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The map label for this gene is zraS [C]

Identifier: 170749935

GI number: 170749935

Start: 3751332

End: 3753419

Strand: Reverse

Name: zraS [C]

Synonym: Mrad2831_3535

Alternate gene names: 170749935

Gene position: 3753419-3751332 (Counterclockwise)

Preceding gene: 170749936

Following gene: 170749934

Centisome position: 61.76

GC content: 72.08

Gene sequence:

>2088_bases
GTGACCGACTCCCTCGCCTTCCTCTCCGGCGGCGGCGAGGCCGCGCGGATGATCCGCGCGCGCGACTGGTCGGGTCATCC
CCTGGGGCTTCCGGAGACGTGGCCGGCGGAGTTCCGCGCGGCCCTGTCGCTCGTCCTCAACTCCCCGGAATCGATGATCC
TGGCCTGGGGGCCCGACCTCCACTTCTTCTTCAACGACACCTACTTCCCGCTCCTCGGCCCGCGGTTGCCCTGGGCGATG
GGCGAGCGGTTCGACGTGGTCTGGGCGGATGCCTGGGATCAGGCCAGGCCGATCATCGACGCCGCGCTGGCGGGCCGTCC
GGAGCGCTTCGTCGACCTGCCGTGGCAGCTCGACACCGATCGGGGCGCCCGCGAGACGTGGTGGACCTTCTCGTACTCGC
GGGTTCTCGATGCCGACGGCCGGGTCACCGGCCTGTTCATCCTCACCAACGAGACCACCGGCCGGGTCCGGGCGGACGCC
GCCCTCAAGGAGAGCCAGGGCCGGCTCGAGGCGGCGCTGGCGGAGCTGCGCGATCTGAACGCCACCTTGGCGCAGCAGGT
CGAGGAGCGCACGGCCGACCGCAACGCCCTGTGGACGCTCTCGTCCGACATGATGCTGCGCTGCCTGTTCGACGGGACGA
TCACCGCGGTGAACCCGGCCTGGACCGAGGTGCTGGGCTGGCGCCCGGACGAACTGGTCGGAACCAAGCTCATCGCCCTC
GTCCATCCGGACGATCTCGACCGCACCGTCGCGGGCGCGGGCCAGCTCTCCGCGGGGTCGAGCCTCGCGCGCTTCGACAA
CCGCTACCGCCACCGGGACGGCGGCTACCGCTGGATCAGCTGGGCGGCCCGGCCGGGGGAGGGGATCATCAACGCCGTCG
GCCGCGATTTCACCGTGGAGCGCGAGCGCGCCGACGCCCTGGCCGCGGCCGAGGAGGCCCTGCGGCAGTCGCAGAAGATG
GAGGCCGTCGGCCAGCTGACCGGCGGCATCGCCCACGACTTCAACAACCTGCTCGCCGGCATCTCCGGCTCGCTGGAGCT
GATCCAGACCCGCCTCGGCCAGGGCCGCGTCATGGATGTGGACCGCTACATCAACGCGGCGCAGGGGGCCTCGAAGCGGG
CCGCGGCGCTGACCCACCGGCTCCTCGCCTTCTCGCGGCGCCAGACCCTCGACCCGAAGCCCACCGACGTGAACCGGCTG
GTGGCCGGCATGGAGGAGCTGATCCGCCGCACCGTGGGCCCCGCCGTAATGGTCGAGGTCGTGGCGCCGCCCGGCCTCTG
GCCGGCCCTGGTCGACCCGCCGCAGCTCGAGAACGCGCTCCTCAACCTGTGCATCAACGCCCGGGACGCGATGCCCGAGG
GGGGGCGCATCGCGATCGAGACCGCCAATGCCTGGCTCGACGAGCGCGCCGCCCGGCGCCACGACATGCCGCCCGGCCAG
TACCTCTCCCTCTGCGTCACCGACACCGGCATCGGCATGTCGCCCGAGATCGTCGGCAAGGTGTTCGAGCCGTTCTTCAC
CACGAAGCCCCTGGGGCAGGGCACCGGCCTCGGCCTGTCGATGATCTACGGCTTCGCGCAGCAATCGGGCGGCCAGGTGC
GGATCCACTCCGAGGTCGGCAAGGGCACCACGGTCTGCCTGTACCTGCCCCGCCATCGCGGCGCGGTCGCCGAGGAGGAC
GCGCACGCCGCCGTCGGCGCGCCGCCGCGGGCCGCGCCGGGCGAGACCGTGCTGGTGGTCGACGACGAGCCGACCGTCCG
CATGCTGGTCACCGAGGTGCTGGAGGATCTCGGCTACACGGCGATCGAGGCCGCCGACAGCGCGGCCGGCCTCAGGGTGC
TGCAATCCGACGTGCGCATCGACCTGCTGGTGTCCGATGTCGGACTGCCGGGCGGCATGAACGGGCGCCAGATGGCCGAG
GCCGGCCGGGTCACGCGCCCGGGCCTCAAGGTCCTGTTCGTCACCGGCTACGCCGAGAGCGCGGTCTTCGGCAACGGGCC
GCTCGATGCCGGGATGCAGGTCATCACCAAGCCGTTCGTGGTGGAGGTGCTGGGCGCCCGCATCCGCGAGATGATCGGAA
CGGCTTGA

Upstream 100 bases:

>100_bases
CGCTCTGAACCGACGTCGCTGAACCGCGACCGGGCATCCTGGACAGGCCGCCGAAGACCGTCATACGCCGTACGCCCATG
ACCTGCACCGCTCAGAGCCC

Downstream 100 bases:

>100_bases
CCGCGCGGCCGGTTCGGGCCTGATCGGCCGGGAATTGCCGGGGAGGAGAGACGCCATGCGGGCGCTGCTGTGCACGAGGC
TCGACGGGCCGGAGCATCTG

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MTDSLAFLSGGGEAARMIRARDWSGHPLGLPETWPAEFRAALSLVLNSPESMILAWGPDLHFFFNDTYFPLLGPRLPWAM
GERFDVVWADAWDQARPIIDAALAGRPERFVDLPWQLDTDRGARETWWTFSYSRVLDADGRVTGLFILTNETTGRVRADA
ALKESQGRLEAALAELRDLNATLAQQVEERTADRNALWTLSSDMMLRCLFDGTITAVNPAWTEVLGWRPDELVGTKLIAL
VHPDDLDRTVAGAGQLSAGSSLARFDNRYRHRDGGYRWISWAARPGEGIINAVGRDFTVERERADALAAAEEALRQSQKM
EAVGQLTGGIAHDFNNLLAGISGSLELIQTRLGQGRVMDVDRYINAAQGASKRAAALTHRLLAFSRRQTLDPKPTDVNRL
VAGMEELIRRTVGPAVMVEVVAPPGLWPALVDPPQLENALLNLCINARDAMPEGGRIAIETANAWLDERAARRHDMPPGQ
YLSLCVTDTGIGMSPEIVGKVFEPFFTTKPLGQGTGLGLSMIYGFAQQSGGQVRIHSEVGKGTTVCLYLPRHRGAVAEED
AHAAVGAPPRAAPGETVLVVDDEPTVRMLVTEVLEDLGYTAIEAADSAAGLRVLQSDVRIDLLVSDVGLPGGMNGRQMAE
AGRVTRPGLKVLFVTGYAESAVFGNGPLDAGMQVITKPFVVEVLGARIREMIGTA

Sequences:

>Translated_695_residues
MTDSLAFLSGGGEAARMIRARDWSGHPLGLPETWPAEFRAALSLVLNSPESMILAWGPDLHFFFNDTYFPLLGPRLPWAM
GERFDVVWADAWDQARPIIDAALAGRPERFVDLPWQLDTDRGARETWWTFSYSRVLDADGRVTGLFILTNETTGRVRADA
ALKESQGRLEAALAELRDLNATLAQQVEERTADRNALWTLSSDMMLRCLFDGTITAVNPAWTEVLGWRPDELVGTKLIAL
VHPDDLDRTVAGAGQLSAGSSLARFDNRYRHRDGGYRWISWAARPGEGIINAVGRDFTVERERADALAAAEEALRQSQKM
EAVGQLTGGIAHDFNNLLAGISGSLELIQTRLGQGRVMDVDRYINAAQGASKRAAALTHRLLAFSRRQTLDPKPTDVNRL
VAGMEELIRRTVGPAVMVEVVAPPGLWPALVDPPQLENALLNLCINARDAMPEGGRIAIETANAWLDERAARRHDMPPGQ
YLSLCVTDTGIGMSPEIVGKVFEPFFTTKPLGQGTGLGLSMIYGFAQQSGGQVRIHSEVGKGTTVCLYLPRHRGAVAEED
AHAAVGAPPRAAPGETVLVVDDEPTVRMLVTEVLEDLGYTAIEAADSAAGLRVLQSDVRIDLLVSDVGLPGGMNGRQMAE
AGRVTRPGLKVLFVTGYAESAVFGNGPLDAGMQVITKPFVVEVLGARIREMIGTA
>Mature_694_residues
TDSLAFLSGGGEAARMIRARDWSGHPLGLPETWPAEFRAALSLVLNSPESMILAWGPDLHFFFNDTYFPLLGPRLPWAMG
ERFDVVWADAWDQARPIIDAALAGRPERFVDLPWQLDTDRGARETWWTFSYSRVLDADGRVTGLFILTNETTGRVRADAA
LKESQGRLEAALAELRDLNATLAQQVEERTADRNALWTLSSDMMLRCLFDGTITAVNPAWTEVLGWRPDELVGTKLIALV
HPDDLDRTVAGAGQLSAGSSLARFDNRYRHRDGGYRWISWAARPGEGIINAVGRDFTVERERADALAAAEEALRQSQKME
AVGQLTGGIAHDFNNLLAGISGSLELIQTRLGQGRVMDVDRYINAAQGASKRAAALTHRLLAFSRRQTLDPKPTDVNRLV
AGMEELIRRTVGPAVMVEVVAPPGLWPALVDPPQLENALLNLCINARDAMPEGGRIAIETANAWLDERAARRHDMPPGQY
LSLCVTDTGIGMSPEIVGKVFEPFFTTKPLGQGTGLGLSMIYGFAQQSGGQVRIHSEVGKGTTVCLYLPRHRGAVAEEDA
HAAVGAPPRAAPGETVLVVDDEPTVRMLVTEVLEDLGYTAIEAADSAAGLRVLQSDVRIDLLVSDVGLPGGMNGRQMAEA
GRVTRPGLKVLFVTGYAESAVFGNGPLDAGMQVITKPFVVEVLGARIREMIGTA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=26.5560165975104, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=396, Percent_Identity=25.2525252525253, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI48994928, Length=575, Percent_Identity=24.5217391304348, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=413, Percent_Identity=24.455205811138, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI145693157, Length=265, Percent_Identity=27.9245283018868, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790300, Length=252, Percent_Identity=26.984126984127, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87081816, Length=203, Percent_Identity=27.0935960591133, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75409; Mature: 75278

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSLAFLSGGGEAARMIRARDWSGHPLGLPETWPAEFRAALSLVLNSPESMILAWGPDL
CCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCE
HFFFNDTYFPLLGPRLPWAMGERFDVVWADAWDQARPIIDAALAGRPERFVDLPWQLDTD
EEEECCEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHEEECCEEECCC
RGARETWWTFSYSRVLDADGRVTGLFILTNETTGRVRADAALKESQGRLEAALAELRDLN
CCCCCEEEEEEEHEEECCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ATLAQQVEERTADRNALWTLSSDMMLRCLFDGTITAVNPAWTEVLGWRPDELVGTKLIAL
HHHHHHHHHHCCCCCEEEEECHHHHEEEEECCCEEECCHHHHHHHCCCCCHHHCCEEEEE
VHPDDLDRTVAGAGQLSAGSSLARFDNRYRHRDGGYRWISWAARPGEGIINAVGRDFTVE
ECCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCCEEC
RERADALAAAEEALRQSQKMEAVGQLTGGIAHDFNNLLAGISGSLELIQTRLGQGRVMDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEH
DRYINAAQGASKRAAALTHRLLAFSRRQTLDPKPTDVNRLVAGMEELIRRTVGPAVMVEV
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
VAPPGLWPALVDPPQLENALLNLCINARDAMPEGGRIAIETANAWLDERAARRHDMPPGQ
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHCCCCCCC
YLSLCVTDTGIGMSPEIVGKVFEPFFTTKPLGQGTGLGLSMIYGFAQQSGGQVRIHSEVG
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
KGTTVCLYLPRHRGAVAEEDAHAAVGAPPRAAPGETVLVVDDEPTVRMLVTEVLEDLGYT
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCE
AIEAADSAAGLRVLQSDVRIDLLVSDVGLPGGMNGRQMAEAGRVTRPGLKVLFVTGYAES
EEHHCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCC
AVFGNGPLDAGMQVITKPFVVEVLGARIREMIGTA
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDSLAFLSGGGEAARMIRARDWSGHPLGLPETWPAEFRAALSLVLNSPESMILAWGPDL
CCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCE
HFFFNDTYFPLLGPRLPWAMGERFDVVWADAWDQARPIIDAALAGRPERFVDLPWQLDTD
EEEECCEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHEEECCEEECCC
RGARETWWTFSYSRVLDADGRVTGLFILTNETTGRVRADAALKESQGRLEAALAELRDLN
CCCCCEEEEEEEHEEECCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ATLAQQVEERTADRNALWTLSSDMMLRCLFDGTITAVNPAWTEVLGWRPDELVGTKLIAL
HHHHHHHHHHCCCCCEEEEECHHHHEEEEECCCEEECCHHHHHHHCCCCCHHHCCEEEEE
VHPDDLDRTVAGAGQLSAGSSLARFDNRYRHRDGGYRWISWAARPGEGIINAVGRDFTVE
ECCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCCEEC
RERADALAAAEEALRQSQKMEAVGQLTGGIAHDFNNLLAGISGSLELIQTRLGQGRVMDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEH
DRYINAAQGASKRAAALTHRLLAFSRRQTLDPKPTDVNRLVAGMEELIRRTVGPAVMVEV
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
VAPPGLWPALVDPPQLENALLNLCINARDAMPEGGRIAIETANAWLDERAARRHDMPPGQ
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHCCCCCCC
YLSLCVTDTGIGMSPEIVGKVFEPFFTTKPLGQGTGLGLSMIYGFAQQSGGQVRIHSEVG
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
KGTTVCLYLPRHRGAVAEEDAHAAVGAPPRAAPGETVLVVDDEPTVRMLVTEVLEDLGYT
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCE
AIEAADSAAGLRVLQSDVRIDLLVSDVGLPGGMNGRQMAEAGRVTRPGLKVLFVTGYAES
EEHHCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCC
AVFGNGPLDAGMQVITKPFVVEVLGARIREMIGTA
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA