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The map label for this gene is mmlH [H]

Identifier: 170749752

GI number: 170749752

Start: 3558472

End: 3559743

Strand: Direct

Name: mmlH [H]

Synonym: Mrad2831_3351

Alternate gene names: 170749752

Gene position: 3558472-3559743 (Clockwise)

Preceding gene: 170749751

Following gene: 170749753

Centisome position: 58.55

GC content: 69.42

Gene sequence:

>1272_bases
ATGTGGGTGAAAGACACGAGTCCGGCGGAACGCCGGGTCCTGGGCGCGGCCTTCGCGGGCTACGGCGTCGATGCGTTCGA
CTACATGGTCTACACCTTCCTGATCCCGACCCTGGTCGTGGTCTGGGGCCTGACCAAGGTCGAGGCCGGCAACATCGCCA
CCGCCGCGCTGGTGACCTCGGCGATCGGCGGCTGGGCAGCCGGAATCCTGGCGGACCGCTACGGCCGGGTGGTCGTCCTG
CAGGGCACCGTCGCGTGGTTCACCCTGTTCACGGTGCTCAGCGGCTTCACCCACTCGTACGAGCAGCTGCTCGTGACCCG
CGCGCTCCAGGGCTTCGGCTTCGGCGGCGAGTGGTCGGTGGGGTCGGTGCTGATCGCCGAGACGATCCAGGCGCGCTACC
GCGGCAAGGCGGTGGGGCTCGTCCAGTCGAGCTGGGCGGTCGGCTGGGCCTGCGCGGCCATCGCCTTCTGGGCCGTGTTC
GCCCTGGCGGAGCCCGCCGTGGCGTGGCGGATCCTGTTCTGGCTCGGCGCCCTCCCCTCGGTGCTGATCTTCTGGATCCG
CCGCAACATCGAGGACCCCGAGATCTACCGCCAGACCCGCGCCGCGATGCGCGACGTCGGCGATACCGGCAGCTTCCTCG
ACATCTTCTCCCGGCCGCTGATCGGCCGGACCGTGCTGGCGAGCCTGCTCGCGACCGGCATGCAGGGCGGCTACTACGCG
GTGACCACGTGGCTCCCGACCTACTTGAAGACGGAGCGCAACCTCTCGGTGCTGAACACCAGCGGCTACCTGCTGATGCT
CATCTTCGGGTCGTTCGTCGGATACCTGACCAGCGCCTGGCTCTCCGACCGCATCGGGCGCCGTCGCGGCTTCGTCCTGT
TCGGCTTCTGCGCCGGTGTCCTCGTGCTGGCCTACACGCTGATCCCGATCACCGACCCGGTGATGCTGGTCCTCGGCTTC
CCGCTGGGCTTCTTCCTCTCCGGCGTCTTCTCCGGGATGGGCGCCTTCCTGAGCGAGCTGTTCCCGAGCCGGATCCGCGG
CTCCGCACAGGGATTCTGCTACAATTTCGGCCGCGCCACGGGCGCGATCTGCCCGGCCGTAGTAGGCCATCTCAGCGGCT
CGCTGACACTCGGCACCGCCATCGGCGTCGTGGCGGCGGGGGCCTATTGCCTCGTGATCGTCGCGGCGCTTCTCTTGCCG
GAGACGGCGGGCCGCGCGCTCGATTCTTGCACCGCGGATCCGGCCGAGCCGGAACCCGTTGCGGCCCTGTGA

Upstream 100 bases:

>100_bases
GCGCCCGGTCACATGCTGATCACCGACCTCCTCAACCGGGACCTGCCGTTCCTGTGACCCTCCCGGCCGCGTGGCGGCCC
GTCCGCGAAGGAGTTGCGCC

Downstream 100 bases:

>100_bases
GACCCGATCGGCACGCGGAGCGGCGGCGATGACCAGCGTGGACCTCAATTCCGACCTCGGCGAGGGCTACGGCGCCTACG
CCTGCGGCGACGACGCGGCG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MWVKDTSPAERRVLGAAFAGYGVDAFDYMVYTFLIPTLVVVWGLTKVEAGNIATAALVTSAIGGWAAGILADRYGRVVVL
QGTVAWFTLFTVLSGFTHSYEQLLVTRALQGFGFGGEWSVGSVLIAETIQARYRGKAVGLVQSSWAVGWACAAIAFWAVF
ALAEPAVAWRILFWLGALPSVLIFWIRRNIEDPEIYRQTRAAMRDVGDTGSFLDIFSRPLIGRTVLASLLATGMQGGYYA
VTTWLPTYLKTERNLSVLNTSGYLLMLIFGSFVGYLTSAWLSDRIGRRRGFVLFGFCAGVLVLAYTLIPITDPVMLVLGF
PLGFFLSGVFSGMGAFLSELFPSRIRGSAQGFCYNFGRATGAICPAVVGHLSGSLTLGTAIGVVAAGAYCLVIVAALLLP
ETAGRALDSCTADPAEPEPVAAL

Sequences:

>Translated_423_residues
MWVKDTSPAERRVLGAAFAGYGVDAFDYMVYTFLIPTLVVVWGLTKVEAGNIATAALVTSAIGGWAAGILADRYGRVVVL
QGTVAWFTLFTVLSGFTHSYEQLLVTRALQGFGFGGEWSVGSVLIAETIQARYRGKAVGLVQSSWAVGWACAAIAFWAVF
ALAEPAVAWRILFWLGALPSVLIFWIRRNIEDPEIYRQTRAAMRDVGDTGSFLDIFSRPLIGRTVLASLLATGMQGGYYA
VTTWLPTYLKTERNLSVLNTSGYLLMLIFGSFVGYLTSAWLSDRIGRRRGFVLFGFCAGVLVLAYTLIPITDPVMLVLGF
PLGFFLSGVFSGMGAFLSELFPSRIRGSAQGFCYNFGRATGAICPAVVGHLSGSLTLGTAIGVVAAGAYCLVIVAALLLP
ETAGRALDSCTADPAEPEPVAAL
>Mature_423_residues
MWVKDTSPAERRVLGAAFAGYGVDAFDYMVYTFLIPTLVVVWGLTKVEAGNIATAALVTSAIGGWAAGILADRYGRVVVL
QGTVAWFTLFTVLSGFTHSYEQLLVTRALQGFGFGGEWSVGSVLIAETIQARYRGKAVGLVQSSWAVGWACAAIAFWAVF
ALAEPAVAWRILFWLGALPSVLIFWIRRNIEDPEIYRQTRAAMRDVGDTGSFLDIFSRPLIGRTVLASLLATGMQGGYYA
VTTWLPTYLKTERNLSVLNTSGYLLMLIFGSFVGYLTSAWLSDRIGRRRGFVLFGFCAGVLVLAYTLIPITDPVMLVLGF
PLGFFLSGVFSGMGAFLSELFPSRIRGSAQGFCYNFGRATGAICPAVVGHLSGSLTLGTAIGVVAAGAYCLVIVAALLLP
ETAGRALDSCTADPAEPEPVAAL

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=439, Percent_Identity=26.6514806378132, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI87082404, Length=394, Percent_Identity=25.3807106598985, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87082231, Length=272, Percent_Identity=28.3088235294118, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790550, Length=452, Percent_Identity=27.212389380531, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87081723, Length=354, Percent_Identity=27.683615819209, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082320, Length=393, Percent_Identity=24.1730279898219, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788942, Length=395, Percent_Identity=24.5569620253165, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789152, Length=394, Percent_Identity=22.5888324873096, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=432, Percent_Identity=24.537037037037, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45266; Mature: 45266

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVKDTSPAERRVLGAAFAGYGVDAFDYMVYTFLIPTLVVVWGLTKVEAGNIATAALVTS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
AIGGWAAGILADRYGRVVVLQGTVAWFTLFTVLSGFTHSYEQLLVTRALQGFGFGGEWSV
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
GSVLIAETIQARYRGKAVGLVQSSWAVGWACAAIAFWAVFALAEPAVAWRILFWLGALPS
HHHHHHHHHHHHHCCCCEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIFWIRRNIEDPEIYRQTRAAMRDVGDTGSFLDIFSRPLIGRTVLASLLATGMQGGYYA
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
VTTWLPTYLKTERNLSVLNTSGYLLMLIFGSFVGYLTSAWLSDRIGRRRGFVLFGFCAGV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVLAYTLIPITDPVMLVLGFPLGFFLSGVFSGMGAFLSELFPSRIRGSAQGFCYNFGRAT
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCHH
GAICPAVVGHLSGSLTLGTAIGVVAAGAYCLVIVAALLLPETAGRALDSCTADPAEPEPV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
AAL
CCC
>Mature Secondary Structure
MWVKDTSPAERRVLGAAFAGYGVDAFDYMVYTFLIPTLVVVWGLTKVEAGNIATAALVTS
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHH
AIGGWAAGILADRYGRVVVLQGTVAWFTLFTVLSGFTHSYEQLLVTRALQGFGFGGEWSV
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
GSVLIAETIQARYRGKAVGLVQSSWAVGWACAAIAFWAVFALAEPAVAWRILFWLGALPS
HHHHHHHHHHHHHCCCCEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIFWIRRNIEDPEIYRQTRAAMRDVGDTGSFLDIFSRPLIGRTVLASLLATGMQGGYYA
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
VTTWLPTYLKTERNLSVLNTSGYLLMLIFGSFVGYLTSAWLSDRIGRRRGFVLFGFCAGV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVLAYTLIPITDPVMLVLGFPLGFFLSGVFSGMGAFLSELFPSRIRGSAQGFCYNFGRAT
HHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCHH
GAICPAVVGHLSGSLTLGTAIGVVAAGAYCLVIVAALLLPETAGRALDSCTADPAEPEPV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
AAL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]