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The map label for this gene is hisG [H]

Identifier: 170750683

GI number: 170750683

Start: 4544621

End: 4545613

Strand: Direct

Name: hisG [H]

Synonym: Mrad2831_4293

Alternate gene names: 170750683

Gene position: 4544621-4545613 (Clockwise)

Preceding gene: 170750682

Following gene: 170750684

Centisome position: 74.77

GC content: 75.03

Gene sequence:

>993_bases
ATGAGTGCCTCGGACGCGGCCGCCATGCCGCTGATCCTCGCCGTCCCGTCCAAGGGTCGCCTGCAGGAGAATGCCAGCGC
GTTCTTCGGCCGCGCGGGCCTCAAGCTCGCGCAGGGCGCCGGCGCCCGCGACTACCGGGGCAAGCTCATCGGCGTGCCCG
ACGTCGAGGTGCGCTACCTCTCGGCCTCCGAGATCGCCGCGCAGCTCGCCTCGGGCGCCGCCCATCTCGGCGTCACCGGC
GAGGACCTGATCCGCGAGACCCTGCCGGACGTGCGCGGCCAGGTCGAGCTGCTGACGCCGCTCGGCTTCGGCAACGCCAC
CGTGGTGGTGGCGGTGCCCCAGGCCTGGATCGACGTGCGCGACATGTCCGACCTCGACGAGGTCGCGGCCGGCATGCGGA
CCCGTCACGGCCGGCGCCTGCGCGTCGCCACCAAGTACGTGAACCTGACCCGCCGGTTCTTCGCCGAGAAGGGCGTCGCC
GATTACCGGATCGTCGAGAGCCTGGGCGCCACCGAGGGGGCGCCGGCGGCGGGCTCCGCCGAGATCGTGGTCGACATCAC
CACCACGGGGGCGACGCTCTCGGCCAACGCCCTGAAGGTGCTGGACGACGGCATCATCCTGCGCTCGGAGGCGAACCTCG
TCGCCTCGCTCAAGGCGCCCTGGGGCGAGGGCCAGCGGGCCGCGCTCCGCACCGTGCTCGGCCGCATCGCCGCCGAGGAG
CGCGCCCGGACCACCCGGGAGGTGCGCGCCGCCCTGCCGGAGAGCGGCACGATCGACCTCGCCACCCTGGCCGGCCTGCA
CGAGGCCGAGCTGCCCTACGGCGCTCCGCGCGCCCCGGACGGCGAGATCGTCCTGCGCTGTCCCGAGGCCGCGGTGTTCG
AGCTGGCCGGCGCCCTGGTCGAGGCCGGCGCGCGGGCCGTGACGGTGCGGCGGGTCGACTACGCCTTCGCGGCCGAGAAC
CCGCTGGCGGAGCGGCTGCTGGCGCGGCTCTGA

Upstream 100 bases:

>100_bases
GCGGCCGCTACGACGGCCTGCTCGGCCATCTCGGCAGCCCGGCGCCGCTGCCCGCGGTCGGCTGCACCTTCTGGATCGAG
CGCGTCGCGGGAGCCGGCCG

Downstream 100 bases:

>100_bases
GACCGCCGCGCGATGGAGCTGAAATGGCTCGAGGACTTCCTGAGCCTCGCGCGCACCGGCAGCTTCTCGCGCTCGGCGGT
CGAGCGCCACGTCACCCAGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSASDAAAMPLILAVPSKGRLQENASAFFGRAGLKLAQGAGARDYRGKLIGVPDVEVRYLSASEIAAQLASGAAHLGVTG
EDLIRETLPDVRGQVELLTPLGFGNATVVVAVPQAWIDVRDMSDLDEVAAGMRTRHGRRLRVATKYVNLTRRFFAEKGVA
DYRIVESLGATEGAPAAGSAEIVVDITTTGATLSANALKVLDDGIILRSEANLVASLKAPWGEGQRAALRTVLGRIAAEE
RARTTREVRAALPESGTIDLATLAGLHEAELPYGAPRAPDGEIVLRCPEAAVFELAGALVEAGARAVTVRRVDYAFAAEN
PLAERLLARL

Sequences:

>Translated_330_residues
MSASDAAAMPLILAVPSKGRLQENASAFFGRAGLKLAQGAGARDYRGKLIGVPDVEVRYLSASEIAAQLASGAAHLGVTG
EDLIRETLPDVRGQVELLTPLGFGNATVVVAVPQAWIDVRDMSDLDEVAAGMRTRHGRRLRVATKYVNLTRRFFAEKGVA
DYRIVESLGATEGAPAAGSAEIVVDITTTGATLSANALKVLDDGIILRSEANLVASLKAPWGEGQRAALRTVLGRIAAEE
RARTTREVRAALPESGTIDLATLAGLHEAELPYGAPRAPDGEIVLRCPEAAVFELAGALVEAGARAVTVRRVDYAFAAEN
PLAERLLARL
>Mature_329_residues
SASDAAAMPLILAVPSKGRLQENASAFFGRAGLKLAQGAGARDYRGKLIGVPDVEVRYLSASEIAAQLASGAAHLGVTGE
DLIRETLPDVRGQVELLTPLGFGNATVVVAVPQAWIDVRDMSDLDEVAAGMRTRHGRRLRVATKYVNLTRRFFAEKGVAD
YRIVESLGATEGAPAAGSAEIVVDITTTGATLSANALKVLDDGIILRSEANLVASLKAPWGEGQRAALRTVLGRIAAEER
ARTTREVRAALPESGTIDLATLAGLHEAELPYGAPRAPDGEIVLRCPEAAVFELAGALVEAGARAVTVRRVDYAFAAENP
LAERLLARL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=310, Percent_Identity=26.7741935483871, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34722; Mature: 34591

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDAAAMPLILAVPSKGRLQENASAFFGRAGLKLAQGAGARDYRGKLIGVPDVEVRYL
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCEECCCCCEEEEE
SASEIAAQLASGAAHLGVTGEDLIRETLPDVRGQVELLTPLGFGNATVVVAVPQAWIDVR
CHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECHHHHCHH
DMSDLDEVAAGMRTRHGRRLRVATKYVNLTRRFFAEKGVADYRIVESLGATEGAPAAGSA
CCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
EIVVDITTTGATLSANALKVLDDGIILRSEANLVASLKAPWGEGQRAALRTVLGRIAAEE
EEEEEEEECCCEEECCHHEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
RARTTREVRAALPESGTIDLATLAGLHEAELPYGAPRAPDGEIVLRCPEAAVFELAGALV
HHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
EAGARAVTVRRVDYAFAAENPLAERLLARL
HCCCCEEEEEEEEEHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
SASDAAAMPLILAVPSKGRLQENASAFFGRAGLKLAQGAGARDYRGKLIGVPDVEVRYL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCEECCCCCEEEEE
SASEIAAQLASGAAHLGVTGEDLIRETLPDVRGQVELLTPLGFGNATVVVAVPQAWIDVR
CHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECHHHHCHH
DMSDLDEVAAGMRTRHGRRLRVATKYVNLTRRFFAEKGVADYRIVESLGATEGAPAAGSA
CCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
EIVVDITTTGATLSANALKVLDDGIILRSEANLVASLKAPWGEGQRAALRTVLGRIAAEE
EEEEEEEECCCEEECCHHEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
RARTTREVRAALPESGTIDLATLAGLHEAELPYGAPRAPDGEIVLRCPEAAVFELAGALV
HHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
EAGARAVTVRRVDYAFAAENPLAERLLARL
HCCCCEEEEEEEEEHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA