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The map label for this gene is appC [H]

Identifier: 170750970

GI number: 170750970

Start: 4877028

End: 4877960

Strand: Direct

Name: appC [H]

Synonym: Mrad2831_4581

Alternate gene names: 170750970

Gene position: 4877028-4877960 (Clockwise)

Preceding gene: 170750969

Following gene: 170750971

Centisome position: 80.24

GC content: 71.81

Gene sequence:

>933_bases
ATGGCTGGCTCGACCCTCGCATCGCCCTCCGATGAGGCGGTGCCCGTCGCCCGCGCGCCGGCTTCGCCGGGGCGGGAGAC
GTGGCGGCGCTTCCGGCGGCACCGGCTGGCGCTCGCCAGCGTCGGCGTGCTGGCGCTTCTCGTCGCCGGCGTGGTGTTCG
GCGGCCTGCTCTGGCCGGTCGCCATCGACGACATCGACTTCGCGGCCCAGCTCCAGGGTCCGTCCTGGGACCACCCGTTC
GGCACCGACGATCTCGGCCAGGACCTGCTCGCCCGGATGATCTACGGCGGGCGGATCTCGCTCGCGGTCGGCTTCGCCGC
CATGGCGGTGGCGAGCCTGATCGGGGTCTTGGTCGGCGCGCTCGCCGGCATGTCGCGCCGGTTCCTCGACCCGGTGCTGA
TGTGGCTGACCGACCTGTTCCTGTCGCTGCCGCAGCTGCCGCTGCTGCTCCTCGTGATCTACCTGTTCCGCGACAGCCTG
AAGGCCGTGTTCGGCAGCCAGGGCGGCGTGTTCCTGATGATCGTCGCGGTGATCGGGGGCTTACGCTGGATGCCGGTCGC
CCGGCTGGTGCGGGCGCAGTTCCTGAGCCTGCGCGAGAAGGAGTTCGTGGAGGCGGCCCGCTCGCAGGGGGCGACGACCG
GGCACCTCGTGCGCCGCCACATCCTGCCGAACGCGCTGGGGCCGGTGATCGTGGCGGCCTCGATCGAGGTCTCGTCCGCG
ATCATCGCGGAATCGACCCTGTCCTTCCTGGGGCTCGGCTTCCCGCCCGACATCCCGACCTGGGGGCGGCTGCTGTTCGA
CGCCAAGGACCACCTCGACGTCGCCCCGCACTGGGCGCTGTTCCCGGGGGGCGCGATCTTCCTGACCGTGCTGTCGATCA
ACTTCATCGGCGACGGCCTGCGCGACGCCCTCGACCCGCGGCGGGTTCTCTAG

Upstream 100 bases:

>100_bases
ATCGACGCCATGCTGGCCAACGACACGCCGGTGGTGATGGCCGTGACCTTCGTGTTCGCCGGCCTCGTCATCCTGTTCAA
CCTCGTCGCGGACCTGCTCT

Downstream 100 bases:

>100_bases
CGATGGCAGATCCGGTGGACCCGATCCTCTCGGTTTCCGACCTCACCGTCTCCTTCCGCTCGGACGGGCGCTGGCGCGAG
GTCGTGCACGGCGTCTCGTT

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAGSTLASPSDEAVPVARAPASPGRETWRRFRRHRLALASVGVLALLVAGVVFGGLLWPVAIDDIDFAAQLQGPSWDHPF
GTDDLGQDLLARMIYGGRISLAVGFAAMAVASLIGVLVGALAGMSRRFLDPVLMWLTDLFLSLPQLPLLLLVIYLFRDSL
KAVFGSQGGVFLMIVAVIGGLRWMPVARLVRAQFLSLREKEFVEAARSQGATTGHLVRRHILPNALGPVIVAASIEVSSA
IIAESTLSFLGLGFPPDIPTWGRLLFDAKDHLDVAPHWALFPGGAIFLTVLSINFIGDGLRDALDPRRVL

Sequences:

>Translated_310_residues
MAGSTLASPSDEAVPVARAPASPGRETWRRFRRHRLALASVGVLALLVAGVVFGGLLWPVAIDDIDFAAQLQGPSWDHPF
GTDDLGQDLLARMIYGGRISLAVGFAAMAVASLIGVLVGALAGMSRRFLDPVLMWLTDLFLSLPQLPLLLLVIYLFRDSL
KAVFGSQGGVFLMIVAVIGGLRWMPVARLVRAQFLSLREKEFVEAARSQGATTGHLVRRHILPNALGPVIVAASIEVSSA
IIAESTLSFLGLGFPPDIPTWGRLLFDAKDHLDVAPHWALFPGGAIFLTVLSINFIGDGLRDALDPRRVL
>Mature_309_residues
AGSTLASPSDEAVPVARAPASPGRETWRRFRRHRLALASVGVLALLVAGVVFGGLLWPVAIDDIDFAAQLQGPSWDHPFG
TDDLGQDLLARMIYGGRISLAVGFAAMAVASLIGVLVGALAGMSRRFLDPVLMWLTDLFLSLPQLPLLLLVIYLFRDSLK
AVFGSQGGVFLMIVAVIGGLRWMPVARLVRAQFLSLREKEFVEAARSQGATTGHLVRRHILPNALGPVIVAASIEVSSAI
IAESTLSFLGLGFPPDIPTWGRLLFDAKDHLDVAPHWALFPGGAIFLTVLSINFIGDGLRDALDPRRVL

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=288, Percent_Identity=38.5416666666667, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1787498, Length=291, Percent_Identity=43.6426116838488, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1787760, Length=272, Percent_Identity=34.5588235294118, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1789964, Length=308, Percent_Identity=33.7662337662338, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787549, Length=305, Percent_Identity=30.8196721311475, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789889, Length=245, Percent_Identity=29.7959183673469, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788505, Length=237, Percent_Identity=34.1772151898734, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33270; Mature: 33138

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSTLASPSDEAVPVARAPASPGRETWRRFRRHRLALASVGVLALLVAGVVFGGLLWPV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIDDIDFAAQLQGPSWDHPFGTDDLGQDLLARMIYGGRISLAVGFAAMAVASLIGVLVGA
HHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LAGMSRRFLDPVLMWLTDLFLSLPQLPLLLLVIYLFRDSLKAVFGSQGGVFLMIVAVIGG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
LRWMPVARLVRAQFLSLREKEFVEAARSQGATTGHLVRRHILPNALGPVIVAASIEVSSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IIAESTLSFLGLGFPPDIPTWGRLLFDAKDHLDVAPHWALFPGGAIFLTVLSINFIGDGL
HHHHHHHHHHCCCCCCCCCHHHHHHHCCHHCCCCCCCCEECCCHHHHHHHHHHHHHCCHH
RDALDPRRVL
HHHCCCCCCC
>Mature Secondary Structure 
AGSTLASPSDEAVPVARAPASPGRETWRRFRRHRLALASVGVLALLVAGVVFGGLLWPV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]