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The map label for this gene is dxs [H]

Identifier: 229597237

GI number: 229597237

Start: 3673076

End: 3675046

Strand: Reverse

Name: dxs [H]

Synonym: Mrad2831_3459

Alternate gene names: 229597237

Gene position: 3675046-3673076 (Counterclockwise)

Preceding gene: 170749864

Following gene: 170749858

Centisome position: 60.47

GC content: 71.94

Gene sequence:

>1971_bases
TTGGCACTCTCCCCTGAGCAATCGGCGTTGCTGGACCGCGTTCCGTCTCCATCGGCGCTTCGGCGTCTTCCGGAGTCGGA
GCTTCAGGCGGTGGCGGACGCGGTGCGCGCCGAGATGATCGACGCGGTCTCGATCACCGGCGGCCATCTCGGCTCGGGGC
TGGGCGTGGTCGAGCTGACGGTGGCGCTGCACCACGTGTTCGACACCCCCGACGACCGCATCGTCTGGGACGTCGGCCAC
CAGTGCTACCCCCACAAGATCCTCACCGAGCGCCGCGACCGGATCCGCACGCTGCGCCAGGGCGGCGGCCTGTCGGGCTT
CACCAAGCGGAGCGAGAGCGTCTACGATCCCTTCGGCGCCGCCCACTCCTCGACCTCGATCTCGGCCGCGCTGGGCATGG
CGGTCGCCCGCGACCTCGACAACGCCACCGCCAAGCAGAAGGGCGGCGCGCAGAAGCGCCGCAACGCCATCGCGGTGATC
GGCGACGGCTCGATGTCGGCCGGCATGGCCTACGAGGCCCTCAACAACGCCGGCGCCCTGCACTCGCGCCTGATCGTCAT
CCTCAACGACAACGACATGTCGATCGCGCCCCCCGTCGGCGCCATGTCGGCCTACCTCGCCAGGCTGGCGTCGGGTGGCG
CCTACCAGTCCCTGCGCGAGACCGCCAAGCAGCTCGGCAAGCTCCTGCCCAAGGCGCTCTACCAGCGCGCCGCCGCGGCC
GAGGAGTACGCCCGCTCGCTGGTGGTCGGCGGCGGCACCATGTTCGAGGAGATGGGCTTCCACTACGTCGGCCCCGTCGA
CGGGCACAACCTCGACCACCTGCTGCCGGTGCTCAAGAACGTCCGCGACGCCGAGCACGGCCCGATCCTGCTCCACGTCG
TCACCCAGAAGGGCAAGGGCTACGCGCCGGCCGAGGCCTCGGCCGACCGCTACCACGGCGTGGTCAAGTTCGACGTGGTC
TCAGGGATCCAGGCCAAGGCCAAGCCGAACGCGCCGGCCTACACGCGGGTGTTCGGCGAGAGCCTGATCAAGGCGGCCGA
CGCCGACGACAAGGTCGTGGCGATCACCGCCGCCATGCCGGGCGGGACCGGCATCGACCTGTTCGGCAAGGCGCACCCGG
ACAAGACCTTCGACGTGGGCATCGCCGAGCAGCACGCGGTGACGTTCGCGGGCGGTCTGGCGACCGAGGGCTACCGGCCG
TTCGTGGCGATCTACTCGACCTTCCTGCAGCGGGCCTACGACCAGGTGGTGCACGACGTGGCGCTGCAGAACCTGCCCGT
GCGGTTCTGCCTGGACCGGGCGGGCCTGGTCGGCGCGGACGGGGCGACGCACGCGGGCGCGTTCGACCTGGCGTACCTGT
GCTGCCTGCCGAACATGACCGTGATGGCGGCGGCCGACGAGGCCGAGCTGGTGCACATGGTGGCGACCGCCCACGCCCAC
GACACGGGCCCGATCGCGCTGCGCTACCCGCGCGGCGAGGGGGTGGGCGTCGAGCTTCCGGAGCGGGGCGAGGTCCTGGC
GATCGGCAAGGGCCGGGTGGTGCGCCGGGACGCGGAGGCGCGGGTGGCGCTCCTGTCGCTCGGCACGCGTCTGGCGGAGG
CCTTGAAGGCGGCGGACGCGCTGGCCGAGCAGGGCGTGGCGGTGACGGTGGCGGACGCGCGGTTCGCCAAGCCGCTGGAC
GAGGCGCTGATCCTGGATCTGGCGCGCGACCACGAGGTGCTGATCACGGTGGAGGAGGGCTCGCGGGGCGGGTTCGGCGC
GATGGTGCTGCACCTGCTGGCCGAGCGCGGCGCGCTGGACGCGGGCGGCGTGCGGGTGCGGACCATGACGCTGCCGGACG
CCTACCAGGACCACGACAGCCCGGAGAAGATGTACGCCGAGGCAGGCCTCGACGCCAAAACCATCGTCCGGACCGCCCTC
GACACACTGCCCGAGCGGAAGGACAGCCGGTCGCGCCTGCGGCTCGCCTGA

Upstream 100 bases:

>100_bases
CGGGTTCTAGCATGAACGCGCGTCCCCGGGCTGCTGGCGTCGCGGTTGCCGAGGGCCCGCGGCGGAGCCGTCGCCATACT
CGAACGAACGGATGCGAGCA

Downstream 100 bases:

>100_bases
CCGGGCGGGCCGCACCGGCCCCTCGAGAAGCGGGCGGCCGCCGGAGGCCGCCCGCGTCCCGGTCGCGTGACGCCGCGGGC
CCCGGGCGTCTTGCCGGCGC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MALSPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGH
QCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVI
GDGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVV
SGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRP
FVAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLD
EALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTAL
DTLPERKDSRSRLRLA

Sequences:

>Translated_656_residues
MALSPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGH
QCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVI
GDGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVV
SGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRP
FVAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLD
EALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTAL
DTLPERKDSRSRLRLA
>Mature_655_residues
ALSPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELTVALHHVFDTPDDRIVWDVGHQ
CYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGAAHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIG
DGSMSAGMAYEALNNAGALHSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAAE
EYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKGYAPAEASADRYHGVVKFDVVS
GIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMPGGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPF
VAIYSTFLQRAYDQVVHDVALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAHD
TGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADALAEQGVAVTVADARFAKPLDE
ALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALDAGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALD
TLPERKDSRSRLRLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=375, Percent_Identity=28.5333333333333, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI4507521, Length=375, Percent_Identity=28.5333333333333, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI133778974, Length=366, Percent_Identity=27.3224043715847, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI225637459, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI225637461, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI225637463, Length=379, Percent_Identity=27.7044854881267, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1786622, Length=636, Percent_Identity=50.6289308176101, Blast_Score=587, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=424, Percent_Identity=28.0660377358491, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45551847, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550715, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645119, Length=383, Percent_Identity=27.9373368146214, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666278, Length=571, Percent_Identity=26.7950963222417, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69586; Mature: 69455

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELT
CCCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHH
VALHHVFDTPDDRIVWDVGHQCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGA
HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC
AHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIGDGSMSAGMAYEALNNAGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHCCCCC
HSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
CEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKG
HHHHHHEEECCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
YAPAEASADRYHGVVKFDVVSGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMP
CCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPFVAIYSTFLQRAYDQVVHDV
CCCCEECCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
HHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCC
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADA
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAEQGVAVTVADARFAKPLDEALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALD
HHHCCCEEEEECCHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
AGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALDTLPERKDSRSRLRLA
CCCEEEEEEECCCHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure 
ALSPEQSALLDRVPSPSALRRLPESELQAVADAVRAEMIDAVSITGGHLGSGLGVVELT
CCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHH
VALHHVFDTPDDRIVWDVGHQCYPHKILTERRDRIRTLRQGGGLSGFTKRSESVYDPFGA
HHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCC
AHSSTSISAALGMAVARDLDNATAKQKGGAQKRRNAIAVIGDGSMSAGMAYEALNNAGAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHCCCCC
HSRLIVILNDNDMSIAPPVGAMSAYLARLASGGAYQSLRETAKQLGKLLPKALYQRAAAA
CEEEEEEECCCCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEYARSLVVGGGTMFEEMGFHYVGPVDGHNLDHLLPVLKNVRDAEHGPILLHVVTQKGKG
HHHHHHEEECCCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
YAPAEASADRYHGVVKFDVVSGIQAKAKPNAPAYTRVFGESLIKAADADDKVVAITAAMP
CCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTGIDLFGKAHPDKTFDVGIAEQHAVTFAGGLATEGYRPFVAIYSTFLQRAYDQVVHDV
CCCCEECCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALQNLPVRFCLDRAGLVGADGATHAGAFDLAYLCCLPNMTVMAAADEAELVHMVATAHAH
HHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCC
DTGPIALRYPRGEGVGVELPERGEVLAIGKGRVVRRDAEARVALLSLGTRLAEALKAADA
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAEQGVAVTVADARFAKPLDEALILDLARDHEVLITVEEGSRGGFGAMVLHLLAERGALD
HHHCCCEEEEECCHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCC
AGGVRVRTMTLPDAYQDHDSPEKMYAEAGLDAKTIVRTALDTLPERKDSRSRLRLA
CCCEEEEEEECCCHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]