Click here to switch to the map view.

The map label for this gene is gmr [H]

Identifier: 170752119

GI number: 170752119

Start: 6059359

End: 6061032

Strand: Reverse

Name: gmr [H]

Synonym: Mrad2831_5752

Alternate gene names: 170752119

Gene position: 6061032-6059359 (Counterclockwise)

Preceding gene: 170752120

Following gene: 170752117

Centisome position: 99.72

GC content: 69.89

Gene sequence:

>1674_bases
ATGAGCGAGCCCGATTACCCGGAGCGTCAGACCCTGCTCGAGGCCGCCATCCAGGCGCTTCCGGTCGGCGTCGTGGTCCG
TGACGGCCAGGGTCACTGCATCCTGGCCAACGCCGCCGCGCGCGCCCTCGGGGACAGGGCCGTCGCGGCGCTGCCCGCCG
CGCCGTGTGACGCCCGGGATACCGCGGCCGTCGAGGCCGTCGACGACCGGATGTTCGAGGTGCGGACGCGGCCGGTCGCC
GGGGGCCGGGACGCCTTCACGCTCACGACCCTGACCGACGTCACGCACCATCACCGGATCCAGCGTGAGCTGATCACCAA
GGCCTTCATCGACGCCCTCACCGGCCTGCCCAACCGGACGATGTTCGAGCAGAGCATCGCGGATGTCCTGGCAGGATCGG
CGCCGGGGGACCGGTTCGCCCTGGCGTTCATCGATCTCGACAACTTCAAGCACATCAACGACTACTACAGCCACGCCGCG
GGCGACGCCCTGCTGCGCAAGATGTCCGACCGGATCGGCGGCGCCCTGCGCCCGAGCGACCTCCTGGCCCGGATCGGCGG
CGACGAGTTCGTGCTCCTGCTCGCCCCGATCACCGATCGGGACGAGGCGCTGTCCGCCGTGCGCGCCATCTCGGAGCGCC
TGAAGCAGCCGTTCTTCATCGACGGGCACGAGATCTTCGCCTCCGCCTCCATCGGACTCAGCCTCTTCCCGGAGCACGGC
GACAGCTACGAGACCCTCGCCCGGCAGGCCGACAACGCGATGTACCGGGTGAAGGGCGAGTTGAAGGGCGGCGTCAGCCT
CTTCGACGACGCGATGAGCCAGGCCGCCACGGCCCGCATGGCCGTGGAGCAGCGCCTCCGACTGGCGATCCGCGACCGCT
GCTTCTGCTGCGCCTTCCAGCCGAAGGTCGACATGCGCTCCCACGCGGTCACGGGCGTCGAGGTGCTGCTGCGCTGGCGC
GACGAGCTCGGCATGATCCAGGCCCCGGGCGACTTCATCGCCCTGGCCATCGAGCTGGGGCTGATCAACGAGATCACCCT
CCAGCTCCTCTCCGAGACCGTTCAGGCGATGCCCGACATCGACGAGGTGTTCGGACCCGACGTCACCGTGAGCCTCAACA
TCGCCGCTAAGCAGGCCTGCGACGTGCCGTTCATGACCGCCTTCTGCGCCTCGCTGGGCGAGACCGGCCTCGCGGAGCGC
TTCGTCCTCGAACTGACAGAGGAGGCCTTCTTCACGACAGGCCGCTTCCAGAGCGAGGTTCTGCCGAAGATCCGGGCGAT
CGGCGCGCGGGTCTCGATCGACGATTTCGGCGTCGGCTACTCGTCCCTCGCGGCCCTGGCCGACATCACCGCGGACGAGC
TCAAGATCGATCGCTCGTTCATCACCGACATCGATAAGCGACCGCGCAGCCAGATCGTCCTGAAGGCGATCGAGTCGCTC
GGCGCGGCGCTCGGCATGACGGTCGTCGCCGAGGGCGTCGAGACCTTCGAGGAAGTCGCCTACCTGCTCGGCGCGACGCA
GATCCGCTGCGCCCAGGGCTACTACTTCGCCCGCCCGCTCCTGCTCGACCAGATCCGGCAGGCCCAGCCGCCGCGCGTGT
CCGGGACGCGCGGCCCCGCCACGCGCAGCCGCGCCTCGGACCTGCGCGCACCCGGCCTGATGCGGCGCGCCTGA

Upstream 100 bases:

>100_bases
GCCGGCTGCTCCGTCGCCCCCCCGAGACCGGCGATCAGGCCCCGACCGGCGGCCAGGCCGGCGCCCCGCCTGCCAAGTCC
CTGTGGCAGCAGGGCGGGGC

Downstream 100 bases:

>100_bases
CTTCCGCCCCGCGGCGCGACTGCCGACAGCCTCCGACCGGCGGCCGGATCAGCTTGCCGCTGGCGGCGTGCTACGCGGCC
AGCAGCGGTCGCCACACGCC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSEPDYPERQTLLEAAIQALPVGVVVRDGQGHCILANAAARALGDRAVAALPAAPCDARDTAAVEAVDDRMFEVRTRPVA
GGRDAFTLTTLTDVTHHHRIQRELITKAFIDALTGLPNRTMFEQSIADVLAGSAPGDRFALAFIDLDNFKHINDYYSHAA
GDALLRKMSDRIGGALRPSDLLARIGGDEFVLLLAPITDRDEALSAVRAISERLKQPFFIDGHEIFASASIGLSLFPEHG
DSYETLARQADNAMYRVKGELKGGVSLFDDAMSQAATARMAVEQRLRLAIRDRCFCCAFQPKVDMRSHAVTGVEVLLRWR
DELGMIQAPGDFIALAIELGLINEITLQLLSETVQAMPDIDEVFGPDVTVSLNIAAKQACDVPFMTAFCASLGETGLAER
FVLELTEEAFFTTGRFQSEVLPKIRAIGARVSIDDFGVGYSSLAALADITADELKIDRSFITDIDKRPRSQIVLKAIESL
GAALGMTVVAEGVETFEEVAYLLGATQIRCAQGYYFARPLLLDQIRQAQPPRVSGTRGPATRSRASDLRAPGLMRRA

Sequences:

>Translated_557_residues
MSEPDYPERQTLLEAAIQALPVGVVVRDGQGHCILANAAARALGDRAVAALPAAPCDARDTAAVEAVDDRMFEVRTRPVA
GGRDAFTLTTLTDVTHHHRIQRELITKAFIDALTGLPNRTMFEQSIADVLAGSAPGDRFALAFIDLDNFKHINDYYSHAA
GDALLRKMSDRIGGALRPSDLLARIGGDEFVLLLAPITDRDEALSAVRAISERLKQPFFIDGHEIFASASIGLSLFPEHG
DSYETLARQADNAMYRVKGELKGGVSLFDDAMSQAATARMAVEQRLRLAIRDRCFCCAFQPKVDMRSHAVTGVEVLLRWR
DELGMIQAPGDFIALAIELGLINEITLQLLSETVQAMPDIDEVFGPDVTVSLNIAAKQACDVPFMTAFCASLGETGLAER
FVLELTEEAFFTTGRFQSEVLPKIRAIGARVSIDDFGVGYSSLAALADITADELKIDRSFITDIDKRPRSQIVLKAIESL
GAALGMTVVAEGVETFEEVAYLLGATQIRCAQGYYFARPLLLDQIRQAQPPRVSGTRGPATRSRASDLRAPGLMRRA
>Mature_556_residues
SEPDYPERQTLLEAAIQALPVGVVVRDGQGHCILANAAARALGDRAVAALPAAPCDARDTAAVEAVDDRMFEVRTRPVAG
GRDAFTLTTLTDVTHHHRIQRELITKAFIDALTGLPNRTMFEQSIADVLAGSAPGDRFALAFIDLDNFKHINDYYSHAAG
DALLRKMSDRIGGALRPSDLLARIGGDEFVLLLAPITDRDEALSAVRAISERLKQPFFIDGHEIFASASIGLSLFPEHGD
SYETLARQADNAMYRVKGELKGGVSLFDDAMSQAATARMAVEQRLRLAIRDRCFCCAFQPKVDMRSHAVTGVEVLLRWRD
ELGMIQAPGDFIALAIELGLINEITLQLLSETVQAMPDIDEVFGPDVTVSLNIAAKQACDVPFMTAFCASLGETGLAERF
VLELTEEAFFTTGRFQSEVLPKIRAIGARVSIDDFGVGYSSLAALADITADELKIDRSFITDIDKRPRSQIVLKAIESLG
AALGMTVVAEGVETFEEVAYLLGATQIRCAQGYYFARPLLLDQIRQAQPPRVSGTRGPATRSRASDLRAPGLMRRA

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=456, Percent_Identity=35.7456140350877, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI87081921, Length=425, Percent_Identity=28.4705882352941, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790496, Length=263, Percent_Identity=30.7984790874525, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI87081845, Length=256, Percent_Identity=32.03125, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788849, Length=453, Percent_Identity=26.2693156732892, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI226510982, Length=414, Percent_Identity=26.5700483091787, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788502, Length=258, Percent_Identity=33.7209302325581, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788381, Length=420, Percent_Identity=26.1904761904762, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787055, Length=291, Percent_Identity=27.8350515463918, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081743, Length=239, Percent_Identity=28.8702928870293, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081980, Length=270, Percent_Identity=28.5185185185185, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788956, Length=161, Percent_Identity=36.0248447204969, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786507, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081881, Length=197, Percent_Identity=34.010152284264, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI145693134, Length=169, Percent_Identity=34.9112426035503, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1787262, Length=152, Percent_Identity=35.5263157894737, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI87081977, Length=159, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082096, Length=457, Percent_Identity=23.8512035010941, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082007, Length=183, Percent_Identity=32.7868852459016, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786584, Length=170, Percent_Identity=28.2352941176471, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=28.8343558282209, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788085, Length=106, Percent_Identity=32.0754716981132, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 60555; Mature: 60424

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPDYPERQTLLEAAIQALPVGVVVRDGQGHCILANAAARALGDRAVAALPAAPCDARD
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHCCHHHHHCCCCCCCCCC
TAAVEAVDDRMFEVRTRPVAGGRDAFTLTTLTDVTHHHRIQRELITKAFIDALTGLPNRT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
MFEQSIADVLAGSAPGDRFALAFIDLDNFKHINDYYSHAAGDALLRKMSDRIGGALRPSD
HHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LLARIGGDEFVLLLAPITDRDEALSAVRAISERLKQPFFIDGHEIFASASIGLSLFPEHG
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCEECCCCC
DSYETLARQADNAMYRVKGELKGGVSLFDDAMSQAATARMAVEQRLRLAIRDRCFCCAFQ
CHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
PKVDMRSHAVTGVEVLLRWRDELGMIQAPGDFIALAIELGLINEITLQLLSETVQAMPDI
CCCCHHHHHHHHHHHHHHHHHHCCEEECCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCH
DEVFGPDVTVSLNIAAKQACDVPFMTAFCASLGETGLAERFVLELTEEAFFTTGRFQSEV
HHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
LPKIRAIGARVSIDDFGVGYSSLAALADITADELKIDRSFITDIDKRPRSQIVLKAIESL
HHHHHHHCCEEEEHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GAALGMTVVAEGVETFEEVAYLLGATQIRCAQGYYFARPLLLDQIRQAQPPRVSGTRGPA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TRSRASDLRAPGLMRRA
CHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEPDYPERQTLLEAAIQALPVGVVVRDGQGHCILANAAARALGDRAVAALPAAPCDARD
CCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHCCHHHHHCCCCCCCCCC
TAAVEAVDDRMFEVRTRPVAGGRDAFTLTTLTDVTHHHRIQRELITKAFIDALTGLPNRT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
MFEQSIADVLAGSAPGDRFALAFIDLDNFKHINDYYSHAAGDALLRKMSDRIGGALRPSD
HHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LLARIGGDEFVLLLAPITDRDEALSAVRAISERLKQPFFIDGHEIFASASIGLSLFPEHG
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCEECCCCC
DSYETLARQADNAMYRVKGELKGGVSLFDDAMSQAATARMAVEQRLRLAIRDRCFCCAFQ
CHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
PKVDMRSHAVTGVEVLLRWRDELGMIQAPGDFIALAIELGLINEITLQLLSETVQAMPDI
CCCCHHHHHHHHHHHHHHHHHHCCEEECCCHHEEHHHHHHHHHHHHHHHHHHHHHHCCCH
DEVFGPDVTVSLNIAAKQACDVPFMTAFCASLGETGLAERFVLELTEEAFFTTGRFQSEV
HHHCCCCEEEEEEEHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
LPKIRAIGARVSIDDFGVGYSSLAALADITADELKIDRSFITDIDKRPRSQIVLKAIESL
HHHHHHHCCEEEEHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GAALGMTVVAEGVETFEEVAYLLGATQIRCAQGYYFARPLLLDQIRQAQPPRVSGTRGPA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
TRSRASDLRAPGLMRRA
CHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]