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The map label for this gene is zraS [C]

Identifier: 170749686

GI number: 170749686

Start: 3483288

End: 3485627

Strand: Reverse

Name: zraS [C]

Synonym: Mrad2831_3284

Alternate gene names: 170749686

Gene position: 3485627-3483288 (Counterclockwise)

Preceding gene: 170749687

Following gene: 170749685

Centisome position: 57.35

GC content: 73.5

Gene sequence:

>2340_bases
ATGCGGGTTGGACCCAAGATCGCCCTGGTCGGAGGCGTGCCGATCCTCGCCGCCGGCGCGATCGCCATGGCCGGCTGGCT
GCTCCTGGCGCAGGAGGAGCGCGCCCGGCGCGGTGCGGTCCTGGTGGCCGACGTCTACCACGACATCGCCACCGCACGCT
TGGTCCGCGATCAGTACGCCGCCGCGGACGCGCGGGACCGGTCCGCCTATGCCGAGCGCTTCGCCGGCCTGACGGCGCGG
GCCGAGGCCGGTCTCGGCCGGCTCGCCGGCTTCGCCCGCATCGACGAACAGCGCGCGCGGATCGCCTCTGTGGAGCGGGC
CCTGGCCCGCTATCGGGGCGAGATGGACGCCTTCGTCCGGCGGACGCGGGAGAATGACGGCCTGATCCGCGAGATGACGC
AGCGGGCCGACACCCTGATCGACCTCACCGACCGGGCACGCCTGCGGCAGCAGGCCTCGAACGCGGACCTCGCGCGCTCG
ATGGCCGAGAAGGTCGAGGCGCTGCGGGTCGCCCGGGGACTCGTCGCCCGCCTCAACGCCCTGAGAGCCCGGAGCGCGGA
GGGCGCCGTGGTCGCCGCCCGGACCGCCGCCCAGGCGGGAGCGCAGGTTGTGGCCCGGAGCGACGCCCCCGCGGGAGCGG
CGGGCGCGGAGAGCGAGGGCCCGCGCGCGCAGAGCCTTTTCCGCGCCGCCAGCCGCGATCTCGCGACCGCTCTGCGGGCC
GACGGCCGGGATGCCGACGCCGAGTCCCTCGACACGCTCGCCGCCGAGGCGGCGGCGCAGAAACCGGATCTCCGCGCGAA
GCTCGACGGCTGGATCGAGCGCGTTCTGAAGATCGAGACCTCCGGCCAGGAGAGCCTGCACGACGAGGTGGCGCAGCTGC
TCGCCTATTCCGTGGAGGCCAACGAGATCGAGCAGGCCACCCAGAACGTCGCGATCGGCACCCTCAAGCTGGGGCCGCGC
ACCGCCGGCGCCCTCCTGCACCGGGATGCCGCCCTCGCCGAGCGGATGCGCGACGAGGGCGAGCGCCTCGCCCGGAGCGC
CGCCTCGCTGCCGATCTCGCCGCTGATCCAGGCCGAGATGGTCCAGGCCCTCGACGGCTGGCGCGCGCGCCTCACCACCA
CCATCGGGGGCCTGCGGCAGCAGAACGCCATGATCGTCGCGATGGACGGGCTCGCCGCGACGATGATCGACAGCGCCAAG
GCGCTCAACGACGCCTTCGTGGAGGATGCCGACCGGTTCGGCATCTTCATCCAGCGGATCCTGCTCGCCGGCGCAGCCGG
CCTCCTGCTGTTCGGCGCCCTGGTGGTGATCTTCGTCGCCCGCTCGATCCTGGTGCCGCTGCGCGCGCTCCAGGGCGATA
TGGTCATGCTGACCGGGAACCCGGCGGGGGCGGCCGTGCGGGGCACGGCACGCCGGGACGAGCTCGGCGACATCGCCCGC
GCCACCGCGGTCTTCGTGTCCGAGATCACCCGCCGGGAAGGCGCGCTGCGCCGGGCGAAGGATCAGGCGGACGTCGCCCT
GGTCGAGCTGCGCCGGACTCAGGACGACCTCGTCCGGGCCGAGAAGCTCGCCTCCCTCGGGCAGCTCGTGGCCGGAGTCG
CCCACGAGATCAACACGCCGCTCGGCATCGCGCTGACCACCGGGACGCTCATGAGCGACGAGGCGCGGACCTTCCGGACG
GGACTGTCCGCCGGCACGCTGTCGCGCTCCCGGCTGACTCACTTCGTCGACCGGGTCGAGGAGGGCGCCACCCTGCTCTG
CGCCAACCTCACCCGGGCCGCCGACCTCGTCCAGGGCTTTAAGCAGGTCGCGGTCGACCGGGTCAGCGACGAGAGCCGCA
GCGTCGCGCTGGCGACCTGGCTCGACGACCTGCTGACGAGCCTGCGGCCGATGCTGCGCAAGGGCGGCCACGTCGTGGAG
CGCGCCTGCCCGGCGGACCTCGTCATCGTCACCAATCCCGGGGTGCTGGCGCAGATCGTGACCAACCTCGTCGCCAACGC
GGTCGTGCACGGGTTCCGGGCGGGCGAGCCGGGACGGATCACCGTGGACGTGTCGGAACGGGAGGGGGGCCTCGTGCGGA
TGGAGGTTCGCGATACCGGTCAGGGCATCCCGCCGGAGCACCTCGAGCGCATCTTCGACCCGTTCTTCACGACGGCCCGG
AGCGCCGGCAGCACGGGACTCGGCATGCACATCGTCCACAATCTCGTGACCGCCAAGCTCGGCGGCCGCATCGCGGTCAG
CAGCGAGCGCGGTCAGGGGACCGTCGTGCAGGTCGATTTTCCCGCAGAGGGCGCGGGAGCGGCCGCGCGGCCGCGGACCA
GCGCGATCGGCACGCCGTGA

Upstream 100 bases:

>100_bases
CTTGGTCGCCCGGGCGCCAGGACCCGCCGGAGCGCCGCCCGATTGCACCGCACTCCGGCCCGGCCTTAAGTTGCTGCCGG
ACCCCTATGTCGGGACGCGG

Downstream 100 bases:

>100_bases
GGCCGGCCGCGGCATGCCGGGCCGGGCTCCTCGCCCTGGCGGCCGGCCTGGCTTCCGGCCCGCTTTTCGACCCCGGCCCG
GCGGCGGCGCGCACCTTCGT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MRVGPKIALVGGVPILAAGAIAMAGWLLLAQEERARRGAVLVADVYHDIATARLVRDQYAAADARDRSAYAERFAGLTAR
AEAGLGRLAGFARIDEQRARIASVERALARYRGEMDAFVRRTRENDGLIREMTQRADTLIDLTDRARLRQQASNADLARS
MAEKVEALRVARGLVARLNALRARSAEGAVVAARTAAQAGAQVVARSDAPAGAAGAESEGPRAQSLFRAASRDLATALRA
DGRDADAESLDTLAAEAAAQKPDLRAKLDGWIERVLKIETSGQESLHDEVAQLLAYSVEANEIEQATQNVAIGTLKLGPR
TAGALLHRDAALAERMRDEGERLARSAASLPISPLIQAEMVQALDGWRARLTTTIGGLRQQNAMIVAMDGLAATMIDSAK
ALNDAFVEDADRFGIFIQRILLAGAAGLLLFGALVVIFVARSILVPLRALQGDMVMLTGNPAGAAVRGTARRDELGDIAR
ATAVFVSEITRREGALRRAKDQADVALVELRRTQDDLVRAEKLASLGQLVAGVAHEINTPLGIALTTGTLMSDEARTFRT
GLSAGTLSRSRLTHFVDRVEEGATLLCANLTRAADLVQGFKQVAVDRVSDESRSVALATWLDDLLTSLRPMLRKGGHVVE
RACPADLVIVTNPGVLAQIVTNLVANAVVHGFRAGEPGRITVDVSEREGGLVRMEVRDTGQGIPPEHLERIFDPFFTTAR
SAGSTGLGMHIVHNLVTAKLGGRIAVSSERGQGTVVQVDFPAEGAGAAARPRTSAIGTP

Sequences:

>Translated_779_residues
MRVGPKIALVGGVPILAAGAIAMAGWLLLAQEERARRGAVLVADVYHDIATARLVRDQYAAADARDRSAYAERFAGLTAR
AEAGLGRLAGFARIDEQRARIASVERALARYRGEMDAFVRRTRENDGLIREMTQRADTLIDLTDRARLRQQASNADLARS
MAEKVEALRVARGLVARLNALRARSAEGAVVAARTAAQAGAQVVARSDAPAGAAGAESEGPRAQSLFRAASRDLATALRA
DGRDADAESLDTLAAEAAAQKPDLRAKLDGWIERVLKIETSGQESLHDEVAQLLAYSVEANEIEQATQNVAIGTLKLGPR
TAGALLHRDAALAERMRDEGERLARSAASLPISPLIQAEMVQALDGWRARLTTTIGGLRQQNAMIVAMDGLAATMIDSAK
ALNDAFVEDADRFGIFIQRILLAGAAGLLLFGALVVIFVARSILVPLRALQGDMVMLTGNPAGAAVRGTARRDELGDIAR
ATAVFVSEITRREGALRRAKDQADVALVELRRTQDDLVRAEKLASLGQLVAGVAHEINTPLGIALTTGTLMSDEARTFRT
GLSAGTLSRSRLTHFVDRVEEGATLLCANLTRAADLVQGFKQVAVDRVSDESRSVALATWLDDLLTSLRPMLRKGGHVVE
RACPADLVIVTNPGVLAQIVTNLVANAVVHGFRAGEPGRITVDVSEREGGLVRMEVRDTGQGIPPEHLERIFDPFFTTAR
SAGSTGLGMHIVHNLVTAKLGGRIAVSSERGQGTVVQVDFPAEGAGAAARPRTSAIGTP
>Mature_779_residues
MRVGPKIALVGGVPILAAGAIAMAGWLLLAQEERARRGAVLVADVYHDIATARLVRDQYAAADARDRSAYAERFAGLTAR
AEAGLGRLAGFARIDEQRARIASVERALARYRGEMDAFVRRTRENDGLIREMTQRADTLIDLTDRARLRQQASNADLARS
MAEKVEALRVARGLVARLNALRARSAEGAVVAARTAAQAGAQVVARSDAPAGAAGAESEGPRAQSLFRAASRDLATALRA
DGRDADAESLDTLAAEAAAQKPDLRAKLDGWIERVLKIETSGQESLHDEVAQLLAYSVEANEIEQATQNVAIGTLKLGPR
TAGALLHRDAALAERMRDEGERLARSAASLPISPLIQAEMVQALDGWRARLTTTIGGLRQQNAMIVAMDGLAATMIDSAK
ALNDAFVEDADRFGIFIQRILLAGAAGLLLFGALVVIFVARSILVPLRALQGDMVMLTGNPAGAAVRGTARRDELGDIAR
ATAVFVSEITRREGALRRAKDQADVALVELRRTQDDLVRAEKLASLGQLVAGVAHEINTPLGIALTTGTLMSDEARTFRT
GLSAGTLSRSRLTHFVDRVEEGATLLCANLTRAADLVQGFKQVAVDRVSDESRSVALATWLDDLLTSLRPMLRKGGHVVE
RACPADLVIVTNPGVLAQIVTNLVANAVVHGFRAGEPGRITVDVSEREGGLVRMEVRDTGQGIPPEHLERIFDPFFTTAR
SAGSTGLGMHIVHNLVTAKLGGRIAVSSERGQGTVVQVDFPAEGAGAAARPRTSAIGTP

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=265, Percent_Identity=30.9433962264151, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI48994928, Length=277, Percent_Identity=25.6317689530686, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=27.0161290322581, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=271, Percent_Identity=29.1512915129151, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081816, Length=380, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 82760; Mature: 82760

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGPKIALVGGVPILAAGAIAMAGWLLLAQEERARRGAVLVADVYHDIATARLVRDQYA
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AADARDRSAYAERFAGLTARAEAGLGRLAGFARIDEQRARIASVERALARYRGEMDAFVR
HCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RTRENDGLIREMTQRADTLIDLTDRARLRQQASNADLARSMAEKVEALRVARGLVARLNA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRARSAEGAVVAARTAAQAGAQVVARSDAPAGAAGAESEGPRAQSLFRAASRDLATALRA
HHHCCCCCCEEEHHHHHHHCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
DGRDADAESLDTLAAEAAAQKPDLRAKLDGWIERVLKIETSGQESLHDEVAQLLAYSVEA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH
NEIEQATQNVAIGTLKLGPRTAGALLHRDAALAERMRDEGERLARSAASLPISPLIQAEM
HHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VQALDGWRARLTTTIGGLRQQNAMIVAMDGLAATMIDSAKALNDAFVEDADRFGIFIQRI
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAGAAGLLLFGALVVIFVARSILVPLRALQGDMVMLTGNPAGAAVRGTARRDELGDIAR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEECCCCHHHHHHHHH
ATAVFVSEITRREGALRRAKDQADVALVELRRTQDDLVRAEKLASLGQLVAGVAHEINTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGIALTTGTLMSDEARTFRTGLSAGTLSRSRLTHFVDRVEEGATLLCANLTRAADLVQGF
CEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
KQVAVDRVSDESRSVALATWLDDLLTSLRPMLRKGGHVVERACPADLVIVTNPGVLAQIV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCHHHHHH
TNLVANAVVHGFRAGEPGRITVDVSEREGGLVRMEVRDTGQGIPPEHLERIFDPFFTTAR
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
SAGSTGLGMHIVHNLVTAKLGGRIAVSSERGQGTVVQVDFPAEGAGAAARPRTSAIGTP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVGPKIALVGGVPILAAGAIAMAGWLLLAQEERARRGAVLVADVYHDIATARLVRDQYA
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AADARDRSAYAERFAGLTARAEAGLGRLAGFARIDEQRARIASVERALARYRGEMDAFVR
HCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RTRENDGLIREMTQRADTLIDLTDRARLRQQASNADLARSMAEKVEALRVARGLVARLNA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRARSAEGAVVAARTAAQAGAQVVARSDAPAGAAGAESEGPRAQSLFRAASRDLATALRA
HHHCCCCCCEEEHHHHHHHCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
DGRDADAESLDTLAAEAAAQKPDLRAKLDGWIERVLKIETSGQESLHDEVAQLLAYSVEA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCH
NEIEQATQNVAIGTLKLGPRTAGALLHRDAALAERMRDEGERLARSAASLPISPLIQAEM
HHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VQALDGWRARLTTTIGGLRQQNAMIVAMDGLAATMIDSAKALNDAFVEDADRFGIFIQRI
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAGAAGLLLFGALVVIFVARSILVPLRALQGDMVMLTGNPAGAAVRGTARRDELGDIAR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEECCCCHHHHHHHHH
ATAVFVSEITRREGALRRAKDQADVALVELRRTQDDLVRAEKLASLGQLVAGVAHEINTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGIALTTGTLMSDEARTFRTGLSAGTLSRSRLTHFVDRVEEGATLLCANLTRAADLVQGF
CEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHH
KQVAVDRVSDESRSVALATWLDDLLTSLRPMLRKGGHVVERACPADLVIVTNPGVLAQIV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCHHHHHH
TNLVANAVVHGFRAGEPGRITVDVSEREGGLVRMEVRDTGQGIPPEHLERIFDPFFTTAR
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
SAGSTGLGMHIVHNLVTAKLGGRIAVSSERGQGTVVQVDFPAEGAGAAARPRTSAIGTP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]