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The map label for this gene is kbl [C]

Identifier: 170747384

GI number: 170747384

Start: 999996

End: 1001363

Strand: Reverse

Name: kbl [C]

Synonym: Mrad2831_0951

Alternate gene names: 170747384

Gene position: 1001363-999996 (Counterclockwise)

Preceding gene: 170747385

Following gene: 170747380

Centisome position: 16.48

GC content: 70.98

Gene sequence:

>1368_bases
ATGACCGACACGGCACGGCCGGACGGTGGGCGCGCGGCGCTCGCCGGCTTCGTGACCAACCGGCTCGGGCGCGCGACGCC
GCGCCCGGCCCCCGTCAAGACGGCCTCTCCCGCCGGCAAGTCGGCGGCGCAGAACTTCGAGAACCTGCCGGGCTACCGCG
AGCTGAAGCTCCAGCGCCAGGCGGCCGATCTGATCGGCCTGGGCAACCCGTTCTTCCGCGTCCACGACGCCAAGGCCGGG
GCCACGACGCGGATCGACCAGAAGAGCTTCACCAACTTCTCGTCCTACGACTACCTCGGCCTGAACGGCCATCCGCGGGT
GAGCAACGCCGCCCGGGAGGCGATCGAGGCTTACGGCACCTCCGCGTCGGCGAGCCGCGTCGTGGCGGGCGAGCGGCCGG
GGCACATCAGCCTCGAGCAGGCGCTGGCCAAGCACTACCAGTCCGAGGGCTGCATCGTGATGGTGAGCGGCCACGCCACC
AACGTCACGACCATCGGCGCCCTGCTGGAAGCCGGCGACGTGATCTTCCACGACGCGCTGTCCCACAACAGCATCGTCAC
CGGCGCGCAGCTGTCGGGCGCCCAGCGGCGCTCCTTCGCGCATAACGATCTCGACGCCCTGGAGACCCTGCTCCAGTCGA
CCCGCCACGAGCATCGCCGGGCGCTGATCGTGGTCGAGGGCCTCTACAGCATGGACGGCGACGCGCCGGACCTCGCCGGG
CTCGTCGCCCTCAAGAAGCGCTACGACGCGTGGCTGATGGTCGACGAGGCGCACGGCCTCGGCGTCACCGGCCGGACCGG
CGCCGGCCTGTTCGAGCATTGCGGTGTCGACCCCCGCGAGGTCGACATCTGGATGGGCACGCTGTCGAAGACCCTGTCGA
CCTGCGGCGGCTACATCTGCGGCCCGATCGCGCTGATCGAGTACCTGAAGCACACCGCCGGCGGCTTCGTGTACAGCGTC
GGCATGTCGCCGCCGCTCGCGGCCGCGGCCGAGGCGGCGCTCGCCGTGATGCACGCCGAGCCCGAGCGGGTCGAGCGCCT
GCGCCAGAACGGCACCCTGTTCCTGGCCACCGCCAAGAAGCTCGGCCTCGACACCGGTTTCAGCCTCGGCCTCGCGGTCG
TGCCGATCATCGTCGGCGATTCGCTGAAGGCCGTGACCCTGTCGGACCGGCTGTTCCGCCGGGGCATCAACGTGCAGCCG
ATCATCCACCCTGCGGTGCCGGAGCGGGCCTCGCGCCTGCGCTTCTTCCTCACCTCCGAGCACACGCCCGACCAGATCCG
CGACACCGTGAACGCGGTGGCCGAGGAGCTGGCGGCCATCGACAAGGGCGGCTCGCTGATCGAGCAGCTGCTGGCCAAGC
GGGTCTGA

Upstream 100 bases:

>100_bases
TCGTCTCGAAGCATGTCGGCGGTGAGGTCGATGCGCAGATCCTCGCGCCTCTCAAGGAACTCATCGAGCAGACGTCCAGC
GAGATCAAAGAGACCAACTC

Downstream 100 bases:

>100_bases
GCCCGGCCAGGGCCGCGCGCCCCGGTTCTTCGAGACCCTCACGAAGAAGGGGCGCGGATGATATCCGCGCCCCTTCTTCG
TATCGACAGACCGCGGCAGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTDTARPDGGRAALAGFVTNRLGRATPRPAPVKTASPAGKSAAQNFENLPGYRELKLQRQAADLIGLGNPFFRVHDAKAG
ATTRIDQKSFTNFSSYDYLGLNGHPRVSNAAREAIEAYGTSASASRVVAGERPGHISLEQALAKHYQSEGCIVMVSGHAT
NVTTIGALLEAGDVIFHDALSHNSIVTGAQLSGAQRRSFAHNDLDALETLLQSTRHEHRRALIVVEGLYSMDGDAPDLAG
LVALKKRYDAWLMVDEAHGLGVTGRTGAGLFEHCGVDPREVDIWMGTLSKTLSTCGGYICGPIALIEYLKHTAGGFVYSV
GMSPPLAAAAEAALAVMHAEPERVERLRQNGTLFLATAKKLGLDTGFSLGLAVVPIIVGDSLKAVTLSDRLFRRGINVQP
IIHPAVPERASRLRFFLTSEHTPDQIRDTVNAVAEELAAIDKGGSLIEQLLAKRV

Sequences:

>Translated_455_residues
MTDTARPDGGRAALAGFVTNRLGRATPRPAPVKTASPAGKSAAQNFENLPGYRELKLQRQAADLIGLGNPFFRVHDAKAG
ATTRIDQKSFTNFSSYDYLGLNGHPRVSNAAREAIEAYGTSASASRVVAGERPGHISLEQALAKHYQSEGCIVMVSGHAT
NVTTIGALLEAGDVIFHDALSHNSIVTGAQLSGAQRRSFAHNDLDALETLLQSTRHEHRRALIVVEGLYSMDGDAPDLAG
LVALKKRYDAWLMVDEAHGLGVTGRTGAGLFEHCGVDPREVDIWMGTLSKTLSTCGGYICGPIALIEYLKHTAGGFVYSV
GMSPPLAAAAEAALAVMHAEPERVERLRQNGTLFLATAKKLGLDTGFSLGLAVVPIIVGDSLKAVTLSDRLFRRGINVQP
IIHPAVPERASRLRFFLTSEHTPDQIRDTVNAVAEELAAIDKGGSLIEQLLAKRV
>Mature_454_residues
TDTARPDGGRAALAGFVTNRLGRATPRPAPVKTASPAGKSAAQNFENLPGYRELKLQRQAADLIGLGNPFFRVHDAKAGA
TTRIDQKSFTNFSSYDYLGLNGHPRVSNAAREAIEAYGTSASASRVVAGERPGHISLEQALAKHYQSEGCIVMVSGHATN
VTTIGALLEAGDVIFHDALSHNSIVTGAQLSGAQRRSFAHNDLDALETLLQSTRHEHRRALIVVEGLYSMDGDAPDLAGL
VALKKRYDAWLMVDEAHGLGVTGRTGAGLFEHCGVDPREVDIWMGTLSKTLSTCGGYICGPIALIEYLKHTAGGFVYSVG
MSPPLAAAAEAALAVMHAEPERVERLRQNGTLFLATAKKLGLDTGFSLGLAVVPIIVGDSLKAVTLSDRLFRRGINVQPI
IHPAVPERASRLRFFLTSEHTPDQIRDTVNAVAEELAAIDKGGSLIEQLLAKRV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=376, Percent_Identity=34.8404255319149, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4758668, Length=376, Percent_Identity=34.8404255319149, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI7657118, Length=369, Percent_Identity=31.7073170731707, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI284448556, Length=355, Percent_Identity=32.112676056338, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI83977442, Length=395, Percent_Identity=29.3670886075949, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=29.7979797979798, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI83977440, Length=396, Percent_Identity=29.7979797979798, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4502025, Length=348, Percent_Identity=29.8850574712644, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI40316939, Length=348, Percent_Identity=29.8850574712644, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=33.955223880597, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=32.9015544041451, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=34.8571428571429, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32566772, Length=445, Percent_Identity=31.0112359550562, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17560914, Length=454, Percent_Identity=28.8546255506608, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17560912, Length=454, Percent_Identity=28.8546255506608, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=394, Percent_Identity=29.6954314720812, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71982625, Length=290, Percent_Identity=31.0344827586207, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=31.0344827586207, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=359, Percent_Identity=32.5905292479109, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320438, Length=370, Percent_Identity=31.3513513513514, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=26.5454545454545, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=31.5492957746479, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17136286, Length=404, Percent_Identity=30.1980198019802, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17137420, Length=362, Percent_Identity=31.2154696132597, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24653280, Length=285, Percent_Identity=30.5263157894737, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653276, Length=285, Percent_Identity=30.5263157894737, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653278, Length=285, Percent_Identity=30.5263157894737, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48552; Mature: 48421

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTARPDGGRAALAGFVTNRLGRATPRPAPVKTASPAGKSAAQNFENLPGYRELKLQRQ
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
AADLIGLGNPFFRVHDAKAGATTRIDQKSFTNFSSYDYLGLNGHPRVSNAAREAIEAYGT
HHHHHCCCCCCEEEECCCCCCCEECCHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHCC
SASASRVVAGERPGHISLEQALAKHYQSEGCIVMVSGHATNVTTIGALLEAGDVIFHDAL
CCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHC
SHNSIVTGAQLSGAQRRSFAHNDLDALETLLQSTRHEHRRALIVVEGLYSMDGDAPDLAG
CCCCEECCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHHCCCCCCHHHH
LVALKKRYDAWLMVDEAHGLGVTGRTGAGLFEHCGVDPREVDIWMGTLSKTLSTCGGYIC
HHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
GPIALIEYLKHTAGGFVYSVGMSPPLAAAAEAALAVMHAEPERVERLRQNGTLFLATAKK
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHH
LGLDTGFSLGLAVVPIIVGDSLKAVTLSDRLFRRGINVQPIIHPAVPERASRLRFFLTSE
HCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEECC
HTPDQIRDTVNAVAEELAAIDKGGSLIEQLLAKRV
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDTARPDGGRAALAGFVTNRLGRATPRPAPVKTASPAGKSAAQNFENLPGYRELKLQRQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
AADLIGLGNPFFRVHDAKAGATTRIDQKSFTNFSSYDYLGLNGHPRVSNAAREAIEAYGT
HHHHHCCCCCCEEEECCCCCCCEECCHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHCC
SASASRVVAGERPGHISLEQALAKHYQSEGCIVMVSGHATNVTTIGALLEAGDVIFHDAL
CCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHC
SHNSIVTGAQLSGAQRRSFAHNDLDALETLLQSTRHEHRRALIVVEGLYSMDGDAPDLAG
CCCCEECCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHHCCCCCCHHHH
LVALKKRYDAWLMVDEAHGLGVTGRTGAGLFEHCGVDPREVDIWMGTLSKTLSTCGGYIC
HHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHH
GPIALIEYLKHTAGGFVYSVGMSPPLAAAAEAALAVMHAEPERVERLRQNGTLFLATAKK
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEHHH
LGLDTGFSLGLAVVPIIVGDSLKAVTLSDRLFRRGINVQPIIHPAVPERASRLRFFLTSE
HCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEECC
HTPDQIRDTVNAVAEELAAIDKGGSLIEQLLAKRV
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA