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The map label for this gene is phoR [H]

Identifier: 170749987

GI number: 170749987

Start: 3813963

End: 3815234

Strand: Reverse

Name: phoR [H]

Synonym: Mrad2831_3588

Alternate gene names: 170749987

Gene position: 3815234-3813963 (Counterclockwise)

Preceding gene: 170749988

Following gene: 170749985

Centisome position: 62.77

GC content: 76.81

Gene sequence:

>1272_bases
ATGTCCGGCCGCCTGCGCAGCTCCCCCGCCTGGACCGGCGCCGCGATCGCCGCGGGCCTGCTCGGGCTCGCCACGGCCCT
GGCCGGGCGGCTCGACCTCCCGCTGATCCTGATCGGGCTCGCGGCGGTCTGCCTGGGCGGCTGGCTCGGCGGGCGCGGCC
GCGAGGCCCCCGTCGCGCGACCGGCCGCCGCCACGCCGCGCCACGCCGTCGCCGAGGCGCTGCTCGCCCACGTGCCGGAC
CCGGTCATCCTCGTGGACCGGCGCACCCTGGTGCTGGAGGCCAATCCCGCCGCCCGGGCGCTGCTGCCGGCGCTCCATCA
GGCCCGGCCCCTGTCCTTCGCGCTCCGCGACCCGGAGGTCCTCGACGGCATCGAGGCGGTGCTGAGTTCCGGCCTCCCGC
GCCGGGTCGCGCTGTCGACCCGGGTGCCGCTGGAGCGGACCTTCGAGGTCCAGATCGGCGCGCTGCCGATGCCCGACGGG
TCCGGCGTGAGCGCGCTGCTGTTCCTGCGCGACCTCACCTCGGCCCGGCGTCTCGAGGCGATGCGGGTCGATTTCGTCGC
CAACGCGAGCCACGAGCTGCGCACGCCGCTCGCCACCCTGATCGGCTTCATCGAGACCCTGCAGGGTCCGGCCCGCGACG
ACGCGCAGGCCCGGGAGCGCTTCCTGGAGATCATGCGCGTCCAGGCCCAGCGGATGACGCGGCTGATCGACGACCTGCTG
TCGCTGTCGCGGATCGAGCTGCGCGAGCACGTGGCGCCCACCGCGGTGGTCGATCTCGGGGCGCTCGCCCGCCAGATGGT
CGACGCCCAGGGCCTGCCCGCCGAGGCGCGGGGCGCCACGATCCGACTGGAGGAGGGGGCGGGCCCCTACGCGGTCCCCG
GCGACGCCGACGAGCTCGCCCGGGTGATCGAGAACCTGATCGAGAACGCCGTGAAGTACGGCGGCGGCCGGATCAGCGTC
GGGCTCGCCCGCGAGGACGACCCGCGCCTCGGGCGCCGCGTCGTCCTGTCGGTGGCCGACGACGGGCCGGGCATCCCGCC
CGAGCACATCCCGCGGCTGACGGAGCGCTTCTACCGGGTCGACGTCGCGTCGAGCCGCGCCCGCGGCGGCACGGGCCTCG
GGCTCGCCATCGTCAAGCACAGCCTCAACCGCCACCGCGGGCGGCTCGCCATCGAGAGCGCGGCCGGGGAGGGCACGACC
GTGCGGGTCAGCCTGCCGGAATACGGCGCCGCGCCGCCGCAGGCCGCGGCCGATCAGGCCGGCCCGGCGTAG

Upstream 100 bases:

>100_bases
CGGTGCCCGCGATCCCGGCCCGCCGGAGGGCACGGCCGGGCCGTCCGGCCGGGCGTGGCGCGACGAGTCCGAGTCCCGCT
GATCGGCCGGCGCGCCCGCC

Downstream 100 bases:

>100_bases
GGGCCGATCCCGAGCCCGCCCTCGACGCGCCCAACCCAGGCGCGGATCGCCGGGTAGTCCGCGAGGTCGAAGCCGCCCTC
GTGGGCCATGCGCGTGTAGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSGRLRSSPAWTGAAIAAGLLGLATALAGRLDLPLILIGLAAVCLGGWLGGRGREAPVARPAAATPRHAVAEALLAHVPD
PVILVDRRTLVLEANPAARALLPALHQARPLSFALRDPEVLDGIEAVLSSGLPRRVALSTRVPLERTFEVQIGALPMPDG
SGVSALLFLRDLTSARRLEAMRVDFVANASHELRTPLATLIGFIETLQGPARDDAQARERFLEIMRVQAQRMTRLIDDLL
SLSRIELREHVAPTAVVDLGALARQMVDAQGLPAEARGATIRLEEGAGPYAVPGDADELARVIENLIENAVKYGGGRISV
GLAREDDPRLGRRVVLSVADDGPGIPPEHIPRLTERFYRVDVASSRARGGTGLGLAIVKHSLNRHRGRLAIESAAGEGTT
VRVSLPEYGAAPPQAAADQAGPA

Sequences:

>Translated_423_residues
MSGRLRSSPAWTGAAIAAGLLGLATALAGRLDLPLILIGLAAVCLGGWLGGRGREAPVARPAAATPRHAVAEALLAHVPD
PVILVDRRTLVLEANPAARALLPALHQARPLSFALRDPEVLDGIEAVLSSGLPRRVALSTRVPLERTFEVQIGALPMPDG
SGVSALLFLRDLTSARRLEAMRVDFVANASHELRTPLATLIGFIETLQGPARDDAQARERFLEIMRVQAQRMTRLIDDLL
SLSRIELREHVAPTAVVDLGALARQMVDAQGLPAEARGATIRLEEGAGPYAVPGDADELARVIENLIENAVKYGGGRISV
GLAREDDPRLGRRVVLSVADDGPGIPPEHIPRLTERFYRVDVASSRARGGTGLGLAIVKHSLNRHRGRLAIESAAGEGTT
VRVSLPEYGAAPPQAAADQAGPA
>Mature_422_residues
SGRLRSSPAWTGAAIAAGLLGLATALAGRLDLPLILIGLAAVCLGGWLGGRGREAPVARPAAATPRHAVAEALLAHVPDP
VILVDRRTLVLEANPAARALLPALHQARPLSFALRDPEVLDGIEAVLSSGLPRRVALSTRVPLERTFEVQIGALPMPDGS
GVSALLFLRDLTSARRLEAMRVDFVANASHELRTPLATLIGFIETLQGPARDDAQARERFLEIMRVQAQRMTRLIDDLLS
LSRIELREHVAPTAVVDLGALARQMVDAQGLPAEARGATIRLEEGAGPYAVPGDADELARVIENLIENAVKYGGGRISVG
LAREDDPRLGRRVVLSVADDGPGIPPEHIPRLTERFYRVDVASSRARGGTGLGLAIVKHSLNRHRGRLAIESAAGEGTTV
RVSLPEYGAAPPQAAADQAGPA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=341, Percent_Identity=38.7096774193548, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=31.9502074688797, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=31.7991631799163, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788713, Length=368, Percent_Identity=23.9130434782609, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=31.2775330396476, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=29.8319327731092, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=27.0161290322581, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=31.9327731092437, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=30.6382978723404, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=222, Percent_Identity=31.981981981982, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=362, Percent_Identity=29.0055248618785, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=357, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.535864978903, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=29.0178571428571, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=28.755364806867, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=29.7959183673469, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=376, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=28.8702928870293, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44703; Mature: 44572

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRLRSSPAWTGAAIAAGLLGLATALAGRLDLPLILIGLAAVCLGGWLGGRGREAPVAR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PAAATPRHAVAEALLAHVPDPVILVDRRTLVLEANPAARALLPALHQARPLSFALRDPEV
CCCCCCHHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHHHHHHCCCCEEEECCCHH
LDGIEAVLSSGLPRRVALSTRVPLERTFEVQIGALPMPDGSGVSALLFLRDLTSARRLEA
HHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHH
MRVDFVANASHELRTPLATLIGFIETLQGPARDDAQARERFLEIMRVQAQRMTRLIDDLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSRIELREHVAPTAVVDLGALARQMVDAQGLPAEARGATIRLEEGAGPYAVPGDADELA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
RVIENLIENAVKYGGGRISVGLAREDDPRLGRRVVLSVADDGPGIPPEHIPRLTERFYRV
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
DVASSRARGGTGLGLAIVKHSLNRHRGRLAIESAAGEGTTVRVSLPEYGAAPPQAAADQA
HHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCC
GPA
CCC
>Mature Secondary Structure 
SGRLRSSPAWTGAAIAAGLLGLATALAGRLDLPLILIGLAAVCLGGWLGGRGREAPVAR
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PAAATPRHAVAEALLAHVPDPVILVDRRTLVLEANPAARALLPALHQARPLSFALRDPEV
CCCCCCHHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHHHHHHCCCCEEEECCCHH
LDGIEAVLSSGLPRRVALSTRVPLERTFEVQIGALPMPDGSGVSALLFLRDLTSARRLEA
HHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHH
MRVDFVANASHELRTPLATLIGFIETLQGPARDDAQARERFLEIMRVQAQRMTRLIDDLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSRIELREHVAPTAVVDLGALARQMVDAQGLPAEARGATIRLEEGAGPYAVPGDADELA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
RVIENLIENAVKYGGGRISVGLAREDDPRLGRRVVLSVADDGPGIPPEHIPRLTERFYRV
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
DVASSRARGGTGLGLAIVKHSLNRHRGRLAIESAAGEGTTVRVSLPEYGAAPPQAAADQA
HHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCC
GPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]