAATAAAGAAAAGGCATTGATATATCCTTATGATA
GAGAATTTTCTACAATAATA

Product: radical SAM domain-containing protein

Products: NA

Alternate protein names: AnSME; Chondroitin sulfate/heparin utilization regulation protein; Ser-type sulfatase-activating enzyme [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKQNAFFHLFKTRNCCYIYDVNTNLFLKVPKETYSALENYNGDLEALKDDSVILNLKEKGYLSSNRAEEIEHSLTDALES
ILDNSLNTLTLQITQECNLRCSYCVYSGSYLNRSHSHKIMSIDTAKKGIDFIINHSKNSPTVNFAFYGGEPLLRFNFIKE
CVAYAKEKGEGKKITFNMTINGTLLTDEIIKFMKDNEVSLLISMDGPKEIHDKNRVFSNGMGSFDKIMNNINKIKVKFPE
YVEKNVGFNIVMDGQNDFSCINNFFANYDTVKDSRVNATDVSTLGALEEKAISEEFIQDEKYERFKILLHKLGKLDEKYI
SKLLLSQFEHINHTLNVKREANEKVPKKMHPGGPCIPGLNRLFMTVDGKFCPCERVNEESEAMNIGNVNTGFEIEKIKKL
INVGEMTKQKCKNCWAFRYCYLCAAFADDMNELSGVKRAKFCNDVKRNTEEMFKVYCTMMEFGYKFEE

Sequences:

>Translated_468_residues
MKQNAFFHLFKTRNCCYIYDVNTNLFLKVPKETYSALENYNGDLEALKDDSVILNLKEKGYLSSNRAEEIEHSLTDALES
ILDNSLNTLTLQITQECNLRCSYCVYSGSYLNRSHSHKIMSIDTAKKGIDFIINHSKNSPTVNFAFYGGEPLLRFNFIKE
CVAYAKEKGEGKKITFNMTINGTLLTDEIIKFMKDNEVSLLISMDGPKEIHDKNRVFSNGMGSFDKIMNNINKIKVKFPE
YVEKNVGFNIVMDGQNDFSCINNFFANYDTVKDSRVNATDVSTLGALEEKAISEEFIQDEKYERFKILLHKLGKLDEKYI
SKLLLSQFEHINHTLNVKREANEKVPKKMHPGGPCIPGLNRLFMTVDGKFCPCERVNEESEAMNIGNVNTGFEIEKIKKL
INVGEMTKQKCKNCWAFRYCYLCAAFADDMNELSGVKRAKFCNDVKRNTEEMFKVYCTMMEFGYKFEE
>Mature_468_residues
MKQNAFFHLFKTRNCCYIYDVNTNLFLKVPKETYSALENYNGDLEALKDDSVILNLKEKGYLSSNRAEEIEHSLTDALES
ILDNSLNTLTLQITQECNLRCSYCVYSGSYLNRSHSHKIMSIDTAKKGIDFIINHSKNSPTVNFAFYGGEPLLRFNFIKE
CVAYAKEKGEGKKITFNMTINGTLLTDEIIKFMKDNEVSLLISMDGPKEIHDKNRVFSNGMGSFDKIMNNINKIKVKFPE
YVEKNVGFNIVMDGQNDFSCINNFFANYDTVKDSRVNATDVSTLGALEEKAISEEFIQDEKYERFKILLHKLGKLDEKYI
SKLLLSQFEHINHTLNVKREANEKVPKKMHPGGPCIPGLNRLFMTVDGKFCPCERVNEESEAMNIGNVNTGFEIEKIKKL
INVGEMTKQKCKNCWAFRYCYLCAAFADDMNELSGVKRAKFCNDVKRNTEEMFKVYCTMMEFGYKFEE

Specific function: Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6- sulfatase, i

COG id: COG0641

COG function: function code R; Arylsulfatase regulator (Fe-S oxidoreductase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081923, Length=141, Percent_Identity=35.4609929078014, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994973, Length=208, Percent_Identity=27.4038461538462, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 53813; Mature: 53813

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQNAFFHLFKTRNCCYIYDVNTNLFLKVPKETYSALENYNGDLEALKDDSVILNLKEKG
CCCCCEEEEEECCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCEEECCCCEEEEECCCC
YLSSNRAEEIEHSLTDALESILDNSLNTLTLQITQECNLRCSYCVYSGSYLNRSHSHKIM
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCEEE
SIDTAKKGIDFIINHSKNSPTVNFAFYGGEPLLRFNFIKECVAYAKEKGEGKKITFNMTI
EECCHHCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NGTLLTDEIIKFMKDNEVSLLISMDGPKEIHDKNRVFSNGMGSFDKIMNNINKIKVKFPE
CCEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECHH
YVEKNVGFNIVMDGQNDFSCINNFFANYDTVKDSRVNATDVSTLGALEEKAISEEFIQDE
HHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
KYERFKILLHKLGKLDEKYISKLLLSQFEHINHTLNVKREANEKVPKKMHPGGPCIPGLN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEECCHHHHHCCCHHCCCCCCCCCCCC
RLFMTVDGKFCPCERVNEESEAMNIGNVNTGFEIEKIKKLINVGEMTKQKCKNCWAFRYC
EEEEEECCCCCCHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLCAAFADDMNELSGVKRAKFCNDVKRNTEEMFKVYCTMMEFGYKFEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKQNAFFHLFKTRNCCYIYDVNTNLFLKVPKETYSALENYNGDLEALKDDSVILNLKEKG
CCCCCEEEEEECCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCEEECCCCEEEEECCCC
YLSSNRAEEIEHSLTDALESILDNSLNTLTLQITQECNLRCSYCVYSGSYLNRSHSHKIM
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCEEE
SIDTAKKGIDFIINHSKNSPTVNFAFYGGEPLLRFNFIKECVAYAKEKGEGKKITFNMTI
EECCHHCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NGTLLTDEIIKFMKDNEVSLLISMDGPKEIHDKNRVFSNGMGSFDKIMNNINKIKVKFPE
CCEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECHH
YVEKNVGFNIVMDGQNDFSCINNFFANYDTVKDSRVNATDVSTLGALEEKAISEEFIQDE
HHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
KYERFKILLHKLGKLDEKYISKLLLSQFEHINHTLNVKREANEKVPKKMHPGGPCIPGLN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHEECCHHHHHCCCHHCCCCCCCCCCCC
RLFMTVDGKFCPCERVNEESEAMNIGNVNTGFEIEKIKKLINVGEMTKQKCKNCWAFRYC
EEEEEECCCCCCHHHCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLCAAFADDMNELSGVKRAKFCNDVKRNTEEMFKVYCTMMEFGYKFEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1429442; 12663928 [H]