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The map label for this gene is yycF [H]

Identifier: 170750498

GI number: 170750498

Start: 4357566

End: 4358252

Strand: Reverse

Name: yycF [H]

Synonym: Mrad2831_4105

Alternate gene names: 170750498

Gene position: 4358252-4357566 (Counterclockwise)

Preceding gene: 170750500

Following gene: 170750497

Centisome position: 71.71

GC content: 69.58

Gene sequence:

>687_bases
ATGCCGAACGCCTACCGCCTGCTGATCTGCGACGACGACGCGATCCTGCGCGACACCCTGACCGAGCAGCTCGATCTCTG
CGACGAATTCACGGTCTTCACCGAGGCCAACGCCGCGGACGCGATCCGGCGGGTCGCCGCGGAGCGGATCGACCTCGCCG
TGATGGATGTCGGCCTGCCCGACCTCGACGGGCGCGAGGCCGTGCGCCGGATGCGCGCCGGCGGCTTCCGCGGCCCGGTG
ATCATGCTGACGGCCCAGGATTCCGAGGCGGACCACGTCGAGGGCCTGGAGGCCGGCGCCAACGACTACGTCACCAAGCC
GTTCAAGTTCGGCATCCTTCTGGCCCGGATCCGCGCCCACCTGCGCAGCCACGAGGCCTCCGAGGACGCGGTCTTCCAGA
TCGGCCCCTACACGTTCCGCCCGGGGGCCAAGCTCCTCGTCGGCGAGCGCGGCTCGAAGCTGAAGCTCACCGAGAAGGAG
ACCGCGATCCTGCGCTTCCTCTACCGGGCGGGCCGGGCCGTGGTGAACCGCGACACCCTGCTGGCCGAGGTCTGGGGCTA
CAACGCCCAGGTGACCACGCACACGCTGGAGACGCATATCTACCGGCTGCGCCAGAAGATCGAGCCGAACCCCGCCACCG
CCGCGATCCTCGTGACCGAGGGTGGCGGATACAAGTTGCTGCCCTGA

Upstream 100 bases:

>100_bases
TAGGGTCGTCGCGCGATCCTGCCGCGATCTGACATCATCGCATGCTGCACCCGGCAGGCCGCCCCTCGCCCCTCCCGCAG
CACGCACTGGGGCCCGGACG

Downstream 100 bases:

>100_bases
CGAATTGAAGCTTTACGTGTAGGCGATCCGGCGGGTTCGCGTATGCGCAGGGTGGTGAGGCGTTCTTGGGGCTCGACGAC
GATATCGCGATCCTCGCGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPNAYRLLICDDDAILRDTLTEQLDLCDEFTVFTEANAADAIRRVAAERIDLAVMDVGLPDLDGREAVRRMRAGGFRGPV
IMLTAQDSEADHVEGLEAGANDYVTKPFKFGILLARIRAHLRSHEASEDAVFQIGPYTFRPGAKLLVGERGSKLKLTEKE
TAILRFLYRAGRAVVNRDTLLAEVWGYNAQVTTHTLETHIYRLRQKIEPNPATAAILVTEGGGYKLLP

Sequences:

>Translated_228_residues
MPNAYRLLICDDDAILRDTLTEQLDLCDEFTVFTEANAADAIRRVAAERIDLAVMDVGLPDLDGREAVRRMRAGGFRGPV
IMLTAQDSEADHVEGLEAGANDYVTKPFKFGILLARIRAHLRSHEASEDAVFQIGPYTFRPGAKLLVGERGSKLKLTEKE
TAILRFLYRAGRAVVNRDTLLAEVWGYNAQVTTHTLETHIYRLRQKIEPNPATAAILVTEGGGYKLLP
>Mature_227_residues
PNAYRLLICDDDAILRDTLTEQLDLCDEFTVFTEANAADAIRRVAAERIDLAVMDVGLPDLDGREAVRRMRAGGFRGPVI
MLTAQDSEADHVEGLEAGANDYVTKPFKFGILLARIRAHLRSHEASEDAVFQIGPYTFRPGAKLLVGERGSKLKLTEKET
AILRFLYRAGRAVVNRDTLLAEVWGYNAQVTTHTLETHIYRLRQKIEPNPATAAILVTEGGGYKLLP

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=240, Percent_Identity=35, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=35.2173913043478, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.1111111111111, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=33.1818181818182, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI87082012, Length=176, Percent_Identity=35.2272727272727, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=31.2775330396476, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=31.981981981982, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=30.9417040358744, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790860, Length=180, Percent_Identity=35.5555555555556, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI2367329, Length=209, Percent_Identity=35.4066985645933, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788394, Length=178, Percent_Identity=32.0224719101124, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787229, Length=207, Percent_Identity=28.5024154589372, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=167, Percent_Identity=27.5449101796407, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=25.531914893617, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25308; Mature: 25177

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAYRLLICDDDAILRDTLTEQLDLCDEFTVFTEANAADAIRRVAAERIDLAVMDVGLP
CCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCEEEEECCCC
DLDGREAVRRMRAGGFRGPVIMLTAQDSEADHVEGLEAGANDYVTKPFKFGILLARIRAH
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LRSHEASEDAVFQIGPYTFRPGAKLLVGERGSKLKLTEKETAILRFLYRAGRAVVNRDTL
HHHCCCCCCCEEEECCEEECCCCEEEECCCCCEEEECHHHHHHHHHHHHHCHHEECCCHH
LAEVWGYNAQVTTHTLETHIYRLRQKIEPNPATAAILVTEGGGYKLLP
HHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECC
>Mature Secondary Structure 
PNAYRLLICDDDAILRDTLTEQLDLCDEFTVFTEANAADAIRRVAAERIDLAVMDVGLP
CCCEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCEEEEECCCC
DLDGREAVRRMRAGGFRGPVIMLTAQDSEADHVEGLEAGANDYVTKPFKFGILLARIRAH
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LRSHEASEDAVFQIGPYTFRPGAKLLVGERGSKLKLTEKETAILRFLYRAGRAVVNRDTL
HHHCCCCCCCEEEECCEEECCCCEEEECCCCCEEEECHHHHHHHHHHHHHCHHEECCCHH
LAEVWGYNAQVTTHTLETHIYRLRQKIEPNPATAAILVTEGGGYKLLP
HHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]