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The map label for this gene is cobB [H]

Identifier: 170750335

GI number: 170750335

Start: 4190113

End: 4190826

Strand: Reverse

Name: cobB [H]

Synonym: Mrad2831_3938

Alternate gene names: 170750335

Gene position: 4190826-4190113 (Counterclockwise)

Preceding gene: 170750344

Following gene: 170750334

Centisome position: 68.95

GC content: 74.65

Gene sequence:

>714_bases
ATGACGGACCATCCCAGGACGATCTTCGTGCTCACCGGGGCCGGCGTCTCGGCCGAGAGCGGGCTCGGCACGTTCCGGGA
CCGCGGCGGGATCTGGGCGCGGTTCGACCCGATGAAGCTCGCCACCCCGGAGGCCTACGCGGCCGACCCTGACACGGTGC
TCGACTTCTACGACCATCGCCGCCGCGGCGTGGTCGCGGCCGAGCCGAACGCCGCGCATCGTGCCCTGGCGCGGGCCGAG
ACGCGGATCGCCGCGCGGGGCGGGCGGCTGTTCCTGTGCACGCAGAACGTCGACGACCTGCACGAGCGGGCCGGCTCGCG
GGCGATCACCCACATGCACGGCGAGTTGCTCAAGGCCCGCTGCTGCGCCTGCACCGCTGTCACGCCGTGGCGGGCCGACC
TCAGCCGGGCAGACAGCTGCCCCGCCTGCGGCGCGGCGGGCCGGATGCGGCCGGACGTGGTCTGGTTCGGCGAGATGCCG
ATGCACCTCGACGCGATCGAGGCGGCGCTGGCCGAGGCCGACCTGTTCGTGGCGGTGGGCACGTCGGGGGCGGTCTACCC
GGCCGCGGGCTACGTGCGGCAGGCGCGGGCCCTCGGCATCCCGACCTGCGAGGTCAACCTGGAGCCGTCCGACAATGCCG
ACGCCTTCGACGATGCCCGCTACGGGCCGGCGAGCGCCGCGCTGCCGCGCTACCTGGCCGAGCTCGGCCTCTGA

Upstream 100 bases:

>100_bases
AAGCGAGCCGCAGCATTCACCGAGCGGACGCAGCGGGAAAGAAACCGCACCGCCAACCAGCGGACAGATCCGGCCAATCT
CCGGCGCGCAGGAGCAGCCC

Downstream 100 bases:

>100_bases
GGCGGGCGCGGGACCGGCGGCGCGGGTCCCGCGCGGGGATTCGTGACGGGCCGCGGACAGGCCCGACCGCGCGGCGCTCG
CCGTCGATCCTGCCAAGTCA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTDHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVVAAEPNAAHRALARAE
TRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKARCCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMP
MHLDAIEAALAEADLFVAVGTSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAELGL

Sequences:

>Translated_237_residues
MTDHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVVAAEPNAAHRALARAE
TRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKARCCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMP
MHLDAIEAALAEADLFVAVGTSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAELGL
>Mature_236_residues
TDHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVVAAEPNAAHRALARAET
RIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKARCCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPM
HLDAIEAALAEADLFVAVGTSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAELGL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=238, Percent_Identity=42.0168067226891, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI6912664, Length=252, Percent_Identity=39.6825396825397, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI13787215, Length=236, Percent_Identity=39.8305084745763, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI6912662, Length=249, Percent_Identity=29.718875502008, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7657575, Length=222, Percent_Identity=30.6306306306306, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI63054862, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI6912660, Length=215, Percent_Identity=30.6976744186047, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=48.936170212766, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17541892, Length=230, Percent_Identity=29.1304347826087, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137536, Length=240, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571445, Length=242, Percent_Identity=29.3388429752066, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25354; Mature: 25223

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHR
CCCCCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCEECCCCCCCCCCHHHHHHHHHH
RRGVVAAEPNAAHRALARAETRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKAR
HCCEEEECCCHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHH
CCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPMHLDAIEAALAEADLFVAVG
HHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCEEEEEC
TSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAELGL
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHR
CCCCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCEECCCCCCCCCCHHHHHHHHHH
RRGVVAAEPNAAHRALARAETRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKAR
HCCEEEECCCHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHH
CCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPMHLDAIEAALAEADLFVAVG
HHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCEEEEEC
TSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAELGL
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]