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The map label for this gene is glmS [H]

Identifier: 170748836

GI number: 170748836

Start: 2580131

End: 2581957

Strand: Reverse

Name: glmS [H]

Synonym: Mrad2831_2418

Alternate gene names: 170748836

Gene position: 2581957-2580131 (Counterclockwise)

Preceding gene: 170748837

Following gene: 170748835

Centisome position: 42.48

GC content: 71.48

Gene sequence:

>1827_bases
ATGTGCGGCATCGTCGGCATCGTCGGGCGCGACGCGGTGGCGGGGCAGGTGATCGAGGCCCTGCGGCGGCTCGAGTACCG
CGGCTACGATTCCGCCGGCATCGCCACCCTGGAGCACGGCCGGCTGGCGCGGCGCCGGGCCTCGGGCAAGCTGGTCAACC
TGGAGGCCAAGCTCGCCCAGGAGCCGCTCACCGGCACGATCGGCATCGGCCATACCCGCTGGGCGACCCACGGCCGGCCC
AACGAGACCAACGCCCACCCGCACGCCACAGCGCGCCTGGCGGTCGTGCACAACGGCATCATCGAGAATTTCCGCGAGCT
CAAGCAGGAGCTGGAGGCCGACGGCGTCGTCTTCGAGACCGAGACCGACACCGAGGTCGTCGCCCAGCTCGTCAGCCGCA
ACATGGACCGGCAGATGGGGCCGGTCGAGGCGGTCGCCGCCGCCCTGCCGCGGCTGCGCGGCGCCTTCGCGCTGGGCTTC
CTCTTCTCCGGCGAGGAGAACCTGCTGATCGGGGCCCGCCACGGGGCGCCGCTGGCGATCGGCTTCGGCGAGGGCGAGAC
CTACCTGGGCTCCGACGCCCTGGCGCTCGCCCCGTTCACCGACGCGATCACGTATCTCGACGAGGGCGACTGGGCGATCC
TGTCCCGGGGCGGCGCGGAGATCCGCGACGCGTCGGGCGCCACGGTCGAGCGCGCCCGGCAGAAGATCGCCACGCAGGCC
TACCGGATCGACAAGGGCGAGTACCGCCACTTCATGGCCAAGGAGATCCACGAGCAGCCCGAGGTGGTGGGCCGCACGCT
CGCCCACTACGTCGACATGGCGAACGGGCGGGTCATGCTGCCCGAGGCGCTGCCCTTCGACTTCGCCAAGCTCAGCCGCG
TCTACATCACCGCCTGCGGCACGGCCTACTACGCGGGCCTCGTCGCCCGCTACTGGTTCGAGCAGGTGGCGCGCCTGCCG
GTGGAGATCGACGTCGCCTCCGAGGCCCGCTACCGCGAGGCGCCGCTGGAGAAGGACGGGCTGACGCTGGTGATCTCGCA
ATCGGGCGAGACCGCCGACACGCTGGCCTCCCTGCGCTACGCGAAGACCCAGGGCCAGCACACGCTGAGCGTCGTCAACG
TGCCGACCTCGACCATCGCGCGGGAATCCTCCGTGGTGATGCCGACGCTGGCCGGGCCGGAGATCGGCGTCGCCTCCACC
AAGGCGTTCTCGTGCCAGCTCACCGTGCTGCTCTGCCTCGCCATCGCGGCGGGGCGCGCCCGCGGCACGCTCGACGCAGC
GGGCGAGCGGCGCCTGGTCGACGGCCTGATCAAGGCGCCGGGCCTGATGGCGGAGGCGCTGACCCACGAGGCGGCGATCG
AGGGTCTGGCGCGGGAGGTCGCGAAGGCGCGGGACGTGCTCTATCTCGGCCGCGGCACCAGCTACCCGATGGCGCTGGAA
GGCGCGCTGAAGCTCAAGGAGATCAGCTACATCCACGCCGAGGGCTACGCGGCGGGCGAGCTGAAGCACGGGCCGATCGC
CCTGATCGACGAGAGCGTGCCGGTGATCGTCATCGCGCCGCACGACGCGGTGTTCGAGAAGACCGTCTCGAACATGCAGG
AGGTGGCCGCCCGCGGCGGGCGCATCGTGCTGATCGGCGACGCCAAGGGCGCGGCCGAGCACGGGCTGGACACGCTCGCG
ACCTTCACCATGCCGGCGCTCGATCCGACGGTGGCGCCGATCGTGTACGCGGTGCCGATCCAGCTGCTCGCCTACCACAC
GGCGGTGTTCATGGGGAAAGACGTCGACCAGCCCCGCAACCTCGCCAAATCGGTCACGGTCGAGTAG

Upstream 100 bases:

>100_bases
TCCGGTAGAAGTCCCGCTCGGCCCCGCACGGCGCGGGGCGGCCCGGACCTTGCGCAGCGCTGCGCGTAGCCATCCGGGCG
CGACAGCGAGAGACACTCCT

Downstream 100 bases:

>100_bases
GCGCGGCCGACCAGATCGGCGGATCGTGCGGGCGCGGCGCCGTCCTTGCGAGCGGAGCAACCCAGGGCGGCGCAGCTCTC
GCAGTCTGGCGTCGACCGGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGIVGRDAVAGQVIEALRRLEYRGYDSAGIATLEHGRLARRRASGKLVNLEAKLAQEPLTGTIGIGHTRWATHGRP
NETNAHPHATARLAVVHNGIIENFRELKQELEADGVVFETETDTEVVAQLVSRNMDRQMGPVEAVAAALPRLRGAFALGF
LFSGEENLLIGARHGAPLAIGFGEGETYLGSDALALAPFTDAITYLDEGDWAILSRGGAEIRDASGATVERARQKIATQA
YRIDKGEYRHFMAKEIHEQPEVVGRTLAHYVDMANGRVMLPEALPFDFAKLSRVYITACGTAYYAGLVARYWFEQVARLP
VEIDVASEARYREAPLEKDGLTLVISQSGETADTLASLRYAKTQGQHTLSVVNVPTSTIARESSVVMPTLAGPEIGVAST
KAFSCQLTVLLCLAIAAGRARGTLDAAGERRLVDGLIKAPGLMAEALTHEAAIEGLAREVAKARDVLYLGRGTSYPMALE
GALKLKEISYIHAEGYAAGELKHGPIALIDESVPVIVIAPHDAVFEKTVSNMQEVAARGGRIVLIGDAKGAAEHGLDTLA
TFTMPALDPTVAPIVYAVPIQLLAYHTAVFMGKDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGIVGRDAVAGQVIEALRRLEYRGYDSAGIATLEHGRLARRRASGKLVNLEAKLAQEPLTGTIGIGHTRWATHGRP
NETNAHPHATARLAVVHNGIIENFRELKQELEADGVVFETETDTEVVAQLVSRNMDRQMGPVEAVAAALPRLRGAFALGF
LFSGEENLLIGARHGAPLAIGFGEGETYLGSDALALAPFTDAITYLDEGDWAILSRGGAEIRDASGATVERARQKIATQA
YRIDKGEYRHFMAKEIHEQPEVVGRTLAHYVDMANGRVMLPEALPFDFAKLSRVYITACGTAYYAGLVARYWFEQVARLP
VEIDVASEARYREAPLEKDGLTLVISQSGETADTLASLRYAKTQGQHTLSVVNVPTSTIARESSVVMPTLAGPEIGVAST
KAFSCQLTVLLCLAIAAGRARGTLDAAGERRLVDGLIKAPGLMAEALTHEAAIEGLAREVAKARDVLYLGRGTSYPMALE
GALKLKEISYIHAEGYAAGELKHGPIALIDESVPVIVIAPHDAVFEKTVSNMQEVAARGGRIVLIGDAKGAAEHGLDTLA
TFTMPALDPTVAPIVYAVPIQLLAYHTAVFMGKDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIVGIVGRDAVAGQVIEALRRLEYRGYDSAGIATLEHGRLARRRASGKLVNLEAKLAQEPLTGTIGIGHTRWATHGRP
NETNAHPHATARLAVVHNGIIENFRELKQELEADGVVFETETDTEVVAQLVSRNMDRQMGPVEAVAAALPRLRGAFALGF
LFSGEENLLIGARHGAPLAIGFGEGETYLGSDALALAPFTDAITYLDEGDWAILSRGGAEIRDASGATVERARQKIATQA
YRIDKGEYRHFMAKEIHEQPEVVGRTLAHYVDMANGRVMLPEALPFDFAKLSRVYITACGTAYYAGLVARYWFEQVARLP
VEIDVASEARYREAPLEKDGLTLVISQSGETADTLASLRYAKTQGQHTLSVVNVPTSTIARESSVVMPTLAGPEIGVAST
KAFSCQLTVLLCLAIAAGRARGTLDAAGERRLVDGLIKAPGLMAEALTHEAAIEGLAREVAKARDVLYLGRGTSYPMALE
GALKLKEISYIHAEGYAAGELKHGPIALIDESVPVIVIAPHDAVFEKTVSNMQEVAARGGRIVLIGDAKGAAEHGLDTLA
TFTMPALDPTVAPIVYAVPIQLLAYHTAVFMGKDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=36.7732558139535, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=35.9534206695779, Blast_Score=388, Evalue=1e-107,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=49.4290375203915, Blast_Score=570, Evalue=1e-163,
Organism=Escherichia coli, GI1788651, Length=170, Percent_Identity=34.1176470588235, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532899, Length=716, Percent_Identity=34.3575418994413, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539970, Length=715, Percent_Identity=34.965034965035, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=37.962962962963, Blast_Score=293, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=37.9464285714286, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=31.0904872389791, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=211, Percent_Identity=33.175355450237, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=36.5079365079365, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=33.8028169014084, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65166; Mature: 65166

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIVGRDAVAGQVIEALRRLEYRGYDSAGIATLEHGRLARRRASGKLVNLEAKLAQ
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCCEEEEHHHHHC
EPLTGTIGIGHTRWATHGRPNETNAHPHATARLAVVHNGIIENFRELKQELEADGVVFET
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCEEEEC
ETDTEVVAQLVSRNMDRQMGPVEAVAAALPRLRGAFALGFLFSGEENLLIGARHGAPLAI
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEE
GFGEGETYLGSDALALAPFTDAITYLDEGDWAILSRGGAEIRDASGATVERARQKIATQA
ECCCCCCEECCCCEEECCHHHHHHHCCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHHH
YRIDKGEYRHFMAKEIHEQPEVVGRTLAHYVDMANGRVMLPEALPFDFAKLSRVYITACG
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHCEEEEEECH
TAYYAGLVARYWFEQVARLPVEIDVASEARYREAPLEKDGLTLVISQSGETADTLASLRY
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKTQGQHTLSVVNVPTSTIARESSVVMPTLAGPEIGVASTKAFSCQLTVLLCLAIAAGRA
HHCCCCEEEEEEECCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
RGTLDAAGERRLVDGLIKAPGLMAEALTHEAAIEGLAREVAKARDVLYLGRGTSYPMALE
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDESVPVIVIAPHDAVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RIVLIGDAKGAAEHGLDTLATFTMPALDPTVAPIVYAVPIQLLAYHTAVFMGKDVDQPRN
EEEEEECCCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGIVGRDAVAGQVIEALRRLEYRGYDSAGIATLEHGRLARRRASGKLVNLEAKLAQ
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCCEEEEHHHHHC
EPLTGTIGIGHTRWATHGRPNETNAHPHATARLAVVHNGIIENFRELKQELEADGVVFET
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCEEEEC
ETDTEVVAQLVSRNMDRQMGPVEAVAAALPRLRGAFALGFLFSGEENLLIGARHGAPLAI
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEE
GFGEGETYLGSDALALAPFTDAITYLDEGDWAILSRGGAEIRDASGATVERARQKIATQA
ECCCCCCEECCCCEEECCHHHHHHHCCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHHH
YRIDKGEYRHFMAKEIHEQPEVVGRTLAHYVDMANGRVMLPEALPFDFAKLSRVYITACG
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHCEEEEEECH
TAYYAGLVARYWFEQVARLPVEIDVASEARYREAPLEKDGLTLVISQSGETADTLASLRY
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKTQGQHTLSVVNVPTSTIARESSVVMPTLAGPEIGVASTKAFSCQLTVLLCLAIAAGRA
HHCCCCEEEEEEECCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
RGTLDAAGERRLVDGLIKAPGLMAEALTHEAAIEGLAREVAKARDVLYLGRGTSYPMALE
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDESVPVIVIAPHDAVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RIVLIGDAKGAAEHGLDTLATFTMPALDPTVAPIVYAVPIQLLAYHTAVFMGKDVDQPRN
EEEEEECCCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]