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The map label for this gene is galE [C]

Identifier: 170747617

GI number: 170747617

Start: 1247732

End: 1248739

Strand: Reverse

Name: galE [C]

Synonym: Mrad2831_1187

Alternate gene names: 170747617

Gene position: 1248739-1247732 (Counterclockwise)

Preceding gene: 170747618

Following gene: 170747616

Centisome position: 20.55

GC content: 74.01

Gene sequence:

>1008_bases
GTGAGCGGCGCCGCCGCCGGCGGGCCGCCCGGGCCGGGGCTCGCGGGCGCCCGCTGCCTCGTGCTGGGCGGCGGCGGGTT
CCTCGGGCTGAACCTGTGCAACCGCCTCGCGGCGGCGGGCGCCGAGGTCACGTGCTTCAGCCGCAGCCACCCGCAGGCCG
AGGTCCTGGACCGGCGCGTCGCCCGGGTGTCCGGCCAGTTCTCCGACCGCCTCGCCCTCGCCAACGCGGTCGAGCGGCAG
GACGTCGTCTTCCACCTGATCGCCGGCTCGATCCCCGAGAGCTCCAACCGCGACCCGTCGGCGGAGCTCTCGGCCGCGCC
GATCGCCACGCTGCACCTCCTGGAGATCTGCCGCTCGGCCCGGATCGGGAAGCTCGTGTTCGCGTCCTCCGGGGGCGCGA
TCTACGGGATCCCGGGCGCCATCCCGATCCCCGAGCGGGCGCCGACCGACCCGATCTCGGCCTACGGCATCAGCAAGCTG
ATGATCGAGAAGTCGCTGCACCTCTACCGGCACCTGCACGGGATCGACTACCAGATCCTGCGGATCGCCAACCCGTACGG
ACGCTTCCAGCTCGGCACCAAGCACCAGGGCCTGATCGGCAGCTACATCCACCGCGTCCTCACCGACCAGCCGCTGGAGG
TCTGGGGGACCGGCGCGGTGGTGCGCGACTTCCTGCACATCGACGACGTCAGCGACGCCTTCCTGGGCGCCGTCGCCTAC
CGGGGGCCGCACAAGGTACTGAATGTCGGCAGCGGCCGGGGCCTCAGCGTCAACCAGGTCATCGCCGAGCTGAAGGCGGC
CTTCGGGCGGGACCACCTCCCCTGCCTGCACCGGCCGAGCCGCGCCGCCGACGTGCCGGCCAACGTGCTCGACACCGCGC
TGATCCGGGCGGAGCTCGGCTGGCAGCCCCGCGTCCCCCTGCAGGCCGGGCTCACCGGCACCATCGCGTGGATGCGCGCC
CATCTGGCGCGGTCGCGGGCGGCGGGCGCGCCCTCCGGCACCGGCTGA

Upstream 100 bases:

>100_bases
CCCGGCGCGCGCTGCAGGACACAGCCCGGACGCTGCTCGAGCGCCTGATCGCGGCGGGCGAGGCCGGGCCCGAAGGGGCC
CGCCCCGCCGATCCGCGGCC

Downstream 100 bases:

>100_bases
TCGGCCGGATCGTCGATCCGCCCCGGAGCGGCCACGTTTGTCGGCGACAGCGCGCGGCACCGATCCGCGAGGAGACCCCA
TGTCCTTCCTGCACGATCTG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSGAAAGGPPGPGLAGARCLVLGGGGFLGLNLCNRLAAAGAEVTCFSRSHPQAEVLDRRVARVSGQFSDRLALANAVERQ
DVVFHLIAGSIPESSNRDPSAELSAAPIATLHLLEICRSARIGKLVFASSGGAIYGIPGAIPIPERAPTDPISAYGISKL
MIEKSLHLYRHLHGIDYQILRIANPYGRFQLGTKHQGLIGSYIHRVLTDQPLEVWGTGAVVRDFLHIDDVSDAFLGAVAY
RGPHKVLNVGSGRGLSVNQVIAELKAAFGRDHLPCLHRPSRAADVPANVLDTALIRAELGWQPRVPLQAGLTGTIAWMRA
HLARSRAAGAPSGTG

Sequences:

>Translated_335_residues
MSGAAAGGPPGPGLAGARCLVLGGGGFLGLNLCNRLAAAGAEVTCFSRSHPQAEVLDRRVARVSGQFSDRLALANAVERQ
DVVFHLIAGSIPESSNRDPSAELSAAPIATLHLLEICRSARIGKLVFASSGGAIYGIPGAIPIPERAPTDPISAYGISKL
MIEKSLHLYRHLHGIDYQILRIANPYGRFQLGTKHQGLIGSYIHRVLTDQPLEVWGTGAVVRDFLHIDDVSDAFLGAVAY
RGPHKVLNVGSGRGLSVNQVIAELKAAFGRDHLPCLHRPSRAADVPANVLDTALIRAELGWQPRVPLQAGLTGTIAWMRA
HLARSRAAGAPSGTG
>Mature_334_residues
SGAAAGGPPGPGLAGARCLVLGGGGFLGLNLCNRLAAAGAEVTCFSRSHPQAEVLDRRVARVSGQFSDRLALANAVERQD
VVFHLIAGSIPESSNRDPSAELSAAPIATLHLLEICRSARIGKLVFASSGGAIYGIPGAIPIPERAPTDPISAYGISKLM
IEKSLHLYRHLHGIDYQILRIANPYGRFQLGTKHQGLIGSYIHRVLTDQPLEVWGTGAVVRDFLHIDDVSDAFLGAVAYR
GPHKVLNVGSGRGLSVNQVIAELKAAFGRDHLPCLHRPSRAADVPANVLDTALIRAELGWQPRVPLQAGLTGTIAWMRAH
LARSRAAGAPSGTG

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=317, Percent_Identity=25.8675078864353, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI7657641, Length=343, Percent_Identity=25.0728862973761, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI56237023, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI56118217, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI189083684, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=28.698224852071, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI48994969, Length=335, Percent_Identity=25.9701492537313, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788365, Length=340, Percent_Identity=24.4117647058824, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788353, Length=336, Percent_Identity=23.5119047619048, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71982038, Length=350, Percent_Identity=27.7142857142857, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=349, Percent_Identity=28.3667621776504, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539532, Length=340, Percent_Identity=23.2352941176471, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=340, Percent_Identity=25.2941176470588, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=340, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=25.1552795031056, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35282; Mature: 35151

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAAAGGPPGPGLAGARCLVLGGGGFLGLNLCNRLAAAGAEVTCFSRSHPQAEVLDRRV
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
ARVSGQFSDRLALANAVERQDVVFHLIAGSIPESSNRDPSAELSAAPIATLHLLEICRSA
HHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RIGKLVFASSGGAIYGIPGAIPIPERAPTDPISAYGISKLMIEKSLHLYRHLHGIDYQIL
CCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
RIANPYGRFQLGTKHQGLIGSYIHRVLTDQPLEVWGTGAVVRDFLHIDDVSDAFLGAVAY
EECCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHH
RGPHKVLNVGSGRGLSVNQVIAELKAAFGRDHLPCLHRPSRAADVPANVLDTALIRAELG
CCCHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
WQPRVPLQAGLTGTIAWMRAHLARSRAAGAPSGTG
CCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SGAAAGGPPGPGLAGARCLVLGGGGFLGLNLCNRLAAAGAEVTCFSRSHPQAEVLDRRV
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
ARVSGQFSDRLALANAVERQDVVFHLIAGSIPESSNRDPSAELSAAPIATLHLLEICRSA
HHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RIGKLVFASSGGAIYGIPGAIPIPERAPTDPISAYGISKLMIEKSLHLYRHLHGIDYQIL
CCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
RIANPYGRFQLGTKHQGLIGSYIHRVLTDQPLEVWGTGAVVRDFLHIDDVSDAFLGAVAY
EECCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHH
RGPHKVLNVGSGRGLSVNQVIAELKAAFGRDHLPCLHRPSRAADVPANVLDTALIRAELG
CCCHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
WQPRVPLQAGLTGTIAWMRAHLARSRAAGAPSGTG
CCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]