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The map label for this gene is lpxK

Identifier: 170747321

GI number: 170747321

Start: 929942

End: 930922

Strand: Reverse

Name: lpxK

Synonym: Mrad2831_0888

Alternate gene names: 170747321

Gene position: 930922-929942 (Counterclockwise)

Preceding gene: 170747322

Following gene: 170747318

Centisome position: 15.32

GC content: 79.61

Gene sequence:

>981_bases
ATGCGACCGCCGGCCTTCTGGGCCGCGGGGCCGGACCACCCGGCCGCGCGCGGGCTGGGGCCGCTCGGCGCGGTCTACGG
GGCGCTGGCGGCGCGACGGATGGACCGACCCGGCGCGCGGGCCGGCTGCCCGGTCCTGTGCCTGGGCAACTTCACCCTCG
GCGGTGCCGGCAAGACGCCGGCCGCCCTGGCGGTGGCGGCCCTCGTCGCCGAGCTCGGCGCCGCGCCGGCCTTCCTGTCG
CGCGGATACGGCGGCCGGCTCGCGGGTCCGGTGCGGGTCGATCCCGCGCACCACGCCGCCGCCGAGGTCGGCGACGAGCC
GCTGCTCCTCGCCCGCCGCGCCCCCGCGGTCGTCGCCCGCGACCGCCCGGCCGGGGCCGCCCTGTGCCGGAGCCTCGGCG
CCGACGTCATCGTGATGGATGACGGCCTCCAGAACCCGAGCCTCGCGAAGGACCTCAGCCTCGCGGTGGTCGACGGCCCC
GCCGGCCTCGGCAACGGCCTGCCGTTCCCCGCGGGGCCGCTGCGCGCGCCGCTCGCCCGGCAATGGCCGCATGTCGGCGG
CCTGATCGTGATCGGGAACGGGGCCGGAGGCGACGCGGTCGCCCGGGCGGCCGAGCGGCGCGGCCTCCCGGTCCACGGGG
CGCGCCTCGTCCGTGAGGCGGACGATCTGGCCGGCCGCCGCTGCCTCGCCTTCGCGGGGATCGGCCGCCCGGAGAAATTC
TACGCGACCCTGGCCGAGGCGGGGGCGGTGATCGTCGGGACGCGCCCCTACCCCGACCATCATCCCTACCGGGCGCGCGA
GCTGGCGGCCCTTGCCGAGGCGGCCCGGCGCCTCGACGCCGAGCTCGTCACCACCGAGAAGGACGCGGTGCGCCTGCCTC
GGGCCTTCGCGGCGGGCGTGCGGGTGCTGCGCGTCCGCCTCGCGTTCGACGACGCGGAGGCGCTGCGCCGGCAGATCCGC
GGCGCGCTCGGCGCGCCGTGA

Upstream 100 bases:

>100_bases
CGGTGGCGCGCACGCTCGCGGTCCTCGACCCGTTCGTGGCGCAGATGAAGCTCCAGCGCCTCGACCGCGGCAGCCCCGCG
CGCCCGCTCGCGCGGGCCTG

Downstream 100 bases:

>100_bases
GCGTCAGGGGCGGCCGGTTTCCTTCAGCCGCTTGAGGATCGCCTCGGGGGAGACGTACGCCTCCTGGCGGGCGGCGCTCC
AGTAGCGCAGGGCGTCGAGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRPPAFWAAGPDHPAARGLGPLGAVYGALAARRMDRPGARAGCPVLCLGNFTLGGAGKTPAALAVAALVAELGAAPAFLS
RGYGGRLAGPVRVDPAHHAAAEVGDEPLLLARRAPAVVARDRPAGAALCRSLGADVIVMDDGLQNPSLAKDLSLAVVDGP
AGLGNGLPFPAGPLRAPLARQWPHVGGLIVIGNGAGGDAVARAAERRGLPVHGARLVREADDLAGRRCLAFAGIGRPEKF
YATLAEAGAVIVGTRPYPDHHPYRARELAALAEAARRLDAELVTTEKDAVRLPRAFAAGVRVLRVRLAFDDAEALRRQIR
GALGAP

Sequences:

>Translated_326_residues
MRPPAFWAAGPDHPAARGLGPLGAVYGALAARRMDRPGARAGCPVLCLGNFTLGGAGKTPAALAVAALVAELGAAPAFLS
RGYGGRLAGPVRVDPAHHAAAEVGDEPLLLARRAPAVVARDRPAGAALCRSLGADVIVMDDGLQNPSLAKDLSLAVVDGP
AGLGNGLPFPAGPLRAPLARQWPHVGGLIVIGNGAGGDAVARAAERRGLPVHGARLVREADDLAGRRCLAFAGIGRPEKF
YATLAEAGAVIVGTRPYPDHHPYRARELAALAEAARRLDAELVTTEKDAVRLPRAFAAGVRVLRVRLAFDDAEALRRQIR
GALGAP
>Mature_326_residues
MRPPAFWAAGPDHPAARGLGPLGAVYGALAARRMDRPGARAGCPVLCLGNFTLGGAGKTPAALAVAALVAELGAAPAFLS
RGYGGRLAGPVRVDPAHHAAAEVGDEPLLLARRAPAVVARDRPAGAALCRSLGADVIVMDDGLQNPSLAKDLSLAVVDGP
AGLGNGLPFPAGPLRAPLARQWPHVGGLIVIGNGAGGDAVARAAERRGLPVHGARLVREADDLAGRRCLAFAGIGRPEKF
YATLAEAGAVIVGTRPYPDHHPYRARELAALAEAARRLDAELVTTEKDAVRLPRAFAAGVRVLRVRLAFDDAEALRRQIR
GALGAP

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=305, Percent_Identity=35.4098360655738, Blast_Score=128, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_METRJ (B1LYS1)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001753581.1
- GeneID:   6136904
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_0888
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   CLSK2331442
- HAMAP:   MF_00409
- InterPro:   IPR013785
- InterPro:   IPR003758
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 33463; Mature: 33463

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPAFWAAGPDHPAARGLGPLGAVYGALAARRMDRPGARAGCPVLCLGNFTLGGAGKTP
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEECCCCCCH
AALAVAALVAELGAAPAFLSRGYGGRLAGPVRVDPAHHAAAEVGDEPLLLARRAPAVVAR
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEECCHHHHHHHCCCCCEEEECCCCEEEEC
DRPAGAALCRSLGADVIVMDDGLQNPSLAKDLSLAVVDGPAGLGNGLPFPAGPLRAPLAR
CCCHHHHHHHHHCCCEEEECCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHH
QWPHVGGLIVIGNGAGGDAVARAAERRGLPVHGARLVREADDLAGRRCLAFAGIGRPEKF
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHH
YATLAEAGAVIVGTRPYPDHHPYRARELAALAEAARRLDAELVTTEKDAVRLPRAFAAGV
HHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEECCHHHHHCCHHHHHHH
RVLRVRLAFDDAEALRRQIRGALGAP
HHHHEEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPPAFWAAGPDHPAARGLGPLGAVYGALAARRMDRPGARAGCPVLCLGNFTLGGAGKTP
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEECCCCCCH
AALAVAALVAELGAAPAFLSRGYGGRLAGPVRVDPAHHAAAEVGDEPLLLARRAPAVVAR
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEECCHHHHHHHCCCCCEEEECCCCEEEEC
DRPAGAALCRSLGADVIVMDDGLQNPSLAKDLSLAVVDGPAGLGNGLPFPAGPLRAPLAR
CCCHHHHHHHHHCCCEEEECCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHH
QWPHVGGLIVIGNGAGGDAVARAAERRGLPVHGARLVREADDLAGRRCLAFAGIGRPEKF
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHH
YATLAEAGAVIVGTRPYPDHHPYRARELAALAEAARRLDAELVTTEKDAVRLPRAFAAGV
HHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEECCHHHHHCCHHHHHHH
RVLRVRLAFDDAEALRRQIRGALGAP
HHHHEEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA