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The map label for this gene is fucA [C]

Identifier: 170748137

GI number: 170748137

Start: 1828598

End: 1829401

Strand: Reverse

Name: fucA [C]

Synonym: Mrad2831_1719

Alternate gene names: 170748137

Gene position: 1829401-1828598 (Counterclockwise)

Preceding gene: 170748138

Following gene: 170748135

Centisome position: 30.1

GC content: 70.52

Gene sequence:

>804_bases
ATGAGCGCAGCCACACCGTCGATCGTCGCGGACCGGGATACGGACCCCGCCGATCACGCCGCGACCCGCGCGATGCGCGT
CGACCTCGCGGCCGCCTACCGGCTGATCCATCGGCTGGGCCTCGACGACAGCATCTACACCCACATCTCGGCGCGGCTGC
CGGGCGGCGGGCACCGGTTCCTGATCAACCCCTACGGGATGCGCTTCGAGGAGGTGACGCCGGAGAACCTCGTCACCGTC
GACATCGACGGGAAGGTGCTCGAGGACCCGATGGGGCTCGGCATCAACCCGGCCGGGTTCACGATCCACAGCGCCATCCA
CGCCGCGCGCCACGACGCGATCTGCGTGCTGCACACCCACACGGTGGCGGGCGTCGCGGTCTCCTGCCAGGAGGAGGGGC
TCCTGCCCCTGAACCAGTGGTCGATGCAGTTCACGGGGCGCGTCGCCTACCACGCCTACGAGGGCATCGCCCTCGACCTC
GACGAGCGGCAGCGGCTGGTGGCCGATCTCGGCGACAAGCCCGTGATGGTGCTGCGCAATCACGGCCTGCTGACCTGCGG
CCGCACGGTCGGCGAGGCGTTCCGGCTGATGCACAACATGGAGCGCTCGTGCCGGGCGCAGCTGGCGATCCAGGCGGCGG
GCGCGCCGGTGATCCGGCCCTCCTCCGCCATCGCCACCAAGACCGCCGGGCAGTACGCTGCCGGCTACGACCGCGTCGTG
GTCCAGGGAGCGCCCGACAACGAGTGGGCGGCGTTCAAGCGGATGCTGGCGCGGACGGATCCGGATTTCTTCGCGAATGG
GTGA

Upstream 100 bases:

>100_bases
GCCCGGTCCTCGTCCCGGACCGCCTCAGGAATCGCGGGACCGCCTGCGCCGGGCGGCGATCCCGGAGGGCCGACAGGGCC
GACCGGCAGGGAGCCGTCGC

Downstream 100 bases:

>100_bases
GGGCGGAACGGTCGCCGGCTGACCAGTTCGGTCGATGCGCCGCTCTCCGTCATCGCGAGCGCAGTGAAGTGACCCCGGGC
AGCGCGATTCCGGCCAGCCG

Product: class II aldolase/adducin family protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSAATPSIVADRDTDPADHAATRAMRVDLAAAYRLIHRLGLDDSIYTHISARLPGGGHRFLINPYGMRFEEVTPENLVTV
DIDGKVLEDPMGLGINPAGFTIHSAIHAARHDAICVLHTHTVAGVAVSCQEEGLLPLNQWSMQFTGRVAYHAYEGIALDL
DERQRLVADLGDKPVMVLRNHGLLTCGRTVGEAFRLMHNMERSCRAQLAIQAAGAPVIRPSSAIATKTAGQYAAGYDRVV
VQGAPDNEWAAFKRMLARTDPDFFANG

Sequences:

>Translated_267_residues
MSAATPSIVADRDTDPADHAATRAMRVDLAAAYRLIHRLGLDDSIYTHISARLPGGGHRFLINPYGMRFEEVTPENLVTV
DIDGKVLEDPMGLGINPAGFTIHSAIHAARHDAICVLHTHTVAGVAVSCQEEGLLPLNQWSMQFTGRVAYHAYEGIALDL
DERQRLVADLGDKPVMVLRNHGLLTCGRTVGEAFRLMHNMERSCRAQLAIQAAGAPVIRPSSAIATKTAGQYAAGYDRVV
VQGAPDNEWAAFKRMLARTDPDFFANG
>Mature_266_residues
SAATPSIVADRDTDPADHAATRAMRVDLAAAYRLIHRLGLDDSIYTHISARLPGGGHRFLINPYGMRFEEVTPENLVTVD
IDGKVLEDPMGLGINPAGFTIHSAIHAARHDAICVLHTHTVAGVAVSCQEEGLLPLNQWSMQFTGRVAYHAYEGIALDLD
ERQRLVADLGDKPVMVLRNHGLLTCGRTVGEAFRLMHNMERSCRAQLAIQAAGAPVIRPSSAIATKTAGQYAAGYDRVVV
QGAPDNEWAAFKRMLARTDPDFFANG

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826321, Length=197, Percent_Identity=43.1472081218274, Blast_Score=160, Evalue=8e-40,
Organism=Homo sapiens, GI29826323, Length=197, Percent_Identity=43.1472081218274, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI29826319, Length=197, Percent_Identity=43.1472081218274, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI29826325, Length=197, Percent_Identity=43.1472081218274, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI9943848, Length=195, Percent_Identity=38.974358974359, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI9951927, Length=195, Percent_Identity=38.974358974359, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI62912453, Length=195, Percent_Identity=38.974358974359, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI297307158, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI9257192, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI9257190, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI89276787, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI297307160, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI115533216, Length=260, Percent_Identity=37.3076923076923, Blast_Score=156, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI115533218, Length=260, Percent_Identity=37.3076923076923, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71989560, Length=254, Percent_Identity=31.8897637795276, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989550, Length=254, Percent_Identity=31.8897637795276, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989555, Length=254, Percent_Identity=31.8897637795276, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989541, Length=254, Percent_Identity=31.8897637795276, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71989544, Length=254, Percent_Identity=31.8897637795276, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24655685, Length=194, Percent_Identity=37.1134020618557, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363761, Length=194, Percent_Identity=37.1134020618557, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363759, Length=194, Percent_Identity=37.1134020618557, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363753, Length=194, Percent_Identity=37.1134020618557, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363755, Length=194, Percent_Identity=37.1134020618557, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363751, Length=194, Percent_Identity=37.1134020618557, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24655690, Length=194, Percent_Identity=37.1134020618557, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281363763, Length=194, Percent_Identity=37.1134020618557, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281363757, Length=194, Percent_Identity=37.1134020618557, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136738, Length=194, Percent_Identity=37.1134020618557, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28963; Mature: 28832

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAATPSIVADRDTDPADHAATRAMRVDLAAAYRLIHRLGLDDSIYTHISARLPGGGHRF
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCEE
LINPYGMRFEEVTPENLVTVDIDGKVLEDPMGLGINPAGFTIHSAIHAARHDAICVLHTH
EECCCCCEEECCCCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC
TVAGVAVSCQEEGLLPLNQWSMQFTGRVAYHAYEGIALDLDERQRLVADLGDKPVMVLRN
EEEEEEEEECCCCCCCHHCCCEEECCEEEEEEECCEEECHHHHHHHHHHCCCCCEEEEEC
HGLLTCGRTVGEAFRLMHNMERSCRAQLAIQAAGAPVIRPSSAIATKTAGQYAAGYDRVV
CCEEEECHHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCCHHHHCCCCCCCCCCCEEE
VQGAPDNEWAAFKRMLARTDPDFFANG
EECCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAATPSIVADRDTDPADHAATRAMRVDLAAAYRLIHRLGLDDSIYTHISARLPGGGHRF
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCEE
LINPYGMRFEEVTPENLVTVDIDGKVLEDPMGLGINPAGFTIHSAIHAARHDAICVLHTH
EECCCCCEEECCCCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC
TVAGVAVSCQEEGLLPLNQWSMQFTGRVAYHAYEGIALDLDERQRLVADLGDKPVMVLRN
EEEEEEEEECCCCCCCHHCCCEEECCEEEEEEECCEEECHHHHHHHHHHCCCCCEEEEEC
HGLLTCGRTVGEAFRLMHNMERSCRAQLAIQAAGAPVIRPSSAIATKTAGQYAAGYDRVV
CCEEEECHHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCCHHHHCCCCCCCCCCCEEE
VQGAPDNEWAAFKRMLARTDPDFFANG
EECCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]