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The map label for this gene is fhs

Identifier: 170750465

GI number: 170750465

Start: 4321550

End: 4323223

Strand: Reverse

Name: fhs

Synonym: Mrad2831_4072

Alternate gene names: 170750465

Gene position: 4323223-4321550 (Counterclockwise)

Preceding gene: 170750466

Following gene: 170750463

Centisome position: 71.13

GC content: 69.83

Gene sequence:

>1674_bases
ATGCCGTCAGACATCGAGATTGCCCGCGCCGCGACCCTGAAGCCGATCGCGCAGGTCGCCGAGAAGCTCGGCATCCCGGA
TGACGCGCTCCACAATTACGGCAAGCACATCGCCAAGATCGACCACGGCTACATCGCCGGGCTGGAGAGCCGGAAGCCCG
GCAAGCTCGTGCTGGTGACGGCGATCTCCCCGACCCCGGCCGGCGAGGGCAAGACCACCACCACGGTGGGCCTCGGCGAC
GCGCTGAACCGCATCGGCGAGAAGACCATGATCTGCCTGCGCGAGCCCTCGCTCGGGCCGTGCTTCGGCATGAAAGGGGG
CGCTGCCGGCGGCGGCAAGGCGCAGGTCGTGCCGATGGAGCAGATCAACCTGCACTTCACCGGCGACTTCCACGCCATCA
CGTCGGCCCACAGCCTCGCGGCCGCGCTGATCGACAACCACGTCTACTGGGCGAACGAGCTCAACATCGACGTCCGCCGC
ATCCACTGGCGCCGGGTCGTCGACATGAACGACCGCGCGCTGCGCGCGATCACCCAGTCGCTGGGCGGCGTCGCCAACGG
CTTCCCCCGCGAGGACGGGTTCGACATCACGGTGGCCTCCGAGGTGATGGCGGTGTTCTGCCTCGCCAAGGACCTCGCCG
ACCTGGAGGAGCGCCTCGGCCGGATCGTCATCGCCGAGACCCGCGACCGCAAGCTCGTCACCCTCAAGGACGTGAAGGCG
ACCGGCGCCATGACGGTGCTGCTCAAGGACGCCCTGCAGCCGAACCTCGTGCAGACGCTCGAGGGCAACCCGGCGCTGAT
CCACGGCGGCCCCTTCGCCAACATCGCCCACGGATGCAACTCGGTGATCGCCACGCGGGCCGGCCTGCGGCTCGCCGACT
ACACCGTGACGGAGGCCGGCTTCGGCGCCGATCTCGGCGCCGAGAAGTTCTTGGACATCAAGTGCCGGCAGGCGGGGCTG
ACCCCGTCGGCCGTGGTGGTGGTGGCGACGATCCGCGCCCTCAAGATGCACGGCGGCGTCGACAAGAAGAACCTCGGGGC
CGAGAACATCGACGCCCTGGAGAAGGGCTTCGCCAACCTCGCCCGGCACGTCACCAACCTGCGCGGCTTCGGCCTGCCGG
TGGTGGTCGGCGTCAACCACTTCCACGCCGACACCGAGGCCGAGCACGCCAAGCTCAAGGAACTGTGCCGCGAGCGGCTC
GACGTCGAGGCGATCACCTGCCGCCACTGGGCCGAGGGCGGCGCCGGGGCCGAGGAGCTCGCCCGCGCGGTGGTGAAGCT
CAGCCAGGCCGAGCCGGCGCCGATCCGCCACGCCTACGAGACCGAGAGCCGCCTCACCGACAAGATCCGGGCGATCGCCA
CCAAGCTGTACGGCGCCGCCGACATCCAGATCGAGACGAAGGCCGCCGGCAAGCTCGCCACCTTCGAGAAGGACGGCTAC
GGCCACCTGCCGATCTGCATGGCCAAGACCCAGTACTCGTTCTCCACCGACCCGACCCTGATGGGCGCCCCCGAGGGCCA
CATCGTCGGCGTGCGCGACGTCCGCCTCTCGGCCGGTGCCGGCTTCGTGGTGGCGATCTGCGGGGAGATCATGACCATGC
CGGGCCTGCCCCGGGTGCCGGCCGCCGACACGATCCGGCTGGACGCCAACGGCCAGATCGACGGGCTGTTCTGA

Upstream 100 bases:

>100_bases
GCCGTTCGCGGGCGGCCATGCCGCAGCCCGCACGGCAGGAGATTCGCACGGCAAGAGCCGGCGGGCGGGCAGCGTGCCCG
CGACCCAGGGAGGAAGGCCC

Downstream 100 bases:

>100_bases
GGATCGCGCGCGGGGCCCGCCCACGGGCGGGCCCCGCCGTTCGTCTTCGCGAGCGGAGCGGGCCGGATCGGGGGCCGCGC
GCTACGCGGTCCCGAACAGC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPSDIEIARAATLKPIAQVAEKLGIPDDALHNYGKHIAKIDHGYIAGLESRKPGKLVLVTAISPTPAGEGKTTTTVGLGD
ALNRIGEKTMICLREPSLGPCFGMKGGAAGGGKAQVVPMEQINLHFTGDFHAITSAHSLAAALIDNHVYWANELNIDVRR
IHWRRVVDMNDRALRAITQSLGGVANGFPREDGFDITVASEVMAVFCLAKDLADLEERLGRIVIAETRDRKLVTLKDVKA
TGAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRAGLRLADYTVTEAGFGADLGAEKFLDIKCRQAGL
TPSAVVVVATIRALKMHGGVDKKNLGAENIDALEKGFANLARHVTNLRGFGLPVVVGVNHFHADTEAEHAKLKELCRERL
DVEAITCRHWAEGGAGAEELARAVVKLSQAEPAPIRHAYETESRLTDKIRAIATKLYGAADIQIETKAAGKLATFEKDGY
GHLPICMAKTQYSFSTDPTLMGAPEGHIVGVRDVRLSAGAGFVVAICGEIMTMPGLPRVPAADTIRLDANGQIDGLF

Sequences:

>Translated_557_residues
MPSDIEIARAATLKPIAQVAEKLGIPDDALHNYGKHIAKIDHGYIAGLESRKPGKLVLVTAISPTPAGEGKTTTTVGLGD
ALNRIGEKTMICLREPSLGPCFGMKGGAAGGGKAQVVPMEQINLHFTGDFHAITSAHSLAAALIDNHVYWANELNIDVRR
IHWRRVVDMNDRALRAITQSLGGVANGFPREDGFDITVASEVMAVFCLAKDLADLEERLGRIVIAETRDRKLVTLKDVKA
TGAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRAGLRLADYTVTEAGFGADLGAEKFLDIKCRQAGL
TPSAVVVVATIRALKMHGGVDKKNLGAENIDALEKGFANLARHVTNLRGFGLPVVVGVNHFHADTEAEHAKLKELCRERL
DVEAITCRHWAEGGAGAEELARAVVKLSQAEPAPIRHAYETESRLTDKIRAIATKLYGAADIQIETKAAGKLATFEKDGY
GHLPICMAKTQYSFSTDPTLMGAPEGHIVGVRDVRLSAGAGFVVAICGEIMTMPGLPRVPAADTIRLDANGQIDGLF
>Mature_556_residues
PSDIEIARAATLKPIAQVAEKLGIPDDALHNYGKHIAKIDHGYIAGLESRKPGKLVLVTAISPTPAGEGKTTTTVGLGDA
LNRIGEKTMICLREPSLGPCFGMKGGAAGGGKAQVVPMEQINLHFTGDFHAITSAHSLAAALIDNHVYWANELNIDVRRI
HWRRVVDMNDRALRAITQSLGGVANGFPREDGFDITVASEVMAVFCLAKDLADLEERLGRIVIAETRDRKLVTLKDVKAT
GAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRAGLRLADYTVTEAGFGADLGAEKFLDIKCRQAGLT
PSAVVVVATIRALKMHGGVDKKNLGAENIDALEKGFANLARHVTNLRGFGLPVVVGVNHFHADTEAEHAKLKELCRERLD
VEAITCRHWAEGGAGAEELARAVVKLSQAEPAPIRHAYETESRLTDKIRAIATKLYGAADIQIETKAAGKLATFEKDGYG
HLPICMAKTQYSFSTDPTLMGAPEGHIVGVRDVRLSAGAGFVVAICGEIMTMPGLPRVPAADTIRLDANGQIDGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=43.9613526570048, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=43.6392914653784, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=45.2380952380952, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=43.4294871794872, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=43.4294871794872, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=45.0479233226837, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=43.9178515007899, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_METRJ (B1M0D1)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756725.1
- GeneID:   6140130
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_4072
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   CLSK2330235
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59350; Mature: 59219

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDIEIARAATLKPIAQVAEKLGIPDDALHNYGKHIAKIDHGYIAGLESRKPGKLVLVT
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEE
AISPTPAGEGKTTTTVGLGDALNRIGEKTMICLREPSLGPCFGMKGGAAGGGKAQVVPME
EECCCCCCCCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
QINLHFTGDFHAITSAHSLAAALIDNHVYWANELNIDVRRIHWRRVVDMNDRALRAITQS
HEEEEECCCHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEEEEEECCCHHHHHHHHHH
LGGVANGFPREDGFDITVASEVMAVFCLAKDLADLEERLGRIVIAETRDRKLVTLKDVKA
HCHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCC
TGAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRAGLRLADYTVTEAG
CCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCC
FGADLGAEKFLDIKCRQAGLTPSAVVVVATIRALKMHGGVDKKNLGAENIDALEKGFANL
CCCCCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ARHVTNLRGFGLPVVVGVNHFHADTEAEHAKLKELCRERLDVEAITCRHWAEGGAGAEEL
HHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCHHHH
ARAVVKLSQAEPAPIRHAYETESRLTDKIRAIATKLYGAADIQIETKAAGKLATFEKDGY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCC
GHLPICMAKTQYSFSTDPTLMGAPEGHIVGVRDVRLSAGAGFVVAICGEIMTMPGLPRVP
CCCEEEEEECCCCCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
AADTIRLDANGQIDGLF
CCCEEEECCCCCCCCCC
>Mature Secondary Structure 
PSDIEIARAATLKPIAQVAEKLGIPDDALHNYGKHIAKIDHGYIAGLESRKPGKLVLVT
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEE
AISPTPAGEGKTTTTVGLGDALNRIGEKTMICLREPSLGPCFGMKGGAAGGGKAQVVPME
EECCCCCCCCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
QINLHFTGDFHAITSAHSLAAALIDNHVYWANELNIDVRRIHWRRVVDMNDRALRAITQS
HEEEEECCCHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEEEEEECCCHHHHHHHHHH
LGGVANGFPREDGFDITVASEVMAVFCLAKDLADLEERLGRIVIAETRDRKLVTLKDVKA
HCHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCC
TGAMTVLLKDALQPNLVQTLEGNPALIHGGPFANIAHGCNSVIATRAGLRLADYTVTEAG
CCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEEECCC
FGADLGAEKFLDIKCRQAGLTPSAVVVVATIRALKMHGGVDKKNLGAENIDALEKGFANL
CCCCCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ARHVTNLRGFGLPVVVGVNHFHADTEAEHAKLKELCRERLDVEAITCRHWAEGGAGAEEL
HHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCHHHH
ARAVVKLSQAEPAPIRHAYETESRLTDKIRAIATKLYGAADIQIETKAAGKLATFEKDGY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCC
GHLPICMAKTQYSFSTDPTLMGAPEGHIVGVRDVRLSAGAGFVVAICGEIMTMPGLPRVP
CCCEEEEEECCCCCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
AADTIRLDANGQIDGLF
CCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA