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The map label for this gene is pdhR [H]

Identifier: 170748956

GI number: 170748956

Start: 2701822

End: 2702604

Strand: Reverse

Name: pdhR [H]

Synonym: Mrad2831_2543

Alternate gene names: 170748956

Gene position: 2702604-2701822 (Counterclockwise)

Preceding gene: 170748961

Following gene: 170748951

Centisome position: 44.47

GC content: 65.77

Gene sequence:

>783_bases
ATGGAGGAGGACTCGATCAAGGGGGCGAGCGCTGCCGAGAGCACAGCGCGCCACCTGAAGGACCTGATCCGCGAGGGTTC
TCTCAGCCCGGGCGATCATCTACTGCCCGAGCGTGATCTGGCCGTGCAGCTCAACGTGTCGCGCCCGACCTTGCGACAGG
GCATCAAGATCCTGGAGGACGAAGGCCTCATCGTCCAAACGCCCACCGGACGCTCGGTGGCCGCCCTCGGCCGCGGGATC
ACGGACCCGCTGATCGCGCTCATCGCCTCCCATGCGGAGGTCGTGGACGATTACCTGGAGTTCCGGGCGACGACCGAACG
GCTAGCGGCCCGCCTCGCGGCCGAACGCGCGAACAGCGTCGATCGCGAGCGGCTCAGCCTCTGTATGGATCGCATCGACC
GCGCTCACGAGAGCGGCGTCCGGCGCGAGGAGGCGGAGGCGGATGTCGACCTGCACATCGCGGTCTACGAGGCGAGCCAC
AACCTCGTCGTTCTGCACACGATGCGGGCGTTGTCCGGCCTGCTCCGTCAGGGTGTGATCGAGAACCGCGAGACCTTGTT
CTCCCGTCCGGAGACGCGCGACCAACTGCGTGCGCAACATCGGGCGATCTTCGAGAGCGTGCTGGCCGGAAATGCGGAGG
AAGCCGCCAATGCCGCTGAGGCGCACGTTCACTACACGCACCACGCCCTAAGTGAGATCAAAGCATCGGAAGCGCGTCTT
CAGGTATCGTTGCGCAGGCTGAATGGGGGTCGGGTTTCGACACGGCAGAAAGTCGAGCGATAG

Upstream 100 bases:

>100_bases
TGGTAAAACAATTTTACCAATCGTGTCAACTGGACATGGCGCTTGCCCGAGCTACAGTTGTCAGGCGGGGCGGGTTGGTA
CGGGTGAGTGGGAGCGGGAG

Downstream 100 bases:

>100_bases
GCTCTGATCAGCGCAGTAAAGCCTTTGACGCATCGTGACACCGCGAAACATGCGTCCGCTTTCGGGATCCGCATGGCTGT
ATGTGAATGACTTAGTTGAG

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MEEDSIKGASAAESTARHLKDLIREGSLSPGDHLLPERDLAVQLNVSRPTLRQGIKILEDEGLIVQTPTGRSVAALGRGI
TDPLIALIASHAEVVDDYLEFRATTERLAARLAAERANSVDRERLSLCMDRIDRAHESGVRREEAEADVDLHIAVYEASH
NLVVLHTMRALSGLLRQGVIENRETLFSRPETRDQLRAQHRAIFESVLAGNAEEAANAAEAHVHYTHHALSEIKASEARL
QVSLRRLNGGRVSTRQKVER

Sequences:

>Translated_260_residues
MEEDSIKGASAAESTARHLKDLIREGSLSPGDHLLPERDLAVQLNVSRPTLRQGIKILEDEGLIVQTPTGRSVAALGRGI
TDPLIALIASHAEVVDDYLEFRATTERLAARLAAERANSVDRERLSLCMDRIDRAHESGVRREEAEADVDLHIAVYEASH
NLVVLHTMRALSGLLRQGVIENRETLFSRPETRDQLRAQHRAIFESVLAGNAEEAANAAEAHVHYTHHALSEIKASEARL
QVSLRRLNGGRVSTRQKVER
>Mature_260_residues
MEEDSIKGASAAESTARHLKDLIREGSLSPGDHLLPERDLAVQLNVSRPTLRQGIKILEDEGLIVQTPTGRSVAALGRGI
TDPLIALIASHAEVVDDYLEFRATTERLAARLAAERANSVDRERLSLCMDRIDRAHESGVRREEAEADVDLHIAVYEASH
NLVVLHTMRALSGLLRQGVIENRETLFSRPETRDQLRAQHRAIFESVLAGNAEEAANAAEAHVHYTHHALSEIKASEARL
QVSLRRLNGGRVSTRQKVER

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=232, Percent_Identity=37.0689655172414, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790032, Length=244, Percent_Identity=33.1967213114754, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789353, Length=229, Percent_Identity=33.1877729257642, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28769; Mature: 28769

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEDSIKGASAAESTARHLKDLIREGSLSPGDHLLPERDLAVQLNVSRPTLRQGIKILED
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCC
EGLIVQTPTGRSVAALGRGITDPLIALIASHAEVVDDYLEFRATTERLAARLAAERANSV
CCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRERLSLCMDRIDRAHESGVRREEAEADVDLHIAVYEASHNLVVLHTMRALSGLLRQGVI
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHH
ENRETLFSRPETRDQLRAQHRAIFESVLAGNAEEAANAAEAHVHYTHHALSEIKASEARL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVSLRRLNGGRVSTRQKVER
HHHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure
MEEDSIKGASAAESTARHLKDLIREGSLSPGDHLLPERDLAVQLNVSRPTLRQGIKILED
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCC
EGLIVQTPTGRSVAALGRGITDPLIALIASHAEVVDDYLEFRATTERLAARLAAERANSV
CCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRERLSLCMDRIDRAHESGVRREEAEADVDLHIAVYEASHNLVVLHTMRALSGLLRQGVI
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHH
ENRETLFSRPETRDQLRAQHRAIFESVLAGNAEEAANAAEAHVHYTHHALSEIKASEARL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVSLRRLNGGRVSTRQKVER
HHHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]