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The map label for this gene is rmlA [H]

Identifier: 170748795

GI number: 170748795

Start: 2519785

End: 2520684

Strand: Reverse

Name: rmlA [H]

Synonym: Mrad2831_2377

Alternate gene names: 170748795

Gene position: 2520684-2519785 (Counterclockwise)

Preceding gene: 170748796

Following gene: 170748793

Centisome position: 41.47

GC content: 68.0

Gene sequence:

>900_bases
ATGAAGGGCATCGTCCTGGCCGGCGGATCCGGCACGCGCCTGCACCCGGCCACGCTGTCGATCAACAAGCAGCTCCTGCC
GGTCTACGACAAGCCGATGATCTACTACCCGGTCTCGGTGCTGATGCTCGCCGGCATCCGCGAGATCCTGATCATCTCGT
CGCCGGAGCACCTCGACAACTACAAGCGCCTGTTCGGCACCGGCGAGCAGTTCGGCCTCAAGTTCTCCTACGCCCTGCAG
CCGCGGCCGGAGGGCCTCGCCCAGGCCTTCGTGATCGGGCGCGACTTCGTGGGCGACGACGACGTGGCGCTGATCCTCGG
CGACAACCTGTTCTTCGGCGCCGGCATGGGCGAGCTCCTGGAGCGCGCGTCGAGCCGGAAGCAGGGCGCGACGGTCTTCG
CCTACCACGTCGACAACCCGCAGGCCTACGGCGTCGTCAACCTCGACAAGTCGGGGCGGCCGACGAAGATCGTCGAGAAG
CCGCAGAACCCGGAATCGACCTGGGCGGTGACCGGCCTGTACTTCTACGACAACCAGGTGCTCGACATCGCCGCCGACGT
GAAGCCCTCGGCCCGCGGCGAGCTGGAGATCACCAGCGTCAACGAGGCCTACCTGCAGCACGGCCAGCTGCACGTGGAGC
GCATGTCGCGCGGCTACGCGTGGCTCGACACCGGGACCCACGACAGCCTGCTCGAGGCGAGCGAGTTCGTCCGCACGCTG
CAGAACCGGCAGGGCCTCCAGGTGGCCTGCCTGGAGGAGATCGCCTACCTGCAGAAGTTCATCACCCGCGACCAGCTCGT
GGCCCGCGGCGAGATGTTCGCCAAGACCGCCTACGGGCAGAACCTGCTGCGCCTCGCCCGCGAGAGCGAGGACGATCTGC
GCCTGCGCCGGGGCAAGTAG

Upstream 100 bases:

>100_bases
TCACGGCCGCCTACGGCATCGCGCCGCGGCCCTGGCAGGCGGCGCTCGACGACATCCTGGACCGGCTCGTCGGGCCGGTC
TCAGAGGGAGTTTCCAAGCC

Downstream 100 bases:

>100_bases
TCCCGCCGGCGGCGCTCGGTCGCCGCCCCTCTACCGGGGGGCGCAGCCGATGCAGATGCCGCGCATGAGCCGGTCGTTCT
TCGCCTCGCGCGGCGTGCGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKGIVLAGGSGTRLHPATLSINKQLLPVYDKPMIYYPVSVLMLAGIREILIISSPEHLDNYKRLFGTGEQFGLKFSYALQ
PRPEGLAQAFVIGRDFVGDDDVALILGDNLFFGAGMGELLERASSRKQGATVFAYHVDNPQAYGVVNLDKSGRPTKIVEK
PQNPESTWAVTGLYFYDNQVLDIAADVKPSARGELEITSVNEAYLQHGQLHVERMSRGYAWLDTGTHDSLLEASEFVRTL
QNRQGLQVACLEEIAYLQKFITRDQLVARGEMFAKTAYGQNLLRLARESEDDLRLRRGK

Sequences:

>Translated_299_residues
MKGIVLAGGSGTRLHPATLSINKQLLPVYDKPMIYYPVSVLMLAGIREILIISSPEHLDNYKRLFGTGEQFGLKFSYALQ
PRPEGLAQAFVIGRDFVGDDDVALILGDNLFFGAGMGELLERASSRKQGATVFAYHVDNPQAYGVVNLDKSGRPTKIVEK
PQNPESTWAVTGLYFYDNQVLDIAADVKPSARGELEITSVNEAYLQHGQLHVERMSRGYAWLDTGTHDSLLEASEFVRTL
QNRQGLQVACLEEIAYLQKFITRDQLVARGEMFAKTAYGQNLLRLARESEDDLRLRRGK
>Mature_299_residues
MKGIVLAGGSGTRLHPATLSINKQLLPVYDKPMIYYPVSVLMLAGIREILIISSPEHLDNYKRLFGTGEQFGLKFSYALQ
PRPEGLAQAFVIGRDFVGDDDVALILGDNLFFGAGMGELLERASSRKQGATVFAYHVDNPQAYGVVNLDKSGRPTKIVEK
PQNPESTWAVTGLYFYDNQVLDIAADVKPSARGELEITSVNEAYLQHGQLHVERMSRGYAWLDTGTHDSLLEASEFVRTL
QNRQGLQVACLEEIAYLQKFITRDQLVARGEMFAKTAYGQNLLRLARESEDDLRLRRGK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=26.6932270916335, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=26.6932270916335, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=56.9444444444444, Blast_Score=359, Evalue=1e-101,
Organism=Escherichia coli, GI1790224, Length=287, Percent_Identity=57.4912891986063, Blast_Score=352, Evalue=1e-98,
Organism=Escherichia coli, GI1787488, Length=295, Percent_Identity=26.1016949152542, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788355, Length=236, Percent_Identity=24.1525423728814, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=183, Percent_Identity=26.775956284153, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=255, Percent_Identity=25.8823529411765, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355443, Length=245, Percent_Identity=24.8979591836735, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24644084, Length=245, Percent_Identity=24.8979591836735, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33326; Mature: 33326

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLHPATLSINKQLLPVYDKPMIYYPVSVLMLAGIREILIISSPEHLDN
CCCEEEECCCCCEECEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCHHHHH
YKRLFGTGEQFGLKFSYALQPRPEGLAQAFVIGRDFVGDDDVALILGDNLFFGAGMGELL
HHHHHCCCHHHCEEEEEEECCCCHHHHHHHEECCCCCCCCCEEEEEECCEEEECCHHHHH
ERASSRKQGATVFAYHVDNPQAYGVVNLDKSGRPTKIVEKPQNPESTWAVTGLYFYDNQV
HHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHCCCCCCCCCCEEEEEEEEECCEE
LDIAADVKPSARGELEITSVNEAYLQHGQLHVERMSRGYAWLDTGTHDSLLEASEFVRTL
EEEEECCCCCCCCCEEEEECCHHHHHCCHHEEEHHHCCEEEEECCCCHHHHHHHHHHHHH
QNRQGLQVACLEEIAYLQKFITRDQLVARGEMFAKTAYGQNLLRLARESEDDLRLRRGK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCC
>Mature Secondary Structure
MKGIVLAGGSGTRLHPATLSINKQLLPVYDKPMIYYPVSVLMLAGIREILIISSPEHLDN
CCCEEEECCCCCEECEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCHHHHH
YKRLFGTGEQFGLKFSYALQPRPEGLAQAFVIGRDFVGDDDVALILGDNLFFGAGMGELL
HHHHHCCCHHHCEEEEEEECCCCHHHHHHHEECCCCCCCCCEEEEEECCEEEECCHHHHH
ERASSRKQGATVFAYHVDNPQAYGVVNLDKSGRPTKIVEKPQNPESTWAVTGLYFYDNQV
HHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHCCCCCCCCCCEEEEEEEEECCEE
LDIAADVKPSARGELEITSVNEAYLQHGQLHVERMSRGYAWLDTGTHDSLLEASEFVRTL
EEEEECCCCCCCCCEEEEECCHHHHHCCHHEEEHHHCCEEEEECCCCHHHHHHHHHHHHH
QNRQGLQVACLEEIAYLQKFITRDQLVARGEMFAKTAYGQNLLRLARESEDDLRLRRGK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7692217 [H]