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The map label for this gene is lrp [H]

Identifier: 170747938

GI number: 170747938

Start: 1598763

End: 1599248

Strand: Reverse

Name: lrp [H]

Synonym: Mrad2831_1520

Alternate gene names: 170747938

Gene position: 1599248-1598763 (Counterclockwise)

Preceding gene: 170747941

Following gene: 170747931

Centisome position: 26.31

GC content: 67.7

Gene sequence:

>486_bases
GTGACCCTGAAAGAATCGTCCATGTCCGCAGGGCTCGACCGGATCGACCAGAAGATCCTCCGCCTCCTCCAGGCGGACGG
GCGCATGGCCAATGCCGAGATCGCCGAGCGGGTCGGCACCAGCGCGGCCACCTGCCATCGCCGGATCCAGCGCCTGTTCG
CGGACGGGTTCGTGCGGGCGGTCCGGGCGCTGATCGATCCGATGCGGGTCGGACGCGGCACCCTGGTCTTCGTCGGCGTC
GTGCTCGACCGCTCGACCCCCGAGAGTTTCTCGGAATTCGAGGCGGCCGTGCGGGCGATTCCCGCGCTCCTCGACTGTCA
CCTCGTGGCCGGCGACTTCGACTACATGCTGAAGATCCGGGTCTCCGACATGGCCGACTTCAACCGCCTCCACAGCGCCA
CGCTGATCGGCCTGCCGGGGGTGCGCCAGACCCGGACCTTCTTCGTGATGAAGGAGGTGATCGACAACGCGCCCCTCGAT
CTGTGA

Upstream 100 bases:

>100_bases
TACCCGATCCGCGATGAAAGGTGCTCTCGATCTTTCAGCTCAGACATCCCGCCACTTGCGTTGCTGGGCGCCTCAGCTGC
AGAGAATTCCGGATTGAGCT

Downstream 100 bases:

>100_bases
GGCCGCCTACCCCTCCCCGCGCCGTTCCTTCCGCAACGCCTCCCAGCGGTCGAGCCGCTCGGCGATGCGGTTCTCGTAGC
CCCGTTCGGTCGGCTGATAG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MTLKESSMSAGLDRIDQKILRLLQADGRMANAEIAERVGTSAATCHRRIQRLFADGFVRAVRALIDPMRVGRGTLVFVGV
VLDRSTPESFSEFEAAVRAIPALLDCHLVAGDFDYMLKIRVSDMADFNRLHSATLIGLPGVRQTRTFFVMKEVIDNAPLD
L

Sequences:

>Translated_161_residues
MTLKESSMSAGLDRIDQKILRLLQADGRMANAEIAERVGTSAATCHRRIQRLFADGFVRAVRALIDPMRVGRGTLVFVGV
VLDRSTPESFSEFEAAVRAIPALLDCHLVAGDFDYMLKIRVSDMADFNRLHSATLIGLPGVRQTRTFFVMKEVIDNAPLD
L
>Mature_160_residues
TLKESSMSAGLDRIDQKILRLLQADGRMANAEIAERVGTSAATCHRRIQRLFADGFVRAVRALIDPMRVGRGTLVFVGVV
LDRSTPESFSEFEAAVRAIPALLDCHLVAGDFDYMLKIRVSDMADFNRLHSATLIGLPGVRQTRTFFVMKEVIDNAPLDL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=142, Percent_Identity=47.1830985915493, Blast_Score=145, Evalue=1e-36,
Organism=Escherichia coli, GI87081742, Length=142, Percent_Identity=30.2816901408451, Blast_Score=93, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17836; Mature: 17705

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKESSMSAGLDRIDQKILRLLQADGRMANAEIAERVGTSAATCHRRIQRLFADGFVRA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VRALIDPMRVGRGTLVFVGVVLDRSTPESFSEFEAAVRAIPALLDCHLVAGDFDYMLKIR
HHHHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
VSDMADFNRLHSATLIGLPGVRQTRTFFVMKEVIDNAPLDL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLKESSMSAGLDRIDQKILRLLQADGRMANAEIAERVGTSAATCHRRIQRLFADGFVRA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VRALIDPMRVGRGTLVFVGVVLDRSTPESFSEFEAAVRAIPALLDCHLVAGDFDYMLKIR
HHHHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
VSDMADFNRLHSATLIGLPGVRQTRTFFVMKEVIDNAPLDL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]