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The map label for this gene is clpA [C]

Identifier: 170747221

GI number: 170747221

Start: 825649

End: 828135

Strand: Reverse

Name: clpA [C]

Synonym: Mrad2831_0787

Alternate gene names: 170747221

Gene position: 828135-825649 (Counterclockwise)

Preceding gene: 170747222

Following gene: 170747220

Centisome position: 13.63

GC content: 68.15

Gene sequence:

>2487_bases
TTGCCAAGCTTCTCACGCAGCCTAGAACAAGCCCTCCACCGCGCCCTGGCGCTCGCCGGCGAGCGCCGGCACGAATACGC
GACGCTGGAGCATCTCCTGCTCGCCCTGGTGGATGACCAAGATGCGGCCGCGGTCATGCGCGCCTGCAACGTCGAGATCG
ACACGCTCAAGCGCAGCCTGGTCGACTACGTCGACACCGAGCTCTCCAACCTCACCGGCGACGGCCGTCAGGACGCCAAG
CCCACGGCCGGATTCCAGCGCGTCATCCAGCGCGCGGTGATCCACGTCCAGTCCTCGGGCCGCGAGGAGGTGACCGGCGC
CAACGTGCTGGTGGCGATCTTCGCCGAGCGCGAGAGCCACGCCGCCTACTTCCTGCAGGAGCAGGACATGACCCGCTACG
ACGCGGTCAACTACATCAGCCACGGCATCGCCAAGCGGCCCGGCGCCTCCGAGGCGAAGCCGGTGCGCGGCGCCGACGAG
GAGGGCGCCTCCGAGCGGCCGAGCGACGACGGCGATCCCCGCGGCGCCAAGAAGAAGGGCGACGCGCTCGACGCCTACTG
CGTCAACCTCAACAAGAAGGCGCGCGACGGCAAGATCGACCCGCTGATCGGCCGCGAGAGCGAGGTCCAGCGCACCATCC
AGGTGCTCTGCCGGCGGCAGAAGAACAACCCGCTGCTCGTGGGCGATCCCGGCGTCGGCAAGACCGCGATCGCCGAGGGT
CTGGCGCGCAAGATCATCCAGCACGAAGTGCCGGAGGTTCTGGCCGACGCGACCGTCTTCTCCCTCGACATGGGCACGCT
GCTCGCCGGCACCCGCTATCGCGGCGACTTCGAGGAGCGCCTCAAGCAGGTGATGAAGGAGATCGAGGCGCACCCGAACG
CCATCATGTTCATCGACGAGATCCACACGGTGATCGGCGCCGGTGCGACCTCGGGCGGGGCCATGGACGCGTCGAACCTG
CTGAAGCCTGCCCTGGCCTCCGGCACGCTGCGCTGCATCGGCTCGACCACCTACAAGGAGTACCGCCAGTACTTCGAGAA
GGATCGCGCCCTGGTGCGCCGGTTCCAGAAGATCGACGTCAACGAGCCGTCGATCCCCGACACGATCGAGATCGTGAAGG
GGCTGCGGCCGTACTTCGAGGAGTTCCACAAGCTCAAGTACACGACCGAGGCCGTGAAGGCCGCGGTGGAGCTGTCGGCC
CGCTACATCAACGACCGCAAGCTGCCCGACAAGGCGATCGACGTGATCGACGAGACCGGTGCCTCGCAGATGCTGGTGCC
CGAGGCGCGCCGCAAGCGCACCATCGGCATCAAGGAGATCGAGGCGACCATCGCCACGATGGCCCGGATCCCGCCGAAGA
CCGTTTCCAAGGACGACGCGGTGGTGCTCCAGCACCTGACCGAGAACCTGAAGCGGGTGGTCTACGGCCAGCCGAACGCC
ATCGAGGCCCTGACCTCGGCGATCAAGCTGGCCCGGGCCGGCCTGCGCGACCCGGATAAGCCGATCGGCTCGTACCTGTT
CGCGGGCCCGACCGGCGTCGGCAAGACCGAGGCCGCCAAGCAGCTCGCCGCATCCCTCGGCGTCGAGATGCTGCGCTTCG
ACATGTCGGAGTACATGGAGCGCCACACGGTGAGCCGCCTGATCGGCGCGCCCCCCGGCTACGTGGGCTTCGACCAGGGC
GGCCTGCTCACCGACGGGATCGATCAGCACCCGCACTGCGTGCTCCTCCTCGACGAGATCGAGAAGGCGCATCCGGACCT
GTTCAACATCCTGCTGCAGGTGATGGACCACGGGAAGCTGACCGACCACAACGGCAAGCAGGTCGATTTCCGCAACGTCA
TCATCATCATGACGTCGAATGCGGGCGCGTCCGATCTGGCCAAGGCCGCCTACGGCTTCACGCAGTCGAAGCGCTCCGGC
GACGACGTCGAGGCGATCAACCGCCTGTTCGCGCCGGAATTCCGCAACCGGCTCGACGCGATCATCTCGTTCGGCCACCT
GCCGAAGGAGGTGGTGGCGAAGGTGGTGGACAAGTTCGTCCTCCAGCTCGAGGCGCAGCTCGCCGACCGCAACGTCACGA
TCGAGCTCTCCGACGAGGCTCGGGACTGGCTGGTGGAGCACGGCTACGACGACGCGATGGGCGCCCGGCCCATGGCCCGG
CTGATCCAGTCGACCATCAAGACGCCGCTCGCCGACGAGGTCCTGTTCGGCCGGCTGAAGGACGGCGGCGCGGTCCGCGT
GGTCGTCCGCAAGCCGGAGGACGGCGAGGCCAAGACCGGCGCGAAGGACGGCCTGACCTTCGAGTTCCCGGCCGGCCCGG
TCACGCCCAAGCCCGAGAAGGACGTGACCAACGCCGCCAAGCGCCACAAGCGCGCCAAGCCCCGCACCGCGTCCCGGAAG
AAGACGCCGAAGGACAACAAGGGTGGCGGCGGCAGCTCGGGCGGCGGCGTCCGGACCGTGCCGAAGGTGCCACTCGTGCG
CGCCTAA

Upstream 100 bases:

>100_bases
AGGTCATGGACTTCGCGCGCAAACACCAACATCCTCTCCAGTGCGTTATGGAAAAGAAATAGGCGCCGCTCGCGGTAGGC
ACGAAGGACAGAGGCCAGCT

Downstream 100 bases:

>100_bases
TGCTGTGCGTGCCGGCCGGCGGCCTTCCGGACTCGGGGGCCGCCGGTCTATGACCGCCGCGACGCGCATGCGCCGCGGCG
AGGAGGCGCCCGATGACTGA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 828; Mature: 827

Protein sequence:

>828_residues
MPSFSRSLEQALHRALALAGERRHEYATLEHLLLALVDDQDAAAVMRACNVEIDTLKRSLVDYVDTELSNLTGDGRQDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGASEAKPVRGADE
EGASERPSDDGDPRGAKKKGDALDAYCVNLNKKARDGKIDPLIGRESEVQRTIQVLCRRQKNNPLLVGDPGVGKTAIAEG
LARKIIQHEVPEVLADATVFSLDMGTLLAGTRYRGDFEERLKQVMKEIEAHPNAIMFIDEIHTVIGAGATSGGAMDASNL
LKPALASGTLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSIPDTIEIVKGLRPYFEEFHKLKYTTEAVKAAVELSA
RYINDRKLPDKAIDVIDETGASQMLVPEARRKRTIGIKEIEATIATMARIPPKTVSKDDAVVLQHLTENLKRVVYGQPNA
IEALTSAIKLARAGLRDPDKPIGSYLFAGPTGVGKTEAAKQLAASLGVEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGIDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQVDFRNVIIIMTSNAGASDLAKAAYGFTQSKRSG
DDVEAINRLFAPEFRNRLDAIISFGHLPKEVVAKVVDKFVLQLEAQLADRNVTIELSDEARDWLVEHGYDDAMGARPMAR
LIQSTIKTPLADEVLFGRLKDGGAVRVVVRKPEDGEAKTGAKDGLTFEFPAGPVTPKPEKDVTNAAKRHKRAKPRTASRK
KTPKDNKGGGGSSGGGVRTVPKVPLVRA

Sequences:

>Translated_828_residues
MPSFSRSLEQALHRALALAGERRHEYATLEHLLLALVDDQDAAAVMRACNVEIDTLKRSLVDYVDTELSNLTGDGRQDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGASEAKPVRGADE
EGASERPSDDGDPRGAKKKGDALDAYCVNLNKKARDGKIDPLIGRESEVQRTIQVLCRRQKNNPLLVGDPGVGKTAIAEG
LARKIIQHEVPEVLADATVFSLDMGTLLAGTRYRGDFEERLKQVMKEIEAHPNAIMFIDEIHTVIGAGATSGGAMDASNL
LKPALASGTLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSIPDTIEIVKGLRPYFEEFHKLKYTTEAVKAAVELSA
RYINDRKLPDKAIDVIDETGASQMLVPEARRKRTIGIKEIEATIATMARIPPKTVSKDDAVVLQHLTENLKRVVYGQPNA
IEALTSAIKLARAGLRDPDKPIGSYLFAGPTGVGKTEAAKQLAASLGVEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGIDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQVDFRNVIIIMTSNAGASDLAKAAYGFTQSKRSG
DDVEAINRLFAPEFRNRLDAIISFGHLPKEVVAKVVDKFVLQLEAQLADRNVTIELSDEARDWLVEHGYDDAMGARPMAR
LIQSTIKTPLADEVLFGRLKDGGAVRVVVRKPEDGEAKTGAKDGLTFEFPAGPVTPKPEKDVTNAAKRHKRAKPRTASRK
KTPKDNKGGGGSSGGGVRTVPKVPLVRA
>Mature_827_residues
PSFSRSLEQALHRALALAGERRHEYATLEHLLLALVDDQDAAAVMRACNVEIDTLKRSLVDYVDTELSNLTGDGRQDAKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGASEAKPVRGADEE
GASERPSDDGDPRGAKKKGDALDAYCVNLNKKARDGKIDPLIGRESEVQRTIQVLCRRQKNNPLLVGDPGVGKTAIAEGL
ARKIIQHEVPEVLADATVFSLDMGTLLAGTRYRGDFEERLKQVMKEIEAHPNAIMFIDEIHTVIGAGATSGGAMDASNLL
KPALASGTLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSIPDTIEIVKGLRPYFEEFHKLKYTTEAVKAAVELSAR
YINDRKLPDKAIDVIDETGASQMLVPEARRKRTIGIKEIEATIATMARIPPKTVSKDDAVVLQHLTENLKRVVYGQPNAI
EALTSAIKLARAGLRDPDKPIGSYLFAGPTGVGKTEAAKQLAASLGVEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG
LLTDGIDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKLTDHNGKQVDFRNVIIIMTSNAGASDLAKAAYGFTQSKRSGD
DVEAINRLFAPEFRNRLDAIISFGHLPKEVVAKVVDKFVLQLEAQLADRNVTIELSDEARDWLVEHGYDDAMGARPMARL
IQSTIKTPLADEVLFGRLKDGGAVRVVVRKPEDGEAKTGAKDGLTFEFPAGPVTPKPEKDVTNAAKRHKRAKPRTASRKK
TPKDNKGGGGSSGGGVRTVPKVPLVRA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=33.9622641509434, Blast_Score=163, Evalue=7e-40,
Organism=Escherichia coli, GI1787109, Length=770, Percent_Identity=56.6233766233766, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=281, Percent_Identity=53.7366548042705, Blast_Score=295, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=319, Percent_Identity=46.0815047021944, Blast_Score=284, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=364, Percent_Identity=39.8351648351648, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 90665; Mature: 90534

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSRSLEQALHRALALAGERRHEYATLEHLLLALVDDQDAAAVMRACNVEIDTLKRSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
VDYVDTELSNLTGDGRQDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGASEAKPVRGADEEGASERPSDDGDPRGAKKKG
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DALDAYCVNLNKKARDGKIDPLIGRESEVQRTIQVLCRRQKNNPLLVGDPGVGKTAIAEG
CCHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LARKIIQHEVPEVLADATVFSLDMGTLLAGTRYRGDFEERLKQVMKEIEAHPNAIMFIDE
HHHHHHHHHHHHHHHCCHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALASGTLRCIGSTTYKEYRQYFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPSIPDTIEIVKGLRPYFEEFHKLKYTTEAVKAAVELSARYINDRKLPDKAIDVIDETG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
ASQMLVPEARRKRTIGIKEIEATIATMARIPPKTVSKDDAVVLQHLTENLKRVVYGQPNA
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALTSAIKLARAGLRDPDKPIGSYLFAGPTGVGKTEAAKQLAASLGVEMLRFDMSEYME
HHHHHHHHHHHHHCCCCCCCCHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGIDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKQVDFRNVIIIMTSNAGASDLAKAAYGFTQSKRSGDDVEAINRLFAPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
IISFGHLPKEVVAKVVDKFVLQLEAQLADRNVTIELSDEARDWLVEHGYDDAMGARPMAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHCCCCHHHH
LIQSTIKTPLADEVLFGRLKDGGAVRVVVRKPEDGEAKTGAKDGLTFEFPAGPVTPKPEK
HHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCH
DVTNAAKRHKRAKPRTASRKKTPKDNKGGGGSSGGGVRTVPKVPLVRA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSFSRSLEQALHRALALAGERRHEYATLEHLLLALVDDQDAAAVMRACNVEIDTLKRSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
VDYVDTELSNLTGDGRQDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGASEAKPVRGADEEGASERPSDDGDPRGAKKKG
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DALDAYCVNLNKKARDGKIDPLIGRESEVQRTIQVLCRRQKNNPLLVGDPGVGKTAIAEG
CCHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LARKIIQHEVPEVLADATVFSLDMGTLLAGTRYRGDFEERLKQVMKEIEAHPNAIMFIDE
HHHHHHHHHHHHHHHCCHHEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALASGTLRCIGSTTYKEYRQYFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPSIPDTIEIVKGLRPYFEEFHKLKYTTEAVKAAVELSARYINDRKLPDKAIDVIDETG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
ASQMLVPEARRKRTIGIKEIEATIATMARIPPKTVSKDDAVVLQHLTENLKRVVYGQPNA
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALTSAIKLARAGLRDPDKPIGSYLFAGPTGVGKTEAAKQLAASLGVEMLRFDMSEYME
HHHHHHHHHHHHHCCCCCCCCHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGIDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKQVDFRNVIIIMTSNAGASDLAKAAYGFTQSKRSGDDVEAINRLFAPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
IISFGHLPKEVVAKVVDKFVLQLEAQLADRNVTIELSDEARDWLVEHGYDDAMGARPMAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHCCCCHHHH
LIQSTIKTPLADEVLFGRLKDGGAVRVVVRKPEDGEAKTGAKDGLTFEFPAGPVTPKPEK
HHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCH
DVTNAAKRHKRAKPRTASRKKTPKDNKGGGGSSGGGVRTVPKVPLVRA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]