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The map label for this gene is rnc [H]

Identifier: 170749855

GI number: 170749855

Start: 3669965

End: 3670744

Strand: Reverse

Name: rnc [H]

Synonym: Mrad2831_3455

Alternate gene names: 170749855

Gene position: 3670744-3669965 (Counterclockwise)

Preceding gene: 170749856

Following gene: 170749854

Centisome position: 60.4

GC content: 75.51

Gene sequence:

>780_bases
TTGACCGGCCCGGACTTGGACGACGCCGCGCAGCCCCGGGCGAACGCCCGATCCCGGCGGGCCCACAAGCCGCGCCCGCC
CCTGACCGCCCTCGAGGAGCGGATCGGGCACAGCTTCGGCGATCAGGACCTGCTCACCCGCGCGCTGACCCACACCAGCA
AGGCGAGCGGCCGGGGCGGCAGCTACCAGCGCCTGGAATTCCTCGGCGACCGGGTGCTCGGGCTCGCGGTCGCCGACCGG
CTCTACGGCGCCTTCCCGGAGGCCGACGAGGGCGACCTCTCCCGGCGCCTCGCCGCCCTCGTCCGGCGCGAGACCTGCGC
GGCCGTGGCCGCCTCCTGGGAGGTCGGCCCGCACCTGATTCTCGGCCAGGGCGAGGTCATGGGCGGCGGCCGGCGCAACC
AGACGATCCTCGCCGACGTCTGCGAGGCGATCCTGGGCGCGATCTACCTCGACGCCGGGTTCGACGCCGCCCGGGCGGTG
GTCGAGACCCATTTCCGCCCCGGCGAGCCGACCGCGGCGGCCCGGGGCCGCGACGCCAAATCCGCCTTGCAGGAATGGGC
CATGGGCCGCAGCCTGCCGATCCCCACCTACGCGGTGGTGGAGCGCACCGGTCCCGACCACGCGCCCCGGTTCCGCATCG
CCGTGCAGGTCGAGGGCCTCGAGCCCGGCCTCGGTGACGGCACGTCGAAGCGGATCGCCGAGCAGGCCGCCGCCCGGGCG
CTGATGGAGCGGGAGGGAATCGGGGCCTCCGCGGATGCGGAGCCGACGGAGACAGCATGA

Upstream 100 bases:

>100_bases
CCGAGATGATCTTCTTCTCGATCGACGAGGGCACGCCGGCGTGGCAGGTCTGGAACTGGCCGGCCCACGTGCGCTGGTCG
CGCCTGTTCACGACGATCCA

Downstream 100 bases:

>100_bases
GCGCGCACGAGCAGGACGATCACGACGAGCGGGACGGGCCCGACAGCGCGCCGGCCCGGGAGCCCGCGCGCGACCCGTCC
ACCCTTCCCGGCACGCCCGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTGPDLDDAAQPRANARSRRAHKPRPPLTALEERIGHSFGDQDLLTRALTHTSKASGRGGSYQRLEFLGDRVLGLAVADR
LYGAFPEADEGDLSRRLAALVRRETCAAVAASWEVGPHLILGQGEVMGGGRRNQTILADVCEAILGAIYLDAGFDAARAV
VETHFRPGEPTAAARGRDAKSALQEWAMGRSLPIPTYAVVERTGPDHAPRFRIAVQVEGLEPGLGDGTSKRIAEQAAARA
LMEREGIGASADAEPTETA

Sequences:

>Translated_259_residues
MTGPDLDDAAQPRANARSRRAHKPRPPLTALEERIGHSFGDQDLLTRALTHTSKASGRGGSYQRLEFLGDRVLGLAVADR
LYGAFPEADEGDLSRRLAALVRRETCAAVAASWEVGPHLILGQGEVMGGGRRNQTILADVCEAILGAIYLDAGFDAARAV
VETHFRPGEPTAAARGRDAKSALQEWAMGRSLPIPTYAVVERTGPDHAPRFRIAVQVEGLEPGLGDGTSKRIAEQAAARA
LMEREGIGASADAEPTETA
>Mature_258_residues
TGPDLDDAAQPRANARSRRAHKPRPPLTALEERIGHSFGDQDLLTRALTHTSKASGRGGSYQRLEFLGDRVLGLAVADRL
YGAFPEADEGDLSRRLAALVRRETCAAVAASWEVGPHLILGQGEVMGGGRRNQTILADVCEAILGAIYLDAGFDAARAVV
ETHFRPGEPTAAARGRDAKSALQEWAMGRSLPIPTYAVVERTGPDHAPRFRIAVQVEGLEPGLGDGTSKRIAEQAAARAL
MEREGIGASADAEPTETA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=31.4159292035398, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=31.4159292035398, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=42.0289855072464, Blast_Score=160, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17506883, Length=200, Percent_Identity=34, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=200, Percent_Identity=34, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=32.4561403508772, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27550; Mature: 27419

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPDLDDAAQPRANARSRRAHKPRPPLTALEERIGHSFGDQDLLTRALTHTSKASGRGG
CCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
SYQRLEFLGDRVLGLAVADRLYGAFPEADEGDLSRRLAALVRRETCAAVAASWEVGPHLI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LGQGEVMGGGRRNQTILADVCEAILGAIYLDAGFDAARAVVETHFRPGEPTAAARGRDAK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHCCCCHH
SALQEWAMGRSLPIPTYAVVERTGPDHAPRFRIAVQVEGLEPGLGDGTSKRIAEQAAARA
HHHHHHHCCCCCCCCHHEEEECCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
LMEREGIGASADAEPTETA
HHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGPDLDDAAQPRANARSRRAHKPRPPLTALEERIGHSFGDQDLLTRALTHTSKASGRGG
CCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
SYQRLEFLGDRVLGLAVADRLYGAFPEADEGDLSRRLAALVRRETCAAVAASWEVGPHLI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LGQGEVMGGGRRNQTILADVCEAILGAIYLDAGFDAARAVVETHFRPGEPTAAARGRDAK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHCCCCHH
SALQEWAMGRSLPIPTYAVVERTGPDHAPRFRIAVQVEGLEPGLGDGTSKRIAEQAAARA
HHHHHHHCCCCCCCCHHEEEECCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
LMEREGIGASADAEPTETA
HHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA