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The map label for this gene is mmlH [H]

Identifier: 170751217

GI number: 170751217

Start: 5164255

End: 5165490

Strand: Direct

Name: mmlH [H]

Synonym: Mrad2831_4834

Alternate gene names: 170751217

Gene position: 5164255-5165490 (Clockwise)

Preceding gene: 170751216

Following gene: 170751218

Centisome position: 84.97

GC content: 76.13

Gene sequence:

>1236_bases
GTGTTCCGCTGGTACCGCGACGTCGGTCCGGCCGAGCGTCGCACCTTCTGGGCCTGTCTGGGCGGGTGGTCGCTCGACGC
CCTGGACGTGCAGATGTTCAGCCTCGCCATCCCCGCGCTGGTCGCGAGCTTCGGGCTCAGCCGCTCGGAGGCCGGCCTGA
TCGGCGCGGTCACGCTCGTCGCGGCGGCGCTCGGCGGCTGGCTCGGCGGCCTCGCGGCGGACCGGATCGGCCGCGTCCGG
GCCCTCCAGATCACGGTGCTGTGGTTCGCGGTCGCGACCTTCCTGGCGGCCTTCGCGCAGAGCTTCGCCCAGCTGCTGAC
CCTGAAGGCGCTGCAGGGGATCGGCTTCGGCGCCGAGTGGGCGGCCGGCGCCGCGCTGATGGCGGAGGCGATCGGGCCCG
AGCACCGCGGCCGGGCGCTGGGCGCTGTGCAGGGGGGCTGGGCCCTCGGCTGGGGGGCGGCCGTGCTCCTGGCCACCGCG
GCCTTCTCGGTGCTGGATCAGGAGACCGCCTGGCGGGCCCTGTTCGCCTGCGGCCTCGCGCCCGCGCTCCTCCTGCTCTA
CCTCCGCCGCTCGGTCTCGGAGCCGGCGCGGCCGGTCGGAAGGCCGGCCCGGCCGCCGGCCGGATCGCTCGCGATCTTCG
CGCCCGGCCTGCGCCGGGTCACGGTGCTCGCGACGCTGCTCGGCCTGGGCGCCCACGGGGGCTTCCACGCCCTGTTCACG
TGGCTGCCCACCTACCTGAGCGTCGAGCGCGGCGCCTCGGTCCTCGGCACCGGGCTCTACCTCGCGATCATCATCGCGGC
CTTCGGCCTCGGCTGCCTCGTCGCCGGCGGGCTCGTGGACCGGCTCGGGCGGCGCCGGACGGTGGCGCTCTACGCGGCCG
GCTGCATGGCGCTGGTCGTCCTCTACCTGCTGCTGCCGGTCGGCGGCACGGGCCTGCTCCTCCTCGGGGCCCCCCTCGGC
TTCTGCACCGCCGGCATCCCCGCGAGCCTCGCGGCCCTGTTCAGCGAGCTCTTCCCGGACGGCCTGCGCGGGACCGGGAT
GGGCTTCTGCTACAACGCCGGCCGCCTCGCCTCCGGCCTGCTGCCCCTCGGCGTCGGCCTGCTCAGCGAGATCCTCGGGC
TCGGCCGGGCGATCGGCCTGTCGGCCCTCGGTGCCTACGGGCTCGTCCTCCTCGCCGTCGCGCTCCTGCCGGATCGGCAG
TCCGGCGGCGCGCTGATCCCCCAGACCGTGAGATGA

Upstream 100 bases:

>100_bases
TCGACATCCGCTGAGAGGCCGGCGCCTTGACGCGCCGGCGCGCGCGTGCTCATTTATTCATATAAATGACTAGTCCTCTT
CGGAGGGCGGAGGAAAGCCC

Downstream 100 bases:

>100_bases
TCCGATGAACCGGCGCCGCTTCTGCCGCACCCTGCTCGCGGGCGGCGTCACGCTCGCGCTTCCGGCCCGCGGCCGCGCGG
CCGGGCCCGGCTCCGCCGCC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MFRWYRDVGPAERRTFWACLGGWSLDALDVQMFSLAIPALVASFGLSRSEAGLIGAVTLVAAALGGWLGGLAADRIGRVR
ALQITVLWFAVATFLAAFAQSFAQLLTLKALQGIGFGAEWAAGAALMAEAIGPEHRGRALGAVQGGWALGWGAAVLLATA
AFSVLDQETAWRALFACGLAPALLLLYLRRSVSEPARPVGRPARPPAGSLAIFAPGLRRVTVLATLLGLGAHGGFHALFT
WLPTYLSVERGASVLGTGLYLAIIIAAFGLGCLVAGGLVDRLGRRRTVALYAAGCMALVVLYLLLPVGGTGLLLLGAPLG
FCTAGIPASLAALFSELFPDGLRGTGMGFCYNAGRLASGLLPLGVGLLSEILGLGRAIGLSALGAYGLVLLAVALLPDRQ
SGGALIPQTVR

Sequences:

>Translated_411_residues
MFRWYRDVGPAERRTFWACLGGWSLDALDVQMFSLAIPALVASFGLSRSEAGLIGAVTLVAAALGGWLGGLAADRIGRVR
ALQITVLWFAVATFLAAFAQSFAQLLTLKALQGIGFGAEWAAGAALMAEAIGPEHRGRALGAVQGGWALGWGAAVLLATA
AFSVLDQETAWRALFACGLAPALLLLYLRRSVSEPARPVGRPARPPAGSLAIFAPGLRRVTVLATLLGLGAHGGFHALFT
WLPTYLSVERGASVLGTGLYLAIIIAAFGLGCLVAGGLVDRLGRRRTVALYAAGCMALVVLYLLLPVGGTGLLLLGAPLG
FCTAGIPASLAALFSELFPDGLRGTGMGFCYNAGRLASGLLPLGVGLLSEILGLGRAIGLSALGAYGLVLLAVALLPDRQ
SGGALIPQTVR
>Mature_411_residues
MFRWYRDVGPAERRTFWACLGGWSLDALDVQMFSLAIPALVASFGLSRSEAGLIGAVTLVAAALGGWLGGLAADRIGRVR
ALQITVLWFAVATFLAAFAQSFAQLLTLKALQGIGFGAEWAAGAALMAEAIGPEHRGRALGAVQGGWALGWGAAVLLATA
AFSVLDQETAWRALFACGLAPALLLLYLRRSVSEPARPVGRPARPPAGSLAIFAPGLRRVTVLATLLGLGAHGGFHALFT
WLPTYLSVERGASVLGTGLYLAIIIAAFGLGCLVAGGLVDRLGRRRTVALYAAGCMALVVLYLLLPVGGTGLLLLGAPLG
FCTAGIPASLAALFSELFPDGLRGTGMGFCYNAGRLASGLLPLGVGLLSEILGLGRAIGLSALGAYGLVLLAVALLPDRQ
SGGALIPQTVR

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=399, Percent_Identity=25.5639097744361, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082404, Length=395, Percent_Identity=23.7974683544304, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082231, Length=459, Percent_Identity=25.7080610021786, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081723, Length=381, Percent_Identity=30.1837270341207, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790550, Length=343, Percent_Identity=27.1137026239067, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786229, Length=417, Percent_Identity=24.220623501199, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082159, Length=357, Percent_Identity=29.1316526610644, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922874, Length=423, Percent_Identity=23.4042553191489, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42240; Mature: 42240

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRWYRDVGPAERRTFWACLGGWSLDALDVQMFSLAIPALVASFGLSRSEAGLIGAVTLV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AAALGGWLGGLAADRIGRVRALQITVLWFAVATFLAAFAQSFAQLLTLKALQGIGFGAEW
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AAGAALMAEAIGPEHRGRALGAVQGGWALGWGAAVLLATAAFSVLDQETAWRALFACGLA
HHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALLLLYLRRSVSEPARPVGRPARPPAGSLAIFAPGLRRVTVLATLLGLGAHGGFHALFT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHH
WLPTYLSVERGASVLGTGLYLAIIIAAFGLGCLVAGGLVDRLGRRRTVALYAAGCMALVV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LYLLLPVGGTGLLLLGAPLGFCTAGIPASLAALFSELFPDGLRGTGMGFCYNAGRLASGL
HHHHHHCCCCCCEECCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHH
LPLGVGLLSEILGLGRAIGLSALGAYGLVLLAVALLPDRQSGGALIPQTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFRWYRDVGPAERRTFWACLGGWSLDALDVQMFSLAIPALVASFGLSRSEAGLIGAVTLV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
AAALGGWLGGLAADRIGRVRALQITVLWFAVATFLAAFAQSFAQLLTLKALQGIGFGAEW
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AAGAALMAEAIGPEHRGRALGAVQGGWALGWGAAVLLATAAFSVLDQETAWRALFACGLA
HHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALLLLYLRRSVSEPARPVGRPARPPAGSLAIFAPGLRRVTVLATLLGLGAHGGFHALFT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHH
WLPTYLSVERGASVLGTGLYLAIIIAAFGLGCLVAGGLVDRLGRRRTVALYAAGCMALVV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LYLLLPVGGTGLLLLGAPLGFCTAGIPASLAALFSELFPDGLRGTGMGFCYNAGRLASGL
HHHHHHCCCCCCEECCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHH
LPLGVGLLSEILGLGRAIGLSALGAYGLVLLAVALLPDRQSGGALIPQTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]