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The map label for this gene is phoQ [H]

Identifier: 170748301

GI number: 170748301

Start: 2010233

End: 2011576

Strand: Reverse

Name: phoQ [H]

Synonym: Mrad2831_1883

Alternate gene names: 170748301

Gene position: 2011576-2010233 (Counterclockwise)

Preceding gene: 170748302

Following gene: 170748293

Centisome position: 33.1

GC content: 78.35

Gene sequence:

>1344_bases
GTGAGGCGCGACTCCCTCCGCCTCCGGCTCGGCCTCGCGGCGTCCGGCCTGATCGCGCTGGCGCTGGTGCTGGCCGGGAT
CGGCCTCACGGTGATCCTCGACCGGGTGCTCGACGCCCGCACCGTCGCGGAGCTGGACCGGACCGCCAAGCTCATCGCCG
GCCGGGTCGGCCTCGCGCCGGACGGGGCGCCGACGCTCTCGCGGGACCTGCCGGACCCGCGCTTCGCCACGCCCTACGGC
GGCCTGTACTGGCAGGTCGAGGCGGGGTCGCACCTGCTGCGCTCGCGCTCCCTGTGGGACAAGAGCCTCGACCTGGGCCA
AGCCGGGGCGGCCGCGCAGGCCCCCGCCACCCTCGACACGACCGGGCCCGACGGCGGCCGGCTCATCGCGGTGGTGCGGC
CGCTGCAGATCGGCGCGCCGGGCTCCGAGACCGCGCTGCGGGTCGCGGTGGCGGAGGACCGGCGCGGCCTCGCGGCGAGC
CGGACCACGTTCCTGCGCCTGCTCGTCCCGGCCCTGGTCGCCCTGTTCGTCGTCCTGACGCTGGCGATGGGCCTGTTCGT
GCACCGGGCGCTCGGCCCGTTCCGGGTGCTGCAGGCCGAACTCCTGGCGGTCCATGCCGGGCGGCGGGCGCGGCTGCCGG
AGCATTTCCCCGACGAGGTCCGGCCGCTGGTCACCGACCTCAACCGGCTGCTCGACGCGCAGGAGCGGGCCCTGGTCCGC
GCCCGCGACGCCGCCGCCGACATGGCCCACGGCCTCAAGACCCCGCTGGCGGTGCTGGACGCCCTGGCGCGCCGGACCGG
GCCGGCCGACCCGGCGCTGGCGGCCGAGATCGCCGAGCAGGCGCGGGCCATGGGCGGTCAGGTGGAGCGGGCGCTGGCCC
GGGCGCGGGTCGCGGCCGCGGGCGACCTGCGGCGGCGCTCCTGCCGGGTCGCCCCGGTGGCGGAGCGCCTCGTCGCGACC
CTGCGGCGGCTGCCGGAGGGCGACTCCCTGGAATGGACAGTGGCGGTGCCCGAGACCCTCGCCTATCCGGGCGAGGAGGG
CGAGCTGATGGAGGTGCTGGGCAACCTCCTCGACAACGCCCGCAAGTGGGCGCACCGGCGGGTCCGCGTCACCGGGACGG
ACGCCGGCCGCCCGGGCCTCGCCGTCGAGGATGACGGCCCCGGCATGAGCGCCGCGGCCATCGCGGGGATCGGGCGCGGC
CAGCGCTGGGACGAGAGCCGGCCGGGCACCGGCTTCGGCATCGCCATCGCCCGCGACGTCGCCGAGGCCGCGGGCGCCCA
GCTCGATTTCGGCCGCTCGGAGCTGGGCGGCCTGCGGGCGGACCTGCGCTGGCCGGGCGGGTAG

Upstream 100 bases:

>100_bases
CCCTGGAGGCGCTCCTGACCCGCCTGCGCCGCAAGCTCGGGCCGGGGGTGATCGAGACCCGGCGCGGCCAGGGCTACCTC
ATCGCCGGACCGGGCGGATC

Downstream 100 bases:

>100_bases
GGCCACGGGCGCCGCTGGCGGGCGCGACCTGCCCCCTCTCCCGTTCGGGAGAGGGTCGGGGTGAGGGACCGGATGCTTCA
GGACGGAGCACGCCGTCGAC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRRDSLRLRLGLAASGLIALALVLAGIGLTVILDRVLDARTVAELDRTAKLIAGRVGLAPDGAPTLSRDLPDPRFATPYG
GLYWQVEAGSHLLRSRSLWDKSLDLGQAGAAAQAPATLDTTGPDGGRLIAVVRPLQIGAPGSETALRVAVAEDRRGLAAS
RTTFLRLLVPALVALFVVLTLAMGLFVHRALGPFRVLQAELLAVHAGRRARLPEHFPDEVRPLVTDLNRLLDAQERALVR
ARDAAADMAHGLKTPLAVLDALARRTGPADPALAAEIAEQARAMGGQVERALARARVAAAGDLRRRSCRVAPVAERLVAT
LRRLPEGDSLEWTVAVPETLAYPGEEGELMEVLGNLLDNARKWAHRRVRVTGTDAGRPGLAVEDDGPGMSAAAIAGIGRG
QRWDESRPGTGFGIAIARDVAEAAGAQLDFGRSELGGLRADLRWPGG

Sequences:

>Translated_447_residues
MRRDSLRLRLGLAASGLIALALVLAGIGLTVILDRVLDARTVAELDRTAKLIAGRVGLAPDGAPTLSRDLPDPRFATPYG
GLYWQVEAGSHLLRSRSLWDKSLDLGQAGAAAQAPATLDTTGPDGGRLIAVVRPLQIGAPGSETALRVAVAEDRRGLAAS
RTTFLRLLVPALVALFVVLTLAMGLFVHRALGPFRVLQAELLAVHAGRRARLPEHFPDEVRPLVTDLNRLLDAQERALVR
ARDAAADMAHGLKTPLAVLDALARRTGPADPALAAEIAEQARAMGGQVERALARARVAAAGDLRRRSCRVAPVAERLVAT
LRRLPEGDSLEWTVAVPETLAYPGEEGELMEVLGNLLDNARKWAHRRVRVTGTDAGRPGLAVEDDGPGMSAAAIAGIGRG
QRWDESRPGTGFGIAIARDVAEAAGAQLDFGRSELGGLRADLRWPGG
>Mature_447_residues
MRRDSLRLRLGLAASGLIALALVLAGIGLTVILDRVLDARTVAELDRTAKLIAGRVGLAPDGAPTLSRDLPDPRFATPYG
GLYWQVEAGSHLLRSRSLWDKSLDLGQAGAAAQAPATLDTTGPDGGRLIAVVRPLQIGAPGSETALRVAVAEDRRGLAAS
RTTFLRLLVPALVALFVVLTLAMGLFVHRALGPFRVLQAELLAVHAGRRARLPEHFPDEVRPLVTDLNRLLDAQERALVR
ARDAAADMAHGLKTPLAVLDALARRTGPADPALAAEIAEQARAMGGQVERALARARVAAAGDLRRRSCRVAPVAERLVAT
LRRLPEGDSLEWTVAVPETLAYPGEEGELMEVLGNLLDNARKWAHRRVRVTGTDAGRPGLAVEDDGPGMSAAAIAGIGRG
QRWDESRPGTGFGIAIARDVAEAAGAQLDFGRSELGGLRADLRWPGG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=263, Percent_Identity=30.7984790874525, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787894, Length=111, Percent_Identity=39.6396396396396, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47303; Mature: 47303

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRDSLRLRLGLAASGLIALALVLAGIGLTVILDRVLDARTVAELDRTAKLIAGRVGLAP
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGAPTLSRDLPDPRFATPYGGLYWQVEAGSHLLRSRSLWDKSLDLGQAGAAAQAPATLDT
CCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TGPDGGRLIAVVRPLQIGAPGSETALRVAVAEDRRGLAASRTTFLRLLVPALVALFVVLT
CCCCCCEEEEEEECEECCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAMGLFVHRALGPFRVLQAELLAVHAGRRARLPEHFPDEVRPLVTDLNRLLDAQERALVR
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARDAAADMAHGLKTPLAVLDALARRTGPADPALAAEIAEQARAMGGQVERALARARVAAA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
GDLRRRSCRVAPVAERLVATLRRLPEGDSLEWTVAVPETLAYPGEEGELMEVLGNLLDNA
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHH
RKWAHRRVRVTGTDAGRPGLAVEDDGPGMSAAAIAGIGRGQRWDESRPGTGFGIAIARDV
HHHHHCEEEEEECCCCCCCCEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
AEAAGAQLDFGRSELGGLRADLRWPGG
HHHCCCCCCCCHHHHCCCEECCCCCCC
>Mature Secondary Structure
MRRDSLRLRLGLAASGLIALALVLAGIGLTVILDRVLDARTVAELDRTAKLIAGRVGLAP
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGAPTLSRDLPDPRFATPYGGLYWQVEAGSHLLRSRSLWDKSLDLGQAGAAAQAPATLDT
CCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TGPDGGRLIAVVRPLQIGAPGSETALRVAVAEDRRGLAASRTTFLRLLVPALVALFVVLT
CCCCCCEEEEEEECEECCCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAMGLFVHRALGPFRVLQAELLAVHAGRRARLPEHFPDEVRPLVTDLNRLLDAQERALVR
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARDAAADMAHGLKTPLAVLDALARRTGPADPALAAEIAEQARAMGGQVERALARARVAAA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
GDLRRRSCRVAPVAERLVATLRRLPEGDSLEWTVAVPETLAYPGEEGELMEVLGNLLDNA
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHH
RKWAHRRVRVTGTDAGRPGLAVEDDGPGMSAAAIAGIGRGQRWDESRPGTGFGIAIARDV
HHHHHCEEEEEECCCCCCCCEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
AEAAGAQLDFGRSELGGLRADLRWPGG
HHHCCCCCCCCHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA