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The map label for this gene is rprY [H]

Identifier: 170751099

GI number: 170751099

Start: 5018168

End: 5018758

Strand: Direct

Name: rprY [H]

Synonym: Mrad2831_4715

Alternate gene names: 170751099

Gene position: 5018168-5018758 (Clockwise)

Preceding gene: 170751098

Following gene: 170751103

Centisome position: 82.57

GC content: 64.64

Gene sequence:

>591_bases
ATGCCTAGGATACTCTGCGTTGAGGACGACGCGGAAACGGCGAGCCTGCTCGCGGAAGCCCTGGTTGACCTCGGCTACAC
GGTGGAACGCGCCTCGGACGGGGAGGCGGGTTTGTCGGCCATCCAAATGTCACCTCCGGACTTGGTCCTGTGCGACGTGC
GCATGCCGGGGATGAACGGCCTGGACTTGCTCGAGCAACTAGCAGCGGCCGCTCCGCACCTCGCGCGGATCCCATTCGTG
TTCCTCACGGCGCTCGACGATCGCGACAGCGAGATCGCCGCGCGCCGGAAGGGCGCGGATGACTATCTCACCAAGCCGAT
CGACTTCGAGATGCTGGCTGTCGTGGTGGAGCATCGTCTCCGCGCGGGTCGAGGCGGGCAGAGCCAAGACGCGTTCGGCC
ATCTGACCGGCCGGGAACGGGAAGTGTTGACCTGGGCCAGCCGCGGGAAGACGTCCGCGGAGATCGCCCTGATCCTCGAT
CTGCGGGAGCGAACCGTCAACTTCCATTTCGACCAAGCCATGAAGCGCCTGAACGTCGTCAATAGAACGCATGCGGTGGC
CCGTGCGCTCTCGTTGCGGTTGATCGATTGA

Upstream 100 bases:

>100_bases
CATGGTGGCCGCCTCGTCATCGAGAGCGAAGAGGGTCGCGGAACCCGTGCTATGCTGGCGCTGCCGCGGGACGGGGCGCT
GTCATCCCCGGAGTCGGAGC

Downstream 100 bases:

>100_bases
CGGATTTCGGCCGCGTGAACGGTTCCGGCAGACGGTCTGGTCGCGCGCTCCCCATGATGATGTTCTTCGTCCGATCAGAC
ATGCGACGGTCCTTGCCTGC

Product: two component LuxR family transcriptional regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MPRILCVEDDAETASLLAEALVDLGYTVERASDGEAGLSAIQMSPPDLVLCDVRMPGMNGLDLLEQLAAAAPHLARIPFV
FLTALDDRDSEIAARRKGADDYLTKPIDFEMLAVVVEHRLRAGRGGQSQDAFGHLTGREREVLTWASRGKTSAEIALILD
LRERTVNFHFDQAMKRLNVVNRTHAVARALSLRLID

Sequences:

>Translated_196_residues
MPRILCVEDDAETASLLAEALVDLGYTVERASDGEAGLSAIQMSPPDLVLCDVRMPGMNGLDLLEQLAAAAPHLARIPFV
FLTALDDRDSEIAARRKGADDYLTKPIDFEMLAVVVEHRLRAGRGGQSQDAFGHLTGREREVLTWASRGKTSAEIALILD
LRERTVNFHFDQAMKRLNVVNRTHAVARALSLRLID
>Mature_195_residues
PRILCVEDDAETASLLAEALVDLGYTVERASDGEAGLSAIQMSPPDLVLCDVRMPGMNGLDLLEQLAAAAPHLARIPFVF
LTALDDRDSEIAARRKGADDYLTKPIDFEMLAVVVEHRLRAGRGGQSQDAFGHLTGREREVLTWASRGKTSAEIALILDL
RERTVNFHFDQAMKRLNVVNRTHAVARALSLRLID

Specific function: Member of the two-component regulatory system rprX/rprY [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=37.719298245614, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=191, Percent_Identity=32.9842931937173, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788394, Length=203, Percent_Identity=31.5270935960591, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=33.6134453781513, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=32.7731092436975, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786784, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1789402, Length=128, Percent_Identity=32.8125, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788224, Length=62, Percent_Identity=45.1612903225806, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788521, Length=186, Percent_Identity=29.5698924731183, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=106, Percent_Identity=33.0188679245283, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790863, Length=113, Percent_Identity=34.5132743362832, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1787229, Length=122, Percent_Identity=36.0655737704918, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 21560; Mature: 21429

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRILCVEDDAETASLLAEALVDLGYTVERASDGEAGLSAIQMSPPDLVLCDVRMPGMNG
CCCEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCC
LDLLEQLAAAAPHLARIPFVFLTALDDRDSEIAARRKGADDYLTKPIDFEMLAVVVEHRL
HHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
RAGRGGQSQDAFGHLTGREREVLTWASRGKTSAEIALILDLRERTVNFHFDQAMKRLNVV
HCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHH
NRTHAVARALSLRLID
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRILCVEDDAETASLLAEALVDLGYTVERASDGEAGLSAIQMSPPDLVLCDVRMPGMNG
CCEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCC
LDLLEQLAAAAPHLARIPFVFLTALDDRDSEIAARRKGADDYLTKPIDFEMLAVVVEHRL
HHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
RAGRGGQSQDAFGHLTGREREVLTWASRGKTSAEIALILDLRERTVNFHFDQAMKRLNVV
HCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHH
NRTHAVARALSLRLID
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8469117 [H]