Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 170747575

GI number: 170747575

Start: 1203411

End: 1205015

Strand: Reverse

Name: nhaK [H]

Synonym: Mrad2831_1143

Alternate gene names: 170747575

Gene position: 1205015-1203411 (Counterclockwise)

Preceding gene: 170747576

Following gene: 170747572

Centisome position: 19.83

GC content: 73.83

Gene sequence:

>1605_bases
ATGACATCCGTCGCCCTGTTCGAGCTGATCCTCGGCCTCCTCGGCGCGGCCCTGCTGCTGTCGCTGGCGGCCGGGCGCCT
CGGCTTCCCGCCGGCCGCCGCCCTCGTCGTCGGCGGCATGGCGCTGGCGGTGGCGCCGGGCCTGCCGGCCTTCGATCTCG
ACCCGGACCTGATCATGGTCCTGTTCCTGCCGCCGCTCCTGCTCGAATCCGCCTACTTCACCGTCTGGCGCGACTTCCGG
GCGAGCCTCGGCCCGATCCTGTCGCTGTCCCTCGGCGCGGTCCTGTTCACGACCCTCGCGGTCGGGCTCGTCGCCCACGC
GGTGGTGCCGTCCCTGCCCTGGGCCGCCTGCTTCGCCCTCGGCGCCATCGTGTCGCCGCCGGACGCGGTGGCCGCCAAGG
CGGTGCTGGCCCGCGTCGCCCTGCCCCGCCGGATGATCACGGTCCTGGAGGGCGAGAGCCTCGTGAACGACGCCTCGGGC
CTCGTGCTCTACCGCTTCGCGGTGGCGGCGGCCCTGACCGGCAGCTTCAGCGCCGCCGCGGCACTCGGCAGCTTCGCGTG
GCTCGCGGTGGCGGGCGTCGCGGTCGGGATCGCCTGCGGGGTGGCGGTGACGCTCGTGATGCGGCGGATGCACGACGCCA
ACGCCATCACGGTGCTGAGCTTCCTCGCCGCCTACGTCGCCTACCTCGCGGCCGAGGAGATCCACGCCTCCGGCGTCCTG
GCCGTGGTGGCCTGCGGCCTGATGATGGGCGGCCGGGAGCACGAGACCTTCGACGCGCATGCCCGCCGCCATTCCGTGGC
GGTGTGGGAATTCGTCGTGTTCGTTCTGGAGGCCCTGGTCTTCGTGCTGATCGGGCTGGCGCTCCGCGGCGTGCTGGCCC
GGACCGGCGGCCAGCTGGGGGCGCTCTCGGCCGAGATGCCGCTGGCCCTCGCGGTCACCGCGACCTGCGTCGTCGCCCGC
CTGCTCTGGGTGTTCCCCGCCGTCTACCTGCGGCGGCTCCTGTCGCCGCGGTTCCGCGCGCAGGAGCCCTCCCCGAGTCC
GGCCGTGCCGCTGATCCTCGGCTGGGCCGGCATGCGTGGGGTCGTGACCCTGGCGGCCGCCCTGGCCCTGCCGGTGGACT
TTCCCGGCCGCGACGCGATCCTGGTGGCGGCCTTCGCGGTGATCCTGTTCACCGTGCTGGTGCAGGGCACGACCCTGGGG
CCGCTGATCCGCAGCCTCCGCCTCGACCCCGCGGCGCACCTCCCCGACGGCCATCTCGACGCGCCCATGGCCCGCGTGGT
CGTGAACGAGGCCGGACTCGCCGCCCTCGAGGGTTTGGTGTTCCCCGAGACCGGGGCGCTGCAGCACCCGCGCCTCGTCG
AGGAGTATCGGCGCCGGGTGCGGGCGTCCTCGCGGGACCGCGACGAGCGGACGGCGCTGGAGGCCGAGAAGACCGAGCAC
TTCGCCGCCGCGCTGCTCGCCGTGCGCTCAGGCCGGTCGGCCCTGATCGACCTGCACCGACAGGATCGGATTCACAGCTC
GGTGCTGCGGCAGCTGGAGACGGAGATCGACCTGGAGGAACTCCATCTCAAGCGTCTCGCCGGGACCGCACCGGCCCACG
GATAG

Upstream 100 bases:

>100_bases
CGCGGCCCGCACCGCGACCCTGGGCGGCTCGGTATTCATCCGACCCGGAAACGTCCTAGAACGGCCGCGCTTGTCGGAGT
TCCGGCGCCGAGACCGATCG

Downstream 100 bases:

>100_bases
GCGAGGTCGGCGCGGCCGCGGCCATCGACGGGCCGTCAGTGGGCGGCGCAGCCGTCCGCCGGCTGGCCGTAGCCGCTGTA
GACGACCCGCACCTTGTGCC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MTSVALFELILGLLGAALLLSLAAGRLGFPPAAALVVGGMALAVAPGLPAFDLDPDLIMVLFLPPLLLESAYFTVWRDFR
ASLGPILSLSLGAVLFTTLAVGLVAHAVVPSLPWAACFALGAIVSPPDAVAAKAVLARVALPRRMITVLEGESLVNDASG
LVLYRFAVAAALTGSFSAAAALGSFAWLAVAGVAVGIACGVAVTLVMRRMHDANAITVLSFLAAYVAYLAAEEIHASGVL
AVVACGLMMGGREHETFDAHARRHSVAVWEFVVFVLEALVFVLIGLALRGVLARTGGQLGALSAEMPLALAVTATCVVAR
LLWVFPAVYLRRLLSPRFRAQEPSPSPAVPLILGWAGMRGVVTLAAALALPVDFPGRDAILVAAFAVILFTVLVQGTTLG
PLIRSLRLDPAAHLPDGHLDAPMARVVVNEAGLAALEGLVFPETGALQHPRLVEEYRRRVRASSRDRDERTALEAEKTEH
FAAALLAVRSGRSALIDLHRQDRIHSSVLRQLETEIDLEELHLKRLAGTAPAHG

Sequences:

>Translated_534_residues
MTSVALFELILGLLGAALLLSLAAGRLGFPPAAALVVGGMALAVAPGLPAFDLDPDLIMVLFLPPLLLESAYFTVWRDFR
ASLGPILSLSLGAVLFTTLAVGLVAHAVVPSLPWAACFALGAIVSPPDAVAAKAVLARVALPRRMITVLEGESLVNDASG
LVLYRFAVAAALTGSFSAAAALGSFAWLAVAGVAVGIACGVAVTLVMRRMHDANAITVLSFLAAYVAYLAAEEIHASGVL
AVVACGLMMGGREHETFDAHARRHSVAVWEFVVFVLEALVFVLIGLALRGVLARTGGQLGALSAEMPLALAVTATCVVAR
LLWVFPAVYLRRLLSPRFRAQEPSPSPAVPLILGWAGMRGVVTLAAALALPVDFPGRDAILVAAFAVILFTVLVQGTTLG
PLIRSLRLDPAAHLPDGHLDAPMARVVVNEAGLAALEGLVFPETGALQHPRLVEEYRRRVRASSRDRDERTALEAEKTEH
FAAALLAVRSGRSALIDLHRQDRIHSSVLRQLETEIDLEELHLKRLAGTAPAHG
>Mature_533_residues
TSVALFELILGLLGAALLLSLAAGRLGFPPAAALVVGGMALAVAPGLPAFDLDPDLIMVLFLPPLLLESAYFTVWRDFRA
SLGPILSLSLGAVLFTTLAVGLVAHAVVPSLPWAACFALGAIVSPPDAVAAKAVLARVALPRRMITVLEGESLVNDASGL
VLYRFAVAAALTGSFSAAAALGSFAWLAVAGVAVGIACGVAVTLVMRRMHDANAITVLSFLAAYVAYLAAEEIHASGVLA
VVACGLMMGGREHETFDAHARRHSVAVWEFVVFVLEALVFVLIGLALRGVLARTGGQLGALSAEMPLALAVTATCVVARL
LWVFPAVYLRRLLSPRFRAQEPSPSPAVPLILGWAGMRGVVTLAAALALPVDFPGRDAILVAAFAVILFTVLVQGTTLGP
LIRSLRLDPAAHLPDGHLDAPMARVVVNEAGLAALEGLVFPETGALQHPRLVEEYRRRVRASSRDRDERTALEAEKTEHF
AAALLAVRSGRSALIDLHRQDRIHSSVLRQLETEIDLEELHLKRLAGTAPAHG

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=388, Percent_Identity=26.8041237113402, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI15529998, Length=391, Percent_Identity=25.0639386189258, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI27777632, Length=384, Percent_Identity=28.6458333333333, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI27734935, Length=411, Percent_Identity=22.8710462287105, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI194239733, Length=393, Percent_Identity=25.6997455470738, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI41872703, Length=380, Percent_Identity=25.2631578947368, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI4759144, Length=392, Percent_Identity=28.8265306122449, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI110227626, Length=390, Percent_Identity=22.3076923076923, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI5454070, Length=390, Percent_Identity=22.3076923076923, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI294997330, Length=390, Percent_Identity=23.0769230769231, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI14211919, Length=375, Percent_Identity=22.4, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790501, Length=504, Percent_Identity=30.5555555555556, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71999817, Length=448, Percent_Identity=24.5535714285714, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71999819, Length=448, Percent_Identity=24.5535714285714, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71999821, Length=448, Percent_Identity=24.5535714285714, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71980847, Length=399, Percent_Identity=23.3082706766917, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25147678, Length=438, Percent_Identity=24.2009132420091, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71987537, Length=444, Percent_Identity=22.972972972973, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71987535, Length=444, Percent_Identity=22.972972972973, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25150332, Length=413, Percent_Identity=24.455205811138, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71993590, Length=370, Percent_Identity=24.8648648648649, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71993582, Length=370, Percent_Identity=24.8648648648649, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71990932, Length=396, Percent_Identity=23.2323232323232, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71990924, Length=396, Percent_Identity=23.2323232323232, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71992107, Length=326, Percent_Identity=22.0858895705521, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=326, Percent_Identity=22.0858895705521, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987559, Length=439, Percent_Identity=21.4123006833713, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71987545, Length=438, Percent_Identity=21.0045662100457, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320663, Length=372, Percent_Identity=22.3118279569892, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510734, Length=380, Percent_Identity=28.1578947368421, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221510738, Length=380, Percent_Identity=28.1578947368421, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221510732, Length=380, Percent_Identity=28.1578947368421, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221510736, Length=380, Percent_Identity=28.1578947368421, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585580, Length=377, Percent_Identity=28.1167108753316, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24585578, Length=377, Percent_Identity=28.1167108753316, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI221510740, Length=380, Percent_Identity=28.1578947368421, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281360447, Length=437, Percent_Identity=24.4851258581236, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221473212, Length=437, Percent_Identity=21.2814645308924, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221473215, Length=399, Percent_Identity=22.3057644110276, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281364513, Length=376, Percent_Identity=22.6063829787234, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221473222, Length=376, Percent_Identity=22.6063829787234, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56133; Mature: 56002

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVALFELILGLLGAALLLSLAAGRLGFPPAAALVVGGMALAVAPGLPAFDLDPDLIMV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LFLPPLLLESAYFTVWRDFRASLGPILSLSLGAVLFTTLAVGLVAHAVVPSLPWAACFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GAIVSPPDAVAAKAVLARVALPRRMITVLEGESLVNDASGLVLYRFAVAAALTGSFSAAA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCHHHHH
ALGSFAWLAVAGVAVGIACGVAVTLVMRRMHDANAITVLSFLAAYVAYLAAEEIHASGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHH
AVVACGLMMGGREHETFDAHARRHSVAVWEFVVFVLEALVFVLIGLALRGVLARTGGQLG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALSAEMPLALAVTATCVVARLLWVFPAVYLRRLLSPRFRAQEPSPSPAVPLILGWAGMRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHH
VVTLAAALALPVDFPGRDAILVAAFAVILFTVLVQGTTLGPLIRSLRLDPAAHLPDGHLD
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
APMARVVVNEAGLAALEGLVFPETGALQHPRLVEEYRRRVRASSRDRDERTALEAEKTEH
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FAAALLAVRSGRSALIDLHRQDRIHSSVLRQLETEIDLEELHLKRLAGTAPAHG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSVALFELILGLLGAALLLSLAAGRLGFPPAAALVVGGMALAVAPGLPAFDLDPDLIMV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH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HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA