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The map label for this gene is moeA [H]

Identifier: 170751722

GI number: 170751722

Start: 5659415

End: 5660662

Strand: Reverse

Name: moeA [H]

Synonym: Mrad2831_5352

Alternate gene names: 170751722

Gene position: 5660662-5659415 (Counterclockwise)

Preceding gene: 170751725

Following gene: 170751721

Centisome position: 93.14

GC content: 76.76

Gene sequence:

>1248_bases
ATGGGCCGCCTGAGCCCCGACTGCTTCGACGCCGCCACCGCGCCGCTGCGGGTCGCCGACGCGGTGGCTCTGATCCGGGC
GCGACTCCCGATCCTGTCCGGGACCGAGACAGTCCCGCTCGCGGATGCGGACGGCCGGGTCCTCGCGGACGATGTGATCG
CGCCCCTCGATCTGCCTCCCTTCGACAACGCCGCGGTGGACGGCTACGCCCTGCGCGCCGCCGATCTCGCGGCCGGCGGC
GAGACGCGCCTGCCCGTCGGCGGACGCGTGCCGGCCGGCCATCCGGCGGGCGATCCCGGTCCGGGCGCGGCCGTGCGCAT
CTTCACCGGGGCGCCGGTGCCCGCGGGGACCGACACCGTCGTCATGCAGGAGGACGTCCGGATCGACGACGGCAGCGTCA
TCCTGCCCGGAGGACTCGTGTCGGGCGCCAATCGTCGGCGGGCCGGCGAGGACGTCGCCCGCGGCAGCACGGCGCTCCGC
GCCGGGACGCGCCTCGGGCCGCAGCACATCGCACTCGCGGCCGCCTGTGGCCTGGCCGCGCTGCCGCTGCGGACGCCCCT
GACGGTCGCGCTCTTCTCGACCGGCGACGAGCTGACACCGCCCGGCCAGTCCCTGCCGCCGGCCGGGATTTTCGACGCCA
ACCGGCCGATGCTCGCCGCGCTCCTGAGACGCCTCGGCGCCGTCCCCGTCGATCTCGGCATCCTCCGCGACGAGCCCGGA
CCGCTGCGGGCGCGCATCGCGGAGGCGGCGGCGTCCCACGACCTGATCCTGACCTCGGGAGGCGCCTCGGTGGGCGAGGA
GGACCATGTCCGCGCCGCGATCGAGGCTTCGGGCCGACTGACCTTCTGGCGGTTGGCGATCAAGCCCGGCCGCCCGGTCG
CGCTCGGAACCGTGGCCGGCACGCCCGTCATCGGGCTGCCGGGCAACCCGGCCGCCGCCTACGTGACCGCCCTGGCGGTG
CTCGGTCCCCTGGTGCTCCATCTCTCCGGCGCGCGCGACACGGCGCCCGAGCTGGCGATCCGCAGCGGCTTCGCCCGCGG
AAAGCGCCCCGGCCGGCGCGAATACCTGCGCGTCTGCCTCCGGGCCGGCCGGGACGGCCTGCCCGAGGCCGTGCCGGCGC
CCGGCGGCGCGCTGTCCAGTCTCGCGGGCAGCGACGGGCTGGTGGAACTCGCCGAGGATCTGACCGCGATCCGCCCGGGC
GACGCCCTGCCCTATCGACCGCACGGTGCGGTCGGCGCCGGCAGCTGA

Upstream 100 bases:

>100_bases
CCAGGCTTGATCGCGCGGCGCCGATGCCGCAAGTCGCCGTGTCCCAGTCCGCGAGGCCGCCCGTGCCGACACGCTCGCCT
CACTCCAATCCGGCAGCGCC

Downstream 100 bases:

>100_bases
GCTGTTGTTCCGGGCCGCGAGCCTGTAGAGCCTCGGGAGACATCGCCACGACCCGACCGAGACCCCGTGACCCTGCTCGC
CGATCGCGCCCCCGCCAAGG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MGRLSPDCFDAATAPLRVADAVALIRARLPILSGTETVPLADADGRVLADDVIAPLDLPPFDNAAVDGYALRAADLAAGG
ETRLPVGGRVPAGHPAGDPGPGAAVRIFTGAPVPAGTDTVVMQEDVRIDDGSVILPGGLVSGANRRRAGEDVARGSTALR
AGTRLGPQHIALAAACGLAALPLRTPLTVALFSTGDELTPPGQSLPPAGIFDANRPMLAALLRRLGAVPVDLGILRDEPG
PLRARIAEAAASHDLILTSGGASVGEEDHVRAAIEASGRLTFWRLAIKPGRPVALGTVAGTPVIGLPGNPAAAYVTALAV
LGPLVLHLSGARDTAPELAIRSGFARGKRPGRREYLRVCLRAGRDGLPEAVPAPGGALSSLAGSDGLVELAEDLTAIRPG
DALPYRPHGAVGAGS

Sequences:

>Translated_415_residues
MGRLSPDCFDAATAPLRVADAVALIRARLPILSGTETVPLADADGRVLADDVIAPLDLPPFDNAAVDGYALRAADLAAGG
ETRLPVGGRVPAGHPAGDPGPGAAVRIFTGAPVPAGTDTVVMQEDVRIDDGSVILPGGLVSGANRRRAGEDVARGSTALR
AGTRLGPQHIALAAACGLAALPLRTPLTVALFSTGDELTPPGQSLPPAGIFDANRPMLAALLRRLGAVPVDLGILRDEPG
PLRARIAEAAASHDLILTSGGASVGEEDHVRAAIEASGRLTFWRLAIKPGRPVALGTVAGTPVIGLPGNPAAAYVTALAV
LGPLVLHLSGARDTAPELAIRSGFARGKRPGRREYLRVCLRAGRDGLPEAVPAPGGALSSLAGSDGLVELAEDLTAIRPG
DALPYRPHGAVGAGS
>Mature_414_residues
GRLSPDCFDAATAPLRVADAVALIRARLPILSGTETVPLADADGRVLADDVIAPLDLPPFDNAAVDGYALRAADLAAGGE
TRLPVGGRVPAGHPAGDPGPGAAVRIFTGAPVPAGTDTVVMQEDVRIDDGSVILPGGLVSGANRRRAGEDVARGSTALRA
GTRLGPQHIALAAACGLAALPLRTPLTVALFSTGDELTPPGQSLPPAGIFDANRPMLAALLRRLGAVPVDLGILRDEPGP
LRARIAEAAASHDLILTSGGASVGEEDHVRAAIEASGRLTFWRLAIKPGRPVALGTVAGTPVIGLPGNPAAAYVTALAVL
GPLVLHLSGARDTAPELAIRSGFARGKRPGRREYLRVCLRAGRDGLPEAVPAPGGALSSLAGSDGLVELAEDLTAIRPGD
ALPYRPHGAVGAGS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=32.8467153284672, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=32.8467153284672, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1787049, Length=363, Percent_Identity=42.1487603305785, Blast_Score=270, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI25147659, Length=370, Percent_Identity=29.4594594594595, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=293, Percent_Identity=26.2798634812287, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=30.2521008403361, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=30.2521008403361, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41901; Mature: 41770

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLSPDCFDAATAPLRVADAVALIRARLPILSGTETVPLADADGRVLADDVIAPLDLPP
CCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEHHHCCCCCCCCC
FDNAAVDGYALRAADLAAGGETRLPVGGRVPAGHPAGDPGPGAAVRIFTGAPVPAGTDTV
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
VMQEDVRIDDGSVILPGGLVSGANRRRAGEDVARGSTALRAGTRLGPQHIALAAACGLAA
EEECCCEECCCCEEECCHHCCCCCHHCCCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
LPLRTPLTVALFSTGDELTPPGQSLPPAGIFDANRPMLAALLRRLGAVPVDLGILRDEPG
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
PLRARIAEAAASHDLILTSGGASVGEEDHVRAAIEASGRLTFWRLAIKPGRPVALGTVAG
HHHHHHHHHHCCCCEEEECCCCCCCCHHHHEEEECCCCCEEEEEEEECCCCCEEEEEECC
TPVIGLPGNPAAAYVTALAVLGPLVLHLSGARDTAPELAIRSGFARGKRPGRREYLRVCL
CCEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
RAGRDGLPEAVPAPGGALSSLAGSDGLVELAEDLTAIRPGDALPYRPHGAVGAGS
HHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRLSPDCFDAATAPLRVADAVALIRARLPILSGTETVPLADADGRVLADDVIAPLDLPP
CCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEHHHCCCCCCCCC
FDNAAVDGYALRAADLAAGGETRLPVGGRVPAGHPAGDPGPGAAVRIFTGAPVPAGTDTV
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
VMQEDVRIDDGSVILPGGLVSGANRRRAGEDVARGSTALRAGTRLGPQHIALAAACGLAA
EEECCCEECCCCEEECCHHCCCCCHHCCCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
LPLRTPLTVALFSTGDELTPPGQSLPPAGIFDANRPMLAALLRRLGAVPVDLGILRDEPG
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
PLRARIAEAAASHDLILTSGGASVGEEDHVRAAIEASGRLTFWRLAIKPGRPVALGTVAG
HHHHHHHHHHCCCCEEEECCCCCCCCHHHHEEEECCCCCEEEEEEEECCCCCEEEEEECC
TPVIGLPGNPAAAYVTALAVLGPLVLHLSGARDTAPELAIRSGFARGKRPGRREYLRVCL
CCEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
RAGRDGLPEAVPAPGGALSSLAGSDGLVELAEDLTAIRPGDALPYRPHGAVGAGS
HHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]