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The map label for this gene is serA [H]

Identifier: 170747892

GI number: 170747892

Start: 1539245

End: 1540159

Strand: Reverse

Name: serA [H]

Synonym: Mrad2831_1474

Alternate gene names: 170747892

Gene position: 1540159-1539245 (Counterclockwise)

Preceding gene: 170747893

Following gene: 170747886

Centisome position: 25.34

GC content: 74.64

Gene sequence:

>915_bases
ATGCGCGCTGTGTTCGTGGACGCCAGCGAGACCCTGGCGGCGGTGGCCCGGCGGCTGTTGCGCCCCGACGACCCGCCCTT
CGCGATCCACGCGGATCCCGGCATCGCGCCGCAGGATCTGCCCGCGATCCTCGACGGCGCCGAGACCGCGGTGATCGACC
ACACCGCCCTCCCCCTCGACGTGGCCCGGGCCTGCGCGGGCCTGAAGCACGTCGTGTTCCTCGGCACCGGCGCCCGCAGC
TACATGGACCCGGAGGCGCTCCGGGACGCGCTCGGCGTCACCGTCCACACCATCAAGGGCTACGGCGACACGGCGGTCGC
CGAGTGCGCCTTCGCGCTGATGTGGGCCGCCGCCCGCGGCCTGCCCGAGATGGACCGGGCGATGCGCGCCGGATCCTGGC
TGCGCACGGAGGGGATCCAGCTCACCGGCAAGACCGTCGGCCTCGTCGGGTTCGGCGGGATCGCCGCCGAGATGGCGCGC
CTCTGCCGGGGTGTGGGCATGCGGGTGCTCGCCTGGAACCGGACACCGAAGGCCCATCCCGGCGTCGACTTCGTCCCCCT
CGACCGCCTGCTCGCCGAGAGCGACGTGGTCTCGCTCCACCTGCTCCTCACCGACGCGACGCGCGGCTTCCTGTCGGCCG
CGCGGATCGCCGCGATGAAGCCCGGCGCGATGCTGATCAACACCGCCCGCGGGGCGGTGCTCGACGAGGCCGCCCTGGTC
GAGGCCCTGCGCACCGGCCAGGTGGCGCGGGCCGGGCTCGACGTGTTCACGGTCGAGCCCCTGCCGGCGGATCACCCGCT
GGCGAGCCTGCCGAACGTCACCCTGTCGGCGCACTCGGCGTTCCGCACGCCCGAGGCCAGCGACAACCTGATCGGCGCCG
CCCTCGCGCATTGCCGGCGGATCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGGGACGGCGGCATCCCCCGATCGGGCCTTGGCACGGCCCGCGCACCGGACGCATCGTGGCCGGACGGGGCCGGACGGG
GCCGGATGAGGGAGACGCCG

Downstream 100 bases:

>100_bases
GGGATCGGCCGCGCGATCCTCAGTGCTCGGTGCCCGGCATGTTCGGCCGCGGCGCGCCGCCGTGGTGGTGGATCAGGTTC
GAGCGCTCCGGGCTGCCCTT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRAVFVDASETLAAVARRLLRPDDPPFAIHADPGIAPQDLPAILDGAETAVIDHTALPLDVARACAGLKHVVFLGTGARS
YMDPEALRDALGVTVHTIKGYGDTAVAECAFALMWAAARGLPEMDRAMRAGSWLRTEGIQLTGKTVGLVGFGGIAAEMAR
LCRGVGMRVLAWNRTPKAHPGVDFVPLDRLLAESDVVSLHLLLTDATRGFLSAARIAAMKPGAMLINTARGAVLDEAALV
EALRTGQVARAGLDVFTVEPLPADHPLASLPNVTLSAHSAFRTPEASDNLIGAALAHCRRIAAG

Sequences:

>Translated_304_residues
MRAVFVDASETLAAVARRLLRPDDPPFAIHADPGIAPQDLPAILDGAETAVIDHTALPLDVARACAGLKHVVFLGTGARS
YMDPEALRDALGVTVHTIKGYGDTAVAECAFALMWAAARGLPEMDRAMRAGSWLRTEGIQLTGKTVGLVGFGGIAAEMAR
LCRGVGMRVLAWNRTPKAHPGVDFVPLDRLLAESDVVSLHLLLTDATRGFLSAARIAAMKPGAMLINTARGAVLDEAALV
EALRTGQVARAGLDVFTVEPLPADHPLASLPNVTLSAHSAFRTPEASDNLIGAALAHCRRIAAG
>Mature_304_residues
MRAVFVDASETLAAVARRLLRPDDPPFAIHADPGIAPQDLPAILDGAETAVIDHTALPLDVARACAGLKHVVFLGTGARS
YMDPEALRDALGVTVHTIKGYGDTAVAECAFALMWAAARGLPEMDRAMRAGSWLRTEGIQLTGKTVGLVGFGGIAAEMAR
LCRGVGMRVLAWNRTPKAHPGVDFVPLDRLLAESDVVSLHLLLTDATRGFLSAARIAAMKPGAMLINTARGAVLDEAALV
EALRTGQVARAGLDVFTVEPLPADHPLASLPNVTLSAHSAFRTPEASDNLIGAALAHCRRIAAG

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=295, Percent_Identity=30.8474576271186, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI6912396, Length=182, Percent_Identity=36.2637362637363, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=28.9285714285714, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=28.9285714285714, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI145580575, Length=280, Percent_Identity=28.9285714285714, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=27.5, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=27.5, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=31.6793893129771, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082289, Length=296, Percent_Identity=32.7702702702703, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789279, Length=195, Percent_Identity=34.8717948717949, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081824, Length=245, Percent_Identity=28.1632653061224, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=225, Percent_Identity=28.8888888888889, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=174, Percent_Identity=27.0114942528736, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=217, Percent_Identity=32.7188940092166, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=217, Percent_Identity=32.258064516129, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=169, Percent_Identity=33.7278106508876, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=229, Percent_Identity=28.82096069869, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=86, Percent_Identity=39.5348837209302, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571528, Length=170, Percent_Identity=39.4117647058824, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574286, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585516, Length=205, Percent_Identity=33.1707317073171, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585514, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574282, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574284, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI45551003, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI45552429, Length=187, Percent_Identity=33.1550802139037, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=29.9212598425197, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921140, Length=206, Percent_Identity=31.0679611650485, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 31850; Mature: 31850

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVFVDASETLAAVARRLLRPDDPPFAIHADPGIAPQDLPAILDGAETAVIDHTALPLD
CCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCHH
VARACAGLKHVVFLGTGARSYMDPEALRDALGVTVHTIKGYGDTAVAECAFALMWAAARG
HHHHHCCCEEEEEEECCCHHCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCC
LPEMDRAMRAGSWLRTEGIQLTGKTVGLVGFGGIAAEMARLCRGVGMRVLAWNRTPKAHP
CHHHHHHHHCCCCEECCCEEEECCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCC
GVDFVPLDRLLAESDVVSLHLLLTDATRGFLSAARIAAMKPGAMLINTARGAVLDEAALV
CCCEEHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
EALRTGQVARAGLDVFTVEPLPADHPLASLPNVTLSAHSAFRTPEASDNLIGAALAHCRR
HHHHHCHHHHCCCCEEEECCCCCCCCHHHCCCCEEECCHHHCCCCCCCHHHHHHHHHHHH
IAAG
HCCC
>Mature Secondary Structure
MRAVFVDASETLAAVARRLLRPDDPPFAIHADPGIAPQDLPAILDGAETAVIDHTALPLD
CCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCHH
VARACAGLKHVVFLGTGARSYMDPEALRDALGVTVHTIKGYGDTAVAECAFALMWAAARG
HHHHHCCCEEEEEEECCCHHCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCC
LPEMDRAMRAGSWLRTEGIQLTGKTVGLVGFGGIAAEMARLCRGVGMRVLAWNRTPKAHP
CHHHHHHHHCCCCEECCCEEEECCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCC
GVDFVPLDRLLAESDVVSLHLLLTDATRGFLSAARIAAMKPGAMLINTARGAVLDEAALV
CCCEEHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
EALRTGQVARAGLDVFTVEPLPADHPLASLPNVTLSAHSAFRTPEASDNLIGAALAHCRR
HHHHHCHHHHCCCCEEEECCCCCCCCHHHCCCCEEECCHHHCCCCCCCHHHHHHHHHHHH
IAAG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]