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The map label for this gene is hisC [H]

Identifier: 170748293

GI number: 170748293

Start: 2003272

End: 2004387

Strand: Reverse

Name: hisC [H]

Synonym: Mrad2831_1875

Alternate gene names: 170748293

Gene position: 2004387-2003272 (Counterclockwise)

Preceding gene: 170748301

Following gene: 170748292

Centisome position: 32.98

GC content: 73.84

Gene sequence:

>1116_bases
ATGTCCGCCCCCCGACCCGCCCGTCCGGAACCGCGTCCCGGCGTCCTGGCGATCGACACCTACGTGCCCGGCAAGAGCGG
GCGGCCCGGCGGCGGCAAGGTCTACAAGCTGTCCTCCAACGAGACGCCCCTCGGCCCGAGCCCGGCGGCGCTCGCGGCGC
TCCACGCGGCGACCGCCAAGCTCGAGACCTACCCGGACGGGCGCGCCACCGCCTTGCGCACCGCCATCGCCCGGCGCTAC
GGGCTCGATCCCGAGCGGATCGTCTGCGGCGCCGGCTCGGACGAGCTCCTGTCGCTGCTGGCCTACGCGTATTGCGGGCC
GGGCGCCGAGGGCATCTACTCCGAGCACGGATTCCTGGTCTACCGGATCGCCATCCTGGCCTCGGGCGGCGAGGCGGTGG
TCGCGCCCGAGCGCGACCTGACCGTCGACGTCGACGCGATCCTGGCCCGGCTCACGGACCGGACCCGGATCGTCTACGTC
ACGAACCCCAACAACCCGACCGGCACCTACCTGCCCTTCGACGAGATCCGCCGCCTCCACGCCGGCCTGCCGCCGCACGT
GCTGCTGGTGATCGACGGCGCCTACGCCGAGTACGTCCGGGCCAACGACTACTCGGCCGGGCTCGAGCTGGCGCTCGAGG
CCGAGAACGTCGTGATGACCCGCACCTTCTCGAAGATCCACGGCCTCGCCGCCGTCCGGATCGGCTGGATGGTCGCGCCG
TCCCACGTGGCGGACGCGGTCAACCGGATCCGGGGGCCGTTCAACGTCTCGGGCCCGGCGATCGCCGCGGGCTCGGCGGC
GATCGCCGACGAGGCGCACATGGCGGCGGCCGCCGCCCACAATTCCGAGTGGCTGCCGAAGCTCACCGCGGGCGCCCGCG
CCCTCGGCCTGGAGGTCACGCCGAGCGTCGCGAACTTCCTGCTGATCCACTTCCCCGACGCGCCGGGCCGCTCGGCGGAG
GACGCGGACGCGTTCCTGACCGAGCGCGGCCTCATCACCCGGCGGGTCACCGCCTACGGCCTGCCCAACGCCCTGCGGGT
GACGGTGGCGGGCGCCGAGGCGAACGAAGCCTTCCTGGCGGCGCTCGGCGACTTCGTGCGGGGCCACCATGGCTGA

Upstream 100 bases:

>100_bases
GGCCGGCGCCGGAGGAGGCGGGCCCGGGTTCACCGGAGGAGGAAATGCTGTAGACGGGCGCGGAACCGATCGAACCCCGC
GCATCCCGAGTCGCACTGCA

Downstream 100 bases:

>100_bases
GACATCCGAGGGCGTCCCCGCGATCGACCGCCTCGCCATCGTCGGCCTCGGGCTGATCGGCTCCTCGATCGCCCGGGCGG
CGCGGCGCTACGGCCTCGCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSAPRPARPEPRPGVLAIDTYVPGKSGRPGGGKVYKLSSNETPLGPSPAALAALHAATAKLETYPDGRATALRTAIARRY
GLDPERIVCGAGSDELLSLLAYAYCGPGAEGIYSEHGFLVYRIAILASGGEAVVAPERDLTVDVDAILARLTDRTRIVYV
TNPNNPTGTYLPFDEIRRLHAGLPPHVLLVIDGAYAEYVRANDYSAGLELALEAENVVMTRTFSKIHGLAAVRIGWMVAP
SHVADAVNRIRGPFNVSGPAIAAGSAAIADEAHMAAAAAHNSEWLPKLTAGARALGLEVTPSVANFLLIHFPDAPGRSAE
DADAFLTERGLITRRVTAYGLPNALRVTVAGAEANEAFLAALGDFVRGHHG

Sequences:

>Translated_371_residues
MSAPRPARPEPRPGVLAIDTYVPGKSGRPGGGKVYKLSSNETPLGPSPAALAALHAATAKLETYPDGRATALRTAIARRY
GLDPERIVCGAGSDELLSLLAYAYCGPGAEGIYSEHGFLVYRIAILASGGEAVVAPERDLTVDVDAILARLTDRTRIVYV
TNPNNPTGTYLPFDEIRRLHAGLPPHVLLVIDGAYAEYVRANDYSAGLELALEAENVVMTRTFSKIHGLAAVRIGWMVAP
SHVADAVNRIRGPFNVSGPAIAAGSAAIADEAHMAAAAAHNSEWLPKLTAGARALGLEVTPSVANFLLIHFPDAPGRSAE
DADAFLTERGLITRRVTAYGLPNALRVTVAGAEANEAFLAALGDFVRGHHG
>Mature_370_residues
SAPRPARPEPRPGVLAIDTYVPGKSGRPGGGKVYKLSSNETPLGPSPAALAALHAATAKLETYPDGRATALRTAIARRYG
LDPERIVCGAGSDELLSLLAYAYCGPGAEGIYSEHGFLVYRIAILASGGEAVVAPERDLTVDVDAILARLTDRTRIVYVT
NPNNPTGTYLPFDEIRRLHAGLPPHVLLVIDGAYAEYVRANDYSAGLELALEAENVVMTRTFSKIHGLAAVRIGWMVAPS
HVADAVNRIRGPFNVSGPAIAAGSAAIADEAHMAAAAAHNSEWLPKLTAGARALGLEVTPSVANFLLIHFPDAPGRSAED
ADAFLTERGLITRRVTAYGLPNALRVTVAGAEANEAFLAALGDFVRGHHG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=26.1363636363636, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=27.1767810026385, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38990; Mature: 38858

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRPARPEPRPGVLAIDTYVPGKSGRPGGGKVYKLSSNETPLGPSPAALAALHAATAK
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
LETYPDGRATALRTAIARRYGLDPERIVCGAGSDELLSLLAYAYCGPGAEGIYSEHGFLV
HCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEE
YRIAILASGGEAVVAPERDLTVDVDAILARLTDRTRIVYVTNPNNPTGTYLPFDEIRRLH
EEEEEEECCCCEEEECCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHH
AGLPPHVLLVIDGAYAEYVRANDYSAGLELALEAENVVMTRTFSKIHGLAAVRIGWMVAP
CCCCCEEEEEEECCHHHHEECCCCCCCEEEEEECCCEEEEEHHHHHHHHEEEEEEEEECC
SHVADAVNRIRGPFNVSGPAIAAGSAAIADEAHMAAAAAHNSEWLPKLTAGARALGLEVT
HHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCEEECEEEC
PSVANFLLIHFPDAPGRSAEDADAFLTERGLITRRVTAYGLPNALRVTVAGAEANEAFLA
CCHHCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCEEEEEEECCCCCHHHHH
ALGDFVRGHHG
HHHHHHHCCCC
>Mature Secondary Structure 
SAPRPARPEPRPGVLAIDTYVPGKSGRPGGGKVYKLSSNETPLGPSPAALAALHAATAK
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
LETYPDGRATALRTAIARRYGLDPERIVCGAGSDELLSLLAYAYCGPGAEGIYSEHGFLV
HCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEE
YRIAILASGGEAVVAPERDLTVDVDAILARLTDRTRIVYVTNPNNPTGTYLPFDEIRRLH
EEEEEEECCCCEEEECCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHH
AGLPPHVLLVIDGAYAEYVRANDYSAGLELALEAENVVMTRTFSKIHGLAAVRIGWMVAP
CCCCCEEEEEEECCHHHHEECCCCCCCEEEEEECCCEEEEEHHHHHHHHEEEEEEEEECC
SHVADAVNRIRGPFNVSGPAIAAGSAAIADEAHMAAAAAHNSEWLPKLTAGARALGLEVT
HHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCEEECEEEC
PSVANFLLIHFPDAPGRSAEDADAFLTERGLITRRVTAYGLPNALRVTVAGAEANEAFLA
CCHHCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCEEEEEEECCCCCHHHHH
ALGDFVRGHHG
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA