Click here to switch to the map view.

The map label for this gene is pdxA1 [H]

Identifier: 170751031

GI number: 170751031

Start: 4937494

End: 4938519

Strand: Reverse

Name: pdxA1 [H]

Synonym: Mrad2831_4642

Alternate gene names: 170751031

Gene position: 4938519-4937494 (Counterclockwise)

Preceding gene: 170751032

Following gene: 170751028

Centisome position: 81.25

GC content: 72.12

Gene sequence:

>1026_bases
GTGACCCAACATCTCGCCATCACCATGGGCGATCCCGCCGGCATCGGCCCCGAGATCATCGTCAAGGCCGCGGCCCGGCT
GAAGGACCGGATCGCGGCGGGCGACCTGAAGCTCGTGGTCATCGGCAGCGCCCCGGCCCTGCGCCGGGCCGAGCAGGCGC
TCGGCCTCCTGCCGGAGGCCATCCCGGAGGTCGCCGAGGCCGGCGACTGGCCGGCGCTGTGCTGCCTCCAGGCCGACGCC
GAGGGCGCGCCCATCGAGCCCGGCCGGCTCTCCGCCGACGGCGGGCGCTTCGCCTACAAGGCGATCGAGGCCGGCGTCCG
CCTGGCCATGGCGGGGCGGATCGGCGGCATCGTCACGGCGCCGCTCAACAAGGAGGCGCTCAACAAGGCCGGCTACCACT
ATGCCGGCCATACCGAGATGCTGGCGGAGCTGACCGGGGTGCGCGGGTCGGTGATGATGCTGGCCCACGGCAACATGCGG
GTCTCCCACGTCACCACCCACGTCGCCCTGGAGGACGTGCCGAAGCGCCTGACCCCGGAGCGGCTGCGCCTCGTCATCGA
CCTCACCGACAAGGCCCTGAAGGGGCTCGGCCTCGCCAAGCCCAAGATCGCGGTCGCCGCGCTCAACCCCCATGCCGGCG
AGGGCGGCCTGTTCGGGCGCCAGGACATCGACGTCAGCGCGCCGGTGATCGCGGCGGCCAACGCCGACGGGCTCGACGTG
CACGGGCCGGTGCCGGGCGACACGGTGTTCGTGAAGCTGCGCGCGGGCCAGTACGACGCGGTGGTGGCCATGTACCACGA
CCAGGGGCACATCCCGGTGAAGCTGCTCGGCTTCGAGATCGATCCCGCCACGGGCAAGTGGATGGACCTGTCGGGCGTGA
ACATCACCCTGGGCCTGCCGATCATCCGCACCTCGGTCGATCACGGCACCGCCTTCGACATCGCCGGCACCGGCGTCGCC
AACGAGCGCAGCCTCATCGAGGCGATCGAGTTCGCCGAGAAGCTCGCGGCCAGCCGAGCGGCGTGA

Upstream 100 bases:

>100_bases
ACGGGCTGCCGGTCGTGTCGAAGTCCGGCGCCTTCGGAACAGAGGGCGTCTGGCGCGACCTCCTCCACCAGAACGGCTTC
CCGCACGACAGGAGCGCCCC

Downstream 100 bases:

>100_bases
GACTCGGCGGCGTGAGACTCGGCGGATGACGGGGGCGGCGATCCGCGCCCCCGTCCCGAGGTGCCGCGGCGGTCGCGATC
ATCGCCGGAGCCGGCCTCCG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 1 [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTQHLAITMGDPAGIGPEIIVKAAARLKDRIAAGDLKLVVIGSAPALRRAEQALGLLPEAIPEVAEAGDWPALCCLQADA
EGAPIEPGRLSADGGRFAYKAIEAGVRLAMAGRIGGIVTAPLNKEALNKAGYHYAGHTEMLAELTGVRGSVMMLAHGNMR
VSHVTTHVALEDVPKRLTPERLRLVIDLTDKALKGLGLAKPKIAVAALNPHAGEGGLFGRQDIDVSAPVIAAANADGLDV
HGPVPGDTVFVKLRAGQYDAVVAMYHDQGHIPVKLLGFEIDPATGKWMDLSGVNITLGLPIIRTSVDHGTAFDIAGTGVA
NERSLIEAIEFAEKLAASRAA

Sequences:

>Translated_341_residues
MTQHLAITMGDPAGIGPEIIVKAAARLKDRIAAGDLKLVVIGSAPALRRAEQALGLLPEAIPEVAEAGDWPALCCLQADA
EGAPIEPGRLSADGGRFAYKAIEAGVRLAMAGRIGGIVTAPLNKEALNKAGYHYAGHTEMLAELTGVRGSVMMLAHGNMR
VSHVTTHVALEDVPKRLTPERLRLVIDLTDKALKGLGLAKPKIAVAALNPHAGEGGLFGRQDIDVSAPVIAAANADGLDV
HGPVPGDTVFVKLRAGQYDAVVAMYHDQGHIPVKLLGFEIDPATGKWMDLSGVNITLGLPIIRTSVDHGTAFDIAGTGVA
NERSLIEAIEFAEKLAASRAA
>Mature_340_residues
TQHLAITMGDPAGIGPEIIVKAAARLKDRIAAGDLKLVVIGSAPALRRAEQALGLLPEAIPEVAEAGDWPALCCLQADAE
GAPIEPGRLSADGGRFAYKAIEAGVRLAMAGRIGGIVTAPLNKEALNKAGYHYAGHTEMLAELTGVRGSVMMLAHGNMRV
SHVTTHVALEDVPKRLTPERLRLVIDLTDKALKGLGLAKPKIAVAALNPHAGEGGLFGRQDIDVSAPVIAAANADGLDVH
GPVPGDTVFVKLRAGQYDAVVAMYHDQGHIPVKLLGFEIDPATGKWMDLSGVNITLGLPIIRTSVDHGTAFDIAGTGVAN
ERSLIEAIEFAEKLAASRAA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=338, Percent_Identity=38.4615384615385, Blast_Score=204, Evalue=9e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35519; Mature: 35387

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHLAITMGDPAGIGPEIIVKAAARLKDRIAAGDLKLVVIGSAPALRRAEQALGLLPEA
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCHHH
IPEVAEAGDWPALCCLQADAEGAPIEPGRLSADGGRFAYKAIEAGVRLAMAGRIGGIVTA
HHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHCEEEEEECCCCCEEEC
PLNKEALNKAGYHYAGHTEMLAELTGVRGSVMMLAHGNMRVSHVTTHVALEDVPKRLTPE
CCCHHHHHHCCCEECCHHHHHHHHHCCCCEEEEEEECCEEEEEEEEEHHHHHHHHHCCCC
RLRLVIDLTDKALKGLGLAKPKIAVAALNPHAGEGGLFGRQDIDVSAPVIAAANADGLDV
CEEEEEEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCEE
HGPVPGDTVFVKLRAGQYDAVVAMYHDQGHIPVKLLGFEIDPATGKWMDLSGVNITLGLP
CCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEEEEECCCCCCEEEECCCEEEECCC
IIRTSVDHGTAFDIAGTGVANERSLIEAIEFAEKLAASRAA
EEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQHLAITMGDPAGIGPEIIVKAAARLKDRIAAGDLKLVVIGSAPALRRAEQALGLLPEA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCHHH
IPEVAEAGDWPALCCLQADAEGAPIEPGRLSADGGRFAYKAIEAGVRLAMAGRIGGIVTA
HHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHCEEEEEECCCCCEEEC
PLNKEALNKAGYHYAGHTEMLAELTGVRGSVMMLAHGNMRVSHVTTHVALEDVPKRLTPE
CCCHHHHHHCCCEECCHHHHHHHHHCCCCEEEEEEECCEEEEEEEEEHHHHHHHHHCCCC
RLRLVIDLTDKALKGLGLAKPKIAVAALNPHAGEGGLFGRQDIDVSAPVIAAANADGLDV
CEEEEEEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCEE
HGPVPGDTVFVKLRAGQYDAVVAMYHDQGHIPVKLLGFEIDPATGKWMDLSGVNITLGLP
CCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEEEEECCCCCCEEEECCCEEEECCC
IIRTSVDHGTAFDIAGTGVANERSLIEAIEFAEKLAASRAA
EEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]