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The map label for this gene is hisZ [H]

Identifier: 170750682

GI number: 170750682

Start: 4543482

End: 4544624

Strand: Direct

Name: hisZ [H]

Synonym: Mrad2831_4292

Alternate gene names: 170750682

Gene position: 4543482-4544624 (Clockwise)

Preceding gene: 170750681

Following gene: 170750683

Centisome position: 74.75

GC content: 76.38

Gene sequence:

>1143_bases
ATGACACGACCGGAGGCGGGCGAGACGGGGGCGGGGGACGCGGCGCGCGCGCGGCTCTCCGCGCATCTGGCGGCGGCGGG
CTACCGGCCGGTGACGCCGCCGGTGCTGCAACCGCTGGAGCCGTTCCTCGAACTGTCGGGCGAGGATATCCGCCGGCGGA
TCTTCGTCACCCAGGACGCGGGCGGCGCCGAGCTGTGCCTGCGGCCCGAGTTCACCATTCCGGTCTGCCGCCTGCACCGG
GCGGAAGCCGACGGGCAGGCGGCCGATTACAGCTATTGCGGCCCGGTCTTCCGGCTCGCCGCCGACGAGCCCGACGAGTT
CTTCCAGGCCGGCATCGAGTCGATCGGGCGGACCGACACGCCGGCGGCCGATGCCGAGGTGCTGGGCCTCGCCCTGGAGG
GCCTCGCGCTGTTCGGCCGGACCGACCCGGCGGTGCGGCTCGGCGACATGGGCCTGACCGTGGCGCTCCTCGACGGGCTC
GCGGTCCCGCCCGCCGCCAAGCGCCGGACGCTCCGGGCGCTCGCCGCCGGGCGCTCGCTCGACGCCGTGACCAACGGCGC
GGAGGGCACCCGTCCGGAGGATCCCCACGCCGGCCTGCTGGCGGCGATCCAGGGCCAGGACCCGCGCGGGGTGCGCGCCT
TCGTGGAGGACGTGCTGGCCATCGCCGGGATCTCGGCGGTGGGCGGGCGCAGCGCCGGCGAGATCGCCGAGCGCTTCCTC
GCCAAGGCCGCCGCGCAGGCCCATGGCGGGGCCGGGCTCAACGCCGAGAACCGCGCGCTCCTCGACCGCTACCGGGCGAT
CGCCGGCCATCCGGACGCCGCCGCCCGCGACCTGCGGGCGCTCGTCGCCGACGCGGGCATCCGGCACGACGCCCTCGCGG
CCGCCCTCGACCTGTTCGAGGAGCGCACCGGCTTCATCGCGGCCCGCGGCCTGCCGATCGAGCGCTTCCGCTTCCAGGGC
GGCTTCGCCCGCAACCTCGACTACTACACCGGCTTCATCTTCGAGGTGACCGAGCGGGACGGCCCGACCCTGGTCGGCGG
CGGCCGCTACGACGGCCTGCTCGGCCATCTCGGCAGCCCGGCGCCGCTGCCCGCGGTCGGCTGCACCTTCTGGATCGAGC
GCGTCGCGGGAGCCGGCCGATGA

Upstream 100 bases:

>100_bases
GCGGCGCCGCGGCACGTCTCGCCGCGCCGAGTGTCGCCAAGTCCGGTCGCGGTTGCTACAGAGCGCCCGCGAGGTGGATT
GCCCCGCGAGGTGGATCGCG

Downstream 100 bases:

>100_bases
GTGCCTCGGACGCGGCCGCCATGCCGCTGATCCTCGCCGTCCCGTCCAAGGGTCGCCTGCAGGAGAATGCCAGCGCGTTC
TTCGGCCGCGCGGGCCTCAA

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTRPEAGETGAGDAARARLSAHLAAAGYRPVTPPVLQPLEPFLELSGEDIRRRIFVTQDAGGAELCLRPEFTIPVCRLHR
AEADGQAADYSYCGPVFRLAADEPDEFFQAGIESIGRTDTPAADAEVLGLALEGLALFGRTDPAVRLGDMGLTVALLDGL
AVPPAAKRRTLRALAAGRSLDAVTNGAEGTRPEDPHAGLLAAIQGQDPRGVRAFVEDVLAIAGISAVGGRSAGEIAERFL
AKAAAQAHGGAGLNAENRALLDRYRAIAGHPDAAARDLRALVADAGIRHDALAAALDLFEERTGFIAARGLPIERFRFQG
GFARNLDYYTGFIFEVTERDGPTLVGGGRYDGLLGHLGSPAPLPAVGCTFWIERVAGAGR

Sequences:

>Translated_380_residues
MTRPEAGETGAGDAARARLSAHLAAAGYRPVTPPVLQPLEPFLELSGEDIRRRIFVTQDAGGAELCLRPEFTIPVCRLHR
AEADGQAADYSYCGPVFRLAADEPDEFFQAGIESIGRTDTPAADAEVLGLALEGLALFGRTDPAVRLGDMGLTVALLDGL
AVPPAAKRRTLRALAAGRSLDAVTNGAEGTRPEDPHAGLLAAIQGQDPRGVRAFVEDVLAIAGISAVGGRSAGEIAERFL
AKAAAQAHGGAGLNAENRALLDRYRAIAGHPDAAARDLRALVADAGIRHDALAAALDLFEERTGFIAARGLPIERFRFQG
GFARNLDYYTGFIFEVTERDGPTLVGGGRYDGLLGHLGSPAPLPAVGCTFWIERVAGAGR
>Mature_379_residues
TRPEAGETGAGDAARARLSAHLAAAGYRPVTPPVLQPLEPFLELSGEDIRRRIFVTQDAGGAELCLRPEFTIPVCRLHRA
EADGQAADYSYCGPVFRLAADEPDEFFQAGIESIGRTDTPAADAEVLGLALEGLALFGRTDPAVRLGDMGLTVALLDGLA
VPPAAKRRTLRALAAGRSLDAVTNGAEGTRPEDPHAGLLAAIQGQDPRGVRAFVEDVLAIAGISAVGGRSAGEIAERFLA
KAAAQAHGGAGLNAENRALLDRYRAIAGHPDAAARDLRALVADAGIRHDALAAALDLFEERTGFIAARGLPIERFRFQGG
FARNLDYYTGFIFEVTERDGPTLVGGGRYDGLLGHLGSPAPLPAVGCTFWIERVAGAGR

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004516 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 39830; Mature: 39699

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPEAGETGAGDAARARLSAHLAAAGYRPVTPPVLQPLEPFLELSGEDIRRRIFVTQDA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHEEEEEEEECC
GGAELCLRPEFTIPVCRLHRAEADGQAADYSYCGPVFRLAADEPDEFFQAGIESIGRTDT
CCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHCCCCCC
PAADAEVLGLALEGLALFGRTDPAVRLGDMGLTVALLDGLAVPPAAKRRTLRALAAGRSL
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCH
DAVTNGAEGTRPEDPHAGLLAAIQGQDPRGVRAFVEDVLAIAGISAVGGRSAGEIAERFL
HHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AKAAAQAHGGAGLNAENRALLDRYRAIAGHPDAAARDLRALVADAGIRHDALAAALDLFE
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ERTGFIAARGLPIERFRFQGGFARNLDYYTGFIFEVTERDGPTLVGGGRYDGLLGHLGSP
HHCCEEEECCCCHHHHEECCCCCCCCHHHEEEEEEEECCCCCEEEECCCCCHHHHCCCCC
APLPAVGCTFWIERVAGAGR
CCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRPEAGETGAGDAARARLSAHLAAAGYRPVTPPVLQPLEPFLELSGEDIRRRIFVTQDA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHEEEEEEEECC
GGAELCLRPEFTIPVCRLHRAEADGQAADYSYCGPVFRLAADEPDEFFQAGIESIGRTDT
CCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHCCCCCC
PAADAEVLGLALEGLALFGRTDPAVRLGDMGLTVALLDGLAVPPAAKRRTLRALAAGRSL
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCH
DAVTNGAEGTRPEDPHAGLLAAIQGQDPRGVRAFVEDVLAIAGISAVGGRSAGEIAERFL
HHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AKAAAQAHGGAGLNAENRALLDRYRAIAGHPDAAARDLRALVADAGIRHDALAAALDLFE
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ERTGFIAARGLPIERFRFQGGFARNLDYYTGFIFEVTERDGPTLVGGGRYDGLLGHLGSP
HHCCEEEECCCCHHHHEECCCCCCCCHHHEEEEEEEECCCCCEEEECCCCCHHHHCCCCC
APLPAVGCTFWIERVAGAGR
CCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]