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The map label for this gene is Hgd [H]

Identifier: 170749653

GI number: 170749653

Start: 3443430

End: 3444335

Strand: Reverse

Name: Hgd [H]

Synonym: Mrad2831_3250

Alternate gene names: 170749653

Gene position: 3444335-3443430 (Counterclockwise)

Preceding gene: 170749654

Following gene: 170749652

Centisome position: 56.67

GC content: 71.3

Gene sequence:

>906_bases
ATGAACGGGAACCGGATCGGCTTCATCGGGCTCGGCAACATGGGCGGCCGCATGACGCGCAGCCTGACCGGGGCGGGGAT
TGACGTCGTCGGCTTCGACACCGACCCGGAGGCTGCGGCGCGCTGGGGCGCGACGGAAGCGGCCTCGATCGCCGCGGTCG
TCGGTGCGGCCGACGTGATCCTGATGTCGCTGCCCGACAGCAAGGTGGTTGAGCGCGTCGTGCTGGGCGAGGGCGGCGTC
CTCGCGGGCTGCCGGGACGGGCAGATCGTCGTCGACCTCAGCACGGCCGCGGCCAGCTCGACGCGCCGAATCGCCGGGGC
CCTGGCCGAGCGCGGCGTCGCCTACGTCGACGCGGGCATCTCCGGCGGCGCCGCCGCGGCCGAGACGGGCACGCTGACCC
TGATGGTCGGCGGCGATCAGGCGGTGATCGACCGGCTGGGCTGGGTCTTCGCGCCGATCGCCCGGAAGGTCGTCGTGATG
GGCGGCTCCGGCGCCGGCCACACGACCAAGCTGCTGAACAACTTCCTCAACGCGGTCAGCCTCGCCGCCACCGCGGAGGT
CATGGTCGCGGGCCGGAAGGCCGGGCTCGACCTGCACCGGCTCCTGGAGGTGCTGAACGCCTCCAGCGGCGTCAACTTCG
CGACGCTGAACCGTTTCCCGAAGATCGTCGACGGCGACTACCTGGAAGGCGGCCTGACCGGCAAGCTGATGACCAAGGAC
GTCGTGCTCTACACCGATCTCCTGCACGAGCTCGGCGTCGCCTCCCTGAACGCGTCGGGCCCGATGGCGAGCTTCGGCCT
CGCCACGGCGCTCGGCTACGGCGACGTCATCTCCAACCGCGTCGTCGATGCCATCGGCGACGTCTCCGGCGGCGTCCGGC
TCCACGAGAACGGACACGAGAACTGA

Upstream 100 bases:

>100_bases
GCGGCCTGATCGGCACCGTGGGCGCGCTCATCGGGCCGGAGACCAAGGACGTCGATTTCGGCACCGGCCACTGAGCCGGA
CGCCGCGCGGAGGACGCAGC

Downstream 100 bases:

>100_bases
GAGGATATCATGCAGATCTTCCATGGCCGCGAGAAGAGCGCGAAATCCGAGAGCCGCGGGCCGACCTTCACCGGGCAGGT
CTGGGCCGACCCGGTGATGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNGNRIGFIGLGNMGGRMTRSLTGAGIDVVGFDTDPEAAARWGATEAASIAAVVGAADVILMSLPDSKVVERVVLGEGGV
LAGCRDGQIVVDLSTAAASSTRRIAGALAERGVAYVDAGISGGAAAAETGTLTLMVGGDQAVIDRLGWVFAPIARKVVVM
GGSGAGHTTKLLNNFLNAVSLAATAEVMVAGRKAGLDLHRLLEVLNASSGVNFATLNRFPKIVDGDYLEGGLTGKLMTKD
VVLYTDLLHELGVASLNASGPMASFGLATALGYGDVISNRVVDAIGDVSGGVRLHENGHEN

Sequences:

>Translated_301_residues
MNGNRIGFIGLGNMGGRMTRSLTGAGIDVVGFDTDPEAAARWGATEAASIAAVVGAADVILMSLPDSKVVERVVLGEGGV
LAGCRDGQIVVDLSTAAASSTRRIAGALAERGVAYVDAGISGGAAAAETGTLTLMVGGDQAVIDRLGWVFAPIARKVVVM
GGSGAGHTTKLLNNFLNAVSLAATAEVMVAGRKAGLDLHRLLEVLNASSGVNFATLNRFPKIVDGDYLEGGLTGKLMTKD
VVLYTDLLHELGVASLNASGPMASFGLATALGYGDVISNRVVDAIGDVSGGVRLHENGHEN
>Mature_301_residues
MNGNRIGFIGLGNMGGRMTRSLTGAGIDVVGFDTDPEAAARWGATEAASIAAVVGAADVILMSLPDSKVVERVVLGEGGV
LAGCRDGQIVVDLSTAAASSTRRIAGALAERGVAYVDAGISGGAAAAETGTLTLMVGGDQAVIDRLGWVFAPIARKVVVM
GGSGAGHTTKLLNNFLNAVSLAATAEVMVAGRKAGLDLHRLLEVLNASSGVNFATLNRFPKIVDGDYLEGGLTGKLMTKD
VVLYTDLLHELGVASLNASGPMASFGLATALGYGDVISNRVVDAIGDVSGGVRLHENGHEN

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=250, Percent_Identity=34.4, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=26.4285714285714, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI145693186, Length=251, Percent_Identity=34.6613545816733, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786719, Length=203, Percent_Identity=34.9753694581281, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790315, Length=252, Percent_Identity=29.3650793650794, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789092, Length=275, Percent_Identity=31.2727272727273, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=265, Percent_Identity=33.5849056603774, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24655230, Length=247, Percent_Identity=31.1740890688259, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19922568, Length=247, Percent_Identity=31.1740890688259, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=26.1484098939929, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30500; Mature: 30500

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGNRIGFIGLGNMGGRMTRSLTGAGIDVVGFDTDPEAAARWGATEAASIAAVVGAADVI
CCCCEEEEEEECCCCCHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHEEE
LMSLPDSKVVERVVLGEGGVLAGCRDGQIVVDLSTAAASSTRRIAGALAERGVAYVDAGI
EEECCCHHHHHHHHCCCCCEEEECCCCEEEEEECHHHCHHHHHHHHHHHHCCEEEEECCC
SGGAAAAETGTLTLMVGGDQAVIDRLGWVFAPIARKVVVMGGSGAGHTTKLLNNFLNAVS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHH
LAATAEVMVAGRKAGLDLHRLLEVLNASSGVNFATLNRFPKIVDGDYLEGGLTGKLMTKD
HHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHH
VVLYTDLLHELGVASLNASGPMASFGLATALGYGDVISNRVVDAIGDVSGGVRLHENGHE
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEECCCCCC
N
C
>Mature Secondary Structure
MNGNRIGFIGLGNMGGRMTRSLTGAGIDVVGFDTDPEAAARWGATEAASIAAVVGAADVI
CCCCEEEEEEECCCCCHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHEEE
LMSLPDSKVVERVVLGEGGVLAGCRDGQIVVDLSTAAASSTRRIAGALAERGVAYVDAGI
EEECCCHHHHHHHHCCCCCEEEECCCCEEEEEECHHHCHHHHHHHHHHHHCCEEEEECCC
SGGAAAAETGTLTLMVGGDQAVIDRLGWVFAPIARKVVVMGGSGAGHTTKLLNNFLNAVS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHH
LAATAEVMVAGRKAGLDLHRLLEVLNASSGVNFATLNRFPKIVDGDYLEGGLTGKLMTKD
HHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHH
VVLYTDLLHELGVASLNASGPMASFGLATALGYGDVISNRVVDAIGDVSGGVRLHENGHE
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEECCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA