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The map label for this gene is gmk [H]

Identifier: 170750118

GI number: 170750118

Start: 3958573

End: 3959235

Strand: Direct

Name: gmk [H]

Synonym: Mrad2831_3720

Alternate gene names: 170750118

Gene position: 3958573-3959235 (Clockwise)

Preceding gene: 170750117

Following gene: 170750130

Centisome position: 65.13

GC content: 70.14

Gene sequence:

>663_bases
ATGACCGAGGCGGCCGGGAACGTCTCCGACTCGATCGCGCGGCGCGGGTTGATCCTGATCCTCTCCTCGCCCTCCGGGGC
GGGGAAGACCACCCTGACGCGGGCGATCGCGCAGGATCCGAGCTGGGCGCTCGACCTGTCGATCTCGGTGACCACGCGGG
GGCGGCGGCCCTCGGAGATCGACGGGCGGCACTACCACTTCATTGATCGCGAGGCGTTCGACGACCTGCGCAACCGCGAC
GACCTGCTCGAATGGGCCGAGGTCCACGGCAACTTCTACGGCACGCCCCGGCGGCCGGTGGAGAAGGTGCTCGGCTCCGG
CCGGGACATGATCTTCGACATCGACTACCAGGGCACGCGGCAGGTTCGCTCCAAGCTCGCCCAGGACGTGGTGACGGTCT
TCATCCTGCCGCCCAGCATGGCCGAGCTGCGCCAGCGCCTGGAGCGCCGGGCGGAGGATTCCGCCGAGACGATCGAGAAG
CGTCTCGCCAACGCCCGGACGGAGATCCAGCGCTGGGTCGAGTACGACTACGTCATCGTCAACGACGACCTGCAGAACGC
CTTCCGGGCCCTCCAGGGGATCCTGGCGGCCGAGCGTCTCCGGCGGGCGCGCCGCACCGGACTCGCCCCCTTCGTCGAGG
GCCTGCTGGCCGAGACGCCGTGA

Upstream 100 bases:

>100_bases
GAGCAGTTCCGCGAGCAGGTGCAGAACATCGAGTGATGCCGGGCACGATGCCGGATCGGGACGTGAGGATGCGGATGCGA
AACGTCGGGGAGCCACGCGC

Downstream 100 bases:

>100_bases
TCCGGCCCTAGCGACGGATCAGCACGACGCCGCCGATCAGGAGCGCGATCCCGAGGAGGCGCGGCAGGTCGACGGGCCGC
TGCGCGAGGCCGAGCAGGCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTEAAGNVSDSIARRGLILILSSPSGAGKTTLTRAIAQDPSWALDLSISVTTRGRRPSEIDGRHYHFIDREAFDDLRNRD
DLLEWAEVHGNFYGTPRRPVEKVLGSGRDMIFDIDYQGTRQVRSKLAQDVVTVFILPPSMAELRQRLERRAEDSAETIEK
RLANARTEIQRWVEYDYVIVNDDLQNAFRALQGILAAERLRRARRTGLAPFVEGLLAETP

Sequences:

>Translated_220_residues
MTEAAGNVSDSIARRGLILILSSPSGAGKTTLTRAIAQDPSWALDLSISVTTRGRRPSEIDGRHYHFIDREAFDDLRNRD
DLLEWAEVHGNFYGTPRRPVEKVLGSGRDMIFDIDYQGTRQVRSKLAQDVVTVFILPPSMAELRQRLERRAEDSAETIEK
RLANARTEIQRWVEYDYVIVNDDLQNAFRALQGILAAERLRRARRTGLAPFVEGLLAETP
>Mature_219_residues
TEAAGNVSDSIARRGLILILSSPSGAGKTTLTRAIAQDPSWALDLSISVTTRGRRPSEIDGRHYHFIDREAFDDLRNRDD
LLEWAEVHGNFYGTPRRPVEKVLGSGRDMIFDIDYQGTRQVRSKLAQDVVTVFILPPSMAELRQRLERRAEDSAETIEKR
LANARTEIQRWVEYDYVIVNDDLQNAFRALQGILAAERLRRARRTGLAPFVEGLLAETP

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=38.1443298969072, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=38.1443298969072, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=38.1443298969072, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=29.9465240641711, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21536464, Length=186, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118263, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505237, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=28.75, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=46.3541666666667, Blast_Score=181, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=36.2637362637363, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=36.2637362637363, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=36.4130434782609, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=30.3867403314917, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45554489, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116007136, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=30.3867403314917, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551002, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85816106, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85816281, Length=206, Percent_Identity=27.1844660194175, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24891; Mature: 24760

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAAGNVSDSIARRGLILILSSPSGAGKTTLTRAIAQDPSWALDLSISVTTRGRRPSEI
CCCCCCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCC
DGRHYHFIDREAFDDLRNRDDLLEWAEVHGNFYGTPRRPVEKVLGSGRDMIFDIDYQGTR
CCCEEEEECHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEECCCCCHH
QVRSKLAQDVVTVFILPPSMAELRQRLERRAEDSAETIEKRLANARTEIQRWVEYDYVIV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEE
NDDLQNAFRALQGILAAERLRRARRTGLAPFVEGLLAETP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TEAAGNVSDSIARRGLILILSSPSGAGKTTLTRAIAQDPSWALDLSISVTTRGRRPSEI
CCCCCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCC
DGRHYHFIDREAFDDLRNRDDLLEWAEVHGNFYGTPRRPVEKVLGSGRDMIFDIDYQGTR
CCCEEEEECHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEECCCCCHH
QVRSKLAQDVVTVFILPPSMAELRQRLERRAEDSAETIEKRLANARTEIQRWVEYDYVIV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEE
NDDLQNAFRALQGILAAERLRRARRTGLAPFVEGLLAETP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA