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The map label for this gene is hmrR [H]

Identifier: 170748951

GI number: 170748951

Start: 2696944

End: 2697417

Strand: Reverse

Name: hmrR [H]

Synonym: Mrad2831_2538

Alternate gene names: 170748951

Gene position: 2697417-2696944 (Counterclockwise)

Preceding gene: 170748956

Following gene: 170748941

Centisome position: 44.38

GC content: 73.42

Gene sequence:

>474_bases
ATGAACATCGGCCAGGCTGCCCGGGCCTCCGGGGTTTCGGCCAAGATGATCCGGCACTACGAGAGCATCGGCCTCGTGCC
CCCGGCCGACCGGCGGGACAGCGGCTACCGGGACTACGGCGCCGCCGACCTGCACCGGCTCGGCTTCATTCGGCACGCCC
GGGACCTCGGCTTCTCCCTGGAGCGCATCAGGGTACTGCTCGGCCTCTGGAGCGACCCCGGCCGGAGCAACGCCGACGTG
AAGGCCATCGCCAGGGCGCACGTCCGGGAGCTTGAGGATCGCGCCCGCCAACTCAACGAGATGGCCGATGCCCTGCGCAC
CCTGGCGGACGCCTGCGACGGCGACGGGCGACCGGACTGCCCGATCATCGCCAGCCTGGAGACCGGGGCGGACGTCCCGG
CCTGCCACGCGTCCCCCGCCCCGACGGCGTCGGCACCCCCGGCGCCTCGCGGGAAGGCCCGGGCAAAGCGTTGA

Upstream 100 bases:

>100_bases
CGCTCCCGGTGCGGGGCGGCGGGCGTGGTCGCTCGTCATGGGTTGCGGAAGGTTGTGAACCTTCCCATCATAGTAAGGTC
AACACGGGGTTGGTTCCGTC

Downstream 100 bases:

>100_bases
GGACGGGACGGCCCCGCTCGCAATGCCCGGACGGCCGCCTCACATCCTCATCGACTTGCCCATTCCCTCGCAGCAGCAGC
CCTTCTTGCCGCCCTTCATG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNIGQAARASGVSAKMIRHYESIGLVPPADRRDSGYRDYGAADLHRLGFIRHARDLGFSLERIRVLLGLWSDPGRSNADV
KAIARAHVRELEDRARQLNEMADALRTLADACDGDGRPDCPIIASLETGADVPACHASPAPTASAPPAPRGKARAKR

Sequences:

>Translated_157_residues
MNIGQAARASGVSAKMIRHYESIGLVPPADRRDSGYRDYGAADLHRLGFIRHARDLGFSLERIRVLLGLWSDPGRSNADV
KAIARAHVRELEDRARQLNEMADALRTLADACDGDGRPDCPIIASLETGADVPACHASPAPTASAPPAPRGKARAKR
>Mature_157_residues
MNIGQAARASGVSAKMIRHYESIGLVPPADRRDSGYRDYGAADLHRLGFIRHARDLGFSLERIRVLLGLWSDPGRSNADV
KAIARAHVRELEDRARQLNEMADALRTLADACDGDGRPDCPIIASLETGADVPACHASPAPTASAPPAPRGKARAKR

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=126, Percent_Identity=44.4444444444444, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1789687, Length=131, Percent_Identity=40.4580152671756, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16872; Mature: 16872

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGQAARASGVSAKMIRHYESIGLVPPADRRDSGYRDYGAADLHRLGFIRHARDLGFSL
CCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHH
ERIRVLLGLWSDPGRSNADVKAIARAHVRELEDRARQLNEMADALRTLADACDGDGRPDC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PIIASLETGADVPACHASPAPTASAPPAPRGKARAKR
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIGQAARASGVSAKMIRHYESIGLVPPADRRDSGYRDYGAADLHRLGFIRHARDLGFSL
CCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHH
ERIRVLLGLWSDPGRSNADVKAIARAHVRELEDRARQLNEMADALRTLADACDGDGRPDC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PIIASLETGADVPACHASPAPTASAPPAPRGKARAKR
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]