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The map label for this gene is cynR [H]

Identifier: 170750959

GI number: 170750959

Start: 4864526

End: 4865422

Strand: Direct

Name: cynR [H]

Synonym: Mrad2831_4570

Alternate gene names: 170750959

Gene position: 4864526-4865422 (Clockwise)

Preceding gene: 170750950

Following gene: 170750961

Centisome position: 80.04

GC content: 73.8

Gene sequence:

>897_bases
GTGAAGCACCTGCGCACCGTCACTTACGTCGCCGAGGTCGCCCGCGCCGGCTCGATCCGGCGCGCCGCGGAGCGCTTGAA
CCTCACGCCCTCGGCCCTGACCCGGCAGATCCAGGATCTCGAGTACGAGCTCGGCACGCCGATCTTCGAGCGCCTGCCGC
AGGGGATGCGGCTCAACGCGGCCGGCGAGCTCTTCGCCCGGCACATCCGCGACCAGGCGGCCGATCTCGACCGGGTCCGC
TCGCAGATCGCCGACCTGTCGGGCGTGCGGCGGGGGCATGTGGCGCTCGCCTGCAGCCAGGCCTTCGTCACCCAGGTGGT
GCCCGAGGAGGTCGAGGCCTACCGCGCCCGGTTTCCGCAGGTCGGCTTCACCGTGCAGGTCCGCGACCACGCCCAGGCGG
TCACCGCCCTGGCGGCTTTCGAGGCCGACCTCGCCCTGATCCTGCAGCCGCCGCCCTCGGCGGAGCTGCACCCGCTCTAT
GCCGGCCACCAGACCCTGTGCGCGCTGATGCGCCGGGGCCACGCGCTGGCGGCGGAACGCGGGCCCGTGCGCCTGCGCGA
CTGCCTCGCGCACGCCCTCGCGCTGCCCGACCGGTCGCTCGCCATCCGCCACCACATCGAGCACGCGCTGGCCCGGCGGG
GCGTCGAGCTGCGGCCCGTGGTGGAGTCGGGCTCGCTTGAGTTCCTGCGCAACCTCACCCTGCGGGAGGACGTGGTCAGC
CTGCAGGTACCCAGCGGCATCCCGGAGGACCCGCGCCTCCACAGCCGGCCGATCGACACCCGCGATCTCACCCCGATGAC
GCTGGTCCTGGCGCAGCTGCGCGGGCGCTCGCTCTCGGTGGCCGCCGCCAAGTTCGCCGACCAGCTCGTCGTCCGGCTCA
ACCGGGAAGGGACCTGA

Upstream 100 bases:

>100_bases
GTCCCGATGTGCCGACGCTACGGGCACCACCTGTTGCGAGGAAGTGCTATTTTCTGAGCGTGCCGTTGCCTCGCGGGCAA
CGGTCGGGCAGGGTGCGGGC

Downstream 100 bases:

>100_bases
ACGGGAAGGGGCCTGACCGTCGCCCCGCTCAGGCGGGCAGGCCGGCAAGGGCCAGCGCCTCGGCGTATCGCTGCCCCAGC
GCGGCGACCGGGAAGGGGAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKHLRTVTYVAEVARAGSIRRAAERLNLTPSALTRQIQDLEYELGTPIFERLPQGMRLNAAGELFARHIRDQAADLDRVR
SQIADLSGVRRGHVALACSQAFVTQVVPEEVEAYRARFPQVGFTVQVRDHAQAVTALAAFEADLALILQPPPSAELHPLY
AGHQTLCALMRRGHALAAERGPVRLRDCLAHALALPDRSLAIRHHIEHALARRGVELRPVVESGSLEFLRNLTLREDVVS
LQVPSGIPEDPRLHSRPIDTRDLTPMTLVLAQLRGRSLSVAAAKFADQLVVRLNREGT

Sequences:

>Translated_298_residues
MKHLRTVTYVAEVARAGSIRRAAERLNLTPSALTRQIQDLEYELGTPIFERLPQGMRLNAAGELFARHIRDQAADLDRVR
SQIADLSGVRRGHVALACSQAFVTQVVPEEVEAYRARFPQVGFTVQVRDHAQAVTALAAFEADLALILQPPPSAELHPLY
AGHQTLCALMRRGHALAAERGPVRLRDCLAHALALPDRSLAIRHHIEHALARRGVELRPVVESGSLEFLRNLTLREDVVS
LQVPSGIPEDPRLHSRPIDTRDLTPMTLVLAQLRGRSLSVAAAKFADQLVVRLNREGT
>Mature_298_residues
MKHLRTVTYVAEVARAGSIRRAAERLNLTPSALTRQIQDLEYELGTPIFERLPQGMRLNAAGELFARHIRDQAADLDRVR
SQIADLSGVRRGHVALACSQAFVTQVVPEEVEAYRARFPQVGFTVQVRDHAQAVTALAAFEADLALILQPPPSAELHPLY
AGHQTLCALMRRGHALAAERGPVRLRDCLAHALALPDRSLAIRHHIEHALARRGVELRPVVESGSLEFLRNLTLREDVVS
LQVPSGIPEDPRLHSRPIDTRDLTPMTLVLAQLRGRSLSVAAAKFADQLVVRLNREGT

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=245, Percent_Identity=26.9387755102041, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788748, Length=292, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=225, Percent_Identity=24.8888888888889, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=231, Percent_Identity=24.2424242424242, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32955; Mature: 32955

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLRTVTYVAEVARAGSIRRAAERLNLTPSALTRQIQDLEYELGTPIFERLPQGMRLNA
CCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEECH
AGELFARHIRDQAADLDRVRSQIADLSGVRRGHVALACSQAFVTQVVPEEVEAYRARFPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCC
VGFTVQVRDHAQAVTALAAFEADLALILQPPPSAELHPLYAGHQTLCALMRRGHALAAER
CCEEEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCC
GPVRLRDCLAHALALPDRSLAIRHHIEHALARRGVELRPVVESGSLEFLRNLTLREDVVS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHE
LQVPSGIPEDPRLHSRPIDTRDLTPMTLVLAQLRGRSLSVAAAKFADQLVVRLNREGT
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHLRTVTYVAEVARAGSIRRAAERLNLTPSALTRQIQDLEYELGTPIFERLPQGMRLNA
CCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEECH
AGELFARHIRDQAADLDRVRSQIADLSGVRRGHVALACSQAFVTQVVPEEVEAYRARFPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCC
VGFTVQVRDHAQAVTALAAFEADLALILQPPPSAELHPLYAGHQTLCALMRRGHALAAER
CCEEEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCC
GPVRLRDCLAHALALPDRSLAIRHHIEHALARRGVELRPVVESGSLEFLRNLTLREDVVS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHE
LQVPSGIPEDPRLHSRPIDTRDLTPMTLVLAQLRGRSLSVAAAKFADQLVVRLNREGT
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]