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The map label for this gene is iorA [H]

Identifier: 170750330

GI number: 170750330

Start: 4185002

End: 4185481

Strand: Direct

Name: iorA [H]

Synonym: Mrad2831_3933

Alternate gene names: 170750330

Gene position: 4185002-4185481 (Clockwise)

Preceding gene: 170750329

Following gene: 170750331

Centisome position: 68.86

GC content: 71.25

Gene sequence:

>480_bases
ATGATCAAACTCACCGTGAACGGGGCTGCGCGCAGCTTCGACGGCGACCCCGACATGCCGCTGCTGTGGTACCTGCGGGA
CGAGCTCGGGCTCACCGGCACCAAGTTCGGCTGCGGCGTCTCGCTCTGCGGGGCCTGCACCATCCATCTCGGCGGCGCGG
CGACCCGCGCCTGCATCACGCCGGTCTCGGCGGCCGCTGGCCAGGAGGTCGTGACCATCGAGGGGCTGTCGCCGGACGGC
AACCACCCCGTGCAGGTGGCGTGGCGCGACCAGAACGTCGCCCAGTGCGGCTTCTGCCAGTGCGGCCAGATCATGCAGGC
GGCCGCCCTCCTCAAGGACACGCCCAAGCCCACCGACGACGACATCGACACCACGATGAGCGGCAACATCTGCCGCTGCG
GCACCTACCCGCGCATCCGCGCCGCGATCCATCAGGCCGCCGGCCAGCCGGCGCCCGCCAGCAAGGGAGAGCGCCTGTGA

Upstream 100 bases:

>100_bases
TCCGCAACGGGGAACGTGAGCCGGCTAAGCCGGTCGTGGCCCCCGGCCCGGCTCGGACCCGACTGAACGCCGCTCCGGCG
CCGCCAGACAGGACGCAACG

Downstream 100 bases:

>100_bases
TCCACGACGCCAAGCTGAGCGCCGAGCGCGCCGCCGGCACCAGGCCGGCCCTCGACAACGTCAGCCGCCGCGGCATCCTC
GGCGGCGCCGGCGCCCTGGT

Product: 2Fe-2S iron-sulfur cluster binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGAATRACITPVSAAAGQEVVTIEGLSPDG
NHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPTDDDIDTTMSGNICRCGTYPRIRAAIHQAAGQPAPASKGERL

Sequences:

>Translated_159_residues
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGAATRACITPVSAAAGQEVVTIEGLSPDG
NHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPTDDDIDTTMSGNICRCGTYPRIRAAIHQAAGQPAPASKGERL
>Mature_159_residues
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGAATRACITPVSAAAGQEVVTIEGLSPDG
NHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPTDDDIDTTMSGNICRCGTYPRIRAAIHQAAGQPAPASKGERL

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=135, Percent_Identity=38.5185185185185, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI71773480, Length=133, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=42.6829268292683, Blast_Score=121, Evalue=2e-29,
Organism=Escherichia coli, GI1789232, Length=141, Percent_Identity=39.0070921985816, Blast_Score=85, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=145, Percent_Identity=41.3793103448276, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=38.0645161290323, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32566215, Length=154, Percent_Identity=35.7142857142857, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17737937, Length=133, Percent_Identity=38.3458646616541, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=34.7826086956522, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=33.7662337662338, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=33.5483870967742, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24647195, Length=162, Percent_Identity=31.4814814814815, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647197, Length=162, Percent_Identity=31.4814814814815, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16630; Mature: 16630

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGAATRACIT
CEEEEECCCCCCCCCCCCCCEEEEEEHHCCCCCCCCCCCEEECCEEEEEECCCCHHHHHC
PVSAAAGQEVVTIEGLSPDGNHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPTDD
CCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
DIDTTMSGNICRCGTYPRIRAAIHQAAGQPAPASKGERL
CCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGAATRACIT
CEEEEECCCCCCCCCCCCCCEEEEEEHHCCCCCCCCCCCEEECCEEEEEECCCCHHHHHC
PVSAAAGQEVVTIEGLSPDGNHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPTDD
CCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
DIDTTMSGNICRCGTYPRIRAAIHQAAGQPAPASKGERL
CCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]