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The map label for this gene is fcbA1 [H]

Identifier: 170751110

GI number: 170751110

Start: 5031228

End: 5032787

Strand: Direct

Name: fcbA1 [H]

Synonym: Mrad2831_4726

Alternate gene names: 170751110

Gene position: 5031228-5032787 (Clockwise)

Preceding gene: 170751109

Following gene: 170751111

Centisome position: 82.78

GC content: 70.38

Gene sequence:

>1560_bases
ATGCTTGATCTCGGCACCAGCTTCCTTGCGAGCGTCTCCCGCGATCCCCGCGCCCTGGCCCTCGTCGACGGGGAGACCCG
GCTGAGCTACGCGGAGTGGTTCGGGGTCATCTCCGCAACCGTGGCCGGGCTCGACCGGCTCGGGCTGAAGCCCGGCGACC
ACCTCGTCACGGTCCTCCAGAACCGGCAAGAGGCGGCGACCCTCCACTGGGCCTGCCAGTTCGCGGGCATCGTGATCACG
CCGATCAACTGGCGGGCCAAGGCCGAGGAGATCGATTACGCGGTCGAGAACGCGCAGGCCCGCGCCATCGCCTACGAACC
GGTCTCGGCCGGGAGCCTGCGAGACAGCGCGGCGTCGCAGCGAATCCCGCGCATCGCCGTCGGCACGCCACCCGGCCCCG
GCGAGACGGCCTTCGCCGACCTCGCCGCCACCGAGGGGCCTCCGGTGACGCCCCGGGCCGACGCGGAGGCGATCTCGCTG
ATGCTCTACACCTCCGGCACCACCGCCAAGCCCAAGGGGGTCCCGCGGCGACACCGGGCGGAGCGCGCGGCGGCCGTGGC
CCATGTGGCGCAAAACCTCTACGGGCGCGGCGAGCGCACCCTCGGCGTGATGCCGCTCTATCACACGATGGGGGTGCGCT
CGCTCCTCGCCATGTCGCTGATCGGCGGGACCTTCGTCTGCCTCCCCCGGTTCGACGTGGCCGGCGCGCTGCGGCTGATC
GCGGCCGAGCGGATCACCAACCTCTACCTCGTGCCGACCCTCTATCACGACCTCGTGCACCATCGGGATTTCCCGGCGAC
CGACACGACCTCCGTGCGCAAGCTCGGCTTCGCCGGAGCGCCGATGACGGACGGCCTGCTCGCCCGCCTGACCGAGGCGT
TCCGGCCGGATCTGTTCGTCAATCATTACGGCTCGTCGGAGGTCTACACCTTTACGATCAACCACGAGGCGGCGGTGAAA
CCCGGTTCGGCCGGGCGGGCGGGCCTCAACACGATGGTGCGCGTCGTACCCATGGGGGGCGACCCAGGCCGAACCGCCGC
GCCGGGCGAGGAGGGCGAGATCGCCGTCATCGCCAAGGGCGACGAAGCCTTCGAGGGCTACTGGCATCGCCCCGAAGCCG
ACGCGAAGGCCTTTCGTGATGGCTGGTACTTCACCGGCGATACCGGCTTCGCCGACGCCGATGGCGACCTCTACGTCACC
GGCCGGGTGGACGACATGATCATCACCGGGGGCGAGAACGTTTCGCCCGTCGAGATCGAGAGCCGCCTCTCCTTGCATCC
GGCCGTGTCCGAAGTCGCCGTTGTGGGCCTGCCCGACGAGCGCTGGGGTCGGATCGTCGCGGCCTTCATCAAGCGGAGCG
GCAGCACCGACGAAGCGGCGCTCGATGCCCATTGCCGGGCGGGCGGCCTGCCGAGTCACAAGCTGCCGCGCCGGTACGTC
TTCGTGGACGAGATCCCGAAATCGCCGGTCGGCAAGCTGCTGCGCCGCCAACTCGTGGCCGGCGAGTACGTCCTGGAAGG
CGGGGCCGAGCCCCATGCCGAAGGTCACGAGGCTGCCTGA

Upstream 100 bases:

>100_bases
TGCCGCTGCACCGGCTACGCGCCGATCATCGAGGCCGCCCTGGAGGCGGCTGCGGAACTCAGGGGCGACATCCCGGCCCC
GTCATCCCCGGAGGCCGCCC

Downstream 100 bases:

>100_bases
CGGTCCCGCCCCCACTCCGAATCACAAGCGAGAGACCAAACCCATGACGAGCGACACCCACACCATCGACCCGCGCCTGA
CGAACCTCGACGGGTTCCGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: 4-CBA:CoA ligase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MLDLGTSFLASVSRDPRALALVDGETRLSYAEWFGVISATVAGLDRLGLKPGDHLVTVLQNRQEAATLHWACQFAGIVIT
PINWRAKAEEIDYAVENAQARAIAYEPVSAGSLRDSAASQRIPRIAVGTPPGPGETAFADLAATEGPPVTPRADAEAISL
MLYTSGTTAKPKGVPRRHRAERAAAVAHVAQNLYGRGERTLGVMPLYHTMGVRSLLAMSLIGGTFVCLPRFDVAGALRLI
AAERITNLYLVPTLYHDLVHHRDFPATDTTSVRKLGFAGAPMTDGLLARLTEAFRPDLFVNHYGSSEVYTFTINHEAAVK
PGSAGRAGLNTMVRVVPMGGDPGRTAAPGEEGEIAVIAKGDEAFEGYWHRPEADAKAFRDGWYFTGDTGFADADGDLYVT
GRVDDMIITGGENVSPVEIESRLSLHPAVSEVAVVGLPDERWGRIVAAFIKRSGSTDEAALDAHCRAGGLPSHKLPRRYV
FVDEIPKSPVGKLLRRQLVAGEYVLEGGAEPHAEGHEAA

Sequences:

>Translated_519_residues
MLDLGTSFLASVSRDPRALALVDGETRLSYAEWFGVISATVAGLDRLGLKPGDHLVTVLQNRQEAATLHWACQFAGIVIT
PINWRAKAEEIDYAVENAQARAIAYEPVSAGSLRDSAASQRIPRIAVGTPPGPGETAFADLAATEGPPVTPRADAEAISL
MLYTSGTTAKPKGVPRRHRAERAAAVAHVAQNLYGRGERTLGVMPLYHTMGVRSLLAMSLIGGTFVCLPRFDVAGALRLI
AAERITNLYLVPTLYHDLVHHRDFPATDTTSVRKLGFAGAPMTDGLLARLTEAFRPDLFVNHYGSSEVYTFTINHEAAVK
PGSAGRAGLNTMVRVVPMGGDPGRTAAPGEEGEIAVIAKGDEAFEGYWHRPEADAKAFRDGWYFTGDTGFADADGDLYVT
GRVDDMIITGGENVSPVEIESRLSLHPAVSEVAVVGLPDERWGRIVAAFIKRSGSTDEAALDAHCRAGGLPSHKLPRRYV
FVDEIPKSPVGKLLRRQLVAGEYVLEGGAEPHAEGHEAA
>Mature_519_residues
MLDLGTSFLASVSRDPRALALVDGETRLSYAEWFGVISATVAGLDRLGLKPGDHLVTVLQNRQEAATLHWACQFAGIVIT
PINWRAKAEEIDYAVENAQARAIAYEPVSAGSLRDSAASQRIPRIAVGTPPGPGETAFADLAATEGPPVTPRADAEAISL
MLYTSGTTAKPKGVPRRHRAERAAAVAHVAQNLYGRGERTLGVMPLYHTMGVRSLLAMSLIGGTFVCLPRFDVAGALRLI
AAERITNLYLVPTLYHDLVHHRDFPATDTTSVRKLGFAGAPMTDGLLARLTEAFRPDLFVNHYGSSEVYTFTINHEAAVK
PGSAGRAGLNTMVRVVPMGGDPGRTAAPGEEGEIAVIAKGDEAFEGYWHRPEADAKAFRDGWYFTGDTGFADADGDLYVT
GRVDDMIITGGENVSPVEIESRLSLHPAVSEVAVVGLPDERWGRIVAAFIKRSGSTDEAALDAHCRAGGLPSHKLPRRYV
FVDEIPKSPVGKLLRRQLVAGEYVLEGGAEPHAEGHEAA

Specific function: Catalyzes the formation of chlorobenzoyl-CoA via a 2 step reaction. First 4-chlorobenzoate is adenylated by ATP, followed by acyl transfer from the 4-chlorobenzoyl-AMP intermediate to CoA. Benzoate, 4-bromobenzoate, 4- iodobenzoate and 4-fluorobenzoate al

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=542, Percent_Identity=27.6752767527675, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI187761345, Length=524, Percent_Identity=28.4351145038168, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI187761343, Length=524, Percent_Identity=28.4351145038168, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI38505220, Length=538, Percent_Identity=28.996282527881, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI122937307, Length=516, Percent_Identity=28.2945736434109, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI42544132, Length=508, Percent_Identity=26.5748031496063, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI115511026, Length=522, Percent_Identity=27.7777777777778, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI157311624, Length=490, Percent_Identity=26.9387755102041, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI157311622, Length=490, Percent_Identity=26.9387755102041, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI58082049, Length=490, Percent_Identity=26.9387755102041, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI195947378, Length=391, Percent_Identity=25.3196930946292, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI28416953, Length=537, Percent_Identity=24.3947858472998, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI13375727, Length=530, Percent_Identity=24.3396226415094, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1788107, Length=488, Percent_Identity=27.6639344262295, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI221142682, Length=495, Percent_Identity=26.6666666666667, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI145693145, Length=475, Percent_Identity=25.6842105263158, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786810, Length=500, Percent_Identity=26.2, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790505, Length=376, Percent_Identity=27.1276595744681, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786529, Length=555, Percent_Identity=25.4054054054054, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788595, Length=289, Percent_Identity=26.9896193771626, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994690, Length=499, Percent_Identity=28.4569138276553, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994694, Length=499, Percent_Identity=28.4569138276553, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994703, Length=499, Percent_Identity=28.4569138276553, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17538037, Length=514, Percent_Identity=27.2373540856031, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17557194, Length=540, Percent_Identity=27.2222222222222, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32563687, Length=501, Percent_Identity=25.5489021956088, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17559526, Length=518, Percent_Identity=26.8339768339768, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560308, Length=544, Percent_Identity=26.1029411764706, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=24.950884086444, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17531443, Length=530, Percent_Identity=24.9056603773585, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560140, Length=496, Percent_Identity=25.4032258064516, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71996755, Length=500, Percent_Identity=26.2, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71985884, Length=348, Percent_Identity=27.0114942528736, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115534440, Length=540, Percent_Identity=24.0740740740741, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=28.328611898017, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=392, Percent_Identity=27.2959183673469, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319264, Length=391, Percent_Identity=27.3657289002558, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355181, Length=470, Percent_Identity=27.0212765957447, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581924, Length=529, Percent_Identity=26.2759924385633, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18859661, Length=472, Percent_Identity=25.8474576271186, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922652, Length=496, Percent_Identity=27.2177419354839, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI20130357, Length=384, Percent_Identity=26.8229166666667, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24648253, Length=515, Percent_Identity=24.2718446601942, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656500, Length=481, Percent_Identity=26.4033264033264, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24648255, Length=517, Percent_Identity=24.7582205029014, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21356441, Length=511, Percent_Identity=24.0704500978474, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648257, Length=518, Percent_Identity=24.3243243243243, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356947, Length=234, Percent_Identity=32.4786324786325, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161076582, Length=349, Percent_Identity=26.3610315186246, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358303, Length=428, Percent_Identity=22.8971962616822, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24653035, Length=342, Percent_Identity=26.0233918128655, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648260, Length=362, Percent_Identity=26.7955801104972, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281365686, Length=308, Percent_Identity=25.3246753246753, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45552801, Length=549, Percent_Identity=23.4972677595628, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550496, Length=549, Percent_Identity=23.4972677595628, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355225, Length=323, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.2.1.33 [H]

Molecular weight: Translated: 55556; Mature: 55556

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLGTSFLASVSRDPRALALVDGETRLSYAEWFGVISATVAGLDRLGLKPGDHLVTVLQ
CCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NRQEAATLHWACQFAGIVITPINWRAKAEEIDYAVENAQARAIAYEPVSAGSLRDSAASQ
CCCHHHHHHEEEEECCEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
RIPRIAVGTPPGPGETAFADLAATEGPPVTPRADAEAISLMLYTSGTTAKPKGVPRRHRA
CCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHH
ERAAAVAHVAQNLYGRGERTLGVMPLYHTMGVRSLLAMSLIGGTFVCLPRFDVAGALRLI
HHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHH
AAERITNLYLVPTLYHDLVHHRDFPATDTTSVRKLGFAGAPMTDGLLARLTEAFRPDLFV
HHHHHCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCEEE
NHYGSSEVYTFTINHEAAVKPGSAGRAGLNTMVRVVPMGGDPGRTAAPGEEGEIAVIAKG
EECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECC
DEAFEGYWHRPEADAKAFRDGWYFTGDTGFADADGDLYVTGRVDDMIITGGENVSPVEIE
CHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEHH
SRLSLHPAVSEVAVVGLPDERWGRIVAAFIKRSGSTDEAALDAHCRAGGLPSHKLPRRYV
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
FVDEIPKSPVGKLLRRQLVAGEYVLEGGAEPHAEGHEAA
EEECCCCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLDLGTSFLASVSRDPRALALVDGETRLSYAEWFGVISATVAGLDRLGLKPGDHLVTVLQ
CCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NRQEAATLHWACQFAGIVITPINWRAKAEEIDYAVENAQARAIAYEPVSAGSLRDSAASQ
CCCHHHHHHEEEEECCEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
RIPRIAVGTPPGPGETAFADLAATEGPPVTPRADAEAISLMLYTSGTTAKPKGVPRRHRA
CCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHH
ERAAAVAHVAQNLYGRGERTLGVMPLYHTMGVRSLLAMSLIGGTFVCLPRFDVAGALRLI
HHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHH
AAERITNLYLVPTLYHDLVHHRDFPATDTTSVRKLGFAGAPMTDGLLARLTEAFRPDLFV
HHHHHCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCEEE
NHYGSSEVYTFTINHEAAVKPGSAGRAGLNTMVRVVPMGGDPGRTAAPGEEGEIAVIAKG
EECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECC
DEAFEGYWHRPEADAKAFRDGWYFTGDTGFADADGDLYVTGRVDDMIITGGENVSPVEIE
CHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEHH
SRLSLHPAVSEVAVVGLPDERWGRIVAAFIKRSGSTDEAALDAHCRAGGLPSHKLPRRYV
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
FVDEIPKSPVGKLLRRQLVAGEYVLEGGAEPHAEGHEAA
EEECCCCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA