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The map label for this gene is frlR [H]

Identifier: 170751216

GI number: 170751216

Start: 5163428

End: 5164168

Strand: Direct

Name: frlR [H]

Synonym: Mrad2831_4833

Alternate gene names: 170751216

Gene position: 5163428-5164168 (Clockwise)

Preceding gene: 170751212

Following gene: 170751217

Centisome position: 84.96

GC content: 73.68

Gene sequence:

>741_bases
ATGACCGCAACGTCCGCGCCGCAGCCCGATCTCCGTCTGCCGCTCTATCAGCGCCTGCGGGACGAGATCGCCTTCCAGAT
CGCCAGCAACGTCTGGCGCTCGGGCGAGCCGATCCCCACGGAGGCGGAGCTGGCGGCGACCCACCGGGTCGCCATCGGCA
CCGTGCGCAAGGCGATCGACGTCCTCGTCGCCGACGGCCTCGTCGAGCGTCAGCAGGGCCGCGGCACCTTCGTGCGGCGG
CCGCGCTTCGACCGGTCCCTGTTCCGGTTCTTCCGGCATCTCGGGCCGGACGGCACGCAGGCGGTGCCGGAGGGGCGGAT
CCTGTCGCGCGAGGCCCGTCCGGCCCCCGCGGCCGCACGCGAGGCCCTCGGTCTCGACGCGCGCGGCGCGGCGATCCGCC
TGATCCGGACGCGCCACCTGCAGGGCCGCCCGATCCTGTCCGAGGCGATCTGGCTGCCGGCCGCACGGTTCGCACCGATC
CTGACCGCCCCGCTGACGGAGATCGGCGACCTCCTCTACCCCGCCTACGAGCGCCTCTGCGGCGAGATCGTCGCCCGCGC
CGAGGAGACCCTGACCGTCGGCATCGCCGACGCGACCGACGCCGAGCGCCTCGAGATCGCGGACGGAGACCCGGTCGTGG
TCATCGAGCGCCTCGCCTTCGGCTTCGACGCCCGCCCGATCGAGTGGCGCGTGACCCGCGGTGCGGCCAAGGACTTCCGG
TATCACGTCGACATCCGCTGA

Upstream 100 bases:

>100_bases
TAGGTCCAGTCCTGCGACGCTGTGGACCGGCCCCTCGGGCACGCCGACACCGCTGTGCCACCCATTGGCGTCTGCCGGCG
TTGGTCATACAGTCATACAC

Downstream 100 bases:

>100_bases
GAGGCCGGCGCCTTGACGCGCCGGCGCGCGCGTGCTCATTTATTCATATAAATGACTAGTCCTCTTCGGAGGGCGGAGGA
AAGCCCGTGTTCCGCTGGTA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTATSAPQPDLRLPLYQRLRDEIAFQIASNVWRSGEPIPTEAELAATHRVAIGTVRKAIDVLVADGLVERQQGRGTFVRR
PRFDRSLFRFFRHLGPDGTQAVPEGRILSREARPAPAAAREALGLDARGAAIRLIRTRHLQGRPILSEAIWLPAARFAPI
LTAPLTEIGDLLYPAYERLCGEIVARAEETLTVGIADATDAERLEIADGDPVVVIERLAFGFDARPIEWRVTRGAAKDFR
YHVDIR

Sequences:

>Translated_246_residues
MTATSAPQPDLRLPLYQRLRDEIAFQIASNVWRSGEPIPTEAELAATHRVAIGTVRKAIDVLVADGLVERQQGRGTFVRR
PRFDRSLFRFFRHLGPDGTQAVPEGRILSREARPAPAAAREALGLDARGAAIRLIRTRHLQGRPILSEAIWLPAARFAPI
LTAPLTEIGDLLYPAYERLCGEIVARAEETLTVGIADATDAERLEIADGDPVVVIERLAFGFDARPIEWRVTRGAAKDFR
YHVDIR
>Mature_245_residues
TATSAPQPDLRLPLYQRLRDEIAFQIASNVWRSGEPIPTEAELAATHRVAIGTVRKAIDVLVADGLVERQQGRGTFVRRP
RFDRSLFRFFRHLGPDGTQAVPEGRILSREARPAPAAAREALGLDARGAAIRLIRTRHLQGRPILSEAIWLPAARFAPIL
TAPLTEIGDLLYPAYERLCGEIVARAEETLTVGIADATDAERLEIADGDPVVVIERLAFGFDARPIEWRVTRGAAKDFRY
HVDIR

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=216, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1786950, Length=233, Percent_Identity=26.1802575107296, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790118, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790540, Length=207, Percent_Identity=29.951690821256, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27314; Mature: 27182

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSAPQPDLRLPLYQRLRDEIAFQIASNVWRSGEPIPTEAELAATHRVAIGTVRKAID
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLVADGLVERQQGRGTFVRRPRFDRSLFRFFRHLGPDGTQAVPEGRILSREARPAPAAAR
HHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHH
EALGLDARGAAIRLIRTRHLQGRPILSEAIWLPAARFAPILTAPLTEIGDLLYPAYERLC
HHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEIVARAEETLTVGIADATDAERLEIADGDPVVVIERLAFGFDARPIEWRVTRGAAKDFR
HHHHHHHHHHEEEEECCCCCCCEEEECCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCE
YHVDIR
EEEECC
>Mature Secondary Structure 
TATSAPQPDLRLPLYQRLRDEIAFQIASNVWRSGEPIPTEAELAATHRVAIGTVRKAID
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLVADGLVERQQGRGTFVRRPRFDRSLFRFFRHLGPDGTQAVPEGRILSREARPAPAAAR
HHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHH
EALGLDARGAAIRLIRTRHLQGRPILSEAIWLPAARFAPILTAPLTEIGDLLYPAYERLC
HHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEIVARAEETLTVGIADATDAERLEIADGDPVVVIERLAFGFDARPIEWRVTRGAAKDFR
HHHHHHHHHHEEEEECCCCCCCEEEECCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCE
YHVDIR
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]