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The map label for this gene is degP [H]

Identifier: 170750918

GI number: 170750918

Start: 4807084

End: 4808634

Strand: Direct

Name: degP [H]

Synonym: Mrad2831_4529

Alternate gene names: 170750918

Gene position: 4807084-4808634 (Clockwise)

Preceding gene: 170750917

Following gene: 170750919

Centisome position: 79.09

GC content: 71.63

Gene sequence:

>1551_bases
ATGCACCCCGTCGCGAGCGCCCCCGAGGCGCTGTTCGGCCGCGCCCCGGCGCAGCCCCGCTCCCGCGCCCGCGCGCTGAT
GGCCTCGATCCTGATCGGCGCCTCCGTCAGCGTCTCCGTGGCCGCGGCCGCCCTGCCGGTCCCGGCCTTCGCCAAGGGGC
CGGCCTCCCTCGCCGACCTCGCCGAGCAGGTCACCGACGCGGTGGTGAACATCTCCGCGTCCACCACGGTCGAGGCCCGG
GCCGGCCGCGCCGGGCCGCAGGTGCCCCCGGGCACCCCGTTCGAGGACCTGTTCGAGGAGTTCTTCAACCGGCGCGGCGG
CCGCGGCGGCGGTGGCGGCGACAGCGACGGGCCGCGCCAGCAGCGCAAGTCGAACTCGCTGGGCTCCGGCTTCATCATCG
ATTCCGCCGGCCTCGTGGTGACGAACAACCACGTCATCGGCGACGCCAACGACATCCAGGTCATCCTGCACGACGGCACC
AAGCTGAAGGCCGAGATCGTCGGCAAGGATTCGAAGATCGACCTCGCGGTCCTGCGGGTGAAGCCCCCGGCCGACCGCAC
GCTGAAGGCGGTGCCGTTCGGCGATTCCGACAAGATGCGGCCGGGCGACTGGGTCATCGCCATCGGCAACCCGTTCGGGC
TCGGCGGCTCGGTGTCGGCCGGCATCGTCTCGGCGCGGGGCCGGAACATCGAGTCAGGCCCCTACGACAACTACATCCAG
ACGGACGCGGCCATCAACAAGGGCAATTCCGGCGGCCCGCTGTTCAACATGGACGGCGAGGTGATCGGCATCAACACGGC
GATCCTGTCGCCGACCGGCGGCTCCGTGGGCATCGGCTTCGCGGTTCCCTCGGGCACGGCCAAGCCCGTGATCGACCAGC
TGCGCGACTTCGGCGAGGTCCGCCGCGGCTGGCTCGGCGTGCGCATCCAGAACGTCGACGACACCACCGCCGAGGCGCTC
AACCTCAAGGGCGGCGCGCGGGGCGCCCTGGTGGCCGGCGTCGACGAGAAGGGACCGGCCAAGACCGCCGGGATCGAGGT
CGGCGACGTGATCCTGAAGTTCAACGGCGCGCCGGTGAAGGCCTCGGGCGACCTGCCGCGCATCGTCGCCTCGACCCCGG
TCGGCCAGAAGGTCGACGTGGTCGTCATGCGCAAGGGCGAGGAGGTGACGAAGCCCGTCACCCTCGGCCGCCTGGAGGAC
AGCGACAAGCCGCAGCTCGCCAACCTGCGCCAGCCGGAGCCCGAGAGCGCGACCCGGCAGGCGCTCGGCCTCAACCTCTC
CGGCATGACCGACGAGCTGCGCAAGAAGTACTCCATCAAGGACACCGTGAAGGGCGTGGTCGTCACCCGCGTCGACCCGA
ACTCGACCGCCGCCGACAAGCGGATCCAGCCCGGCGAGGTGATCGTCGAGGTCGGCCAGGAGGCGGTGAGCACCCCCGCG
GAGGTGACCAAGCGGATCGACGCCCTGAAGAAGGACGGGCGCAAGTCGGTGCTGCTGCTGGTGGCGGGCGCCACCGGCGA
CGTGCGCTTCGTGGCGGTCGGCCTCGACTGA

Upstream 100 bases:

>100_bases
CGCCCCGGCGCCCGGGGATTACCGTGCAGGACAACCCGCGGGCGATCGACCGTCGGTCGAGGCCCGCGGGACCGGAAACG
CGTTCTTGAAGAGGTCGACC

Downstream 100 bases:

>100_bases
GCCGCCTCATCCGCGTTGCCGAGGGCCGTCGCTCCGCGGGGAGCGGCGGCCCTCGCGCGTTCAGGGGGCCCCACATTGAC
GCTGCGCCGCGGCACGGCAC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MHPVASAPEALFGRAPAQPRSRARALMASILIGASVSVSVAAAALPVPAFAKGPASLADLAEQVTDAVVNISASTTVEAR
AGRAGPQVPPGTPFEDLFEEFFNRRGGRGGGGGDSDGPRQQRKSNSLGSGFIIDSAGLVVTNNHVIGDANDIQVILHDGT
KLKAEIVGKDSKIDLAVLRVKPPADRTLKAVPFGDSDKMRPGDWVIAIGNPFGLGGSVSAGIVSARGRNIESGPYDNYIQ
TDAAINKGNSGGPLFNMDGEVIGINTAILSPTGGSVGIGFAVPSGTAKPVIDQLRDFGEVRRGWLGVRIQNVDDTTAEAL
NLKGGARGALVAGVDEKGPAKTAGIEVGDVILKFNGAPVKASGDLPRIVASTPVGQKVDVVVMRKGEEVTKPVTLGRLED
SDKPQLANLRQPEPESATRQALGLNLSGMTDELRKKYSIKDTVKGVVVTRVDPNSTAADKRIQPGEVIVEVGQEAVSTPA
EVTKRIDALKKDGRKSVLLLVAGATGDVRFVAVGLD

Sequences:

>Translated_516_residues
MHPVASAPEALFGRAPAQPRSRARALMASILIGASVSVSVAAAALPVPAFAKGPASLADLAEQVTDAVVNISASTTVEAR
AGRAGPQVPPGTPFEDLFEEFFNRRGGRGGGGGDSDGPRQQRKSNSLGSGFIIDSAGLVVTNNHVIGDANDIQVILHDGT
KLKAEIVGKDSKIDLAVLRVKPPADRTLKAVPFGDSDKMRPGDWVIAIGNPFGLGGSVSAGIVSARGRNIESGPYDNYIQ
TDAAINKGNSGGPLFNMDGEVIGINTAILSPTGGSVGIGFAVPSGTAKPVIDQLRDFGEVRRGWLGVRIQNVDDTTAEAL
NLKGGARGALVAGVDEKGPAKTAGIEVGDVILKFNGAPVKASGDLPRIVASTPVGQKVDVVVMRKGEEVTKPVTLGRLED
SDKPQLANLRQPEPESATRQALGLNLSGMTDELRKKYSIKDTVKGVVVTRVDPNSTAADKRIQPGEVIVEVGQEAVSTPA
EVTKRIDALKKDGRKSVLLLVAGATGDVRFVAVGLD
>Mature_516_residues
MHPVASAPEALFGRAPAQPRSRARALMASILIGASVSVSVAAAALPVPAFAKGPASLADLAEQVTDAVVNISASTTVEAR
AGRAGPQVPPGTPFEDLFEEFFNRRGGRGGGGGDSDGPRQQRKSNSLGSGFIIDSAGLVVTNNHVIGDANDIQVILHDGT
KLKAEIVGKDSKIDLAVLRVKPPADRTLKAVPFGDSDKMRPGDWVIAIGNPFGLGGSVSAGIVSARGRNIESGPYDNYIQ
TDAAINKGNSGGPLFNMDGEVIGINTAILSPTGGSVGIGFAVPSGTAKPVIDQLRDFGEVRRGWLGVRIQNVDDTTAEAL
NLKGGARGALVAGVDEKGPAKTAGIEVGDVILKFNGAPVKASGDLPRIVASTPVGQKVDVVVMRKGEEVTKPVTLGRLED
SDKPQLANLRQPEPESATRQALGLNLSGMTDELRKKYSIKDTVKGVVVTRVDPNSTAADKRIQPGEVIVEVGQEAVSTPA
EVTKRIDALKKDGRKSVLLLVAGATGDVRFVAVGLD

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=257, Percent_Identity=37.7431906614786, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4506141, Length=278, Percent_Identity=35.2517985611511, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=33.5849056603774, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=35.7894736842105, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1786356, Length=478, Percent_Identity=37.2384937238494, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789629, Length=464, Percent_Identity=39.2241379310345, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI1789630, Length=292, Percent_Identity=38.6986301369863, Blast_Score=164, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=32.4137931034483, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53400; Mature: 53400

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVASAPEALFGRAPAQPRSRARALMASILIGASVSVSVAAAALPVPAFAKGPASLADL
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCHHHHHH
AEQVTDAVVNISASTTVEARAGRAGPQVPPGTPFEDLFEEFFNRRGGRGGGGGDSDGPRQ
HHHHHHHHEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHH
QRKSNSLGSGFIIDSAGLVVTNNHVIGDANDIQVILHDGTKLKAEIVGKDSKIDLAVLRV
HHHCCCCCCCEEEECCCEEEECCEEECCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEE
KPPADRTLKAVPFGDSDKMRPGDWVIAIGNPFGLGGSVSAGIVSARGRNIESGPYDNYIQ
CCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
TDAAINKGNSGGPLFNMDGEVIGINTAILSPTGGSVGIGFAVPSGTAKPVIDQLRDFGEV
CCHHHCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
RRGWLGVRIQNVDDTTAEALNLKGGARGALVAGVDEKGPAKTAGIEVGDVILKFNGAPVK
HCCEEEEEEECCCCCCHHHEECCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCEE
ASGDLPRIVASTPVGQKVDVVVMRKGEEVTKPVTLGRLEDSDKPQLANLRQPEPESATRQ
CCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHH
ALGLNLSGMTDELRKKYSIKDTVKGVVVTRVDPNSTAADKRIQPGEVIVEVGQEAVSTPA
HHCCCCCCCCHHHHHHCCHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHCHHHHCCHH
EVTKRIDALKKDGRKSVLLLVAGATGDVRFVAVGLD
HHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MHPVASAPEALFGRAPAQPRSRARALMASILIGASVSVSVAAAALPVPAFAKGPASLADL
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCHHHHHH
AEQVTDAVVNISASTTVEARAGRAGPQVPPGTPFEDLFEEFFNRRGGRGGGGGDSDGPRQ
HHHHHHHHEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHH
QRKSNSLGSGFIIDSAGLVVTNNHVIGDANDIQVILHDGTKLKAEIVGKDSKIDLAVLRV
HHHCCCCCCCEEEECCCEEEECCEEECCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEE
KPPADRTLKAVPFGDSDKMRPGDWVIAIGNPFGLGGSVSAGIVSARGRNIESGPYDNYIQ
CCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEE
TDAAINKGNSGGPLFNMDGEVIGINTAILSPTGGSVGIGFAVPSGTAKPVIDQLRDFGEV
CCHHHCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
RRGWLGVRIQNVDDTTAEALNLKGGARGALVAGVDEKGPAKTAGIEVGDVILKFNGAPVK
HCCEEEEEEECCCCCCHHHEECCCCCCCEEEECCCCCCCCCCCCCEEEEEEEEECCCCEE
ASGDLPRIVASTPVGQKVDVVVMRKGEEVTKPVTLGRLEDSDKPQLANLRQPEPESATRQ
CCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHH
ALGLNLSGMTDELRKKYSIKDTVKGVVVTRVDPNSTAADKRIQPGEVIVEVGQEAVSTPA
HHCCCCCCCCHHHHHHCCHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHCHHHHCCHH
EVTKRIDALKKDGRKSVLLLVAGATGDVRFVAVGLD
HHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]