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The map label for this gene is envZ [H]

Identifier: 170748890

GI number: 170748890

Start: 2633648

End: 2635057

Strand: Reverse

Name: envZ [H]

Synonym: Mrad2831_2472

Alternate gene names: 170748890

Gene position: 2635057-2633648 (Counterclockwise)

Preceding gene: 170748891

Following gene: 170748888

Centisome position: 43.36

GC content: 74.33

Gene sequence:

>1410_bases
ATGAGCGGCCTGGGGCGGCTCCGCGCGCGGCTGCGCCCGAAGACCATCGCGGGCCAGATCGCGCTGCTCGTGGTCGCCGG
CATCGCGGTCGCCCACGTGGTCGCCACCGCGGCCTTCCTGATCCTGCACGAGTCGCAGAATCCCGACACGCTGCCGGGCG
TGGCCGCGAGCCGCCTCGGGGTCCTGGTGAGGCTCATGGACGCCGCAGACCCGGCGGCGCGACCGGCCCTCCTGGCGAGC
GGTCGCAGCCTGCCGCTGATCCACGTGGAGCCCTGGGACGGGACGGTGCCGTCGGGGGCGACGTCGCCGCCCGACCTGCC
GGTGATCCGGAAGCTGCGCAACGGCGCCGGTCGGCCCGTGACGATCACCGACCTCTCGGCGGCCGATCCCGAGCGCGGCC
GGTCGGACGCGCGTCTCCATATCGGCGTCGTCACGCCGACGGGGGCGCGGCTCCAGGCGACGCTGCCGAACGATCCCCTC
CGGGGTCCCCGCCAGGGGGCGCTGATCTTCACCCTGGTGTTCCTGGCGCTGACGCTGGCGCTGCTCTGCGTCTGGGCCAC
CCGCGCCCTCACGGCGCCGCTGAAGCGGCTCGCGGGCGCCGCCGAGGCGTTCGGCGCCCGCGACGACCACGTGGCGCTGC
CGGAGGCGGGCCCGCGCGAGGTCCTCGCCGTGTCCCGGGCGCTGGACCGGATGCGGTCGCGCGTCCGCCGCCTGATCGAC
GATCGGACCCAGATGCTGGCAGCGATCAGCCACGACCTGCGCACGCCGATCACCCGGCTCCGCCTGCGTGCCGAGTTCAT
CGAGGACGAGAATGCCCGGGCCTCGACCCTGCGCGACCTCGACCAGATGAACGGCCTCGTCGAGGCGGCGCTCTCCTTCG
TGCGCGACGGCCAGATCCGGGACGCGAACAGCCACAGCCTCGTGGATCTCGCCTCGGTGGTGCAGACGGTCTGCGACGAC
TTCTCGGATTTCGGCGCCCCGGTCAGCGTCAGCCGCAGCCGGCACGTCCTGGTCCAGGGCCGGCCCGAGGAGCTCCAGCG
GGCGGTGACCAACCTCGTGGACAACGCCGTGAAGTACGGCGGGCGGGCCGACGTTCAGATGGAGGCCTCCGAGCGCGGTG
TCCGGGTCTGCATCTTGGATAACGGCCCGGGGATCCCCGAGGCGGAGCGCGAGGCGATGCTCCAGCCCTTCGTGCGCGGC
GACCGGGCGCGCAATCTCAACGAGGCGAGCGGCTTCGGCCTCGGCCTCTCGATCGTGCAGGCCATCGTCGAGGCCCATAA
CGGGCGCCTGCGGCTGGAGAACCGCCCCGAGGGCGGGCTCTGCGCGGCGATCGAGCTGCCCCTGGCCGCCCAGGCCTTCG
CGGGTCGCGCGGCGCAGAAGCCCGCGCCGCTCCCGGCCGAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCGGATCCGCCAGAAGATCGAGCGCGACACCCGCAACCCCGAGTTCATCCGCACGATCCGGTCCGGCGGCTACCTGTTC
ACGCCCGAGGTCACGCGGTC

Downstream 100 bases:

>100_bases
GGCCGCCCCGGGGGTCGCGTCCGGCCTACGCCGCCCGCACGTTGCGGAGGAACTGCGCCACCTCGGCGCGGAGCTGCTCC
GAGCGCGTGGCCAGGGCGTC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSGLGRLRARLRPKTIAGQIALLVVAGIAVAHVVATAAFLILHESQNPDTLPGVAASRLGVLVRLMDAADPAARPALLAS
GRSLPLIHVEPWDGTVPSGATSPPDLPVIRKLRNGAGRPVTITDLSAADPERGRSDARLHIGVVTPTGARLQATLPNDPL
RGPRQGALIFTLVFLALTLALLCVWATRALTAPLKRLAGAAEAFGARDDHVALPEAGPREVLAVSRALDRMRSRVRRLID
DRTQMLAAISHDLRTPITRLRLRAEFIEDENARASTLRDLDQMNGLVEAALSFVRDGQIRDANSHSLVDLASVVQTVCDD
FSDFGAPVSVSRSRHVLVQGRPEELQRAVTNLVDNAVKYGGRADVQMEASERGVRVCILDNGPGIPEAEREAMLQPFVRG
DRARNLNEASGFGLGLSIVQAIVEAHNGRLRLENRPEGGLCAAIELPLAAQAFAGRAAQKPAPLPAEAA

Sequences:

>Translated_469_residues
MSGLGRLRARLRPKTIAGQIALLVVAGIAVAHVVATAAFLILHESQNPDTLPGVAASRLGVLVRLMDAADPAARPALLAS
GRSLPLIHVEPWDGTVPSGATSPPDLPVIRKLRNGAGRPVTITDLSAADPERGRSDARLHIGVVTPTGARLQATLPNDPL
RGPRQGALIFTLVFLALTLALLCVWATRALTAPLKRLAGAAEAFGARDDHVALPEAGPREVLAVSRALDRMRSRVRRLID
DRTQMLAAISHDLRTPITRLRLRAEFIEDENARASTLRDLDQMNGLVEAALSFVRDGQIRDANSHSLVDLASVVQTVCDD
FSDFGAPVSVSRSRHVLVQGRPEELQRAVTNLVDNAVKYGGRADVQMEASERGVRVCILDNGPGIPEAEREAMLQPFVRG
DRARNLNEASGFGLGLSIVQAIVEAHNGRLRLENRPEGGLCAAIELPLAAQAFAGRAAQKPAPLPAEAA
>Mature_468_residues
SGLGRLRARLRPKTIAGQIALLVVAGIAVAHVVATAAFLILHESQNPDTLPGVAASRLGVLVRLMDAADPAARPALLASG
RSLPLIHVEPWDGTVPSGATSPPDLPVIRKLRNGAGRPVTITDLSAADPERGRSDARLHIGVVTPTGARLQATLPNDPLR
GPRQGALIFTLVFLALTLALLCVWATRALTAPLKRLAGAAEAFGARDDHVALPEAGPREVLAVSRALDRMRSRVRRLIDD
RTQMLAAISHDLRTPITRLRLRAEFIEDENARASTLRDLDQMNGLVEAALSFVRDGQIRDANSHSLVDLASVVQTVCDDF
SDFGAPVSVSRSRHVLVQGRPEELQRAVTNLVDNAVKYGGRADVQMEASERGVRVCILDNGPGIPEAEREAMLQPFVRGD
RARNLNEASGFGLGLSIVQAIVEAHNGRLRLENRPEGGLCAAIELPLAAQAFAGRAAQKPAPLPAEAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=327, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=29.5620437956204, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787894, Length=289, Percent_Identity=30.4498269896194, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=27.8169014084507, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=31.2757201646091, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=28.7719298245614, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=326, Percent_Identity=28.2208588957055, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=246, Percent_Identity=28.8617886178862, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=23.7918215613383, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786783, Length=281, Percent_Identity=26.3345195729537, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=26.962457337884, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=28.0172413793103, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788279, Length=316, Percent_Identity=25.6329113924051, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=271, Percent_Identity=25.0922509225092, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=24.3478260869565, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=27.6094276094276, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=354, Percent_Identity=24.8587570621469, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49971; Mature: 49840

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLGRLRARLRPKTIAGQIALLVVAGIAVAHVVATAAFLILHESQNPDTLPGVAASRLG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHH
VLVRLMDAADPAARPALLASGRSLPLIHVEPWDGTVPSGATSPPDLPVIRKLRNGAGRPV
HHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCE
TITDLSAADPERGRSDARLHIGVVTPTGARLQATLPNDPLRGPRQGALIFTLVFLALTLA
EEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LLCVWATRALTAPLKRLAGAAEAFGARDDHVALPEAGPREVLAVSRALDRMRSRVRRLID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRTQMLAAISHDLRTPITRLRLRAEFIEDENARASTLRDLDQMNGLVEAALSFVRDGQIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DANSHSLVDLASVVQTVCDDFSDFGAPVSVSRSRHVLVQGRPEELQRAVTNLVDNAVKYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCC
GRADVQMEASERGVRVCILDNGPGIPEAEREAMLQPFVRGDRARNLNEASGFGLGLSIVQ
CCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHH
AIVEAHNGRLRLENRPEGGLCAAIELPLAAQAFAGRAAQKPAPLPAEAA
HHHHHCCCEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGLGRLRARLRPKTIAGQIALLVVAGIAVAHVVATAAFLILHESQNPDTLPGVAASRLG
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHH
VLVRLMDAADPAARPALLASGRSLPLIHVEPWDGTVPSGATSPPDLPVIRKLRNGAGRPV
HHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCE
TITDLSAADPERGRSDARLHIGVVTPTGARLQATLPNDPLRGPRQGALIFTLVFLALTLA
EEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LLCVWATRALTAPLKRLAGAAEAFGARDDHVALPEAGPREVLAVSRALDRMRSRVRRLID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DRTQMLAAISHDLRTPITRLRLRAEFIEDENARASTLRDLDQMNGLVEAALSFVRDGQIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DANSHSLVDLASVVQTVCDDFSDFGAPVSVSRSRHVLVQGRPEELQRAVTNLVDNAVKYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCC
GRADVQMEASERGVRVCILDNGPGIPEAEREAMLQPFVRGDRARNLNEASGFGLGLSIVQ
CCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHH
AIVEAHNGRLRLENRPEGGLCAAIELPLAAQAFAGRAAQKPAPLPAEAA
HHHHHCCCEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]