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The map label for this gene is zraS [C]

Identifier: 170749683

GI number: 170749683

Start: 3477917

End: 3480262

Strand: Direct

Name: zraS [C]

Synonym: Mrad2831_3281

Alternate gene names: 170749683

Gene position: 3477917-3480262 (Clockwise)

Preceding gene: 170749679

Following gene: 170749684

Centisome position: 57.22

GC content: 73.19

Gene sequence:

>2346_bases
ATGACCCGCGGGTTCGGGCGGTCCGGGATCGCGCGCCGCGTCCTCGTGGTCGGCGCGATCCCGATCCTCGTCGCGGCCGC
CATCGCGCTGGGCGCCTGGATCCTGCTCTACGAGGCCGAGCGCGCCCGGACCGGCGCCGTGGTGGCGACGGAGACGGCGC
AGACGCTCACGTCGATGAACCGGGCGCGGGCGGACGCCGTCAGCGGCGGCACCGCGCGGCGGGACGAGGCCGAGCGCCGC
TTCGACGAGCGGGCCGCCACCGCGGCCGGGCAGCTCGAACGTCTCGAGGGTCTCGCGCGCACGCGCGGCCAGTCCGCGCT
CGTGGCGACCGTCACGGGCGATCTGAACTCGCAGGTGACGCGGATGCGCTCGCTCCTGCTCTCCGAGCGCACGGCGACCG
CCACGATCGCCGACATGGCCCGGCGGGCGGACGCCCTGGTCGCGCTGACCGACGTCGCGCGCCGGCGCCAGCAGCAGGAC
AATGCCCAGTTGATCGCCGTCCTGGCCGTCAAGGATGCCGAGCTGGAGCGGAATCAGGGCGTCGTCACCGCCCTCCGGGA
GCTGCGCGAGGCGATCAGCACCGCGGAGCTGAACCGGGCGCGCATCGGCCGCCCGGTCTTCCCGATCGAGTTCGACGAAC
TCGCCGCCGACCTGCGCCAGCTCGACGCCGTGGGCGACCGGCTACGCCGCGTCCTGCGGGTCGACGGCGAGGCGGGGGCG
GCGGACCGGGCGACGGAGCTCCTGAAGGCGTATCGCGACCGGAGCCGGACCGAGGACGACCTCAACCGGGTCCTGTCCGA
GGGCTTCGAATTGACCCGCGCCACCCAGGCCGGCCGCGTCCTAGTCGAGTGGTGCGACCAGCTCGTCCAAGTGAGCGTCG
CCCGCCAGAACCGGCTGTACGAGGAGGTCGCGCTCCTGATCCGTCACTCGGTCCTCTCGAACGAGGCCGAACTCTCCGCC
CAGGACATCGCCCTCACGGCCCTGCGCCTCGCCCGGCGGACCGATGCGGCGCTCGCGCGCCGGGACACCGCGGAGGCGTC
GCGGGTGCTGGAGGCGGGCGCGGAGCTGTCGGGCACGTCCCGGACGCTGCTCATCCCGGTGAGCATCCGGGACGAGATGG
CGGAGGCGATCGACGGCTGGCGCGCGCAGCTCGCCGCGACGATCGAGAAGATCGGCGAGCAGAACGACACCATCGCCGAC
ATGGACAGCCGCGCCGCCACGATGAGCGCCAACGCGCAGACCCTGAGCCGGGCCTTCATCGACGATGCCGACCAGTTCGG
CAGCGTGATCCGGCAGCTCCTGGTCGTCGGGGCAGTGGGCGCCCTGTGCCTCGGGATCGGCGCCGCCGCCGCGGTGGCGC
GCTCGATCACCCGGCCGCTGCACGCCCTGCAGCACAGCATCGTCACGGCCGCCGCCGCGCCCGCCCCAGAGGATATCGGC
CGCGACGGCCACCTGCTCACGCGGCGCGACGAACTCGGCGACATCGCCAGGGCGACGAACGCGTTCCTGGAGCAGATCCG
CCGTCGCGAGGCGGACCGGCGCAACGCCTCGCAGCGGGCCGACGACGCGCTCACCACTCTGCGGCAGGCCCAGGAGGACC
TGATCCGCGCGGAGCGGCTCGCGTCGCTCGGCCAGCTCGTGGCGGGCGTCTCGCACGAGATCAGCACCCCGCTCGGCATC
GCCCTGACCACGGCGACGCAGGTCCAGTCCGACTCGGCCGCGTTCGAGCGGCTGGTGGGCGAGAACCAGCTCTCCCGCTC
GCGGCTGACCCAGTATGCCGGGCGGATGCGGGAGGGCGCTCAGCTCCTGACCAGCAACCTGATGCGCGCGGCCGACCTCC
TCTACAGTTTCAAGCAGGTGGCGGCCGATCAGGCCATCGAGGACCGCCGCGCGCTGAACCTCGCGGACTGGATCGACGAG
TTGCTGAAGAGCCTGCGCGCCCTGGCGCGACCGGGCCGGCACGTCTTCGTGGTCGAATGCCCGCCCGATCTCGTCGTCGA
CACGCTGCCGGGCATCCTGGCGCAGGTCGTGTCGAACGCTGTCAAGAACGCGATCGAGCACGGCTTTCAGGAGCGGGAGG
GTGGCCGCATCACCATCACGGGGATCCGGTCCGGGGACGGCATCGGCCTCTCGATCGCCGATGACGGGCGCGGCATCGAC
GGCGCCGACCTCGGCCGCGTGTTCGACCCGTTCTTCACCACGGCGCGTGCCCGCGGCGGGACGGGCCTCGGCCTGCACAT
CGTCCACAACCTCGTGGTCAACCGCCTCCAGGGGCGGGTCGAACTGCAGAGCAGCGCGGGCGCCGGCACGGTGCTGCGGC
TGTGGCTTCCGGAGCGGCTGGCATGA

Upstream 100 bases:

>100_bases
ATCGCGCCGATGGCAGAATAACGGAATGTGTCGTCGCGGAATCGGCGACCGATCGGGAGGCCGCACGGGTGACGGGGCGC
GGGACACGGTGCGAGGCGCG

Downstream 100 bases:

>100_bases
GCGGAGCGCGGCAACCGGCGCGGCGCGGGGACGGCCGCCTGAGGCCGCTGATGTCCGGCGCGCTCGCCGGCCTGCTCCTC
GCGCTGCGCCCGCTGCCCGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MTRGFGRSGIARRVLVVGAIPILVAAAIALGAWILLYEAERARTGAVVATETAQTLTSMNRARADAVSGGTARRDEAERR
FDERAATAAGQLERLEGLARTRGQSALVATVTGDLNSQVTRMRSLLLSERTATATIADMARRADALVALTDVARRRQQQD
NAQLIAVLAVKDAELERNQGVVTALRELREAISTAELNRARIGRPVFPIEFDELAADLRQLDAVGDRLRRVLRVDGEAGA
ADRATELLKAYRDRSRTEDDLNRVLSEGFELTRATQAGRVLVEWCDQLVQVSVARQNRLYEEVALLIRHSVLSNEAELSA
QDIALTALRLARRTDAALARRDTAEASRVLEAGAELSGTSRTLLIPVSIRDEMAEAIDGWRAQLAATIEKIGEQNDTIAD
MDSRAATMSANAQTLSRAFIDDADQFGSVIRQLLVVGAVGALCLGIGAAAAVARSITRPLHALQHSIVTAAAAPAPEDIG
RDGHLLTRRDELGDIARATNAFLEQIRRREADRRNASQRADDALTTLRQAQEDLIRAERLASLGQLVAGVSHEISTPLGI
ALTTATQVQSDSAAFERLVGENQLSRSRLTQYAGRMREGAQLLTSNLMRAADLLYSFKQVAADQAIEDRRALNLADWIDE
LLKSLRALARPGRHVFVVECPPDLVVDTLPGILAQVVSNAVKNAIEHGFQEREGGRITITGIRSGDGIGLSIADDGRGID
GADLGRVFDPFFTTARARGGTGLGLHIVHNLVVNRLQGRVELQSSAGAGTVLRLWLPERLA

Sequences:

>Translated_781_residues
MTRGFGRSGIARRVLVVGAIPILVAAAIALGAWILLYEAERARTGAVVATETAQTLTSMNRARADAVSGGTARRDEAERR
FDERAATAAGQLERLEGLARTRGQSALVATVTGDLNSQVTRMRSLLLSERTATATIADMARRADALVALTDVARRRQQQD
NAQLIAVLAVKDAELERNQGVVTALRELREAISTAELNRARIGRPVFPIEFDELAADLRQLDAVGDRLRRVLRVDGEAGA
ADRATELLKAYRDRSRTEDDLNRVLSEGFELTRATQAGRVLVEWCDQLVQVSVARQNRLYEEVALLIRHSVLSNEAELSA
QDIALTALRLARRTDAALARRDTAEASRVLEAGAELSGTSRTLLIPVSIRDEMAEAIDGWRAQLAATIEKIGEQNDTIAD
MDSRAATMSANAQTLSRAFIDDADQFGSVIRQLLVVGAVGALCLGIGAAAAVARSITRPLHALQHSIVTAAAAPAPEDIG
RDGHLLTRRDELGDIARATNAFLEQIRRREADRRNASQRADDALTTLRQAQEDLIRAERLASLGQLVAGVSHEISTPLGI
ALTTATQVQSDSAAFERLVGENQLSRSRLTQYAGRMREGAQLLTSNLMRAADLLYSFKQVAADQAIEDRRALNLADWIDE
LLKSLRALARPGRHVFVVECPPDLVVDTLPGILAQVVSNAVKNAIEHGFQEREGGRITITGIRSGDGIGLSIADDGRGID
GADLGRVFDPFFTTARARGGTGLGLHIVHNLVVNRLQGRVELQSSAGAGTVLRLWLPERLA
>Mature_780_residues
TRGFGRSGIARRVLVVGAIPILVAAAIALGAWILLYEAERARTGAVVATETAQTLTSMNRARADAVSGGTARRDEAERRF
DERAATAAGQLERLEGLARTRGQSALVATVTGDLNSQVTRMRSLLLSERTATATIADMARRADALVALTDVARRRQQQDN
AQLIAVLAVKDAELERNQGVVTALRELREAISTAELNRARIGRPVFPIEFDELAADLRQLDAVGDRLRRVLRVDGEAGAA
DRATELLKAYRDRSRTEDDLNRVLSEGFELTRATQAGRVLVEWCDQLVQVSVARQNRLYEEVALLIRHSVLSNEAELSAQ
DIALTALRLARRTDAALARRDTAEASRVLEAGAELSGTSRTLLIPVSIRDEMAEAIDGWRAQLAATIEKIGEQNDTIADM
DSRAATMSANAQTLSRAFIDDADQFGSVIRQLLVVGAVGALCLGIGAAAAVARSITRPLHALQHSIVTAAAAPAPEDIGR
DGHLLTRRDELGDIARATNAFLEQIRRREADRRNASQRADDALTTLRQAQEDLIRAERLASLGQLVAGVSHEISTPLGIA
LTTATQVQSDSAAFERLVGENQLSRSRLTQYAGRMREGAQLLTSNLMRAADLLYSFKQVAADQAIEDRRALNLADWIDEL
LKSLRALARPGRHVFVVECPPDLVVDTLPGILAQVVSNAVKNAIEHGFQEREGGRITITGIRSGDGIGLSIADDGRGIDG
ADLGRVFDPFFTTARARGGTGLGLHIVHNLVVNRLQGRVELQSSAGAGTVLRLWLPERLA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=253, Percent_Identity=32.8063241106719, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=445, Percent_Identity=26.9662921348315, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=27.6859504132231, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=355, Percent_Identity=25.6338028169014, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=30.8641975308642, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84391; Mature: 84260

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50885 HAMP ; PS00099 THIOLASE_3 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGFGRSGIARRVLVVGAIPILVAAAIALGAWILLYEAERARTGAVVATETAQTLTSMN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCEEEHHHHHHHHHHH
RARADAVSGGTARRDEAERRFDERAATAAGQLERLEGLARTRGQSALVATVTGDLNSQVT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
RMRSLLLSERTATATIADMARRADALVALTDVARRRQQQDNAQLIAVLAVKDAELERNQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHCCC
VVTALRELREAISTAELNRARIGRPVFPIEFDELAADLRQLDAVGDRLRRVLRVDGEAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADRATELLKAYRDRSRTEDDLNRVLSEGFELTRATQAGRVLVEWCDQLVQVSVARQNRLY
HHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVALLIRHSVLSNEAELSAQDIALTALRLARRTDAALARRDTAEASRVLEAGAELSGTS
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RTLLIPVSIRDEMAEAIDGWRAQLAATIEKIGEQNDTIADMDSRAATMSANAQTLSRAFI
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHCCCHHHHHHHHH
DDADQFGSVIRQLLVVGAVGALCLGIGAAAAVARSITRPLHALQHSIVTAAAAPAPEDIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
RDGHLLTRRDELGDIARATNAFLEQIRRREADRRNASQRADDALTTLRQAQEDLIRAERL
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGQLVAGVSHEISTPLGIALTTATQVQSDSAAFERLVGENQLSRSRLTQYAGRMREGA
HHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
QLLTSNLMRAADLLYSFKQVAADQAIEDRRALNLADWIDELLKSLRALARPGRHVFVVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
PPDLVVDTLPGILAQVVSNAVKNAIEHGFQEREGGRITITGIRSGDGIGLSIADDGRGID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEEEEECCCCCEEEECCCCCCCC
GADLGRVFDPFFTTARARGGTGLGLHIVHNLVVNRLQGRVELQSSAGAGTVLRLWLPERL
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCCHHC
A
C
>Mature Secondary Structure 
TRGFGRSGIARRVLVVGAIPILVAAAIALGAWILLYEAERARTGAVVATETAQTLTSMN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCEEEHHHHHHHHHHH
RARADAVSGGTARRDEAERRFDERAATAAGQLERLEGLARTRGQSALVATVTGDLNSQVT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
RMRSLLLSERTATATIADMARRADALVALTDVARRRQQQDNAQLIAVLAVKDAELERNQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHCCC
VVTALRELREAISTAELNRARIGRPVFPIEFDELAADLRQLDAVGDRLRRVLRVDGEAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADRATELLKAYRDRSRTEDDLNRVLSEGFELTRATQAGRVLVEWCDQLVQVSVARQNRLY
HHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVALLIRHSVLSNEAELSAQDIALTALRLARRTDAALARRDTAEASRVLEAGAELSGTS
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RTLLIPVSIRDEMAEAIDGWRAQLAATIEKIGEQNDTIADMDSRAATMSANAQTLSRAFI
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHCCCHHHHHHHHH
DDADQFGSVIRQLLVVGAVGALCLGIGAAAAVARSITRPLHALQHSIVTAAAAPAPEDIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
RDGHLLTRRDELGDIARATNAFLEQIRRREADRRNASQRADDALTTLRQAQEDLIRAERL
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGQLVAGVSHEISTPLGIALTTATQVQSDSAAFERLVGENQLSRSRLTQYAGRMREGA
HHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
QLLTSNLMRAADLLYSFKQVAADQAIEDRRALNLADWIDELLKSLRALARPGRHVFVVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
PPDLVVDTLPGILAQVVSNAVKNAIEHGFQEREGGRITITGIRSGDGIGLSIADDGRGID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEEEEECCCCCEEEECCCCCCCC
GADLGRVFDPFFTTARARGGTGLGLHIVHNLVVNRLQGRVELQSSAGAGTVLRLWLPERL
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCCHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]