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The map label for this gene is cyaB [H]

Identifier: 170752025

GI number: 170752025

Start: 5987461

End: 5988726

Strand: Reverse

Name: cyaB [H]

Synonym: Mrad2831_5657

Alternate gene names: 170752025

Gene position: 5988726-5987461 (Counterclockwise)

Preceding gene: 170752026

Following gene: 170752024

Centisome position: 98.53

GC content: 71.01

Gene sequence:

>1266_bases
ATGACCCCCGGCGCCCCGAACGCCAAGATCCTGGTCGTCGACGACGAGCCGGATCTCGAGGCGCTGATCACCCAGAAATT
CCGCCGCCAGATCCGCCAGGGCCTCGTCACCTTCCTGTTCGCCCACGACGGGCAGGAGGCGCTGGACCGCCTCTCGGAGA
GCCGCGACGTCGATCTGGTCGTCTCCGACATCAACATGCCGCGGATGGACGGGCTGACTCTACTCGCCAAGCTGCAGGAC
CTCCCGGAGCGCCCCTCGATCATCATCGTCTCGGCCTACGGTGACATGGCGAACATCCGCACCGCCATGAACCGGGGCGC
CTTCGACTTCCTGACGAAGCCGATCGACTTCGCCGACCTGGAGACGACGATCGAGCGGACGCTGCGCCACGTCGAGGACC
TGCGCGAGGGGCGGCGCCGGCAATCGCTCGCCGAGCGGGCCCACGCCTCCCTGGCCCGGTACTTCTCGCCGAACCTCGCC
GAGCGGCTCGCCGGGGACGCGTCCGGTCTCGAGCTCGGCGGCCACCGCCGCGACGTGGCCTCGCTGTTCACCGACATCGC
CGGCTTCACAAGCTTGGTGGAGAGCCTCGACCCGGTGCAGCTCGCCGAGATCCTCAACGGCTACTTCGCCGAGATGACCG
ACGTTGTCTTCGCCCACGAGGGGACGGTGGCCAAGATCGTCGGCGACGCCCTGCACGTGCTGTTCGGCGCGCCGGGGGAC
CAGCCGGACCACGCGGCCCGGGCCGTGGCGTGTGCCCTCGCCCTGGACGAGGCGGCCGAGGCCTTCCGCGGGCGCTGGCG
CGAGCGCGGGATCGAGATCGGCGTGACGCGGATCGGCGTTCATGCCGGGCCGGCGATCGTGGGCAATTTCGGCGGCGGCC
GGTACTTCGACTACACGGCCTACGGCGACACCATCAACACCGCCGCCCGTCTGGAGAACGCCAACAAGGCGTTCGGCACC
CGGATCTGCGTCAGCGACGCCGTCGTGATCCGCGCCGGTCAGTTCCGCGGTCGCCCCCTCGGCGACCTCCTCCTGCGCGG
CAAGCAGACGGCCCTGCGCGCCTACGAACCCCTGACCGAGGCTGCCTACGCGGACGCGCTGCTCGCCCAGTACCAGGACG
CCTACGCGAAGCTCGACGCCGGGGAGGCGGGCGCCCTTCCGGCCTTCGCGGCGCTGGTCGGGCTGCGTCCCGACGACGGG
GTCGCGGCCTACCACCTGAAGCGCCTGCTGAACGGCAGCAGCGGCAGCCGGGTCGAGGTCCGCTGA

Upstream 100 bases:

>100_bases
TCCGCGCCGCCGGCGCCGTGGGCCTGATCACCAAGCCGATCGACTTCGCCGTGCTGAAGGCCGAGATCGATCGCCGGCTG
TCCGCCTTCGCGGGGACCGA

Downstream 100 bases:

>100_bases
GCCCTGCACCCGCGCCGGGCGCCCCGATCGGCGGCCGCGATAGCCCTGGCATGAGGCAGCGCCTATTACCGTCCCCGGGG
CGAGCGATCGGGATCCCGCC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTPGAPNAKILVVDDEPDLEALITQKFRRQIRQGLVTFLFAHDGQEALDRLSESRDVDLVVSDINMPRMDGLTLLAKLQD
LPERPSIIIVSAYGDMANIRTAMNRGAFDFLTKPIDFADLETTIERTLRHVEDLREGRRRQSLAERAHASLARYFSPNLA
ERLAGDASGLELGGHRRDVASLFTDIAGFTSLVESLDPVQLAEILNGYFAEMTDVVFAHEGTVAKIVGDALHVLFGAPGD
QPDHAARAVACALALDEAAEAFRGRWRERGIEIGVTRIGVHAGPAIVGNFGGGRYFDYTAYGDTINTAARLENANKAFGT
RICVSDAVVIRAGQFRGRPLGDLLLRGKQTALRAYEPLTEAAYADALLAQYQDAYAKLDAGEAGALPAFAALVGLRPDDG
VAAYHLKRLLNGSSGSRVEVR

Sequences:

>Translated_421_residues
MTPGAPNAKILVVDDEPDLEALITQKFRRQIRQGLVTFLFAHDGQEALDRLSESRDVDLVVSDINMPRMDGLTLLAKLQD
LPERPSIIIVSAYGDMANIRTAMNRGAFDFLTKPIDFADLETTIERTLRHVEDLREGRRRQSLAERAHASLARYFSPNLA
ERLAGDASGLELGGHRRDVASLFTDIAGFTSLVESLDPVQLAEILNGYFAEMTDVVFAHEGTVAKIVGDALHVLFGAPGD
QPDHAARAVACALALDEAAEAFRGRWRERGIEIGVTRIGVHAGPAIVGNFGGGRYFDYTAYGDTINTAARLENANKAFGT
RICVSDAVVIRAGQFRGRPLGDLLLRGKQTALRAYEPLTEAAYADALLAQYQDAYAKLDAGEAGALPAFAALVGLRPDDG
VAAYHLKRLLNGSSGSRVEVR
>Mature_420_residues
TPGAPNAKILVVDDEPDLEALITQKFRRQIRQGLVTFLFAHDGQEALDRLSESRDVDLVVSDINMPRMDGLTLLAKLQDL
PERPSIIIVSAYGDMANIRTAMNRGAFDFLTKPIDFADLETTIERTLRHVEDLREGRRRQSLAERAHASLARYFSPNLAE
RLAGDASGLELGGHRRDVASLFTDIAGFTSLVESLDPVQLAEILNGYFAEMTDVVFAHEGTVAKIVGDALHVLFGAPGDQ
PDHAARAVACALALDEAAEAFRGRWRERGIEIGVTRIGVHAGPAIVGNFGGGRYFDYTAYGDTINTAARLENANKAFGTR
ICVSDAVVIRAGQFRGRPLGDLLLRGKQTALRAYEPLTEAAYADALLAQYQDAYAKLDAGEAGALPAFAALVGLRPDDGV
AAYHLKRLLNGSSGSRVEVR

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. When Activated By Zras It Acts In Conjunction With Sigma-54 To Regulate The Expression Of Zrap. Positively Autoregulates The Expression Of The Zrasr Operon. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=247, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4580422, Length=295, Percent_Identity=29.1525423728814, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4504217, Length=270, Percent_Identity=24.8148148148148, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI134152694, Length=213, Percent_Identity=26.2910798122066, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557255, Length=139, Percent_Identity=30.2158273381295, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI222080083, Length=226, Percent_Identity=27.8761061946903, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI24497587, Length=134, Percent_Identity=30.5970149253731, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=32.8125, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=32.2314049586777, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=140, Percent_Identity=32.8571428571429, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71989822, Length=248, Percent_Identity=28.6290322580645, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508769, Length=198, Percent_Identity=29.7979797979798, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561804, Length=234, Percent_Identity=25.6410256410256, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=301, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=224, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI86564713, Length=212, Percent_Identity=26.8867924528302, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=195, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=224, Percent_Identity=27.2321428571429, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330470, Length=294, Percent_Identity=28.2312925170068, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221330468, Length=294, Percent_Identity=28.2312925170068, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI161078020, Length=243, Percent_Identity=29.2181069958848, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62484298, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62484477, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574512, Length=219, Percent_Identity=29.2237442922374, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161076872, Length=219, Percent_Identity=29.2237442922374, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116008008, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24663839, Length=209, Percent_Identity=27.7511961722488, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663843, Length=209, Percent_Identity=27.7511961722488, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366459, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366457, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366455, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI56292422, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI56292424, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666940, Length=203, Percent_Identity=29.064039408867, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585694, Length=151, Percent_Identity=27.1523178807947, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85725044, Length=174, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 45628; Mature: 45497

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGAPNAKILVVDDEPDLEALITQKFRRQIRQGLVTFLFAHDGQEALDRLSESRDVDLV
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
VSDINMPRMDGLTLLAKLQDLPERPSIIIVSAYGDMANIRTAMNRGAFDFLTKPIDFADL
EECCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHH
ETTIERTLRHVEDLREGRRRQSLAERAHASLARYFSPNLAERLAGDASGLELGGHRRDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHH
SLFTDIAGFTSLVESLDPVQLAEILNGYFAEMTDVVFAHEGTVAKIVGDALHVLFGAPGD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
QPDHAARAVACALALDEAAEAFRGRWRERGIEIGVTRIGVHAGPAIVGNFGGGRYFDYTA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCCEEEEEE
YGDTINTAARLENANKAFGTRICVSDAVVIRAGQFRGRPLGDLLLRGKQTALRAYEPLTE
CCCCHHHHHHHCCCCHHHCCCHHHCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHH
AAYADALLAQYQDAYAKLDAGEAGALPAFAALVGLRPDDGVAAYHLKRLLNGSSGSRVEV
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEE
R
C
>Mature Secondary Structure 
TPGAPNAKILVVDDEPDLEALITQKFRRQIRQGLVTFLFAHDGQEALDRLSESRDVDLV
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEE
VSDINMPRMDGLTLLAKLQDLPERPSIIIVSAYGDMANIRTAMNRGAFDFLTKPIDFADL
EECCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHH
ETTIERTLRHVEDLREGRRRQSLAERAHASLARYFSPNLAERLAGDASGLELGGHRRDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHH
SLFTDIAGFTSLVESLDPVQLAEILNGYFAEMTDVVFAHEGTVAKIVGDALHVLFGAPGD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
QPDHAARAVACALALDEAAEAFRGRWRERGIEIGVTRIGVHAGPAIVGNFGGGRYFDYTA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCCEEEEEE
YGDTINTAARLENANKAFGTRICVSDAVVIRAGQFRGRPLGDLLLRGKQTALRAYEPLTE
CCCCHHHHHHHCCCCHHHCCCHHHCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHH
AAYADALLAQYQDAYAKLDAGEAGALPAFAALVGLRPDDGVAAYHLKRLLNGSSGSRVEV
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEE
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]