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The map label for this gene is mrdB [H]

Identifier: 170748775

GI number: 170748775

Start: 2493848

End: 2495014

Strand: Reverse

Name: mrdB [H]

Synonym: Mrad2831_2357

Alternate gene names: 170748775

Gene position: 2495014-2493848 (Counterclockwise)

Preceding gene: 170748777

Following gene: 170748774

Centisome position: 41.05

GC content: 69.32

Gene sequence:

>1167_bases
ATGATGTCACGCGCGGAACGCACCCCCCTGACGGACTGGTGGTGGACGGTGGACCGCGGCCTGCTCGCGGCGCTGTTCGC
GCTGATGGTCGCGGGCCTCGTCTTCCTGATGGGCGGCGGCCCGCCCGTCGCCGAGCGGATCGGCCTGCCGACCTTCTACT
TCCTCAACCGACAGGCGATGTACCTCGCGCCGACCATCCTGCTGATCTGCGCGGTCTCGTTCCTGTCGCTGCGCGGCATC
CGGCGGCTCGCGCTCGTCACGTGGATCCTGGGCGTCGTCCTGTGCCTGCTCGCCGGCAAGTTCGGGCCCGAGATCAAGGG
CGCGCACCGCTGGATCCAGTTCGGCTCCTTCGGCCTGCAGCCCTCGGAGTTCGTGAAGCCGGCCTTCGTGGTCGTCGCCG
CCTGGGCCTTCTCGGAGGGCGCCCAGCGCCGCGACATGCCCGGCGGCATCCTGGCGCTGCTGCTCCTGCCGATCACCATC
GTGCCGCTGCTGCTCCAGCCCGATTTCGGCCAGACCATGCTGATTACCATGGTGTGGTGCGCGCTGTTCTTCGTGGCCGG
CCTCCACCTGATCTGGGTGGCCGTCCTGGGCGTGCTGGGCCTCGGAGGTGTGTTCGCTGCCTACCTGTTCTTCCACCACG
TCCGCGAGCGCTTCAACAAGTTCCTCGACCGGGATTCCGGCGGCGGCTTCCAGGACTTCTGGTCGCGCGAGTCGTTCCGC
TCGGGCGGCTGGTTCGGAACCGGGCCGGGCGAGGGCGTGGCCAAGCGCCACCTGCCGGACGCGCATACCGACTTCATCTT
CTCGGTCACCGGCGAGGAGTTCGGCGTGATCGTCTGCCTGTGCCTCGTGGCCCTCTTCGCCTTCATCGTGCTGCGCGGCC
TCAAGCTCGCGCGGCGCACGGACGACACCTTCTCGCGGCTGGCGATCACCGGGTTGACCACGCTGTTCGGCCTCCAGGCC
TGCATCAACATGGCGGTGAACACCCAGCTGATGCCCGCCAAGGGCATGACCCTGCCGTTCGTCTCCTACGGCGGCTCCTC
GCTGATCTCGCTGGCGCTCGGCACCGGCTTCCTCGTCGCCCTGACCCGCAAGCGCCCCCGCACCGTGATGCTCAGCCAGA
AGCCCCCCGGCACCGCGCCCGCCACCGTCGCCGGAGTGATGCGGTGA

Upstream 100 bases:

>100_bases
ACGGATGCGTCGGCCATAAGGCTCCGTTTACCATTCCTGCCGAGGATCCGGGCCGACCCGCGCGGATCGGCATCCGCGCG
GCCTGGAGTCGTTGCCCGGC

Downstream 100 bases:

>100_bases
CGGTCTTCACGCCCACGATCCTGCTCTGTGCCGGCGGCACCGGCGGCCATCTCTTCCCCGCCGAGAGTCTCGCCCACGCG
CTGCGGGCCCGCGGCATCCG

Product: cell cycle protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MMSRAERTPLTDWWWTVDRGLLAALFALMVAGLVFLMGGGPPVAERIGLPTFYFLNRQAMYLAPTILLICAVSFLSLRGI
RRLALVTWILGVVLCLLAGKFGPEIKGAHRWIQFGSFGLQPSEFVKPAFVVVAAWAFSEGAQRRDMPGGILALLLLPITI
VPLLLQPDFGQTMLITMVWCALFFVAGLHLIWVAVLGVLGLGGVFAAYLFFHHVRERFNKFLDRDSGGGFQDFWSRESFR
SGGWFGTGPGEGVAKRHLPDAHTDFIFSVTGEEFGVIVCLCLVALFAFIVLRGLKLARRTDDTFSRLAITGLTTLFGLQA
CINMAVNTQLMPAKGMTLPFVSYGGSSLISLALGTGFLVALTRKRPRTVMLSQKPPGTAPATVAGVMR

Sequences:

>Translated_388_residues
MMSRAERTPLTDWWWTVDRGLLAALFALMVAGLVFLMGGGPPVAERIGLPTFYFLNRQAMYLAPTILLICAVSFLSLRGI
RRLALVTWILGVVLCLLAGKFGPEIKGAHRWIQFGSFGLQPSEFVKPAFVVVAAWAFSEGAQRRDMPGGILALLLLPITI
VPLLLQPDFGQTMLITMVWCALFFVAGLHLIWVAVLGVLGLGGVFAAYLFFHHVRERFNKFLDRDSGGGFQDFWSRESFR
SGGWFGTGPGEGVAKRHLPDAHTDFIFSVTGEEFGVIVCLCLVALFAFIVLRGLKLARRTDDTFSRLAITGLTTLFGLQA
CINMAVNTQLMPAKGMTLPFVSYGGSSLISLALGTGFLVALTRKRPRTVMLSQKPPGTAPATVAGVMR
>Mature_388_residues
MMSRAERTPLTDWWWTVDRGLLAALFALMVAGLVFLMGGGPPVAERIGLPTFYFLNRQAMYLAPTILLICAVSFLSLRGI
RRLALVTWILGVVLCLLAGKFGPEIKGAHRWIQFGSFGLQPSEFVKPAFVVVAAWAFSEGAQRRDMPGGILALLLLPITI
VPLLLQPDFGQTMLITMVWCALFFVAGLHLIWVAVLGVLGLGGVFAAYLFFHHVRERFNKFLDRDSGGGFQDFWSRESFR
SGGWFGTGPGEGVAKRHLPDAHTDFIFSVTGEEFGVIVCLCLVALFAFIVLRGLKLARRTDDTFSRLAITGLTTLFGLQA
CINMAVNTQLMPAKGMTLPFVSYGGSSLISLALGTGFLVALTRKRPRTVMLSQKPPGTAPATVAGVMR

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786277, Length=358, Percent_Identity=30.4469273743017, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786853, Length=294, Percent_Identity=32.312925170068, Blast_Score=121, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 42335; Mature: 42335

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCCEEEEECCCCCCCCHHHHHCCC
>Mature Secondary Structure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EECCCCCEEEEECCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]