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The map label for this gene is ilvC [H]

Identifier: 170751697

GI number: 170751697

Start: 5636427

End: 5637446

Strand: Direct

Name: ilvC [H]

Synonym: Mrad2831_5327

Alternate gene names: 170751697

Gene position: 5636427-5637446 (Clockwise)

Preceding gene: 170751696

Following gene: 170751698

Centisome position: 92.74

GC content: 66.57

Gene sequence:

>1020_bases
ATGCGGGTGTATTACGATCGCGACGCCGACCTGAACCTGATCAAGGGCAAGAAGGTCGCCATCGTCGGCTACGGCAGCCA
GGGCCACGCCCACGCGCTCAACCTGCGCGATTCCGGCGTGAAGGACATCGTCATCGCGCTGCGCGAGGGCTCCGCCACCG
CCAAGAAGGCCGAGCACGAGGGCTTCAAGGTTCTCTCGGTCGCCGAGGCCGCCAAGTGGGCCGACGTGGTGATGATGCTC
ACCCCCGACGAGCTGCAGGGCGACATCTACCGCGAGTCCCTCGAGGGCAACATGAAGCAGGGCGCCGCGCTGCTGTTCGC
CCACGGCCTCAACGTCCACTTCAACCTGATCGAGCCGCGCAAGGATCTCGACGTCCTGATGGTCGCCCCGAAGGGCCCGG
GCCACACCGTGCGCTCCGAGTACCTCCGCGGCGGCGGCGTGCCGACCCTGATCGCCATCGCGCAGGACGCCTCCGGCAAC
GCCCACGATCTCGGCCTGTCGTACGCCTCGGCGAACGGCGGCGGCCGCGCCGGCATCATCGAGACGACCTTCAAGGAAGA
GTGCGAGACCGACCTGTTCGGCGAGCAGGCCGTGCTCTGCGGCGGCCTCGTCGAGCTGATCAAGGCCGGCTTCGAGACCC
TGGTCGAGGCGGGCTACGCCCCCGAGATGGCCTATTTCGAGTGCCTCCACGAGGTGAAGCTGATCGTCGACCTCATCTAC
GAGGGCGGCATCGCCAACATGAACTACTCGATCTCCAACACGGCCGAGTACGGCGAGTACGTCACCGGCCCGCGCATCGT
CACGCCCGAGACCAAGGCCGAGATGAAGCGCGTGCTGAACGACATCCAGTCGGGCACCTTCACGCGCAACTGGATGCTGG
AGAACAAGGTCAACCAGACCTCGTTCAAGGCGACCCGCGCGAAGCTCGCCGCCCACCCGATCGAGGAGGTCGGCGCCAAG
CTCCGCGGCATGATGCCGTGGATCTCCGAGAAGGCGCTCGTCGACAAGACCCGCAACTGA

Upstream 100 bases:

>100_bases
CGAGATCCGGCGCGATGCGGGCCGCGCCGTCGAGCAGTTCCTGGCCCTCTACGGCCGGGCCCAACCCGACCCGAAACACC
AAGCTTAAGAGGAGACAGAC

Downstream 100 bases:

>100_bases
GCCCGAACCGTGCGGCCGGGCCTCGCTCGGCCGCGCCGCCAGGGGCCGGTCACGCGTGAGCGTGGTCGGCCCTTCGTCTT
CCCGGTTGCCCTGTCCGAAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLNLIKGKKVAIVGYGSQGHAHALNLRDSGVKDIVIALREGSATAKKAEHEGFKVLSVAEAAKWADVVMML
TPDELQGDIYRESLEGNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTPETKAEMKRVLNDIQSGTFTRNWMLENKVNQTSFKATRAKLAAHPIEEVGAK
LRGMMPWISEKALVDKTRN

Sequences:

>Translated_339_residues
MRVYYDRDADLNLIKGKKVAIVGYGSQGHAHALNLRDSGVKDIVIALREGSATAKKAEHEGFKVLSVAEAAKWADVVMML
TPDELQGDIYRESLEGNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTPETKAEMKRVLNDIQSGTFTRNWMLENKVNQTSFKATRAKLAAHPIEEVGAK
LRGMMPWISEKALVDKTRN
>Mature_339_residues
MRVYYDRDADLNLIKGKKVAIVGYGSQGHAHALNLRDSGVKDIVIALREGSATAKKAEHEGFKVLSVAEAAKWADVVMML
TPDELQGDIYRESLEGNMKQGAALLFAHGLNVHFNLIEPRKDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGN
AHDLGLSYASANGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIVTPETKAEMKRVLNDIQSGTFTRNWMLENKVNQTSFKATRAKLAAHPIEEVGAK
LRGMMPWISEKALVDKTRN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=41.296928327645, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323387, Length=293, Percent_Identity=33.4470989761092, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36932; Mature: 36932

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLNLIKGKKVAIVGYGSQGHAHALNLRDSGVKDIVIALREGSATAKKAEHE
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHCC
GFKVLSVAEAAKWADVVMMLTPDELQGDIYRESLEGNMKQGAALLFAHGLNVHFNLIEPR
CCEEEEHHHHHHHEEEEEEECCHHHHHHHHHHHHCCCHHCCEEEEEEECCEEEEEEECCC
KDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGNAHDLGLSYASANGGGRAGII
CCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIVTPETKAEMKRVLNDIQSGTFTRNWMLENKVNQT
CCCCCCCCEECCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
SFKATRAKLAAHPIEEVGAKLRGMMPWISEKALVDKTRN
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRVYYDRDADLNLIKGKKVAIVGYGSQGHAHALNLRDSGVKDIVIALREGSATAKKAEHE
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHCC
GFKVLSVAEAAKWADVVMMLTPDELQGDIYRESLEGNMKQGAALLFAHGLNVHFNLIEPR
CCEEEEHHHHHHHEEEEEEECCHHHHHHHHHHHHCCCHHCCEEEEEEECCEEEEEEECCC
KDLDVLMVAPKGPGHTVRSEYLRGGGVPTLIAIAQDASGNAHDLGLSYASANGGGRAGII
CCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIKAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIVTPETKAEMKRVLNDIQSGTFTRNWMLENKVNQT
CCCCCCCCEECCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
SFKATRAKLAAHPIEEVGAKLRGMMPWISEKALVDKTRN
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA