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The map label for this gene is dxr [H]

Identifier: 170749844

GI number: 170749844

Start: 3660593

End: 3661771

Strand: Reverse

Name: dxr [H]

Synonym: Mrad2831_3444

Alternate gene names: 170749844

Gene position: 3661771-3660593 (Counterclockwise)

Preceding gene: 170749845

Following gene: 170749842

Centisome position: 60.25

GC content: 74.22

Gene sequence:

>1179_bases
GTGACCCAGGTCGTCACCGTCTTCGGCGCCACCGGCTCGATCGGCCGCTCCACCGCCGACCTCCTGGCCCAGCACGCCGA
CCGGTTCCGCGTCGGCGCCCTGGTGGGCGGCAAGGATCCCGTCGCCCTGGCCAAGGTCGCCCGCGAGCTCAACGCCTCCT
TCGCGGCGCTCGCCGACGAGGCCGCGGGCCCGGCGCTGGCCGAGGCCCTGTCGGGCTCCGGCATCCCGAGCGGGGCGGGG
GAGGCGGCCGTCATGGAGGCCGCCGCCCGCGACGCCGACATCGTCGTCGCCGCCGTGAGCGGGGCGGCGGGGCTGAAATC
GACCCACGCGGCCCTTCGGCTCGGCCGCAAGGTCGCCCTCGCCAACAAGGAGAGCCTCGTCTGCGCCGGCGACGCCTTCA
TGCGCGACGCCGCCCGCTACGGCGCCACGATCCTGCCGATGGATTCCGAGCACGACGCGCTGAGCCAGGCGCTGGCCGGC
CGGCCGCTCGCCGACGTCCGCACCATGATGATCACGGCCTCGGGCGGCCCGTTCCGGACCTGGAGCCGCGAGCGGATCGC
CGCCGCCTCCGCGGCCGAGGCCGCCGCCCATCCGACCTGGTCGATGGGGATGAAGATCAACATCGATTCGGCGAGCCTGA
TGAACAAGGGGCTCGAGCTGATCGAGGCGCACCACCTGTTCGGCATCGAGCCCGAGCGGCTCGACGTCGTGGTGCACCCG
CAATCGGTGATCCACGGGATGGTCTACTGGCTCGACGGCGCCGTGACCGCCGAGCTGGCGCTGCCCGACATGCGCGTGCC
GATCTCGCACTGCCTCGGCCTCGGTGACCGGCTCACGATCCAGCGGGGCCGGCCCCTCGACCTCGTGAAGCTCGGATCGC
TCACCTTCGAGGCCGCGGACGAGGCGCGCTTCCCGTGCCTGCGGATCGCCCGCGCGGCGCTGGCGGCGGGCGGTGCGGCG
CCGACCGTGATGAACGCGGCCAACGAGATCGCGGTGGCGGCCTTCATCGCCGGCCGGATCGGCTTCTACGGGATCAGCGA
TCTGGTCGAGCGCGCCTGCGCGCACTTCGCCGGCCGGTACCGGACCGCGCCCGCCGACGTCGACGAGGCGCTCGCCATCG
ATGCCCACGTGCGGATCTGGAGCGCCGAGGCCCTGCCGGAGCTGCGCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
GACAGGCTCGACGGATTCTTCGCGGTCGCCGTGCTGGCGGCCGTCTATCTCGCCCTGCGCGGCGGCGGTCTGATCCCGTG
ACGATGAGGGAGTTGAACCC

Downstream 100 bases:

>100_bases
ACCCGGTCATTGCGAGCGCGGCGAAGCAACCCAGGTCGGCGCAACATTCTGCGAGCGTCGCGCCGCTGGATCGCTTCGCC
GCGCTCGCAACGACGTTTCC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTQVVTVFGATGSIGRSTADLLAQHADRFRVGALVGGKDPVALAKVARELNASFAALADEAAGPALAEALSGSGIPSGAG
EAAVMEAAARDADIVVAAVSGAAGLKSTHAALRLGRKVALANKESLVCAGDAFMRDAARYGATILPMDSEHDALSQALAG
RPLADVRTMMITASGGPFRTWSRERIAAASAAEAAAHPTWSMGMKINIDSASLMNKGLELIEAHHLFGIEPERLDVVVHP
QSVIHGMVYWLDGAVTAELALPDMRVPISHCLGLGDRLTIQRGRPLDLVKLGSLTFEAADEARFPCLRIARAALAAGGAA
PTVMNAANEIAVAAFIAGRIGFYGISDLVERACAHFAGRYRTAPADVDEALAIDAHVRIWSAEALPELRAAG

Sequences:

>Translated_392_residues
MTQVVTVFGATGSIGRSTADLLAQHADRFRVGALVGGKDPVALAKVARELNASFAALADEAAGPALAEALSGSGIPSGAG
EAAVMEAAARDADIVVAAVSGAAGLKSTHAALRLGRKVALANKESLVCAGDAFMRDAARYGATILPMDSEHDALSQALAG
RPLADVRTMMITASGGPFRTWSRERIAAASAAEAAAHPTWSMGMKINIDSASLMNKGLELIEAHHLFGIEPERLDVVVHP
QSVIHGMVYWLDGAVTAELALPDMRVPISHCLGLGDRLTIQRGRPLDLVKLGSLTFEAADEARFPCLRIARAALAAGGAA
PTVMNAANEIAVAAFIAGRIGFYGISDLVERACAHFAGRYRTAPADVDEALAIDAHVRIWSAEALPELRAAG
>Mature_391_residues
TQVVTVFGATGSIGRSTADLLAQHADRFRVGALVGGKDPVALAKVARELNASFAALADEAAGPALAEALSGSGIPSGAGE
AAVMEAAARDADIVVAAVSGAAGLKSTHAALRLGRKVALANKESLVCAGDAFMRDAARYGATILPMDSEHDALSQALAGR
PLADVRTMMITASGGPFRTWSRERIAAASAAEAAAHPTWSMGMKINIDSASLMNKGLELIEAHHLFGIEPERLDVVVHPQ
SVIHGMVYWLDGAVTAELALPDMRVPISHCLGLGDRLTIQRGRPLDLVKLGSLTFEAADEARFPCLRIARAALAAGGAAP
TVMNAANEIAVAAFIAGRIGFYGISDLVERACAHFAGRYRTAPADVDEALAIDAHVRIWSAEALPELRAAG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=390, Percent_Identity=43.5897435897436, Blast_Score=275, Evalue=5e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40620; Mature: 40489

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVVTVFGATGSIGRSTADLLAQHADRFRVGALVGGKDPVALAKVARELNASFAALADE
CCEEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHH
AAGPALAEALSGSGIPSGAGEAAVMEAAARDADIVVAAVSGAAGLKSTHAALRLGRKVAL
HCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEE
ANKESLVCAGDAFMRDAARYGATILPMDSEHDALSQALAGRPLADVRTMMITASGGPFRT
CCCCCEEEECHHHHHHHHHHCCEEECCCCCHHHHHHHHCCCCHHHEEEEEEEECCCCCCC
WSRERIAAASAAEAAAHPTWSMGMKINIDSASLMNKGLELIEAHHLFGIEPERLDVVVHP
CCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
QSVIHGMVYWLDGAVTAELALPDMRVPISHCLGLGDRLTIQRGRPLDLVKLGSLTFEAAD
HHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCEEEECCCCCCCEEEECCEEEECCC
EARFPCLRIARAALAAGGAAPTVMNAANEIAVAAFIAGRIGFYGISDLVERACAHFAGRY
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
RTAPADVDEALAIDAHVRIWSAEALPELRAAG
CCCCCCCHHHEEEECEEEEEEHHHCCHHHCCC
>Mature Secondary Structure 
TQVVTVFGATGSIGRSTADLLAQHADRFRVGALVGGKDPVALAKVARELNASFAALADE
CEEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHH
AAGPALAEALSGSGIPSGAGEAAVMEAAARDADIVVAAVSGAAGLKSTHAALRLGRKVAL
HCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEE
ANKESLVCAGDAFMRDAARYGATILPMDSEHDALSQALAGRPLADVRTMMITASGGPFRT
CCCCCEEEECHHHHHHHHHHCCEEECCCCCHHHHHHHHCCCCHHHEEEEEEEECCCCCCC
WSRERIAAASAAEAAAHPTWSMGMKINIDSASLMNKGLELIEAHHLFGIEPERLDVVVHP
CCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
QSVIHGMVYWLDGAVTAELALPDMRVPISHCLGLGDRLTIQRGRPLDLVKLGSLTFEAAD
HHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCEEEECCCCCCCEEEECCEEEECCC
EARFPCLRIARAALAAGGAAPTVMNAANEIAVAAFIAGRIGFYGISDLVERACAHFAGRY
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
RTAPADVDEALAIDAHVRIWSAEALPELRAAG
CCCCCCCHHHEEEECEEEEEEHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA