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The map label for this gene is Hgd [H]

Identifier: 170751209

GI number: 170751209

Start: 5155128

End: 5156012

Strand: Direct

Name: Hgd [H]

Synonym: Mrad2831_4826

Alternate gene names: 170751209

Gene position: 5155128-5156012 (Clockwise)

Preceding gene: 170751208

Following gene: 170751210

Centisome position: 84.82

GC content: 72.54

Gene sequence:

>885_bases
ATGACCATCGCAACGGTAGGGGTCGTCGGGCTCGGCAATATGGGTCTGGGCATGGCCGCGACCCTGGCCCGCAAGGGCTT
CGCGGTCCTCGGCTACGACATCGACGCGGGCCGGCGCCCCGCTGCCGAGGCGGCCGGCGTCACCACCCTCGACGCCCTCA
ACGACGTGCTCCGCCGGGCCGACGCCCTGGTGTTCTCGCTGCCGCTGGCGCGGGACGTGGAGGCGGTGGTCACCGCGGAG
GGCGGCCTCCTGTCCCGGACCGACCGGAAGGTCGTGGTGATCGACACCTCGACCTCGGATCCCGGCACGACACGGCGCCT
CGCCGAGCGCCTCGCCGCGGCCGGTCACGCGCTCCTCGACGCCCCGGTGAGCGGCGGCCCGTCCGGCGCCGCCGAGGGCA
CCCTGACCATGATGATCGGCGGAGCGGAGGCGGATTACGAACTGGCCCGTCCGGTCCTGGAGGCGATGTCGGCCCGCGCG
CCGCATGTCGGGCCGTCGGGCGCCGGCAACATCGTCAAGCTCGTCAACAACCTGCTGGTGGCGGCCCATCTCGTGACCAC
CGGCGAGGCCCTGCGCCTGTCCGAGGCGGCGGGCCTCTCGGCCGAAGAGGCCGTCAAGGTCGTGAACACCGCGACCGGCC
GCAGCGCGATCAGCGAAATCATGGTCCCGCGCTGGGTCCAGTCCGGCACCTTCGACAGCGGCTTCTCGGCCGGCCTGATG
CGCAAGGACGTGCGCCTCGCCCTCGAACTCGCCGCCGAATGCGGGATCGACCTGCCGCTCTCCGCCGAGGTGAAGCGCAT
CTGGCAGGCCACGCAGGCCGCCATCCCCGACACGGCCGACTTCACCCGCATGGCCGATTACCGCGATCCCAAGGGAGCCC
ACTGA

Upstream 100 bases:

>100_bases
CCTACCGTGCTGGATTTCCGCACGTTACGTGCAAAAATCCATGATTGTAGCAACGCTCGTTTGCCGAGATCATCCTCCCG
CACGGTGAGGACGGATCGGT

Downstream 100 bases:

>100_bases
TGTCCGGCACGCCGCACTCGCCCGCCGCCGATCGGGTCGCCGCCCTCCTGGCCGACCTGCTGCCGGGCGGCCGCATCGGC
AGCGTCGTGGCCGGCGAGAT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTIATVGVVGLGNMGLGMAATLARKGFAVLGYDIDAGRRPAAEAAGVTTLDALNDVLRRADALVFSLPLARDVEAVVTAE
GGLLSRTDRKVVVIDTSTSDPGTTRRLAERLAAAGHALLDAPVSGGPSGAAEGTLTMMIGGAEADYELARPVLEAMSARA
PHVGPSGAGNIVKLVNNLLVAAHLVTTGEALRLSEAAGLSAEEAVKVVNTATGRSAISEIMVPRWVQSGTFDSGFSAGLM
RKDVRLALELAAECGIDLPLSAEVKRIWQATQAAIPDTADFTRMADYRDPKGAH

Sequences:

>Translated_294_residues
MTIATVGVVGLGNMGLGMAATLARKGFAVLGYDIDAGRRPAAEAAGVTTLDALNDVLRRADALVFSLPLARDVEAVVTAE
GGLLSRTDRKVVVIDTSTSDPGTTRRLAERLAAAGHALLDAPVSGGPSGAAEGTLTMMIGGAEADYELARPVLEAMSARA
PHVGPSGAGNIVKLVNNLLVAAHLVTTGEALRLSEAAGLSAEEAVKVVNTATGRSAISEIMVPRWVQSGTFDSGFSAGLM
RKDVRLALELAAECGIDLPLSAEVKRIWQATQAAIPDTADFTRMADYRDPKGAH
>Mature_293_residues
TIATVGVVGLGNMGLGMAATLARKGFAVLGYDIDAGRRPAAEAAGVTTLDALNDVLRRADALVFSLPLARDVEAVVTAEG
GLLSRTDRKVVVIDTSTSDPGTTRRLAERLAAAGHALLDAPVSGGPSGAAEGTLTMMIGGAEADYELARPVLEAMSARAP
HVGPSGAGNIVKLVNNLLVAAHLVTTGEALRLSEAAGLSAEEAVKVVNTATGRSAISEIMVPRWVQSGTFDSGFSAGLMR
KDVRLALELAAECGIDLPLSAEVKRIWQATQAAIPDTADFTRMADYRDPKGAH

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=30.2083333333333, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=23.7931034482759, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=32.9861111111111, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786719, Length=271, Percent_Identity=31.3653136531365, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790315, Length=282, Percent_Identity=30.8510638297872, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789092, Length=271, Percent_Identity=29.8892988929889, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=29.2592592592593, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=32.312925170068, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=32.312925170068, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI28574115, Length=271, Percent_Identity=23.9852398523985, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30280; Mature: 30149

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIATVGVVGLGNMGLGMAATLARKGFAVLGYDIDAGRRPAAEAAGVTTLDALNDVLRRA
CEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
DALVFSLPLARDVEAVVTAEGGLLSRTDRKVVVIDTSTSDPGTTRRLAERLAAAGHALLD
HHHEEECCCHHCCCEEEECCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHEE
APVSGGPSGAAEGTLTMMIGGAEADYELARPVLEAMSARAPHVGPSGAGNIVKLVNNLLV
CCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AAHLVTTGEALRLSEAAGLSAEEAVKVVNTATGRSAISEIMVPRWVQSGTFDSGFSAGLM
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
RKDVRLALELAAECGIDLPLSAEVKRIWQATQAAIPDTADFTRMADYRDPKGAH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIATVGVVGLGNMGLGMAATLARKGFAVLGYDIDAGRRPAAEAAGVTTLDALNDVLRRA
EEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
DALVFSLPLARDVEAVVTAEGGLLSRTDRKVVVIDTSTSDPGTTRRLAERLAAAGHALLD
HHHEEECCCHHCCCEEEECCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHEE
APVSGGPSGAAEGTLTMMIGGAEADYELARPVLEAMSARAPHVGPSGAGNIVKLVNNLLV
CCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AAHLVTTGEALRLSEAAGLSAEEAVKVVNTATGRSAISEIMVPRWVQSGTFDSGFSAGLM
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
RKDVRLALELAAECGIDLPLSAEVKRIWQATQAAIPDTADFTRMADYRDPKGAH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA