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The map label for this gene is pntAA [H]

Identifier: 170749207

GI number: 170749207

Start: 2940041

End: 2941270

Strand: Reverse

Name: pntAA [H]

Synonym: Mrad2831_2800

Alternate gene names: 170749207

Gene position: 2941270-2940041 (Counterclockwise)

Preceding gene: 170749208

Following gene: 170749206

Centisome position: 48.39

GC content: 69.84

Gene sequence:

>1230_bases
ATGCGCATTGCTGTGCTGTCCGAGACGGACTCCGCGGAGCCGCGCGTCGCCGCGGTTCCTGAGACCGTCAAGAAGTTCAA
ATCTCTCGGTGCTGACGTCGTGGTGCAGTCCGGAGCGGGCCAGAGGGCCGGCATTCTGGATTCCGAGTACGAGGCCGCCG
GCGCCGGCATAGCGGGGAGCGCCGCCGATGCCGCCAGGGATGCCGACCTCGTGCTGAAGGTCCGGCGCCCGAGCGCCGAA
GAGCTGCCGCAGTTGAAGCGTGGCGCCACCGTGATCGCGATCATGGACCCCTACGGCAACGAGGAAGCCTTGAGGGCGAT
GGCCGAGGCCGGCGTCGACGGCTTCGCCATGGAGCTGATGCCCCGCATCACCCGCGCGCAGGTGATGGACGTCCTGTCCT
CGCAGGCGAATCTCGCCGGTTACCGCGCGGTCGTCGACGGCGCCGCCGAGTACGGCCGGGCGATGCCGATGATGATGACC
GCCGCCGGCACGGTGCCGGCCGCCCGCGTGTTCGTCATGGGCGTCGGCGTGGCCGGCCTCCAGGCCATCGCGACCGCCCG
ACGCCTCGGCGCGGTCGTCACCGCCACCGATGTCCGGCCCGCCACCAAGGAGCAGGTCGAATCGCTGGGCGCCAAGTTCG
TCGCCGTCGAGGACGACGAGTTCAAGCAGGCCGAGACCGCCGGCGGTTACGCCAAGGAGATGTCGGCCGAGTATCAGAAG
AAGCAGGCAGAGCTGGTCAAGGGCCACATCGCCAAGCAGGATATCGTCATCACCACCGCGCTGATCCCCGGCCGGCCGGC
GCCGAAGCTGGTCTCCGAGGAGATGGTGGCGTCGATGAAGCCGGGTTCGGTGCTGGTCGACCTCGCGGTGGAGCGCGGCG
GCAACGTCGCCGGCGCCAAGGCCGGCGAGGTCGTCACGAACGACCGCGGCGTGAAGATCGTCGGCCACGTCAATGTGCCG
GGGCGGCTCGCCGCCACGTCGTCGAGCCTCTACGCCCGCAACCTCTACGCCTTCGTCGAGACCCTGATCGACAAGGAGTC
GAAGGCGCTGGCCATCAACTGGGACGACGAGCTGGTGAAGGCCACGAACCTCACCCGCGACGGCGCGGTCGTGCACGCGT
CCTTCCAGCCCAAGACCGATGGCGCAGCCTCGGAAGCCGCCTCCGTGGGGCTGGCCAAGTCGGAGGCCAACAAGGCGTCC
GGCACGGCCACCCCGGCGGGCGCGCAGTGA

Upstream 100 bases:

>100_bases
ACATTCCGGCCGCTTCCAACGCGGTATCGTAGGTCCGCCTCTCGAAAAGCGTCGCCGGTTCGCGCATTCGAAGGCCGAGC
TTTTCCAGGGGAACCCTCGC

Downstream 100 bases:

>100_bases
AGCCCGGCCGAGAGGAGTAGCAGAATGGCAAACGTCATCGTCCCTCCCGATCAGGCCGCCGATCAGGCCCGCGTGCTGGC
CGACGCCGCGCGCGCGGCGG

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRIAVLSETDSAEPRVAAVPETVKKFKSLGADVVVQSGAGQRAGILDSEYEAAGAGIAGSAADAARDADLVLKVRRPSAE
ELPQLKRGATVIAIMDPYGNEEALRAMAEAGVDGFAMELMPRITRAQVMDVLSSQANLAGYRAVVDGAAEYGRAMPMMMT
AAGTVPAARVFVMGVGVAGLQAIATARRLGAVVTATDVRPATKEQVESLGAKFVAVEDDEFKQAETAGGYAKEMSAEYQK
KQAELVKGHIAKQDIVITTALIPGRPAPKLVSEEMVASMKPGSVLVDLAVERGGNVAGAKAGEVVTNDRGVKIVGHVNVP
GRLAATSSSLYARNLYAFVETLIDKESKALAINWDDELVKATNLTRDGAVVHASFQPKTDGAASEAASVGLAKSEANKAS
GTATPAGAQ

Sequences:

>Translated_409_residues
MRIAVLSETDSAEPRVAAVPETVKKFKSLGADVVVQSGAGQRAGILDSEYEAAGAGIAGSAADAARDADLVLKVRRPSAE
ELPQLKRGATVIAIMDPYGNEEALRAMAEAGVDGFAMELMPRITRAQVMDVLSSQANLAGYRAVVDGAAEYGRAMPMMMT
AAGTVPAARVFVMGVGVAGLQAIATARRLGAVVTATDVRPATKEQVESLGAKFVAVEDDEFKQAETAGGYAKEMSAEYQK
KQAELVKGHIAKQDIVITTALIPGRPAPKLVSEEMVASMKPGSVLVDLAVERGGNVAGAKAGEVVTNDRGVKIVGHVNVP
GRLAATSSSLYARNLYAFVETLIDKESKALAINWDDELVKATNLTRDGAVVHASFQPKTDGAASEAASVGLAKSEANKAS
GTATPAGAQ
>Mature_409_residues
MRIAVLSETDSAEPRVAAVPETVKKFKSLGADVVVQSGAGQRAGILDSEYEAAGAGIAGSAADAARDADLVLKVRRPSAE
ELPQLKRGATVIAIMDPYGNEEALRAMAEAGVDGFAMELMPRITRAQVMDVLSSQANLAGYRAVVDGAAEYGRAMPMMMT
AAGTVPAARVFVMGVGVAGLQAIATARRLGAVVTATDVRPATKEQVESLGAKFVAVEDDEFKQAETAGGYAKEMSAEYQK
KQAELVKGHIAKQDIVITTALIPGRPAPKLVSEEMVASMKPGSVLVDLAVERGGNVAGAKAGEVVTNDRGVKIVGHVNVP
GRLAATSSSLYARNLYAFVETLIDKESKALAINWDDELVKATNLTRDGAVVHASFQPKTDGAASEAASVGLAKSEANKAS
GTATPAGAQ

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=418, Percent_Identity=37.799043062201, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI122939153, Length=418, Percent_Identity=37.799043062201, Blast_Score=243, Evalue=3e-64,
Organism=Escherichia coli, GI1787887, Length=370, Percent_Identity=43.7837837837838, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17550456, Length=368, Percent_Identity=44.0217391304348, Blast_Score=290, Evalue=8e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 42320; Mature: 42320

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVLSETDSAEPRVAAVPETVKKFKSLGADVVVQSGAGQRAGILDSEYEAAGAGIAGS
CEEEEEECCCCCCCCEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCC
AADAARDADLVLKVRRPSAEELPQLKRGATVIAIMDPYGNEEALRAMAEAGVDGFAMELM
CHHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVVDGAAEYGRAMPMMMTAAGTVPAARVFVMGVGVAGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCHHHH
QAIATARRLGAVVTATDVRPATKEQVESLGAKFVAVEDDEFKQAETAGGYAKEMSAEYQK
HHHHHHHHHCEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHH
KQAELVKGHIAKQDIVITTALIPGRPAPKLVSEEMVASMKPGSVLVDLAVERGGNVAGAK
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
AGEVVTNDRGVKIVGHVNVPGRLAATSSSLYARNLYAFVETLIDKESKALAINWDDELVK
CCCEEECCCCEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
ATNLTRDGAVVHASFQPKTDGAASEAASVGLAKSEANKASGTATPAGAQ
HHCCCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIAVLSETDSAEPRVAAVPETVKKFKSLGADVVVQSGAGQRAGILDSEYEAAGAGIAGS
CEEEEEECCCCCCCCEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCC
AADAARDADLVLKVRRPSAEELPQLKRGATVIAIMDPYGNEEALRAMAEAGVDGFAMELM
CHHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVVDGAAEYGRAMPMMMTAAGTVPAARVFVMGVGVAGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCCHHHH
QAIATARRLGAVVTATDVRPATKEQVESLGAKFVAVEDDEFKQAETAGGYAKEMSAEYQK
HHHHHHHHHCEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHH
KQAELVKGHIAKQDIVITTALIPGRPAPKLVSEEMVASMKPGSVLVDLAVERGGNVAGAK
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
AGEVVTNDRGVKIVGHVNVPGRLAATSSSLYARNLYAFVETLIDKESKALAINWDDELVK
CCCEEECCCCEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
ATNLTRDGAVVHASFQPKTDGAASEAASVGLAKSEANKASGTATPAGAQ
HHCCCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]