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The map label for this gene is galE [H]

Identifier: 170749864

GI number: 170749864

Start: 3678674

End: 3679621

Strand: Reverse

Name: galE [H]

Synonym: Mrad2831_3464

Alternate gene names: 170749864

Gene position: 3679621-3678674 (Counterclockwise)

Preceding gene: 170749867

Following gene: 229597237

Centisome position: 60.54

GC content: 73.73

Gene sequence:

>948_bases
ATGCGCGTCCTCGTCACCGGAGCGGGAGACTATCTCGGCCGTCGCCTGCTCGAGGCTCTGCGTCGGGACCTGCCCCCGGG
CAGCCGCATCCTCGGCCTCGACCGGAGCCCGCCGCCGCCCCTCGACGGCGTGACGCTGAGGACCGTCGACCCGTTCGACG
CGCGCGACCTCGCCGAGACGGTCGCGGCCTTCGATCCGACCTGCGTGTTCCACCTCGCGGCCCTGGCCTCGGTCGCCCAG
TCGAGCGAGACGCCGTCCTACGCCTGGCGGGCGGAACTGCTCGGCACCCTCAACCTCGCCGAGGCGGTGGCGCGGACCCG
CGCGGCCCTGGTCTTCCTCAGCTCCACCGTCGTCTACGGCGAGGTGTTCCGCGCCTGCGCGCGCCCCGACGAGAGCGTCA
CGCCGCGCCCGGACACGATCTCGGGCCGGACCAAGAACGCCTGCGAGTACATCCTCCGCGACGTCCTGGCGAATGCCCGC
GTCAAGCATCTCGTGCTGCGGCCGTCGAACTACATCGGCGCCGGGCAGAGCGAGACCTTCGTGGTCGCCTCCTTCGCCGG
TCAGATCGCCCGCATCGAGCGGGGGCTGGCGCCGCCGAGCCTCGAGGTCGGCGACCTCTCGGCGGGGCGCGACTTCTTCG
ACGTGGCCGACTTCACCGCGGCCTGCCTGCGCGTGATCGCGCGGATCGACGACCTGCCGGACGGCGGCATCTTCAACGTG
GGATCGGGGGTCGTCACCCCGGTCTCCGACATCCTGGAGACGCTGCGCGGACTGACGGACGCGCGGTTCGACCTGCGCGT
CGCGCCCGGGCGGGTCCGCCCGGCGGGGGTACGCAGCGAGGGCTGCGACCCCGCGGCCTTCGGGACCGCCACCGGATGGG
CGCCGACCATCCCGCTCGCGCAGAGCCTGTCGACGATCCTGGCGGAGGCACGGGCGCGCCTCCGGTGA

Upstream 100 bases:

>100_bases
AGGCGGGGCCCGGTATAGACGCGGCCGACGATCCCGGATTCCGGCGCCCGCGCCGGGACGGGGGACCGCGGGGCTCGAGG
CAGGGTTGAGGGCAAGGGAC

Downstream 100 bases:

>100_bases
TCTGTCACCGTCCGAAGGTGACGGCGACGCCCTCGGACGGGCGCGCGGCTCCGGAAACGCCGGCGGCGCTCGGGAGCGCG
ACCGGTCTCAGCGCGAGAAG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRVLVTGAGDYLGRRLLEALRRDLPPGSRILGLDRSPPPPLDGVTLRTVDPFDARDLAETVAAFDPTCVFHLAALASVAQ
SSETPSYAWRAELLGTLNLAEAVARTRAALVFLSSTVVYGEVFRACARPDESVTPRPDTISGRTKNACEYILRDVLANAR
VKHLVLRPSNYIGAGQSETFVVASFAGQIARIERGLAPPSLEVGDLSAGRDFFDVADFTAACLRVIARIDDLPDGGIFNV
GSGVVTPVSDILETLRGLTDARFDLRVAPGRVRPAGVRSEGCDPAAFGTATGWAPTIPLAQSLSTILAEARARLR

Sequences:

>Translated_315_residues
MRVLVTGAGDYLGRRLLEALRRDLPPGSRILGLDRSPPPPLDGVTLRTVDPFDARDLAETVAAFDPTCVFHLAALASVAQ
SSETPSYAWRAELLGTLNLAEAVARTRAALVFLSSTVVYGEVFRACARPDESVTPRPDTISGRTKNACEYILRDVLANAR
VKHLVLRPSNYIGAGQSETFVVASFAGQIARIERGLAPPSLEVGDLSAGRDFFDVADFTAACLRVIARIDDLPDGGIFNV
GSGVVTPVSDILETLRGLTDARFDLRVAPGRVRPAGVRSEGCDPAAFGTATGWAPTIPLAQSLSTILAEARARLR
>Mature_315_residues
MRVLVTGAGDYLGRRLLEALRRDLPPGSRILGLDRSPPPPLDGVTLRTVDPFDARDLAETVAAFDPTCVFHLAALASVAQ
SSETPSYAWRAELLGTLNLAEAVARTRAALVFLSSTVVYGEVFRACARPDESVTPRPDTISGRTKNACEYILRDVLANAR
VKHLVLRPSNYIGAGQSETFVVASFAGQIARIERGLAPPSLEVGDLSAGRDFFDVADFTAACLRVIARIDDLPDGGIFNV
GSGVVTPVSDILETLRGLTDARFDLRVAPGRVRPAGVRSEGCDPAAFGTATGWAPTIPLAQSLSTILAEARARLR

Specific function: Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71982035, Length=335, Percent_Identity=27.1641791044776, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982038, Length=337, Percent_Identity=26.7062314540059, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33566; Mature: 33566

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVTGAGDYLGRRLLEALRRDLPPGSRILGLDRSPPPPLDGVTLRTVDPFDARDLAET
CEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHH
VAAFDPTCVFHLAALASVAQSSETPSYAWRAELLGTLNLAEAVARTRAALVFLSSTVVYG
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVFRACARPDESVTPRPDTISGRTKNACEYILRDVLANARVKHLVLRPSNYIGAGQSETF
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCEE
VVASFAGQIARIERGLAPPSLEVGDLSAGRDFFDVADFTAACLRVIARIDDLPDGGIFNV
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GSGVVTPVSDILETLRGLTDARFDLRVAPGRVRPAGVRSEGCDPAAFGTATGWAPTIPLA
CCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
QSLSTILAEARARLR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLVTGAGDYLGRRLLEALRRDLPPGSRILGLDRSPPPPLDGVTLRTVDPFDARDLAET
CEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHH
VAAFDPTCVFHLAALASVAQSSETPSYAWRAELLGTLNLAEAVARTRAALVFLSSTVVYG
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVFRACARPDESVTPRPDTISGRTKNACEYILRDVLANARVKHLVLRPSNYIGAGQSETF
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCEE
VVASFAGQIARIERGLAPPSLEVGDLSAGRDFFDVADFTAACLRVIARIDDLPDGGIFNV
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
GSGVVTPVSDILETLRGLTDARFDLRVAPGRVRPAGVRSEGCDPAAFGTATGWAPTIPLA
CCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
QSLSTILAEARARLR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8355614 [H]