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The map label for this gene is hmuU [H]

Identifier: 170750978

GI number: 170750978

Start: 4885214

End: 4886266

Strand: Direct

Name: hmuU [H]

Synonym: Mrad2831_4589

Alternate gene names: 170750978

Gene position: 4885214-4886266 (Clockwise)

Preceding gene: 170750977

Following gene: 170750979

Centisome position: 80.38

GC content: 76.64

Gene sequence:

>1053_bases
GTGAGCCGCCGTTCCGCGACGCCCTGGGTGCTGGGCATCCTGGCGGCCCTGGTGCTCGCCGCCGCCCTGCTCTCCGTGAG
CCTCGGGGCGATCCGCATCCCGCCGGAGCGGGTCCTCGCGGCCCTGACCGGGGAGGGGAGCGATCCGGCCCGCGCCCGGG
ACGCGCTGGTGATCCTCTCGATCCGCCTGCCCCGCACCCTGCTGGGGCTGCTGGTCGGGGCCGGGCTGGCGGTCTCCGGA
GCGCTGATGCAGGGGCTGTTCCGCAACCCCCTGGCCGACCCGGCGCTGGTCGGGGTCTCGTCGGGGGCTGGGCTCGCCGC
CGCGGTCATCATCGTGCTCGGCGACCGGATCCTCGCCCGCCTGGGTGTCCCGGGACCGCTGCCCTACGCCGCGCTGCCGG
CCGGGGCCTTCCTCGGCGGCCTGTGCGCGACCCTCATCCTCTACGCCCTCGCGACCCGGTCCGGGCGCACCGCGGTGGCG
ACGATGCTGCTCGCGGGGATCGCGCTGGGGGCGCTGAGCGGCGCGCTGACCGGCCTGCTGACCTTCGTCAGCGACGACCG
GCAACTGCGCGATCTCGCCTTCTGGTCGCTGGGCAGCCTCGGCGGCGCCACCTGGTCCAAGGTCGCGGCCTCGGCGCCGC
TGATCCTGCCGGTGCTGGCCGCGGTCCCGCTCCTGGGCCGCGGCCTGAACGCGCTCGTCCTCGGCGAGGCCGAGGCCTTC
CACCTCGGCGTCCCGGTGGAGCGGCTGAAGCGCGCCTGCATCGTGCTGGTGGCGGTGGCGGTGGCGGTCGGCGCCAGCGT
GGCGGCGGCGGGGGTGATCGGCTTCGTCGGCCTCGTGGTGCCGCACGCCCTGCGGCTGCTGATCGGCCCGGGGCACCGGC
TGCTGCTGCCGGCCGCAGCGCTTCTCGGCGGCGCTTTCCTGGTGCTCGCCGACGTGGTGGCGCGCCTCGTCGCCGCGCCC
GCCGAGCTGCCGATCGGGATCGTCACCGCGCTGGTCGGCGCGCCGGTCTTCCTGTGGCTGCTCCTCGGCCGGGTGCGGGT
GGACGATGTCTGA

Upstream 100 bases:

>100_bases
CGGCTTCGGGCCGCGCACGCCCGAGGCCGCCACCGACCTGATGCGGGCGCTCTATCCGGACCTGCCGCGTGACTGAGCCG
CGCCGCGGCGGGCGGGGCGC

Downstream 100 bases:

>100_bases
CGATGTCTGACGATGTCTGACCATGCCTGATCCGGCCCTGCTCGTGGCCCGCGACCTGACCGTCACGGTGGCGGGGCGCG
CGCTCGTGCGCGACGTCTCC

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSRRSATPWVLGILAALVLAAALLSVSLGAIRIPPERVLAALTGEGSDPARARDALVILSIRLPRTLLGLLVGAGLAVSG
ALMQGLFRNPLADPALVGVSSGAGLAAAVIIVLGDRILARLGVPGPLPYAALPAGAFLGGLCATLILYALATRSGRTAVA
TMLLAGIALGALSGALTGLLTFVSDDRQLRDLAFWSLGSLGGATWSKVAASAPLILPVLAAVPLLGRGLNALVLGEAEAF
HLGVPVERLKRACIVLVAVAVAVGASVAAAGVIGFVGLVVPHALRLLIGPGHRLLLPAAALLGGAFLVLADVVARLVAAP
AELPIGIVTALVGAPVFLWLLLGRVRVDDV

Sequences:

>Translated_350_residues
MSRRSATPWVLGILAALVLAAALLSVSLGAIRIPPERVLAALTGEGSDPARARDALVILSIRLPRTLLGLLVGAGLAVSG
ALMQGLFRNPLADPALVGVSSGAGLAAAVIIVLGDRILARLGVPGPLPYAALPAGAFLGGLCATLILYALATRSGRTAVA
TMLLAGIALGALSGALTGLLTFVSDDRQLRDLAFWSLGSLGGATWSKVAASAPLILPVLAAVPLLGRGLNALVLGEAEAF
HLGVPVERLKRACIVLVAVAVAVGASVAAAGVIGFVGLVVPHALRLLIGPGHRLLLPAAALLGGAFLVLADVVARLVAAP
AELPIGIVTALVGAPVFLWLLLGRVRVDDV
>Mature_349_residues
SRRSATPWVLGILAALVLAAALLSVSLGAIRIPPERVLAALTGEGSDPARARDALVILSIRLPRTLLGLLVGAGLAVSGA
LMQGLFRNPLADPALVGVSSGAGLAAAVIIVLGDRILARLGVPGPLPYAALPAGAFLGGLCATLILYALATRSGRTAVAT
MLLAGIALGALSGALTGLLTFVSDDRQLRDLAFWSLGSLGGATWSKVAASAPLILPVLAAVPLLGRGLNALVLGEAEAFH
LGVPVERLKRACIVLVAVAVAVGASVAAAGVIGFVGLVVPHALRLLIGPGHRLLLPAAALLGGAFLVLADVVARLVAAPA
ELPIGIVTALVGAPVFLWLLLGRVRVDDV

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=47.1186440677966, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1790740, Length=326, Percent_Identity=40.7975460122699, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790741, Length=289, Percent_Identity=36.3321799307958, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786805, Length=328, Percent_Identity=38.109756097561, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786804, Length=318, Percent_Identity=34.9056603773585, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786347, Length=290, Percent_Identity=33.448275862069, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35052; Mature: 34920

Theoretical pI: Translated: 11.56; Mature: 11.56

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRSATPWVLGILAALVLAAALLSVSLGAIRIPPERVLAALTGEGSDPARARDALVILS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCHHHHCEEEEEE
IRLPRTLLGLLVGAGLAVSGALMQGLFRNPLADPALVGVSSGAGLAAAVIIVLGDRILAR
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHHHHHHHHHHH
LGVPGPLPYAALPAGAFLGGLCATLILYALATRSGRTAVATMLLAGIALGALSGALTGLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TFVSDDRQLRDLAFWSLGSLGGATWSKVAASAPLILPVLAAVPLLGRGLNALVLGEAEAF
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCE
HLGVPVERLKRACIVLVAVAVAVGASVAAAGVIGFVGLVVPHALRLLIGPGHRLLLPAAA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LLGGAFLVLADVVARLVAAPAELPIGIVTALVGAPVFLWLLLGRVRVDDV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRRSATPWVLGILAALVLAAALLSVSLGAIRIPPERVLAALTGEGSDPARARDALVILS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCHHHHCEEEEEE
IRLPRTLLGLLVGAGLAVSGALMQGLFRNPLADPALVGVSSGAGLAAAVIIVLGDRILAR
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHHHHHHHHHHH
LGVPGPLPYAALPAGAFLGGLCATLILYALATRSGRTAVATMLLAGIALGALSGALTGLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TFVSDDRQLRDLAFWSLGSLGGATWSKVAASAPLILPVLAAVPLLGRGLNALVLGEAEAF
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCE
HLGVPVERLKRACIVLVAVAVAVGASVAAAGVIGFVGLVVPHALRLLIGPGHRLLLPAAA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LLGGAFLVLADVVARLVAAPAELPIGIVTALVGAPVFLWLLLGRVRVDDV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]