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The map label for this gene is thiL [H]

Identifier: 170750375

GI number: 170750375

Start: 4231811

End: 4232806

Strand: Reverse

Name: thiL [H]

Synonym: Mrad2831_3978

Alternate gene names: 170750375

Gene position: 4232806-4231811 (Counterclockwise)

Preceding gene: 170750376

Following gene: 170750373

Centisome position: 69.64

GC content: 77.91

Gene sequence:

>996_bases
TTGGCCGGGCCGGCCCGCGCCTCCGAGGAGGGGCTGATCGCCCGCTACTTCGCCCCGCTCGCCGGGCCGGGCGCCGACGG
GCTCCGGGACGACGCCGCCGCGCTGACGCCCGCGCCGGGCCACGACCTCGTCCTCACCGTCGACGCCGTGGTGGCGGGGA
TCCACTACTTCGCGGAGGATCCGCCGGCCTCGATCGCCCGCAAGGCCCTCGGCGTGAACCTCTCCGACATCGCCGCCAAG
GGCGCGGTCCCGCGCGGCTTCCTGCTGACCCTGGCGCTCCCCGACGACTGGACGGAGGCCTGGCTCGACGGCTTCGCGCA
GGGGCTCGGCGCGGCGGCCGCGGCGGCCGGCTGCCCGCTGCTGGGCGGCGACACGGTGCGCTCCGGTGGGCCGGCGCTGA
TCTCGGTGAGCGCGTTCGGCGAGGTGCCGACCGGCACCATCGTGCGGCGCACCACCGCGCGGGCGGGCGACCGGATCTGC
GTCACCGGCACGATCGGCGACGCCGCCCTCGGCCTGCGGATGCGCCTGGAGCCCGACGCCCCCTGGGCGTCAGGCCTCGA
CCCGGCGCAGCGGTCCGAACTCGCCGACCGCTACCTGCACCCGCGCCCGCGGCTCGCCGCCGCGCCGGCGGTCCGCCGCC
ACGCCACCGCCGCCATGGACGTCTCCGACGGCCTCGCGGGGGATCTCGCCAAGATGCTGGGGGCGGGCCGCACCGCCCGG
GTGGCGGTGGCCGACGTGCCGCTCTCGGGGGCCGCCCGGAGCGCCTGCGCAGCGGAGCCCGCCCTGATCGAGGCGGTCCT
GACCGGCGGCGACGATTACGAGATCCTCTGCACCGTCGCGCCGGAGCGCCTGGAGGATCTCCGGACCGAGGCCGCGGCCG
CCGGGATCGCCGTCGCCGCCATCGGCACCGTCACCTCAGGCGACGGCCCGCCGCGCTTCGAAATGCGCGATGGCGCCGAG
CGCGTGTTCGCGGCCGGGGCCTTCAGCCACTTCTGA

Upstream 100 bases:

>100_bases
GAGGTCGGGGCCCCGAAGGCCTCCGGCAAGCCGGGCTCGTCCAAGCCGCTCCCCGGCAAAGCTGCGGCTGGGAAACCGTC
GGCCGGGAAGGCCTGAAGCC

Downstream 100 bases:

>100_bases
CGCCCGGATCGCGTCCGGCCGGGCGGCCATCGGGCCGGCGGCGGCCCCGGCCGGGTGGCCGATCTGGCCCCGGACCTCCC
CGATCATCTCGGCGGCGACC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAGPARASEEGLIARYFAPLAGPGADGLRDDAAALTPAPGHDLVLTVDAVVAGIHYFAEDPPASIARKALGVNLSDIAAK
GAVPRGFLLTLALPDDWTEAWLDGFAQGLGAAAAAAGCPLLGGDTVRSGGPALISVSAFGEVPTGTIVRRTTARAGDRIC
VTGTIGDAALGLRMRLEPDAPWASGLDPAQRSELADRYLHPRPRLAAAPAVRRHATAAMDVSDGLAGDLAKMLGAGRTAR
VAVADVPLSGAARSACAAEPALIEAVLTGGDDYEILCTVAPERLEDLRTEAAAAGIAVAAIGTVTSGDGPPRFEMRDGAE
RVFAAGAFSHF

Sequences:

>Translated_331_residues
MAGPARASEEGLIARYFAPLAGPGADGLRDDAAALTPAPGHDLVLTVDAVVAGIHYFAEDPPASIARKALGVNLSDIAAK
GAVPRGFLLTLALPDDWTEAWLDGFAQGLGAAAAAAGCPLLGGDTVRSGGPALISVSAFGEVPTGTIVRRTTARAGDRIC
VTGTIGDAALGLRMRLEPDAPWASGLDPAQRSELADRYLHPRPRLAAAPAVRRHATAAMDVSDGLAGDLAKMLGAGRTAR
VAVADVPLSGAARSACAAEPALIEAVLTGGDDYEILCTVAPERLEDLRTEAAAAGIAVAAIGTVTSGDGPPRFEMRDGAE
RVFAAGAFSHF
>Mature_330_residues
AGPARASEEGLIARYFAPLAGPGADGLRDDAAALTPAPGHDLVLTVDAVVAGIHYFAEDPPASIARKALGVNLSDIAAKG
AVPRGFLLTLALPDDWTEAWLDGFAQGLGAAAAAAGCPLLGGDTVRSGGPALISVSAFGEVPTGTIVRRTTARAGDRICV
TGTIGDAALGLRMRLEPDAPWASGLDPAQRSELADRYLHPRPRLAAAPAVRRHATAAMDVSDGLAGDLAKMLGAGRTARV
AVADVPLSGAARSACAAEPALIEAVLTGGDDYEILCTVAPERLEDLRTEAAAAGIAVAAIGTVTSGDGPPRFEMRDGAER
VFAAGAFSHF

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=330, Percent_Identity=36.969696969697, Blast_Score=154, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33512; Mature: 33381

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPARASEEGLIARYFAPLAGPGADGLRDDAAALTPAPGHDLVLTVDAVVAGIHYFAED
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCC
PPASIARKALGVNLSDIAAKGAVPRGFLLTLALPDDWTEAWLDGFAQGLGAAAAAAGCPL
CHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LGGDTVRSGGPALISVSAFGEVPTGTIVRRTTARAGDRICVTGTIGDAALGLRMRLEPDA
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHHCCCCEEEEEECCCCHHCCEEEEECCCC
PWASGLDPAQRSELADRYLHPRPRLAAAPAVRRHATAAMDVSDGLAGDLAKMLGAGRTAR
CCCCCCCHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEE
VAVADVPLSGAARSACAAEPALIEAVLTGGDDYEILCTVAPERLEDLRTEAAAAGIAVAA
EEEEECCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCEEEEE
IGTVTSGDGPPRFEMRDGAERVFAAGAFSHF
EEEEECCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AGPARASEEGLIARYFAPLAGPGADGLRDDAAALTPAPGHDLVLTVDAVVAGIHYFAED
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCC
PPASIARKALGVNLSDIAAKGAVPRGFLLTLALPDDWTEAWLDGFAQGLGAAAAAAGCPL
CHHHHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LGGDTVRSGGPALISVSAFGEVPTGTIVRRTTARAGDRICVTGTIGDAALGLRMRLEPDA
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHHCCCCEEEEEECCCCHHCCEEEEECCCC
PWASGLDPAQRSELADRYLHPRPRLAAAPAVRRHATAAMDVSDGLAGDLAKMLGAGRTAR
CCCCCCCHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEE
VAVADVPLSGAARSACAAEPALIEAVLTGGDDYEILCTVAPERLEDLRTEAAAAGIAVAA
EEEEECCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHCEEEEE
IGTVTSGDGPPRFEMRDGAERVFAAGAFSHF
EEEEECCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]